ES2727711T3 - Compuestos inhibidores de Apaf-1 - Google Patents
Compuestos inhibidores de Apaf-1 Download PDFInfo
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- ES2727711T3 ES2727711T3 ES10803937T ES10803937T ES2727711T3 ES 2727711 T3 ES2727711 T3 ES 2727711T3 ES 10803937 T ES10803937 T ES 10803937T ES 10803937 T ES10803937 T ES 10803937T ES 2727711 T3 ES2727711 T3 ES 2727711T3
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200901757 | 2009-07-30 | ||
| PCT/ES2010/000349 WO2011012746A2 (es) | 2009-07-30 | 2010-07-29 | Compuestos inhibidores de apaf-1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2727711T3 true ES2727711T3 (es) | 2019-10-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10803937T Active ES2727711T3 (es) | 2009-07-30 | 2010-07-29 | Compuestos inhibidores de Apaf-1 |
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| US (1) | US9040701B2 (enExample) |
| EP (1) | EP2460798B1 (enExample) |
| JP (1) | JP5694320B2 (enExample) |
| KR (1) | KR101786761B1 (enExample) |
| CN (1) | CN102574818B (enExample) |
| AU (1) | AU2010277505B2 (enExample) |
| BR (1) | BR112012002134B8 (enExample) |
| CA (1) | CA2769408C (enExample) |
| EA (1) | EA021838B1 (enExample) |
| ES (1) | ES2727711T3 (enExample) |
| IN (1) | IN2012DN01378A (enExample) |
| MX (1) | MX2012001339A (enExample) |
| NZ (1) | NZ598125A (enExample) |
| TR (1) | TR201907804T4 (enExample) |
| WO (1) | WO2011012746A2 (enExample) |
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| CA2611944A1 (en) | 2005-06-15 | 2006-12-28 | Massachusetts Institute Of Technology | Amine-containing lipids and uses thereof |
| JP6087504B2 (ja) | 2008-11-07 | 2017-03-01 | マサチューセッツ インスティテュート オブ テクノロジー | アミノアルコールリピドイドおよびその使用 |
| SI3338765T1 (sl) | 2009-12-01 | 2019-05-31 | Translate Bio, Inc. | Derivat steroida za dostavo MRNA pri humanih genetskih boleznih |
| EP2609135A4 (en) | 2010-08-26 | 2015-05-20 | Massachusetts Inst Technology | POLY (BETA AMINO ALCOHOLS), THEIR PREPARATION AND USES THEREOF |
| CA2831392C (en) | 2011-03-28 | 2020-04-28 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
| WO2012170930A1 (en) | 2011-06-08 | 2012-12-13 | Shire Human Genetic Therapies, Inc | Lipid nanoparticle compositions and methods for mrna delivery |
| KR102272498B1 (ko) | 2011-10-27 | 2021-07-06 | 메사추세츠 인스티튜트 오브 테크놀로지 | 약물 캡슐화 마이크로스피어를 형성할 수 있는, ｎ-말단 상에 관능화된 아미노산 유도체 |
| WO2013078413A1 (en) * | 2011-11-22 | 2013-05-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modulators of lipid storage |
| WO2013185067A1 (en) | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
| ES2443538B1 (es) * | 2012-07-19 | 2014-11-26 | Consejo Superior De Investigaciones Cientificas (Csic) | Compuestos beta-lactámicos inhibidores de APAF1 |
| CA2884870C (en) | 2012-08-13 | 2022-03-29 | Massachusetts Institute Of Technology | Amine-containing lipidoids and uses thereof |
| MX393573B (es) | 2013-03-14 | 2025-03-21 | Shire Human Genetic Therapies | Composiciones de acido ribonucleico mensajero del regulador transmembrana de fibrosis quistica y metodos y usos relacionados |
