AU2016338557B2 - Combination therapy for treating malignancies - Google Patents

Combination therapy for treating malignancies Download PDF

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Publication number
AU2016338557B2
AU2016338557B2 AU2016338557A AU2016338557A AU2016338557B2 AU 2016338557 B2 AU2016338557 B2 AU 2016338557B2 AU 2016338557 A AU2016338557 A AU 2016338557A AU 2016338557 A AU2016338557 A AU 2016338557A AU 2016338557 B2 AU2016338557 B2 AU 2016338557B2
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AU
Australia
Prior art keywords
compound
azacitidine
day
administered
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2016338557A
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English (en)
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AU2016338557A1 (en
Inventor
Samuel V. Agresta
Vivek Saroj Kumar Chopra
Jorge Dimartino
Laurie KENVIN
Robert Douglas Knight
Kyle J. Macbeth
Krishnan VISWANADHAN
Qiang Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Celgene Corp
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Les Laboratoires Servier SAS
Celgene Corp
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Publication of AU2016338557A1 publication Critical patent/AU2016338557A1/en
Assigned to CELGENE CORPORATION, LES LABORATOIRES SERVIER SAS reassignment CELGENE CORPORATION Request for Assignment Assignors: AGIOS PHARMACEUTICALS, INC., CELGENE CORPORATION
Assigned to LES LABORATOIRES SERVIER, CELGENE CORPORATION reassignment LES LABORATOIRES SERVIER Amend patent request/document other than specification (104) Assignors: CELGENE CORPORATION, LES LABORATOIRES SERVIER SAS
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2016338557A 2015-10-15 2016-10-14 Combination therapy for treating malignancies Active AU2016338557B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562242282P 2015-10-15 2015-10-15
US62/242,282 2015-10-15
PCT/US2016/057042 WO2017066571A1 (en) 2015-10-15 2016-10-14 Combination therapy for treating malignancies

Publications (2)

Publication Number Publication Date
AU2016338557A1 AU2016338557A1 (en) 2018-05-31
AU2016338557B2 true AU2016338557B2 (en) 2022-05-26

Family

ID=58518368

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016338557A Active AU2016338557B2 (en) 2015-10-15 2016-10-14 Combination therapy for treating malignancies

Country Status (28)

Country Link
US (2) US10653710B2 (enExample)
EP (1) EP3362066B1 (enExample)
JP (1) JP7033061B2 (enExample)
KR (1) KR102699521B1 (enExample)
CN (1) CN108697698B (enExample)
AU (1) AU2016338557B2 (enExample)
CA (1) CA3002068A1 (enExample)
CL (1) CL2018000943A1 (enExample)
CY (1) CY1124951T1 (enExample)
DK (1) DK3362066T3 (enExample)
EA (1) EA039829B1 (enExample)
ES (1) ES2897959T3 (enExample)
HR (1) HRP20211790T1 (enExample)
HU (1) HUE057263T2 (enExample)
IL (1) IL258685B (enExample)
LT (1) LT3362066T (enExample)
MA (1) MA43000B1 (enExample)
MD (1) MD3362066T2 (enExample)
MX (1) MX386735B (enExample)
PL (1) PL3362066T3 (enExample)
PT (1) PT3362066T (enExample)
RS (1) RS62829B1 (enExample)
SG (2) SG11201803091PA (enExample)
SI (1) SI3362066T1 (enExample)
SM (1) SMT202100658T1 (enExample)
UA (1) UA123400C2 (enExample)
WO (1) WO2017066571A1 (enExample)
ZA (1) ZA201803166B (enExample)

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WO2015003360A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
US20150031627A1 (en) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
AU2015229214B2 (en) 2014-03-14 2019-07-11 Les Laboratoires Servier Pharmaceutical compositions of therapeutically active compounds
KR20250126877A (ko) 2015-10-15 2025-08-25 르 라보레또레 쎄르비에르 악성 종양의 치료를 위한 조합물 요법
SMT202100658T1 (it) 2015-10-15 2022-03-21 Celgene Corp Terapia combinata per il trattamento dei tumori maligni
KR20250130443A (ko) * 2017-06-12 2025-09-01 르 라보레또레 쎄르비에르 병용 요법을 사용한 뇌 종양 치료 방법
JP2020535112A (ja) * 2017-08-01 2020-12-03 ドイッチェス・クレープスフォルシュングスツェントルムＤｅｕｔｓｃｈｅｓ Ｋｒｅｂｓｆｏｒｓｃｈｕｎｇｓｚｅｎｔｒｕｍ Ｍｉｄｈ１阻害剤とｄｎａ低メチル化剤（ｈｍａ）との組合せ
WO2019099653A1 (en) * 2017-11-16 2019-05-23 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
US10980788B2 (en) * 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
UA129800C2 (uk) * 2018-07-06 2025-08-06 Ле Лаборатуар Сервье Тверда форма івосиденібу
CN109224061B (zh) * 2018-11-16 2022-01-07 上海市肺科医院 化合物ag120或其药学上可接受的盐在制备预防或治疗结核病的药物中的用途
MX2021015993A (es) 2019-06-20 2022-04-06 Celgene Corp Azacitidina en combinación con venetoclax, gilteritinib, midostaurina u otros compuestos para el tratamiento de leucemia o síndrome mielodisplásico.
GB201912411D0 (en) * 2019-08-29 2019-10-16 Johnson Matthey Plc Crystalline forms of ivosidenib
EP4041922A4 (en) * 2019-10-07 2023-11-01 University Hospitals Cleveland Medical Center METHOD FOR TREATING WILD-TYPE ISOCITRATE DEHYDROGENASE-1 CANCER
GB2590601B (en) * 2019-11-13 2024-01-31 Thermo Fisher Scient Bremen Gmbh Method of mass spectrometry
JP7596399B2 (ja) 2020-03-23 2024-12-09 イーライ リリー アンド カンパニー 変異ｉｄｈ阻害剤との併用療法

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