AU2011223710B2 - Optimized monoclonal antibodies against tissue factor pathway inhibitor (TFPI) - Google Patents

Optimized monoclonal antibodies against tissue factor pathway inhibitor (TFPI) Download PDF

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Publication number
AU2011223710B2
AU2011223710B2 AU2011223710A AU2011223710A AU2011223710B2 AU 2011223710 B2 AU2011223710 B2 AU 2011223710B2 AU 2011223710 A AU2011223710 A AU 2011223710A AU 2011223710 A AU2011223710 A AU 2011223710A AU 2011223710 B2 AU2011223710 B2 AU 2011223710B2
Authority
AU
Australia
Prior art keywords
seq
amino acid
antibody
monoclonal antibody
tfpi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2011223710A
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English (en)
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AU2011223710A1 (en
Inventor
Joerg Birkenfeld
Simone Brueckner
Joanna Grudzinska
Junliang Pan
Peter Scholz
Susanne Steinig
Jan Tebbe
Christian Votsmeier
Zhuozhi Wang
Nina Wobst
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Bayer Healthcare LLC
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Bayer Healthcare LLC
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Publication date
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Application filed by Bayer Healthcare LLC filed Critical Bayer Healthcare LLC
Publication of AU2011223710A1 publication Critical patent/AU2011223710A1/en
Priority to AU2013202745A priority Critical patent/AU2013202745B2/en
Application granted granted Critical
Publication of AU2011223710B2 publication Critical patent/AU2011223710B2/en
Priority to AU2016269554A priority patent/AU2016269554B2/en
Priority to AU2018271420A priority patent/AU2018271420B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Filtering Materials (AREA)
AU2011223710A 2010-03-01 2011-03-01 Optimized monoclonal antibodies against tissue factor pathway inhibitor (TFPI) Ceased AU2011223710B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2013202745A AU2013202745B2 (en) 2010-03-01 2013-04-06 Optimized monoclonal antibodies against tissue factor pathway inhibitor (TFPI)
AU2016269554A AU2016269554B2 (en) 2010-03-01 2016-12-09 Optimized monoclonal antibodies against tissue factor pathway inhibitor (TFPI)
AU2018271420A AU2018271420B2 (en) 2010-03-01 2018-12-03 Optimized monoclonal antibodies against tissue factor pathway inhibitor (TFPI)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30929010P 2010-03-01 2010-03-01
US61/309,290 2010-03-01
PCT/US2011/026766 WO2011109452A1 (en) 2010-03-01 2011-03-01 Optimized Monoclonal Antibodies against Tissue Factor Pathway Inhibitor (TFPI)

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013202745A Division AU2013202745B2 (en) 2010-03-01 2013-04-06 Optimized monoclonal antibodies against tissue factor pathway inhibitor (TFPI)

Publications (2)

Publication Number Publication Date
AU2011223710A1 AU2011223710A1 (en) 2012-09-20
AU2011223710B2 true AU2011223710B2 (en) 2016-04-14

Family

ID=44542552

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011223710A Ceased AU2011223710B2 (en) 2010-03-01 2011-03-01 Optimized monoclonal antibodies against tissue factor pathway inhibitor (TFPI)

Country Status (36)

Country Link
US (3) USRE47150E1 (he)
EP (2) EP3345615B1 (he)
JP (4) JP6025570B2 (he)
KR (4) KR101903931B1 (he)
CN (5) CN105001335B (he)
AU (1) AU2011223710B2 (he)
BR (1) BR112012022258A2 (he)
CA (3) CA2791685C (he)
CL (2) CL2012002415A1 (he)
CO (1) CO6620068A2 (he)
CR (1) CR20120453A (he)
CU (1) CU23982B1 (he)
CY (2) CY1119410T1 (he)
DK (2) DK3345615T3 (he)
DO (1) DOP2012000239A (he)
EA (2) EA032189B9 (he)
EC (2) ECSP12012134A (he)
ES (2) ES2642512T3 (he)
GT (1) GT201200252A (he)
HK (2) HK1232232A1 (he)
HR (2) HRP20171472T1 (he)
HU (2) HUE036655T2 (he)
IL (3) IL221551B (he)
LT (2) LT2542257T (he)
ME (2) ME03578B (he)
MX (2) MX2012010198A (he)
MY (1) MY174760A (he)
NZ (2) NZ702494A (he)
PE (1) PE20160538A1 (he)
PH (3) PH12018500639A1 (he)
PL (2) PL3345615T3 (he)
PT (2) PT3345615T (he)
RS (2) RS56409B1 (he)
SG (3) SG10201502587SA (he)
SI (2) SI2542257T1 (he)
WO (1) WO2011109452A1 (he)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA112050C2 (uk) * 2008-08-04 2016-07-25 БАЄР ХЕЛСКЕР ЛЛСі Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi)
AU2009331570C1 (en) * 2008-12-22 2024-04-18 Novo Nordisk A/S Antibodies against tissue factor pathway inhibitor
LT2542257T (lt) * 2010-03-01 2017-11-27 Bayer Healthcare Llc Optimizuoti monokloniniai antikūnai prieš audinių faktoriaus kelio slopiklį (tfpi)
EP2588499B1 (en) * 2010-06-30 2020-04-08 Novo Nordisk A/S Antibodies that are capable of specifically binding tissue factor pathway inhibitor
PT2694544T (pt) * 2011-04-01 2019-04-02 Bayer Healthcare Llc Anticorpos monoclonais contra inibidor da via do fator tecidual (tfpi)
US9975962B2 (en) * 2012-03-30 2018-05-22 Bayer Healthcare Llc Thrombin/plasmin-regulated antibodies that bind TFPI
US9592297B2 (en) * 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
PL2970497T3 (pl) * 2013-03-15 2018-05-30 Bayer Healthcare Llc Warianty przeciwciał anty-TFPI z różnicowym wiązaniem w zakresie pH dla poprawy farmakokinetyki
CA2906095A1 (en) * 2013-03-15 2014-09-18 Bayer Healthcare Llc Pro-drug antibodies against tissue factor pathway inhibitor
EP3262075B1 (en) * 2015-02-25 2024-03-13 Mogam Institute For Biomedical Research Novel antibody binding to tfpi and composition comprising the same
NZ739871A (en) 2015-08-19 2022-05-27 Pfizer Tissue factor pathway inhibitor antibodies and uses thereof
KR102337683B1 (ko) * 2018-09-21 2021-12-13 주식회사 녹십자 고효율 항-tfpi 항체 조성물
MX2021004120A (es) * 2018-10-11 2021-09-10 Pfizer Regimen de dosificacion para antagonistas de tfpi.
CN112442127A (zh) * 2019-08-29 2021-03-05 苏州康宁杰瑞生物科技有限公司 针对tfpi的单克隆抗体
CN117285632A (zh) * 2022-06-17 2023-12-26 安源医药科技（上海）有限公司 针对tfpi的单克隆抗体及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010017196A2 (en) * 2008-08-04 2010-02-11 Bayer Healthcare Llc Monoclonal antibodies against tissue factor pathway inhibitor (tfpi)

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