AU2013220749B2 - Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein - Google Patents

Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein Download PDF

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AU2013220749B2
AU2013220749B2 AU2013220749A AU2013220749A AU2013220749B2 AU 2013220749 B2 AU2013220749 B2 AU 2013220749B2 AU 2013220749 A AU2013220749 A AU 2013220749A AU 2013220749 A AU2013220749 A AU 2013220749A AU 2013220749 B2 AU2013220749 B2 AU 2013220749B2
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stem
nucleotide
sequence
protein
loop
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AU2013220749A1 (en
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Jochen Probst
Thomas Schlake
Andreas Thess
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Curevac SE
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    • C12N15/67General methods for enhancing the expression
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    • A61K48/0066Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • C07K2317/00Immunoglobulins specific features
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    • C12N2840/00Vectors comprising a special translation-regulating system
    • C12N2840/10Vectors comprising a special translation-regulating system regulates levels of translation
    • C12N2840/105Vectors comprising a special translation-regulating system regulates levels of translation enhancing translation

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AU2013220749A 2012-02-15 2013-02-15 Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein Active AU2013220749B2 (en)

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Application Number Priority Date Filing Date Title
PCT/EP2012/000671 WO2013120497A1 (en) 2012-02-15 2012-02-15 Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
AUPCT/EP2012/000671 2012-02-15
PCT/EP2013/000461 WO2013120629A1 (en) 2012-02-15 2013-02-15 Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein

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AU2013220749A1 AU2013220749A1 (en) 2014-07-24
AU2013220749B2 true AU2013220749B2 (en) 2018-05-17

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US (5) US9447431B2 (enEXAMPLES)
EP (2) EP2814963B1 (enEXAMPLES)
JP (3) JP6357111B2 (enEXAMPLES)
KR (1) KR102072013B1 (enEXAMPLES)
CN (2) CN108570468B (enEXAMPLES)
AU (1) AU2013220749B2 (enEXAMPLES)
BR (1) BR112014019627A2 (enEXAMPLES)
CA (1) CA2862476C (enEXAMPLES)
DK (1) DK2814963T3 (enEXAMPLES)
ES (1) ES2806678T3 (enEXAMPLES)
IN (1) IN2014DN05670A (enEXAMPLES)
MX (1) MX359953B (enEXAMPLES)
RU (1) RU2634391C2 (enEXAMPLES)
SG (2) SG11201403944RA (enEXAMPLES)
WO (2) WO2013120497A1 (enEXAMPLES)

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