AU2016306275A1 - RNAi therapy for Hepatitis B virus infection - Google Patents
RNAi therapy for Hepatitis B virus infection Download PDFInfo
- Publication number
- AU2016306275A1 AU2016306275A1 AU2016306275A AU2016306275A AU2016306275A1 AU 2016306275 A1 AU2016306275 A1 AU 2016306275A1 AU 2016306275 A AU2016306275 A AU 2016306275A AU 2016306275 A AU2016306275 A AU 2016306275A AU 2016306275 A1 AU2016306275 A1 AU 2016306275A1
- Authority
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- Australia
- Prior art keywords
- base
- mod
- nucleoside
- artificial sequence
- rnai trigger
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 108091030071 RNAI Proteins 0.000 title claims abstract 675
- 208000002672 hepatitis B Diseases 0.000 title claims 3
- 238000002560 therapeutic procedure Methods 0.000 title claims 2
- 241000700721 Hepatitis B virus Species 0.000 claims abstract description 93
- 239000000203 mixture Substances 0.000 claims abstract description 33
- 238000000034 method Methods 0.000 claims abstract description 14
- 230000014509 gene expression Effects 0.000 claims abstract description 8
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 7
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 4
- 239000003814 drug Substances 0.000 claims abstract 4
- 239000002777 nucleoside Substances 0.000 claims description 1705
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 631
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| PCT/US2016/045714 WO2017027350A2 (en) | 2015-08-07 | 2016-08-05 | Rnai therapy for hepatitis b virus infection |
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2016
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- 2016-08-05 KR KR1020187005140A patent/KR20180038465A/ko not_active Ceased
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- 2016-08-05 JP JP2018506407A patent/JP7336191B2/ja active Active
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| US20170035796A1 (en) | 2017-02-09 |
| CN108271387B (zh) | 2023-06-27 |
| JP2018523668A (ja) | 2018-08-23 |
| US10130651B2 (en) | 2018-11-20 |
| EP3332007A2 (en) | 2018-06-13 |
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| US11534453B2 (en) | 2022-12-27 |
| CN108271387A (zh) | 2018-07-10 |
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| EP3332007A4 (en) | 2019-07-17 |
| CA2991639A1 (en) | 2017-02-16 |
| WO2017027350A2 (en) | 2017-02-16 |
| JP7336191B2 (ja) | 2023-08-31 |
| KR20180038465A (ko) | 2018-04-16 |
| AU2024200142A1 (en) | 2024-02-01 |
| IL257384A (en) | 2018-04-30 |
| US20230355654A1 (en) | 2023-11-09 |
| US20210052624A1 (en) | 2021-02-25 |
| WO2017027350A3 (en) | 2017-03-23 |
| CN115957337A (zh) | 2023-04-14 |
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