| KR20150128687A (ko) | 2013-03-14 | 2015-11-18 | 샤이어 휴먼 지네틱 테라피즈 인크. | 메신저 rna의 정제 방법 |
| WO2014179562A1 (en) | 2013-05-01 | 2014-11-06 | Massachusetts Institute Of Technology | 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof |
| EP3574923A1 (en) | 2013-10-22 | 2019-12-04 | Translate Bio, Inc. | Mrna therapy for phenylketonuria |
| JP6608815B2 (ja) | 2013-10-22 | 2019-11-20 | トランスレイト バイオ， インコーポレイテッド | アルギニノコハク酸合成酵素欠損症のｍＲＮＡ治療 |
| CA2928078A1 (en) | 2013-10-22 | 2015-04-30 | Shire Human Genetic Therapies, Inc. | Lipid formulations for delivery of messenger rna |
| EP3636742B1 (en) | 2014-04-25 | 2025-11-05 | Translate Bio, Inc. | Methods for purification of messenger rna |
| CA2949106C (en) | 2014-05-30 | 2023-10-24 | Shire Human Genetic Therapies, Inc. | Biodegradable lipids for delivery of nucleic acids |
| KR102387898B1 (ko) | 2014-06-24 | 2022-04-15 | 샤이어 휴먼 지네틱 테라피즈 인크. | 핵산의 전달용 입체화학적으로 풍부한 조성물 |
| US9840479B2 (en) | 2014-07-02 | 2017-12-12 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
| WO2016205691A1 (en) | 2015-06-19 | 2016-12-22 | Massachusetts Institute Of Technology | Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell |
| EP3585417B1 (en) | 2017-02-27 | 2023-02-22 | Translate Bio, Inc. | Method of making a codon-optimized cftr mrna |
| AU2018268859B2 (en) | 2017-05-16 | 2024-07-25 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding CFTR |
| EP3781102B1 (en) | 2018-04-19 | 2025-09-24 | Spiral Therapeutics, Inc. | Inner ear drug delivery devices and methods of use |
| US11174500B2 (en) | 2018-08-24 | 2021-11-16 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| WO2020106946A1 (en) | 2018-11-21 | 2020-05-28 | Translate Bio, Inc. | TREATMENT OF CYSTIC FIBROSIS BY DELIVERY OF NEBULIZED mRNA ENCODING CFTR |
| US10561736B1 (en) | 2019-01-09 | 2020-02-18 | Spiral Therapeutics, Inc. | Apoptosis inhibitor formulations for prevention of hearing loss |
| EP3930805A1 (en) | 2019-02-25 | 2022-01-05 | Spiral Therapeutics, Inc. | Intratympanic injector devices and needles for delivery of drugs and methods of use |
| US12360350B2 (en) | 2020-01-24 | 2025-07-15 | Spiral Therapeutics, Inc. | Devices, systems, and methods for otology |
| EP4137131A1 (en) * | 2021-08-17 | 2023-02-22 | Centre National de la Recherche Scientifique (CNRS) | Novel serotonin analogues and their uses for treating iron-associated disorders |
| CN115124449B (zh) * | 2022-05-24 | 2024-02-02 | 上海英诺富成生物科技有限公司 | 一种吲哚化合物及制备方法与应用 |
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| US3560503A (en) * | 1968-09-18 | 1971-02-02 | Council Scient Ind Res | Di-lower alkyl-substituted octahydropyrazinopyrimidinones |
| GB1284582A (en) | 1969-11-10 | 1972-08-09 | Council Scient Ind Res | Substituted piperazinopyrimidinones |
| JPH04234375A (ja) | 1990-12-27 | 1992-08-24 | Ajinomoto Co Inc | 新規２，５−ジオキソピペラジン化合物及びその製造法 |
