AU2014232882B2 - Automated immunoanalyzer system for performing diagnostic assays for allergies and autoimmune diseases - Google Patents

Automated immunoanalyzer system for performing diagnostic assays for allergies and autoimmune diseases Download PDF

Info

Publication number
AU2014232882B2
AU2014232882B2 AU2014232882A AU2014232882A AU2014232882B2 AU 2014232882 B2 AU2014232882 B2 AU 2014232882B2 AU 2014232882 A AU2014232882 A AU 2014232882A AU 2014232882 A AU2014232882 A AU 2014232882A AU 2014232882 B2 AU2014232882 B2 AU 2014232882B2
Authority
AU
Australia
Prior art keywords
complex
immune
conjugate
capture reagent
incubating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2014232882A
Other languages
English (en)
Other versions
AU2014232882A1 (en
Inventor
Douglas John Canfield
Jennifer Bao-Guey Chan
Vanessa Camille Chua
Ronald Norman Diamond
Michelle Fredrika Forshager
Steve Michael GANN
Eric Darnell HALL
Victoria HUNG
Tae Ho Hwang
Fran Zylo Cuaresma Jacalne
Travis KNOX
Yi Luo
Evan Phillip Mcmenamy
John Lewis Morton
Anatoly Moskalev
Nanditha RAGHAVAN
Taylor Addison Reid
Morkoah Blay Reliford
Dennis Edwin Rieger
Bruce Alan Sargeant
Rachel Sarah Schell
Edsel Lawrence Noche Sinson
Marinela Gombosev Stack
Elaine Grace Taine
Teri TAYLOR
Linda Marie Trondle
Stephanie Tuvi Ortega
Mark David Van Cleve
Scott William Vande Wetering
James Weston
Kylie Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hycor Biomedical LLC
Original Assignee
Hycor Biomedical LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hycor Biomedical LLC filed Critical Hycor Biomedical LLC
Publication of AU2014232882A1 publication Critical patent/AU2014232882A1/en
Application granted granted Critical
Publication of AU2014232882B2 publication Critical patent/AU2014232882B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/5695—Mycobacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1011—Control of the position or alignment of the transfer device
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0453—Multiple carousels working in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1062—General features of the devices using the transfer device for another function for testing the liquid while it is in the transfer device
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/04—Batch operation; multisample devices
    • G01N2201/0469—One cell, sequential, e.g. successive samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/064—Stray light conditioning
    • G01N2201/0646—Light seals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides
    • G01N2201/084—Fibres for remote transmission
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/127—Calibration; base line adjustment; drift compensation
    • G01N2201/12707—Pre-test of apparatus, e.g. dark test, sensor test
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/62—Insulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/119163—Automated chemical analysis with aspirator of claimed structure

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Plasma & Fusion (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Robotics (AREA)
AU2014232882A 2013-03-15 2014-03-17 Automated immunoanalyzer system for performing diagnostic assays for allergies and autoimmune diseases Ceased AU2014232882B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361791295P 2013-03-15 2013-03-15
US201361791879P 2013-03-15 2013-03-15
US61/791,879 2013-03-15
US61/791,295 2013-03-15
PCT/US2014/030373 WO2014145581A1 (en) 2013-03-15 2014-03-17 Automated immunoanalyzer system for performing diagnostic assays for allergies and autoimmune diseases

Publications (2)

Publication Number Publication Date
AU2014232882A1 AU2014232882A1 (en) 2015-10-01
AU2014232882B2 true AU2014232882B2 (en) 2018-03-22

Family

ID=50686181

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2014232882A Ceased AU2014232882B2 (en) 2013-03-15 2014-03-17 Automated immunoanalyzer system for performing diagnostic assays for allergies and autoimmune diseases
AU2014232782A Ceased AU2014232782B2 (en) 2013-03-15 2014-03-17 Device and associated methods for performing luminescence and fluorescence measurements of a sample
AU2018220044A Abandoned AU2018220044A1 (en) 2013-03-15 2018-08-22 Device and associated methods for performing luminescence and fluorescence measurements of a sample

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2014232782A Ceased AU2014232782B2 (en) 2013-03-15 2014-03-17 Device and associated methods for performing luminescence and fluorescence measurements of a sample
AU2018220044A Abandoned AU2018220044A1 (en) 2013-03-15 2018-08-22 Device and associated methods for performing luminescence and fluorescence measurements of a sample

Country Status (8)

