EA021838B1 - Производные 2,5-пиперазиндиона в качестве ингибиторов apaf-1 - Google Patents
Производные 2,5-пиперазиндиона в качестве ингибиторов apaf-1 Download PDFInfo
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- EA021838B1 EA021838B1 EA201270215A EA201270215A EA021838B1 EA 021838 B1 EA021838 B1 EA 021838B1 EA 201270215 A EA201270215 A EA 201270215A EA 201270215 A EA201270215 A EA 201270215A EA 021838 B1 EA021838 B1 EA 021838B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- ethyl
- compound
- pharmaceutically acceptable
- aryl
- pathologies
- Prior art date
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200901757 | 2009-07-30 | ||
| PCT/ES2010/000349 WO2011012746A2 (es) | 2009-07-30 | 2010-07-29 | Compuestos inhibidores de apaf-1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201270215A1 EA201270215A1 (ru) | 2012-11-30 |
| EA021838B1 true EA021838B1 (ru) | 2015-09-30 |
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| SI2506857T1 (en) | 2009-12-01 | 2018-08-31 | Translate Bio, Inc. | Delivery of mRNA for the enrichment of proteins and enzymes in human genetic diseases |
| US9193827B2 (en) | 2010-08-26 | 2015-11-24 | Massachusetts Institute Of Technology | Poly(beta-amino alcohols), their preparation, and uses thereof |
| CA2831392C (en) | 2011-03-28 | 2020-04-28 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
| KR20220025112A (ko) | 2011-06-08 | 2022-03-03 | 샤이어 휴먼 지네틱 테라피즈 인크. | Mrna 전달을 위한 지질 나노입자 조성물 및 방법 |
| US9512073B2 (en) | 2011-10-27 | 2016-12-06 | Massachusetts Institute Of Technology | Amino acid-, peptide-and polypeptide-lipids, isomers, compositions, and uses thereof |
| WO2013078413A1 (en) * | 2011-11-22 | 2013-05-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modulators of lipid storage |
| EP3536787A1 (en) | 2012-06-08 | 2019-09-11 | Translate Bio, Inc. | Nuclease resistant polynucleotides and uses thereof |
| ES2443538B1 (es) * | 2012-07-19 | 2014-11-26 | Consejo Superior De Investigaciones Cientificas (Csic) | Compuestos beta-lactámicos inhibidores de APAF1 |
| WO2014028487A1 (en) | 2012-08-13 | 2014-02-20 | Massachusetts Institute Of Technology | Amine-containing lipidoids and uses thereof |
| KR102311614B1 (ko) | 2013-03-14 | 2021-10-08 | 샤이어 휴먼 지네틱 테라피즈 인크. | Cftr mrna 조성물 및 관련 방법 및 사용 |
| EA201591229A1 (ru) | 2013-03-14 | 2016-01-29 | Шир Хьюман Дженетик Терапис, Инк. | Способы очистки матричной рнк |
| US9315472B2 (en) | 2013-05-01 | 2016-04-19 | Massachusetts Institute Of Technology | 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof |
| ES3032935T3 (en) | 2013-10-22 | 2025-07-29 | Translate Bio Inc | Lipid formulations for delivery of messenger rna |
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| WO2015184256A2 (en) | 2014-05-30 | 2015-12-03 | Shire Human Genetic Therapies, Inc. | Biodegradable lipids for delivery of nucleic acids |
| KR102559979B1 (ko) | 2014-06-24 | 2023-07-25 | 샤이어 휴먼 지네틱 테라피즈 인크. | 핵산의 전달용 입체화학적으로 풍부한 조성물 |
| WO2016004202A1 (en) | 2014-07-02 | 2016-01-07 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
| RS64331B1 (sr) | 2015-06-19 | 2023-08-31 | Massachusetts Inst Technology | Alkenil supstituisani 2,5-piperazindioni i njihova primena u sastavima za isporuku agensa u organizam ili ćeliju subjekta |
| MX2019010155A (es) | 2017-02-27 | 2020-12-10 | Translate Bio Inc | Arnm de cftr optimizado por codón novedoso. |
| IL270631B2 (en) | 2017-05-16 | 2024-03-01 | Translate Bio Inc | Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr |
| AU2019256527B2 (en) | 2018-04-19 | 2025-01-23 | Spiral Therapeutics, Inc. | Inner ear drug delivery devices and methods of use |
| US11174500B2 (en) | 2018-08-24 | 2021-11-16 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| AU2019384557B2 (en) | 2018-11-21 | 2025-07-17 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of nebulized mRNA encoding CFTR |
| US10561736B1 (en) | 2019-01-09 | 2020-02-18 | Spiral Therapeutics, Inc. | Apoptosis inhibitor formulations for prevention of hearing loss |
| EP3930805A1 (en) | 2019-02-25 | 2022-01-05 | Spiral Therapeutics, Inc. | Intratympanic injector devices and needles for delivery of drugs and methods of use |
| CA3155003A1 (en) | 2019-09-20 | 2021-03-25 | Translate Bio, Inc. | Mrna encoding engineered cftr |
| CN115426991A (zh) | 2020-01-24 | 2022-12-02 | 斯皮拉尔诊疗有限公司 | 用于治疗耳部疾病的装置、系统和方法 |
| CN118103042A (zh) * | 2021-08-17 | 2024-05-28 | 国家科学研究中心 | 新型血清素衍生物及其用于治疗铁相关病症的用途 |
| EP4137131A1 (en) * | 2021-08-17 | 2023-02-22 | Centre National de la Recherche Scientifique (CNRS) | Novel serotonin analogues and their uses for treating iron-associated disorders |
| CN115124449B (zh) * | 2022-05-24 | 2024-02-02 | 上海英诺富成生物科技有限公司 | 一种吲哚化合物及制备方法与应用 |
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Also Published As
| Publication number | Publication date |
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| KR101786761B1 (ko) | 2017-10-18 |
| CA2769408C (en) | 2017-09-05 |
| AU2010277505B2 (en) | 2016-01-14 |
| JP2013500314A (ja) | 2013-01-07 |
| CN102574818A (zh) | 2012-07-11 |
| BR112012002134B8 (pt) | 2021-05-25 |
| NZ598125A (en) | 2014-05-30 |
| TR201907804T4 (tr) | 2019-06-21 |
| EP2460798B1 (en) | 2019-02-27 |
| ES2727711T3 (es) | 2019-10-18 |
| US9040701B2 (en) | 2015-05-26 |
| KR20120052354A (ko) | 2012-05-23 |
| AU2010277505A1 (en) | 2012-03-08 |
| IN2012DN01378A (enExample) | 2015-06-05 |
| CN102574818B (zh) | 2015-02-25 |
| CA2769408A1 (en) | 2011-02-03 |
| WO2011012746A3 (es) | 2011-07-14 |
| EP2460798A2 (en) | 2012-06-06 |
| EA201270215A1 (ru) | 2012-11-30 |
| MX2012001339A (es) | 2012-03-07 |
| WO2011012746A2 (es) | 2011-02-03 |
| US20120122868A1 (en) | 2012-05-17 |
| BR112012002134B1 (pt) | 2021-03-02 |
| BR112012002134A2 (pt) | 2016-05-31 |
| EP2460798A4 (en) | 2013-02-27 |
| JP5694320B2 (ja) | 2015-04-01 |
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