EA021838B1 - Производные 2,5-пиперазиндиона в качестве ингибиторов apaf-1 - Google Patents
Производные 2,5-пиперазиндиона в качестве ингибиторов apaf-1 Download PDFInfo
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- EA021838B1 EA021838B1 EA201270215A EA201270215A EA021838B1 EA 021838 B1 EA021838 B1 EA 021838B1 EA 201270215 A EA201270215 A EA 201270215A EA 201270215 A EA201270215 A EA 201270215A EA 021838 B1 EA021838 B1 EA 021838B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- ethyl
- compound
- pharmaceutically acceptable
- aryl
- pathologies
- Prior art date
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200901757 | 2009-07-30 | ||
| PCT/ES2010/000349 WO2011012746A2 (es) | 2009-07-30 | 2010-07-29 | Compuestos inhibidores de apaf-1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201270215A1 EA201270215A1 (ru) | 2012-11-30 |
| EA021838B1 true EA021838B1 (ru) | 2015-09-30 |
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| PL3338765T3 (pl) | 2009-12-01 | 2019-06-28 | Translate Bio, Inc. | Pochodna steroidowa dla dostarczania mrna w ludzkich chorobach genetycznych |
| US9193827B2 (en) | 2010-08-26 | 2015-11-24 | Massachusetts Institute Of Technology | Poly(beta-amino alcohols), their preparation, and uses thereof |
| US9238716B2 (en) | 2011-03-28 | 2016-01-19 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
| PT2717893T (pt) | 2011-06-08 | 2019-08-20 | Translate Bio Inc | Composições de nanopartículas lipídicas e métodos para transferência de arnm |
| KR20150000461A (ko) * | 2011-10-27 | 2015-01-02 | 메사추세츠 인스티튜트 오브 테크놀로지 | 약물 캡슐화 마이크로스피어를 형성할 수 있는, ｎ-말단 상에 관능화된 아미노산 유도체 |
| WO2013078413A1 (en) * | 2011-11-22 | 2013-05-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modulators of lipid storage |
| WO2013185067A1 (en) | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
| ES2443538B1 (es) * | 2012-07-19 | 2014-11-26 | Consejo Superior De Investigaciones Cientificas (Csic) | Compuestos beta-lactámicos inhibidores de APAF1 |
| EP2882706A1 (en) | 2012-08-13 | 2015-06-17 | Massachusetts Institute of Technology | Amine-containing lipidoids and uses thereof |
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| ES2981185T3 (es) | 2013-03-14 | 2024-10-07 | Translate Bio Inc | Métodos para la purificación de ARN mensajero |
| WO2014179562A1 (en) | 2013-05-01 | 2014-11-06 | Massachusetts Institute Of Technology | 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof |
| US11224642B2 (en) | 2013-10-22 | 2022-01-18 | Translate Bio, Inc. | MRNA therapy for argininosuccinate synthetase deficiency |
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| WO2015061467A1 (en) | 2013-10-22 | 2015-04-30 | Shire Human Genetic Therapies, Inc. | Lipid formulations for delivery of messenger rna |
| JP6571679B2 (ja) | 2014-04-25 | 2019-09-04 | トランスレイト バイオ， インコーポレイテッド | メッセンジャーｒｎａの精製方法 |
| US10022455B2 (en) | 2014-05-30 | 2018-07-17 | Translate Bio, Inc. | Biodegradable lipids for delivery of nucleic acids |
| CA2952824C (en) | 2014-06-24 | 2023-02-21 | Shire Human Genetic Therapies, Inc. | Stereochemically enriched compositions for delivery of nucleic acids |
| WO2016004202A1 (en) | 2014-07-02 | 2016-01-07 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
| ES2949540T3 (es) | 2015-06-19 | 2023-09-29 | Massachusetts Inst Technology | 2,5-piperazinadionas sustituidas con alquenilo y su uso en composiciones para suministrar un agente a un sujeto o una célula |
| AU2018224326B2 (en) | 2017-02-27 | 2024-01-04 | Translate Bio, Inc. | Novel codon-optimized CFTR mRNA |
| MX2019013752A (es) | 2017-05-16 | 2020-07-20 | Translate Bio Inc | Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr optimizado en codones. |
| AU2019256527B2 (en) | 2018-04-19 | 2025-01-23 | Spiral Therapeutics, Inc. | Inner ear drug delivery devices and methods of use |
| CN118421617A (zh) | 2018-08-24 | 2024-08-02 | 川斯勒佰尔公司 | 用于纯化信使rna的方法 |
| EP3883592A1 (en) | 2018-11-21 | 2021-09-29 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of nebulized mrna encoding cftr |
| US10561736B1 (en) | 2019-01-09 | 2020-02-18 | Spiral Therapeutics, Inc. | Apoptosis inhibitor formulations for prevention of hearing loss |
| WO2020176419A1 (en) | 2019-02-25 | 2020-09-03 | Spiral Therapeutics, Inc. | Intratympanic injector devices and needles for delivery of drugs and methods of use |
| WO2021055609A1 (en) | 2019-09-20 | 2021-03-25 | Translate Bio, Inc. | Mrna encoding engineered cftr |
| WO2021150858A1 (en) | 2020-01-24 | 2021-07-29 | Spiral Therapeutics Inc. | Minimally-invasive tools and methods for accessing the middle and inner ear through the tympanic membrane |
| EP4137131A1 (en) * | 2021-08-17 | 2023-02-22 | Centre National de la Recherche Scientifique (CNRS) | Novel serotonin analogues and their uses for treating iron-associated disorders |
| CN115124449B (zh) * | 2022-05-24 | 2024-02-02 | 上海英诺富成生物科技有限公司 | 一种吲哚化合物及制备方法与应用 |
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| WO2007060524A1 (en) * | 2005-11-23 | 2007-05-31 | Laboratorios Salvat, S.A. | Compounds for the inhibition of apoptosis |
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Also Published As
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| MX2012001339A (es) | 2012-03-07 |
| CA2769408A1 (en) | 2011-02-03 |
| CA2769408C (en) | 2017-09-05 |
| CN102574818A (zh) | 2012-07-11 |
| EP2460798A4 (en) | 2013-02-27 |
| WO2011012746A2 (es) | 2011-02-03 |
| US9040701B2 (en) | 2015-05-26 |
| WO2011012746A3 (es) | 2011-07-14 |
| ES2727711T3 (es) | 2019-10-18 |
| EP2460798A2 (en) | 2012-06-06 |
| US20120122868A1 (en) | 2012-05-17 |
| TR201907804T4 (tr) | 2019-06-21 |
| IN2012DN01378A (enExample) | 2015-06-05 |
| KR20120052354A (ko) | 2012-05-23 |
| CN102574818B (zh) | 2015-02-25 |
| BR112012002134A2 (pt) | 2016-05-31 |
| EP2460798B1 (en) | 2019-02-27 |
| NZ598125A (en) | 2014-05-30 |
| AU2010277505A1 (en) | 2012-03-08 |
| JP5694320B2 (ja) | 2015-04-01 |
| BR112012002134B1 (pt) | 2021-03-02 |
| BR112012002134B8 (pt) | 2021-05-25 |
| JP2013500314A (ja) | 2013-01-07 |
| EA201270215A1 (ru) | 2012-11-30 |
| AU2010277505B2 (en) | 2016-01-14 |
| KR101786761B1 (ko) | 2017-10-18 |
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