Country Link
US (13) US9658225B2 (enExample)
EP (3) EP2972230B1 (enExample)
JP (3) JP6389868B2 (enExample)
CN (4) CN105308437B (enExample)
AU (3) AU2014232882B2 (enExample)
CA (2) CA2905165A1 (enExample)
HK (2) HK1220759A1 (enExample)
WO (2) WO2014145619A1 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8866912B2 (en) 2013-03-10 2014-10-21 Pelican Imaging Corporation System and methods for calibration of an array camera using a single captured image
EP2972230B1 (en) 2013-03-15 2021-07-21 Hycor Biomedical LLC Device and associated method for performing luminescence and fluorescence measurements of a sample
JP6323816B2 (ja) * 2014-05-19 2018-05-16 システム・インスツルメンツ株式会社 自動分析装置、分析システム及び自動分析装置の動作方法
US10661268B2 (en) * 2014-06-30 2020-05-26 Beacon Technologies, LLC Pipette tip system, device and method of use
EP3262397B1 (en) * 2015-02-27 2022-06-08 Hycor Biomedical, LLC Apparatuses for suspending and washing the contents of a plurality of cuvettes
EP3278109A4 (en) * 2015-03-30 2018-08-15 Hycor Biomedical, Inc. Automated immunoanalyzer system for performing diagnostic assays for autoimmune and infectious diseases
US10288633B2 (en) 2015-06-26 2019-05-14 Abbott Laboratories Reaction vessel moving member for moving reaction vessels from a processing track to a rotating device in a diagnostic analyzer
HK1254881A1 (zh) * 2015-07-15 2019-07-26 Hycor Biomedical, Llc 可定制仪器
WO2017015662A1 (en) * 2015-07-23 2017-01-26 Hycor Biomedical, Inc On-board kitting
CN105403692A (zh) * 2015-11-17 2016-03-16 苏州浩欧博生物医药有限公司 检测屋尘螨过敏原特异性IgE抗体的试剂盒及方法
CN105353133A (zh) * 2015-11-17 2016-02-24 苏州浩欧博生物医药有限公司 检测粉尘螨过敏原特异性IgE抗体的试剂盒及方法
CN105353134A (zh) * 2015-11-17 2016-02-24 苏州浩欧博生物医药有限公司 检测狗毛过敏原特异性IgE抗体的试剂盒及方法
TW201832726A (zh) * 2016-11-01 2018-09-16 美商海科生醫有限責任公司 可基於輸入數據建議檢測之免疫檢測系統
CN108132344B (zh) * 2016-11-22 2021-06-29 博阳生物科技（上海）有限公司 免疫测定方法、用于鉴定免疫测定的系统和试剂盒
CN107389615B (zh) * 2016-12-20 2020-03-24 苏州赛德福科学仪器有限公司 一种蒸发光检测装置及基于该装置的蒸发光测量方法
CN107703123A (zh) * 2017-09-15 2018-02-16 江苏浩欧博生物医药股份有限公司 一种血清类胰蛋白酶的化学发光定量检测试剂盒及其制备方法和检测方法
CN111263885B (zh) 2017-09-19 2024-12-06 拜克门寇尔特公司 用于化学发光测量中的模拟光测量和光子计数的系统
CN107766772B (zh) * 2017-11-23 2024-05-17 安派科生物医学科技（丽水）有限公司 一种样品录入装置
CN108593949B (zh) * 2018-02-11 2024-01-26 金博特（北京）生物科技有限公司 一种化学发光免疫分析仪
IT201800008227A1 (it) * 2018-08-29 2020-02-29 Cannavale Giuseppe Metodo e sistema per la determinazione di immunoglobuline totali o dirette contro allergeni o altre molecole in campioni acquosi
EP3867644B1 (en) 2018-08-29 2024-02-21 Cannavale, Giuseppe System and method for solid phase analysis of biological samples
US12163885B2 (en) 2018-08-31 2024-12-10 Shimadzu Corporation Analysis device, analysis method, trace liquid collection device, and trace liquid collection method
CN109030809B (zh) * 2018-10-31 2021-08-20 蓝怡科技集团股份有限公司 一种过敏原IgE抗体自动分析仪
WO2020157789A1 (ja) * 2019-01-28 2020-08-06 株式会社島津製作所 分析装置
CN110596371B (zh) * 2019-09-20 2023-04-07 郑州安图生物工程股份有限公司 一种全自动化学发光测定仪磁珠回收率和试剂针精密性评估方法以及试剂盒
CN111518780B (zh) * 2020-06-04 2022-06-14 郑州伊美诺生物技术有限公司 脱辅基辣根过氧化物酶的制备方法
US11480565B2 (en) 2020-06-12 2022-10-25 Bio-Rad Laboratories, Inc. Automated immunoassay
GB202009823D0 (en) * 2020-06-26 2020-08-12 Stimson William Howard Automated quantitative assay device and a method of performing the quantitative assays
CN112748248B (zh) * 2020-12-23 2022-06-14 郑州安图生物工程股份有限公司 一种牛奶过敏原特异性IgE检测试剂盒
CN112666154A (zh) * 2021-01-26 2021-04-16 安图实验仪器(郑州)有限公司 光学信号检测装置
JP7693173B2 (ja) * 2021-09-24 2025-06-17 学校法人杏林学園 マカダミアナッツアレルゲン特異的ＩｇＥを検出するための方法、マカダミアナッツアレルギー診断用体外診断薬、マカダミアナッツアレルゲン特異的ＩｇＥ検出用キット、およびマカダミアナッツアレルゲンの検出方法
IT202200010064A1 (it) * 2022-05-16 2023-11-16 Optoelettronica Italia S R L Dispositivo e metodo per il rilevamento di biomolecole
CN122535823A (zh) * 2024-01-16 2026-08-07 贝克曼库尔特有限公司 用于自动化临床分析仪的替代底物包和使用方法
WO2025155701A1 (en) * 2024-01-16 2025-07-24 Beckman Coulter, Inc. Automated clinical analyzer with alternative substrate and method of use
CN118501432B (zh) * 2024-07-18 2024-09-27 山东省动物疫病预防与控制中心(山东省人畜共患病流调监测中心) 布鲁氏菌病cf-elisa抗体检测试剂盒

