AU2011329215C1 - Lipoyl compounds and their use for treating ischemic injury - Google Patents

Lipoyl compounds and their use for treating ischemic injury Download PDF

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Publication number
AU2011329215C1
AU2011329215C1 AU2011329215A AU2011329215A AU2011329215C1 AU 2011329215 C1 AU2011329215 C1 AU 2011329215C1 AU 2011329215 A AU2011329215 A AU 2011329215A AU 2011329215 A AU2011329215 A AU 2011329215A AU 2011329215 C1 AU2011329215 C1 AU 2011329215C1
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AU
Australia
Prior art keywords
ischemia
reperfusion injury
pharmaceutically acceptable
composition
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2011329215A
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English (en)
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AU2011329215B2 (en
AU2011329215A1 (en
Inventor
Alexander B. Baguisi
Reinier Beeuwkes
Ralph Casale
Steven A. Kates
Alan S. Lader
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Ischemix LLC
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Ischemix LLC
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Filing date
Publication date
Application filed by Ischemix LLC filed Critical Ischemix LLC
Publication of AU2011329215A1 publication Critical patent/AU2011329215A1/en
Publication of AU2011329215B2 publication Critical patent/AU2011329215B2/en
Application granted granted Critical
Publication of AU2011329215C1 publication Critical patent/AU2011329215C1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2011329215A 2010-11-18 2011-11-10 Lipoyl compounds and their use for treating ischemic injury Ceased AU2011329215C1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US41524110P 2010-11-18 2010-11-18
US41524010P 2010-11-18 2010-11-18
US61/415,240 2010-11-18
US61/415,241 2010-11-18
US201161478310P 2011-04-22 2011-04-22
US61/478,310 2011-04-22
US201161500974P 2011-06-24 2011-06-24
US61/500,974 2011-06-24
PCT/US2011/060259 WO2012067947A1 (en) 2010-11-18 2011-11-10 Lipoyl compounds and their use for treating ischemic injury

Publications (3)

Publication Number Publication Date
AU2011329215A1 AU2011329215A1 (en) 2013-05-30
AU2011329215B2 AU2011329215B2 (en) 2016-04-28
AU2011329215C1 true AU2011329215C1 (en) 2016-08-11

Family

ID=45217651

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011329215A Ceased AU2011329215C1 (en) 2010-11-18 2011-11-10 Lipoyl compounds and their use for treating ischemic injury

Country Status (15)

Country Link
US (2) US8815937B2 (enExample)
EP (1) EP2640423B1 (enExample)
JP (3) JP2014502264A (enExample)
KR (1) KR20140020840A (enExample)
CN (1) CN103561770B (enExample)
AU (1) AU2011329215C1 (enExample)
BR (1) BR112013012057B1 (enExample)
CA (1) CA2817362C (enExample)
DK (1) DK2640423T3 (enExample)
ES (1) ES2640474T3 (enExample)
IL (1) IL226258A (enExample)
MX (1) MX344933B (enExample)
NZ (1) NZ610378A (enExample)
SG (1) SG190794A1 (enExample)
WO (1) WO2012067947A1 (enExample)

Families Citing this family (12)

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US8541396B2 (en) 2009-04-24 2013-09-24 National University Of Singapore Morpholin-4-ium 4 methoxyphenyl (morpholino) phosphinodithioate (GYY4137) as a novel vasodilator agent
US7928067B2 (en) 2009-05-14 2011-04-19 Ischemix Llc Compositions and methods for treating ischemia and ischemia-reperfusion injury
WO2012067947A1 (en) 2010-11-18 2012-05-24 Ischemix Llc Lipoyl compounds and their use for treating ischemic injury
ITFI20120170A1 (it) * 2012-08-28 2014-03-01 Consorzio Interuniversitario Nazion Ale Per La Sci Nuovi composti ad azione anti-allodinica ed anti-iperalgesica.
JP2017509617A (ja) * 2014-02-27 2017-04-06 コンソルツィオ インターユニヴァーシタリオ ナチオナーレ ペル ラ シエンツァ エ テクノロジア デイ マテリアーリ 抗異痛活性および抗痛覚過敏活性を有する新規化合物
WO2015174948A1 (en) 2014-05-14 2015-11-19 Ischemix, LLC Formulations comprising lipoyl compounds
EP3429577B1 (en) * 2016-03-14 2021-12-29 NeoStrata Company, Inc. N-lipoic -amino acid or peptide, derivatives and their uses
RU2657820C1 (ru) * 2017-03-13 2018-06-15 Федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации ФГБОУ ВО ВолгГМУ МЗ РФ 4-(4-Ацетоксибензоиламино)бутаноилглицин, обладающий церебропротекторным действием при ишемии головного мозга
US10744115B2 (en) 2017-04-25 2020-08-18 Ischemix Llc Compositions and methods for treating traumatic brain injury
US20240124520A1 (en) * 2019-10-16 2024-04-18 The Board Of Trustees Of The Leland Stanford Junior University N-acylated histidine dipeptides as anticancer agents
US11306076B2 (en) * 2020-05-11 2022-04-19 Xi'an Taikomed Pharmaceutical Technology Co., Ltd. Silibinin lipoic acid ester with hepatoprotective activity and a method of preparing the same
CN116199666B (zh) * 2023-03-07 2025-02-28 中国药科大学 两亲性化合物及其药物组合物

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US6013663A (en) * 1997-04-02 2000-01-11 Sankyo Company, Limited Dithiolan derivatives, their preparation and their therapeutic effect
EP1371640A1 (en) * 2001-03-19 2003-12-17 Senju Pharmaceutical Co., Ltd. Novel a-lipoic acid derivative and use thereof
JP2006022066A (ja) * 2004-07-09 2006-01-26 Shiseido Co Ltd 重合抑制剤および即時型黒化防止用皮膚外用剤
WO2010147957A2 (en) * 2009-06-15 2010-12-23 Encore Health, Llc Dithiol compounds, derivatives, and uses therefor

Also Published As

Publication number Publication date
IL226258A0 (en) 2013-07-31
US9359325B2 (en) 2016-06-07
CA2817362A1 (en) 2012-05-24
DK2640423T3 (en) 2017-10-02
EP2640423A1 (en) 2013-09-25
NZ610378A (en) 2015-05-29
JP2016033157A (ja) 2016-03-10
US20130237483A1 (en) 2013-09-12
JP6280094B2 (ja) 2018-02-14
CA2817362C (en) 2018-10-23
SG190794A1 (en) 2013-07-31
US8815937B2 (en) 2014-08-26
US20150065564A1 (en) 2015-03-05
BR112013012057B1 (pt) 2021-11-09
ES2640474T3 (es) 2017-11-03
BR112013012057A2 (pt) 2020-08-04
MX344933B (es) 2017-01-11
CN103561770A (zh) 2014-02-05
KR20140020840A (ko) 2014-02-19
WO2012067947A1 (en) 2012-05-24
MX2013005508A (es) 2013-07-17
EP2640423B1 (en) 2017-07-26
CN103561770B (zh) 2016-11-09
IL226258A (en) 2017-02-28
AU2011329215B2 (en) 2016-04-28
JP2018016652A (ja) 2018-02-01
JP2014502264A (ja) 2014-01-30
AU2011329215A1 (en) 2013-05-30

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