AU2010277505B2 - APAF-1 inhibitor compounds - Google Patents
APAF-1 inhibitor compounds Download PDFInfo
- Publication number
- AU2010277505B2 AU2010277505B2 AU2010277505A AU2010277505A AU2010277505B2 AU 2010277505 B2 AU2010277505 B2 AU 2010277505B2 AU 2010277505 A AU2010277505 A AU 2010277505A AU 2010277505 A AU2010277505 A AU 2010277505A AU 2010277505 B2 AU2010277505 B2 AU 2010277505B2
- Authority
- AU
- Australia
- Prior art keywords
- ethyl
- dioxo
- dichlorophenethyl
- thiophen
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 150000001875 compounds Chemical class 0.000 title claims description 70
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- -1 2-(4-fluorophenyl)ethyl Chemical group 0.000 claims description 165
- 125000001072 heteroaryl group Chemical group 0.000 claims description 30
- 125000003118 aryl group Chemical group 0.000 claims description 27
- 125000000217 alkyl group Chemical group 0.000 claims description 22
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- 125000000753 cycloalkyl group Chemical group 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
- 125000001424 substituent group Chemical group 0.000 claims description 10
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- 230000003013 cytotoxicity Effects 0.000 claims description 9
- 125000000623 heterocyclic group Chemical group 0.000 claims description 9
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- 101100439663 Arabidopsis thaliana CHR7 gene Proteins 0.000 claims description 8
- 229910052736 halogen Inorganic materials 0.000 claims description 8
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 8
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- 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 description 7
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- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 6
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- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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| CA2611944A1 (en) | 2005-06-15 | 2006-12-28 | Massachusetts Institute Of Technology | Amine-containing lipids and uses thereof |
| JP6087504B2 (ja) | 2008-11-07 | 2017-03-01 | マサチューセッツ インスティテュート オブ テクノロジー | アミノアルコールリピドイドおよびその使用 |
| SI3338765T1 (sl) | 2009-12-01 | 2019-05-31 | Translate Bio, Inc. | Derivat steroida za dostavo MRNA pri humanih genetskih boleznih |
| EP2609135A4 (en) | 2010-08-26 | 2015-05-20 | Massachusetts Inst Technology | POLY (BETA AMINO ALCOHOLS), THEIR PREPARATION AND USES THEREOF |
| CA2831392C (en) | 2011-03-28 | 2020-04-28 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
| WO2012170930A1 (en) | 2011-06-08 | 2012-12-13 | Shire Human Genetic Therapies, Inc | Lipid nanoparticle compositions and methods for mrna delivery |
| KR102272498B1 (ko) | 2011-10-27 | 2021-07-06 | 메사추세츠 인스티튜트 오브 테크놀로지 | 약물 캡슐화 마이크로스피어를 형성할 수 있는, ｎ-말단 상에 관능화된 아미노산 유도체 |
| WO2013078413A1 (en) * | 2011-11-22 | 2013-05-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modulators of lipid storage |
| WO2013185067A1 (en) | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
| ES2443538B1 (es) * | 2012-07-19 | 2014-11-26 | Consejo Superior De Investigaciones Cientificas (Csic) | Compuestos beta-lactámicos inhibidores de APAF1 |
| CA2884870C (en) | 2012-08-13 | 2022-03-29 | Massachusetts Institute Of Technology | Amine-containing lipidoids and uses thereof |
| MX393573B (es) | 2013-03-14 | 2025-03-21 | Shire Human Genetic Therapies | Composiciones de acido ribonucleico mensajero del regulador transmembrana de fibrosis quistica y metodos y usos relacionados |
| KR20150128687A (ko) | 2013-03-14 | 2015-11-18 | 샤이어 휴먼 지네틱 테라피즈 인크. | 메신저 rna의 정제 방법 |
| WO2014179562A1 (en) | 2013-05-01 | 2014-11-06 | Massachusetts Institute Of Technology | 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof |
| EP3574923A1 (en) | 2013-10-22 | 2019-12-04 | Translate Bio, Inc. | Mrna therapy for phenylketonuria |
| JP6608815B2 (ja) | 2013-10-22 | 2019-11-20 | トランスレイト バイオ， インコーポレイテッド | アルギニノコハク酸合成酵素欠損症のｍＲＮＡ治療 |
| CA2928078A1 (en) | 2013-10-22 | 2015-04-30 | Shire Human Genetic Therapies, Inc. | Lipid formulations for delivery of messenger rna |
| EP3636742B1 (en) | 2014-04-25 | 2025-11-05 | Translate Bio, Inc. | Methods for purification of messenger rna |
| CA2949106C (en) | 2014-05-30 | 2023-10-24 | Shire Human Genetic Therapies, Inc. | Biodegradable lipids for delivery of nucleic acids |
| KR102387898B1 (ko) | 2014-06-24 | 2022-04-15 | 샤이어 휴먼 지네틱 테라피즈 인크. | 핵산의 전달용 입체화학적으로 풍부한 조성물 |
| US9840479B2 (en) | 2014-07-02 | 2017-12-12 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