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120077286A1 (en) * 2001-12-06 2012-03-29 Brown Christopher R Highly sensitive immunoassay systems for detecting multiple allergens

Family Cites Families (161)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT287916B (de) * 1969-04-29 1971-02-10 Schwarz O Verfahren zur Herstellung eines in der Geburtshilfe wertvollen prophylaktischen Mittels
US3628682A (en) 1970-06-29 1971-12-21 Beckman Instruments Inc Lighttight sample introduction system
US4291230A (en) 1979-03-07 1981-09-22 Baxter Travenol Laboratories, Inc. Fluorometric analyzer including shutter means for simultaneously shielding sample and photodetector during sample change
US5643566A (en) * 1982-09-23 1997-07-01 Cetus Corporation Formulation processes for lipophilic proteins
US4849337A (en) * 1983-01-31 1989-07-18 Minnesota Mining And Manufacturing Company Assaying allergen specific IgE levels with fluorogenic enzyme labeled antibody
FI831936A0 (fi) * 1983-05-30 1983-05-30 Labsystems Oy Anordning foer maetning av fluorescens, turbiditet, luminescens eller absorption
GB8505899D0 (en) 1985-03-07 1985-04-11 Boots Celltech Diagnostics Assay reagents
US4778751A (en) 1986-05-12 1988-10-18 Diagnostic Products Corporation Method for measuring antigens or antibodies in biological fluids using ligand labeled antigens or ligand labeled antibodies
US5320808A (en) 1988-08-02 1994-06-14 Abbott Laboratories Reaction cartridge and carousel for biological sample analyzer
JP2656564B2 (ja) 1988-08-26 1997-09-24 株式会社日立製作所 免疫分析方法
DE3901857A1 (de) 1989-01-23 1990-07-26 Boehringer Mannheim Gmbh Verfahren zur bestimmung von hiv 2 antikoerpern
US5196306A (en) 1989-03-29 1993-03-23 E. I. Du Pont De Nemours And Company Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system
JPH04106471A (ja) * 1990-08-28 1992-04-08 Hitachi Ltd 生体関連物質の測定装置
ES2148144T3 (es) 1990-11-20 2000-10-16 Dade Behring Marburg Gmbh Procedimiento para la estabilizacion de conjugados de enzima.
SE9004047L (sv) 1990-12-19 1992-06-20 Francisco Batista Metod foer immobilisering av tiolfoereningar via aktivering av polymerer, aktiverade polymerer, och produkter erhaallna med metoden
JPH04348258A (ja) * 1991-05-27 1992-12-03 Kowa Co 多チャンネル光学測定装置
DK130991D0 (da) 1991-07-04 1991-07-04 Immunodex K S Polymere konjugater
US5395938A (en) 1992-08-21 1995-03-07 Nichols Institute Diagnostics Biotinylated chemiluminescent labels and their conjugates, assays and assay kits
JP3207933B2 (ja) 1992-09-09 2001-09-10 株式会社ヤトロン アクリジニウム誘導体の発光方法及びそれを用いた検査対象物質の検出方法
US5698397A (en) 1995-06-07 1997-12-16 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US6399397B1 (en) 1992-09-14 2002-06-04 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5736410A (en) 1992-09-14 1998-04-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5674698A (en) 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US6087188A (en) 1992-11-13 2000-07-11 Alk A/S Two-site immunoassay for an antibody with chemiluminescent label and biotin bound ligand
US5395752A (en) 1993-03-19 1995-03-07 Ciba Corning Diagnostics Corp. Long emission wavelength chemiluminescent compounds and their use in test assays
AU679008B2 (en) 1993-05-06 1997-06-19 Chiron Diagnostics Corporation Mixed luminescent conjugate test assays
US5468453A (en) 1993-06-14 1995-11-21 Cirrus Diagnostics, Inc. Low carryover pipette probe
US6348310B1 (en) 1994-03-04 2002-02-19 Promega Corporation Quantitation of individual protein kinase activity
GB2289334B (en) 1994-05-10 1998-08-26 Molecular Light Technology Lim Enzyme linked chemiluminescent assay
DE4418223A1 (de) 1994-05-25 1995-11-30 Boehringer Mannheim Gmbh Verfahren zum Nachweis des Vorliegens eines Insulin-abhängigen Diabetes mellitus