| WO1992019595A1 (en) * | 1991-05-07 | 1992-11-12 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| JPH05117246A (ja) | 1991-10-23 | 1993-05-14 | Ajinomoto Co Inc | 新規２，５−ジオキソピペラジン化合物とその製造法及びα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル誘導体の製造法 |
| WO1996000391A1 (en) * | 1994-06-23 | 1996-01-04 | Affymax Technologies N.V. | Methods for the synthesis of diketopiperazines |
| CA2434184A1 (en) * | 2001-01-19 | 2002-09-12 | Pharmacopeia, Inc. | Bisaryl derivatives having fsh receptor modulatory activity |
| EP1571970B1 (en) | 2002-10-02 | 2011-08-17 | DMI Biosciences, Inc. | Diagnosis and monitoring of diseases |
| EP1698703A4 (en) | 2003-11-28 | 2011-08-17 | Kyowa Hakko Bio Co Ltd | PROCESS FOR DIPEPTIDE PRODUCTION |
| ES2296484B1 (es) | 2005-11-23 | 2009-04-01 | Fundacion De La Comunidad Valenciana Centro De Investigacion Principe Felipe (90%) | Composicion farmaceutica para inhibir la apoptosis. |
| ES2293834B1 (es) | 2006-07-20 | 2009-02-16 | Consejo Superior Investig. Cientificas | Compuesto con actividad inhibidora de las interacciones ubc13-uev, composiciones farmaceuticas que lo comprenden y sus aplicaciones terapeuticas. |
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2010
- 2010-07-29 ES ES10803937T patent/ES2727711T3/es active Active
- 2010-07-29 WO PCT/ES2010/000349 patent/WO2011012746A2/es not_active Ceased
- 2010-07-29 AU AU2010277505A patent/AU2010277505B2/en not_active Ceased
- 2010-07-29 NZ NZ598125A patent/NZ598125A/en not_active IP Right Cessation
- 2010-07-29 KR KR1020127005131A patent/KR101786761B1/ko not_active Expired - Fee Related
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- 2010-07-29 JP JP2012522195A patent/JP5694320B2/ja not_active Expired - Fee Related
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- 2010-07-29 IN IN1378DEN2012 patent/IN2012DN01378A/en unknown
- 2010-07-29 EA EA201270215A patent/EA021838B1/ru not_active IP Right Cessation
- 2010-07-29 TR TR2019/07804T patent/TR201907804T4/tr unknown
- 2010-07-29 EP EP10803937.1A patent/EP2460798B1/en active Active
- 2010-07-29 US US13/387,240 patent/US9040701B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010277505A1 (en) | 2012-03-08 |
| BR112012002134A2 (pt) | 2016-05-31 |
| BR112012002134B8 (pt) | 2021-05-25 |
| KR20120052354A (ko) | 2012-05-23 |
| EA201270215A1 (ru) | 2012-11-30 |
| CA2769408A1 (en) | 2011-02-03 |
| AU2010277505B2 (en) | 2016-01-14 |
| JP5694320B2 (ja) | 2015-04-01 |
| US9040701B2 (en) | 2015-05-26 |
| CN102574818B (zh) | 2015-02-25 |
| US20120122868A1 (en) | 2012-05-17 |
| WO2011012746A2 (es) | 2011-02-03 |
| EP2460798B1 (en) | 2019-02-27 |
| JP2013500314A (ja) | 2013-01-07 |
| TR201907804T4 (tr) | 2019-06-21 |
| BR112012002134B1 (pt) | 2021-03-02 |
| CN102574818A (zh) | 2012-07-11 |
| MX2012001339A (es) | 2012-03-07 |
| NZ598125A (en) | 2014-05-30 |
| WO2011012746A3 (es) | 2011-07-14 |
| KR101786761B1 (ko) | 2017-10-18 |
| EP2460798A4 (en) | 2013-02-27 |
| CA2769408C (en) | 2017-09-05 |
| EP2460798A2 (en) | 2012-06-06 |
| EA021838B1 (ru) | 2015-09-30 |
| IN2012DN01378A (enExample) | 2015-06-05 |
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