AU2015330731B2 - Treatment of cancer using TLR9 agonist with checkpoint inhibitors - Google Patents

Treatment of cancer using TLR9 agonist with checkpoint inhibitors Download PDF

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Publication number
AU2015330731B2
AU2015330731B2 AU2015330731A AU2015330731A AU2015330731B2 AU 2015330731 B2 AU2015330731 B2 AU 2015330731B2 AU 2015330731 A AU2015330731 A AU 2015330731A AU 2015330731 A AU2015330731 A AU 2015330731A AU 2015330731 B2 AU2015330731 B2 AU 2015330731B2
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Prior art keywords
cancer
inhibitor
tumor
immune checkpoint
cell
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Ceased
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AU2015330731A
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AU2015330731A1 (en
Inventor
Sudhir Agrawal
Wayne JIANG
Daqing Wang
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Aceragen Inc
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Idera Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
AU2015330731A 2014-10-10 2015-10-09 Treatment of cancer using TLR9 agonist with checkpoint inhibitors Ceased AU2015330731B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020250293A AU2020250293A1 (en) 2014-10-10 2020-10-09 Treatment of cancer using TLR9 agonist with checkpoint inhibitors

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462062274P 2014-10-10 2014-10-10
US62/062,274 2014-10-10
US201562218934P 2015-09-15 2015-09-15
US62/218,934 2015-09-15
PCT/US2015/054899 WO2016057898A1 (en) 2014-10-10 2015-10-09 Treatment of cancer using tlr9 agonist with checkpoint inhibitors

Related Child Applications (1)

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AU2020250293A Division AU2020250293A1 (en) 2014-10-10 2020-10-09 Treatment of cancer using TLR9 agonist with checkpoint inhibitors

Publications (2)

Publication Number Publication Date
AU2015330731A1 AU2015330731A1 (en) 2017-05-04
AU2015330731B2 true AU2015330731B2 (en) 2020-07-09

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AU2015330731A Ceased AU2015330731B2 (en) 2014-10-10 2015-10-09 Treatment of cancer using TLR9 agonist with checkpoint inhibitors
AU2020250293A Abandoned AU2020250293A1 (en) 2014-10-10 2020-10-09 Treatment of cancer using TLR9 agonist with checkpoint inhibitors

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Country Status (11)

Country Link
US (3) US20160101128A1 (https=)
EP (2) EP3204040B1 (https=)
JP (2) JP6991857B2 (https=)
KR (1) KR20170072244A (https=)
CN (2) CN115040532A (https=)
AU (2) AU2015330731B2 (https=)
CA (1) CA2964155A1 (https=)
ES (1) ES2908056T3 (https=)
IL (1) IL251669B2 (https=)
MX (2) MX391478B (https=)
WO (1) WO2016057898A1 (https=)

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