US6800452B1 (en) 1994-08-08 2004-10-05 Science Applications International Corporation Automated methods for simultaneously performing a plurality of signal-based assays
DE4439452A1 (de) 1994-11-04 1996-05-09 Boehringer Mannheim Gmbh Antikörperklassenspezifisches Entstörungsreagenz
JP2815545B2 (ja) 1994-11-07 1998-10-27 日本分光株式会社 液体クロマトグラフ用検出器
US5952238A (en) 1995-02-02 1999-09-14 Chugai Seiyaku Kabushiki Kaisha Method of assaying specimen substance by controlling dose of chemiluminescence
US6140045A (en) 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
NZ306051A (en) 1995-03-10 1999-11-29 Meso Scale Technologies Llc Testing using electrochemiluminescence
JPH08313539A (ja) * 1995-05-16 1996-11-29 Nittec Co Ltd 容器およびこの容器を用いた液体撹拌・洗浄・磁性体微粒子捕集方法並びに該容器を用いた免疫化学検査装置
US5879885A (en) 1995-06-07 1999-03-09 Gen-Probe Incorporated Compositions for detecting and quantifying biological samples
US5690907A (en) 1995-06-08 1997-11-25 The Jewish Hospital Of St. Louis Avidin-biotin conjugated emulsions as a site specific binding system
IL114149A0 (en) 1995-06-14 1995-10-31 Yeda Res & Dev Modified avidin and streptavidin molecules and use thereof
US5770700A (en) * 1996-01-25 1998-06-23 Genetics Institute, Inc. Liquid factor IX formulations
US5776487A (en) 1996-04-19 1998-07-07 Pasteur Sanofi Diagnostics Liposome reagents for immunoassays
SE9602234D0 (sv) 1996-06-06 1996-06-06 Pharmacia Ab A novel diagnostic method utilizing ECP, and reagents to be used in the methods
US5942407A (en) 1996-06-25 1999-08-24 Immunomatrix, Inc. Light-emitting immunoassay
GB9712818D0 (en) 1996-07-08 1997-08-20 Cambridge Antibody Tech Labelling and selection of specific binding molecules
SE9603379D0 (sv) 1996-09-17 1996-09-17 Pharmacia & Upjohn Ab Anordning för att detektera när en mätsond kommer i kontakt med en vätskeyta
US5776785A (en) 1996-12-30 1998-07-07 Diagnostic Products Corporation Method and apparatus for immunoassay using fluorescent induced surface plasma emission
US6432662B1 (en) 1997-04-15 2002-08-13 Pierce Chemical Company Assay of peroxidase activity
US6165800A (en) 1997-05-30 2000-12-26 Bayer Corporation Chemiluminescent energy transfer conjugates and their uses as labels in binding assays
US5929049A (en) 1997-08-08 1999-07-27 Dade Behring Marburg Gmbh Polysaccharide conjugates of biomolecules
JP3366842B2 (ja) * 1997-08-29 2003-01-14 エーザイ株式会社 電気化学発光測定用セル
US5922558A (en) 1997-09-12 1999-07-13 Lumigen, Inc. Methods and compositions for generating chemiluminescence with a peroxidase
WO1999018438A1 (en) 1997-10-02 1999-04-15 Aclara Biosciences, Inc. Capillary assays involving separation of free and bound species
US6180340B1 (en) 1997-10-31 2001-01-30 Gen-Probe Incorporated Extended dynamic range assays
SE9704935D0 (sv) 1997-12-30 1997-12-30 Pharmacia & Upjohn Diag Ab Analysmetod med partiklar
US6235480B1 (en) 1998-03-13 2001-05-22 Promega Corporation Detection of nucleic acid hybrids
US6068979A (en) 1998-04-22 2000-05-30 Lumigen, Inc. Simplified sequential chemiluminescent detection
SE9801563D0 (sv) 1998-04-30 1998-04-30 Pharmacia & Upjohn Diag Ab Förfarande med separation och kit att användas vid förfarandet
US6153442A (en) 1998-05-20 2000-11-28 Dade Behring Inc. Reagents and methods for specific binding assays
US6303325B1 (en) 1998-05-29 2001-10-16 Dade Behring Inc. Method for detecting analytes
US6379909B1 (en) 1998-06-24 2002-04-30 Alk-Abello A/S Method of detecting an antibody in a liquid sample
ATE423101T1 (de) 1998-08-11 2009-03-15 Siemens Healthcare Diagnostics Im nahen infrarot chemilumineszente akridinium derivate und ihre verwendung
US6236456B1 (en) 1998-08-18 2001-05-22 Molecular Devices Corporation Optical system for a scanning fluorometer
US6399299B1 (en) 1998-11-02 2002-06-04 Perkinelmer Life Sciences, Inc. Amplified array analysis system
US7759133B2 (en) 1998-12-22 2010-07-20 Alk-Abello A/S Method of detecting and/or quantifying a specific IgE antibody in a liquid sample