| WO2016205691A1 (en) | 2015-06-19 | 2016-12-22 | Massachusetts Institute Of Technology | Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell |
| EP3585417B1 (en) | 2017-02-27 | 2023-02-22 | Translate Bio, Inc. | Method of making a codon-optimized cftr mrna |
| AU2018268859B2 (en) | 2017-05-16 | 2024-07-25 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding CFTR |
| EP3781102B1 (en) | 2018-04-19 | 2025-09-24 | Spiral Therapeutics, Inc. | Inner ear drug delivery devices and methods of use |
| US11174500B2 (en) | 2018-08-24 | 2021-11-16 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| WO2020106946A1 (en) | 2018-11-21 | 2020-05-28 | Translate Bio, Inc. | TREATMENT OF CYSTIC FIBROSIS BY DELIVERY OF NEBULIZED mRNA ENCODING CFTR |
| US10561736B1 (en) | 2019-01-09 | 2020-02-18 | Spiral Therapeutics, Inc. | Apoptosis inhibitor formulations for prevention of hearing loss |
| EP3930805A1 (en) | 2019-02-25 | 2022-01-05 | Spiral Therapeutics, Inc. | Intratympanic injector devices and needles for delivery of drugs and methods of use |
| US12360350B2 (en) | 2020-01-24 | 2025-07-15 | Spiral Therapeutics, Inc. | Devices, systems, and methods for otology |
| EP4137131A1 (en) * | 2021-08-17 | 2023-02-22 | Centre National de la Recherche Scientifique (CNRS) | Novel serotonin analogues and their uses for treating iron-associated disorders |
| CN115124449B (zh) * | 2022-05-24 | 2024-02-02 | 上海英诺富成生物科技有限公司 | 一种吲哚化合物及制备方法与应用 |
Citations (1)
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| US5281585A (en) * | 1991-05-07 | 1994-01-25 | Merck & Co., Inc. | Fibrinogen receptor antagonists for inhibiting aggregation of blood platelets |
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| US3560503A (en) * | 1968-09-18 | 1971-02-02 | Council Scient Ind Res | Di-lower alkyl-substituted octahydropyrazinopyrimidinones |
| GB1284582A (en) | 1969-11-10 | 1972-08-09 | Council Scient Ind Res | Substituted piperazinopyrimidinones |
| JPH04234375A (ja) | 1990-12-27 | 1992-08-24 | Ajinomoto Co Inc | 新規２，５−ジオキソピペラジン化合物及びその製造法 |
| JPH05117246A (ja) | 1991-10-23 | 1993-05-14 | Ajinomoto Co Inc | 新規２，５−ジオキソピペラジン化合物とその製造法及びα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル誘導体の製造法 |
| WO1996000391A1 (en) * | 1994-06-23 | 1996-01-04 | Affymax Technologies N.V. | Methods for the synthesis of diketopiperazines |
| CA2434184A1 (en) * | 2001-01-19 | 2002-09-12 | Pharmacopeia, Inc. | Bisaryl derivatives having fsh receptor modulatory activity |
| EP1571970B1 (en) | 2002-10-02 | 2011-08-17 | DMI Biosciences, Inc. | Diagnosis and monitoring of diseases |
| EP1698703A4 (en) | 2003-11-28 | 2011-08-17 | Kyowa Hakko Bio Co Ltd | PROCESS FOR DIPEPTIDE PRODUCTION |
| ES2296484B1 (es) | 2005-11-23 | 2009-04-01 | Fundacion De La Comunidad Valenciana Centro De Investigacion Principe Felipe (90%) | Composicion farmaceutica para inhibir la apoptosis. |
| ES2293834B1 (es) | 2006-07-20 | 2009-02-16 | Consejo Superior Investig. Cientificas | Compuesto con actividad inhibidora de las interacciones ubc13-uev, composiciones farmaceuticas que lo comprenden y sus aplicaciones terapeuticas. |
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2010
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5281585A (en) * | 1991-05-07 | 1994-01-25 | Merck & Co., Inc. | Fibrinogen receptor antagonists for inhibiting aggregation of blood platelets |
Non-Patent Citations (2)
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| Goktalay, G., et al, European Journal of Pharmacology, 2006, 530, 95-102 * |
| Saxena, R., et al, Journal of Medicinal Chemistry, 1971, 14(10), 929-31 * |
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| AU2010277505A1 (en) | 2012-03-08 |
| BR112012002134A2 (pt) | 2016-05-31 |
| BR112012002134B8 (pt) | 2021-05-25 |
| KR20120052354A (ko) | 2012-05-23 |
| EA201270215A1 (ru) | 2012-11-30 |
| CA2769408A1 (en) | 2011-02-03 |
| JP5694320B2 (ja) | 2015-04-01 |
| US9040701B2 (en) | 2015-05-26 |
| CN102574818B (zh) | 2015-02-25 |
| US20120122868A1 (en) | 2012-05-17 |
| WO2011012746A2 (es) | 2011-02-03 |
| EP2460798B1 (en) | 2019-02-27 |
| JP2013500314A (ja) | 2013-01-07 |
| TR201907804T4 (tr) | 2019-06-21 |
| ES2727711T3 (es) | 2019-10-18 |
| BR112012002134B1 (pt) | 2021-03-02 |
| CN102574818A (zh) | 2012-07-11 |
| MX2012001339A (es) | 2012-03-07 |
| NZ598125A (en) | 2014-05-30 |
| WO2011012746A3 (es) | 2011-07-14 |
| KR101786761B1 (ko) | 2017-10-18 |
| EP2460798A4 (en) | 2013-02-27 |
| CA2769408C (en) | 2017-09-05 |
| EP2460798A2 (en) | 2012-06-06 |
| EA021838B1 (ru) | 2015-09-30 |
| IN2012DN01378A (enExample) | 2015-06-05 |
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