DE60000386T2 (de) * 1999-01-25 2003-01-09 Hamamatsu Photonics K.K., Hamamatsu Adapter für eine pipette, pipette zur absorptionsmessung, verfahren und vorrichtung zur absorptionsmessung
WO2001003721A1 (en) 1999-07-12 2001-01-18 Merlin Biomedical & Pharmaceutical, Ltd. Improved assays for detecting human immunodeficiency virus infection
US6783948B1 (en) 1999-07-30 2004-08-31 Bayer Corporation Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes
ES2265957T3 (es) 1999-08-06 2007-03-01 Phadia Ab Un metodo y un aparato para determinar analitos.
US6902889B1 (en) 1999-08-06 2005-06-07 Pharmacia Diagnostics Ab Analytical method and advice
US8153367B2 (en) 1999-10-29 2012-04-10 Perkinelmer Las, Inc. Amplified array analysis system
US6852986B1 (en) 1999-11-12 2005-02-08 E. I. Du Pont De Nemours And Company Fluorometer with low heat-generating light source
US6812038B1 (en) 1999-11-18 2004-11-02 Pharmacia Diagnostics Ab Assay device and use thereof
US7018810B1 (en) 1999-12-07 2006-03-28 Amgen Inc. Chordin-like molecules and uses thereof
US7018847B2 (en) 2000-05-05 2006-03-28 Pharmacia Diagnostics Ab Assay device with timer function
US6958214B2 (en) 2000-07-10 2005-10-25 Sequenom, Inc. Polymorphic kinase anchor proteins and nucleic acids encoding the same
US6777198B2 (en) 2000-10-11 2004-08-17 Pharmacia Diagnostics Ab Assay method and kit therefor
AU2001294832A1 (en) * 2000-10-31 2002-05-15 Dpc Cirrus, Inc. Automated immunoassay analyzer and method of using the same
US20030031685A1 (en) 2000-12-29 2003-02-13 Sabine Stumvoll Pure allergen component
US6872828B2 (en) 2001-12-20 2005-03-29 Lumigen, Inc. Compounds for generating chemiluminescence with a peroxidase
US7247726B2 (en) 2001-02-26 2007-07-24 Lumigen, Inc. Compounds for generating chemiluminescence with a peroxidase
US7143960B2 (en) * 2001-03-14 2006-12-05 3M Innovative Properties Company Liquid sample reservoir suitable for use with a spraying apparatus
JP2002272498A (ja) * 2001-03-21 2002-09-24 Olympus Optical Co Ltd 生化学的検査方法
KR20020075996A (ko) 2001-03-27 2002-10-09 (주) 바이오알레텍 잎응애(귤응애, 점박이응애, 사과응애) 조항원을 함유하는피부시험 시약 및 혈청 특이 ＩｇＥ, ＩｇＧ 아형 항체검출 키트
US7364872B1 (en) 2001-03-30 2008-04-29 Nanoprobes Test methods using enzymatic deposition and alteration of metals
US7691598B2 (en) 2001-03-30 2010-04-06 Nanoprobes, Inc. Method for detecting a target molecule by metal deposition
US7888060B2 (en) 2001-03-30 2011-02-15 Nanoprobes, Inc. Method for detecting a target using enzyme directed deposition of elemental metal
US6670113B2 (en) 2001-03-30 2003-12-30 Nanoprobes Enzymatic deposition and alteration of metals
US7262019B2 (en) 2001-05-03 2007-08-28 Immunetics, Inc. System and methods for detection of Bacillus anthracis related analytes in biological fluids
US7381797B2 (en) 2001-05-09 2008-06-03 Surmodics, Inc. Stabilization of H2O2 under alkaline conditions for use in luminescence, fluorescence and colorimetric assays for enhanced detection of peroxidase type assays
WO2002097122A1 (en) 2001-05-26 2002-12-05 One Cell Systems, Inc. Secretion of proteins by encapsulated cells
DE10136863A1 (de) * 2001-07-28 2003-02-20 Berthold Tech Gmbh & Co Kg Vorrichtung zur wahlweisen Messung von insbesondere Lumineszenz- und/oder Fluoreszenzstrahlung
SE0103072D0 (sv) 2001-09-17 2001-09-17 Pharmacia Diagnostics Ab Multi-analyte assay device with multi-spot detection zone
US20040023309A1 (en) 2001-11-27 2004-02-05 Franz Noll Immunoassay and kit for an early and simultaneous detection of biochemical markers in a patient's sample
US6972326B2 (en) 2001-12-03 2005-12-06 Molecular Probes, Inc. Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes
US7560556B2 (en) 2001-12-20 2009-07-14 Lumigen, Inc. Assay methods using chemiluminescent detection of peroxidase
US7445894B2 (en) 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
CN1665790A (zh) 2002-05-03 2005-09-07 莫莱丘莱尔探针公司 用于检测和分离磷酸化分子的组合物及方法
AU2003245317A1 (en) * 2002-05-20 2003-12-12 The Government Of The United States Of America As Represented By The Secretary, Department Of Health Elisa assay of serum soluble cd22 to assess tumor burden/relapse in subjects with leukemia and lymphoma
US6897036B2 (en) 2002-06-06 2005-05-24 Lumigen, Inc. Fluorescent detection of peroxidase enzymes
AU2003273219A1 (en) 2002-07-12 2004-02-02 Dana-Farber Cancer Institute, Inc. Novel compositions and methods for the generation of mhc class ii compounds by peptide exchange
KR101115797B1 (ko) 2002-08-01 2012-07-27 이뮤노메딕스, 인코오포레이티드 알파 태아 단백질 Ｉｍｍｕ31 항체 및 융합단백질, 및이들의 이용 방법
CN100442052C (zh) * 2002-08-15 2008-12-10 陕西西大北美基因股份有限公司 磁性荧光微球及其制备方法和采用该磁性荧光微球进行生物分子检测的方法
US6924154B2 (en) 2002-08-20 2005-08-02 Quest Diagnostics Investments Incorporated Hydrophilic chemilumescent acridinium labeling reagents
US7285424B2 (en) * 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7309615B2 (en) 2002-09-27 2007-12-18 Siemens Medical Solutions Diagnostic High quantum yield acridinium compounds and their uses in improving assay sensitivity
US7319041B2 (en) 2002-09-27 2008-01-15 Siemens Medical Solutions Diagnostic Applications of acridinium compounds and derivatives in homogeneous assays
SE0300958D0 (sv) 2003-04-02 2003-04-02 Pharmacia Diagnostics Ab Analytical method and kit therof
US7393638B2 (en) 2003-07-01 2008-07-01 Asiagen Corporation Assay system and methods for detecting SARS-CV
WO2005021800A2 (en) 2003-08-22 2005-03-10 Sirna Therapeutics, Inc. Detection and quantitation of nucleic acid molecules in biological samples
JP2005147826A (ja) * 2003-11-14 2005-06-09 Hamamatsu Photonics Kk 蛍光測定装置
SE528508C2 (sv) 2004-03-30 2006-11-28 Phadia Ab Provtagningsanordning för uttag och insamling av ett prov av kapillärt blod
EP1769243A2 (en) 2004-05-15 2007-04-04 Genentech, Inc. Cross-screening system and methods for detecting a molecule having binding affinity for a target molecule
US20060008895A1 (en) 2004-07-08 2006-01-12 Hsiu-Mei Chen Microarray chip for detection of immunoglobulin
DE102005026163A1 (de) 2004-08-24 2006-03-02 Dade Behring Marburg Gmbh Gegen den Marburg I Polymorphismus der Faktor VII aktivierenden Protease (FSAP) gerichtete Antikörper, ihre Herstellung und Verwendung
ES2550177T3 (es) 2004-11-03 2015-11-05 Iris Molecular Diagnostics, Inc. Microburbujas para concentración de afinidad
US7074622B2 (en) 2004-11-15 2006-07-11 Eastman Kodak Company Method and system for sorting and separating particles
US7183119B2 (en) 2004-11-15 2007-02-27 Eastman Kodak Company Method for sensitive detection of multiple biological analytes
US7479391B2 (en) * 2004-12-10 2009-01-20 Tecan Trading Ag Pipetting apparatus with integrated liquid level and/or gas bubble detection
JP2006170662A (ja) * 2004-12-13 2006-06-29 Olympus Corp 粒子状担体およびこれを用いた生体関連物質の処理方法
US20080124738A1 (en) 2005-03-01 2008-05-29 Pritest, Inc Compositions and methods of testing for tuberculosis and mycobacterium infection
WO2006116683A1 (en) 2005-04-27 2006-11-02 The Trustees Of The University Of Pennsylvania Nanostructure enhanced luminescence
CA2606721A1 (en) 2005-05-02 2006-11-09 The Curators Of The University Of Missouri Detection of carbohydrate biomarkers
GB2425974A (en) 2005-05-09 2006-11-15 Orion Diagnostica Oy Sonication of a medium
DK1891447T3 (da) 2005-05-23 2011-10-17 Phadia Ab Totrins laterale flowassayfremgangsmåder og -anordninger
WO2007030748A2 (en) 2005-09-09 2007-03-15 The University Of Chicago Methods and compositions for diagnosis and immunotherapy of pollen allergy
US20070161055A1 (en) 2005-10-31 2007-07-12 Invitrogen Corporation Immunosorbent assay support and method of use
US7521577B2 (en) 2006-01-12 2009-04-21 Molecular Probes, Inc. Heavy metal binding compounds and their method of use
US7439014B2 (en) * 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
CA2680532C (en) 2006-04-18 2017-03-21 Advanced Liquid Logic, Inc. Droplet-based pyrosequencing
US7727723B2 (en) 2006-04-18 2010-06-01 Advanced Liquid Logic, Inc. Droplet-based pyrosequencing
US7799534B2 (en) 2006-05-09 2010-09-21 Beckman Coulter, Inc. Nonseparation assay methods
WO2007133710A2 (en) 2006-05-11 2007-11-22 Raindance Technologies, Inc. Microfluidic devices and methods of use thereof
EP2066812A4 (en) 2006-09-21 2010-04-28 Univ Rochester COMPOSITIONS AND METHODS RELATED TO PROTEIN SHIFT THERAPY FOR MYOTONE DYSTROPHY
US7674629B2 (en) 2007-03-15 2010-03-09 Saint Louis University Method for improving chemiluminescent signal
US7906293B2 (en) 2007-04-09 2011-03-15 Abbott Laboratories Acridinium phenyl esters useful in the analysis of biological
US7985557B2 (en) 2007-05-23 2011-07-26 Ventana Medical Systems, Inc. Polymeric carriers for immunohistochemistry and in situ hybridization
EP2181334B1 (en) 2007-08-22 2015-11-04 Phadia AB Read-out method and apparatus
CN104297506B (zh) 2007-10-02 2017-05-03 赛拉诺斯股份有限公司 模块化现场护理装置及其应用
US20100075374A1 (en) 2007-11-08 2010-03-25 Ambergen, Inc. Methods for capturing nascent proteins
US7842475B2 (en) 2008-01-08 2010-11-30 Siemens Healthcare Diagnostics Inc. Stabilization of solid support assay reagents
WO2009099379A1 (en) 2008-02-08 2009-08-13 Phadia Ab Method, computer program product and system for enabling clinical decision support
CN101514991A (zh) * 2008-02-19 2009-08-26 北京科美东雅生物技术有限公司 甲胎蛋白磁微粒化学发光免疫分析测定试剂盒及其制备方法
US9562900B2 (en) * 2008-02-21 2017-02-07 Otc Biotechnologies, Llc Methods and compositions of nucleic acid ligands for detection of foodborne and waterborne pathogens
CN101545913A (zh) * 2008-03-25 2009-09-30 北京科美东雅生物技术有限公司 三碘甲腺原氨酸磁微粒化学发光免疫分析测定试剂盒及其制备方法
US8541178B2 (en) * 2008-05-13 2013-09-24 Genentech, Inc. Analysis of antibody drug conjugates by bead-based affinity capture and mass spectrometry
US9063150B2 (en) * 2008-09-02 2015-06-23 The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control Prevention Method for detection of antigen-specific antibodies in biological samples
US9476880B2 (en) 2008-11-21 2016-10-25 Future Medical Diagnostics Co., Ltd. Methods, devices and kits for detecting or monitoring acute kidney injury
FI20095061A0 (fi) * 2009-01-26 2009-01-26 Wallac Oy Optisen mittauslaitteen runkomoduuli
EP2382471A4 (en) * 2009-01-29 2012-09-05 Siemens Healthcare Diagnostics MICROARRAYS FOR ALLERGEN SPECIFIC IGE
US8846414B2 (en) * 2009-09-29 2014-09-30 Advanced Liquid Logic, Inc. Detection of cardiac markers on a droplet actuator
CN101696973A (zh) 2009-10-30 2010-04-21 深圳市博卡生物技术有限公司 一种过敏原特异性IgE抗体免疫分析检测试剂盒及其制备方法
EP3151015A1 (en) * 2010-11-15 2017-04-05 F. Hoffmann-La Roche AG Instrument and method for the automated thermal treatment of liquid samples
CN102478571A (zh) * 2010-11-23 2012-05-30 南京神州英诺华医疗科技有限公司 一种新的过敏原体外诊断实验方法及其装置
CN201897571U (zh) * 2010-11-23 2011-07-13 天津陆海石油设备系统工程有限责任公司 加装保护壳的石油定量荧光仪用比色皿支架
US8658613B2 (en) * 2010-11-30 2014-02-25 Otc Biotechnologies, Llc Methods and compositions of nucleic acid ligands for detection of clinical analytes related to human health
EP2677316A4 (en) * 2011-02-15 2014-05-14 Kyowa Medex Co Ltd STREPTAVIDINE-RELATED MAGNETIC PARTICLES AND METHOD FOR THE PRODUCTION THEREOF
EP2972230B1 (en) 2013-03-15 2021-07-21 Hycor Biomedical LLC Device and associated method for performing luminescence and fluorescence measurements of a sample
WO2017015662A1 (en) 2015-07-23 2017-01-26 Hycor Biomedical, Inc On-board kitting
KR20180094109A (ko) 2016-01-07 2018-08-22 어플라이드 머티어리얼스, 인코포레이티드 원격 플라즈마 소스 및 dc 전극을 구비하는 원자 층 에칭 시스템
TW201832726A (zh) 2016-11-01 2018-09-16 美商海科生醫有限責任公司 可基於輸入數據建議檢測之免疫檢測系統

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120077286A1 (en) * 2001-12-06 2012-03-29 Brown Christopher R Highly sensitive immunoassay systems for detecting multiple allergens

Also Published As

Publication number Publication date
HK1220759A1 (zh) 2017-05-12
WO2014145581A1 (en) 2014-09-18
JP2016524124A (ja) 2016-08-12
US20170212110A1 (en) 2017-07-27
AU2014232782A1 (en) 2015-09-24
US9766233B2 (en) 2017-09-19
AU2018220044A1 (en) 2018-09-06
AU2014232782B2 (en) 2018-05-24
US9658225B2 (en) 2017-05-23
CN105308458B (zh) 2017-11-28
HK1258277A1 (zh) 2019-11-08
CN105308437B (zh) 2018-01-19
US20140274784A1 (en) 2014-09-18
HK1220760A1 (zh) 2017-05-12
US20170205410A1 (en) 2017-07-20
WO2014145619A1 (en) 2014-09-18
US10739262B2 (en) 2020-08-11
CN105308458A (zh) 2016-02-03
US10732110B2 (en) 2020-08-04
JP6553020B2 (ja) 2019-07-31
US20150177146A1 (en) 2015-06-25
CA2905165A1 (en) 2014-09-18
US20200371029A1 (en) 2020-11-26
US20150204871A1 (en) 2015-07-23
US10732111B2 (en) 2020-08-04
US9075055B2 (en) 2015-07-07
CN107817232B (zh) 2021-08-17
US20140273277A1 (en) 2014-09-18
AU2014232782A8 (en) 2016-06-16
US20150204867A1 (en) 2015-07-23
EP2972230B1 (en) 2021-07-21
US11204323B2 (en) 2021-12-21
WO2014145581A4 (en) 2014-11-13
EP2972230A1 (en) 2016-01-20
US20170370928A1 (en) 2017-12-28
EP2972361A1 (en) 2016-01-20
US9651550B2 (en) 2017-05-16
US20210293709A1 (en) 2021-09-23
US20170212111A1 (en) 2017-07-27
CN108445242B (zh) 2022-03-04
JP2016517529A (ja) 2016-06-16
JP6389868B2 (ja) 2018-09-12
US9753033B2 (en) 2017-09-05
US20150177145A1 (en) 2015-06-25
WO2014145619A8 (en) 2016-06-09
US20170370841A1 (en) 2017-12-28
US10955346B2 (en) 2021-03-23
CA2905178A1 (en) 2014-09-18
CN108445242A (zh) 2018-08-24
CN107817232A (zh) 2018-03-20
AU2014232882A1 (en) 2015-10-01
US9658226B2 (en) 2017-05-23
EP3933384A1 (en) 2022-01-05
HK1252561A1 (zh) 2019-05-31
US12693221B2 (en) 2026-07-28
CN105308437A (zh) 2016-02-03
JP2019049538A (ja) 2019-03-28

Similar Documents

Publication Publication Date Title
US10732111B2 (en) Automated immunoanalyzer system for performing diagnostic assays for allergies and autoimmune diseases
US6087188A (en) Two-site immunoassay for an antibody with chemiluminescent label and biotin bound ligand
RU2608656C2 (ru) Связанные со стрептавидином магнитные частицы и способ их изготовления
EP0267317B1 (en) Method for the detection of proteins and viruses
US8956823B2 (en) Anti-antibody reagent
US10488408B2 (en) Detection of target molecules in a sample by using a magnetic field
EA017380B1 (ru) Определение антигенов, расположенных на эритроцитах, и антиэритроцитарных антител
JP5005511B2 (ja) 非特異反応を減少させた免疫診断薬
CN101711361A (zh) 检测感染的多元方法
FI111194B (fi) Kaksikohtainen immuunitesti vasta-aineelle käyttäen kemiluminisoivaa leimaa ja biotiiniin sidottua ligandia
WO2013135371A1 (en) Real time diagnostic assays using an evanescence biosensor
KR101548284B1 (ko) 신규한 시료 내 검출대상물의 검출방법 및 그를 이용한 검출키트
EP3800474A1 (en) Detection of multiple analytes
CN1322330C (zh) 钴胺素的分析方法
JPS6281566A (ja) 微粒子の螢光強度測定による定量方法
GB2432211A (en) Agglutination-based assay system
HK1252561B (en) Automated immunoanalyzer system for performing diagnostic assays for allergies and autoimmune diseases
CA2137238A1 (en) Immunoassay method
JPH08114595A (ja) 特異的結合測定法
RU2519023C2 (ru) Способ детектирования концентрации аналита с широким динамическим диапазоном
JP2004012170A (ja) 免疫学的測定法および測定用キット
JP2004020344A (ja) 微小粒子固相上に固定化された物質の測定法

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired