AU2009311461B2 - Improved anti-CD19 antibodies - Google Patents

Improved anti-CD19 antibodies

Info

Publication number
AU2009311461B2
AU2009311461B2 AU2009311461A AU2009311461A AU2009311461B2 AU 2009311461 B2 AU2009311461 B2 AU 2009311461B2 AU 2009311461 A AU2009311461 A AU 2009311461A AU 2009311461 A AU2009311461 A AU 2009311461A AU 2009311461 B2 AU2009311461 B2 AU 2009311461B2
Authority
AU
Australia
Prior art keywords
antibody
fragment
antibodies
seq
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2009311461A
Other languages
English (en)
Other versions
AU2009311461A1 (en
Inventor
David M. Goldenberg
Hans J. Hansen
Zhengxing Qu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunomedics Inc
Original Assignee
Immunomedics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunomedics Inc filed Critical Immunomedics Inc
Publication of AU2009311461A1 publication Critical patent/AU2009311461A1/en
Application granted granted Critical
Publication of AU2009311461B2 publication Critical patent/AU2009311461B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
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    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
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  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
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  • Optics & Photonics (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
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  • Biomedical Technology (AREA)
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  • Obesity (AREA)
  • Transplantation (AREA)
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  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2009311461A 2008-11-07 2009-10-22 Improved anti-CD19 antibodies Ceased AU2009311461B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/266,999 2008-11-07
US12/266,999 US7902338B2 (en) 2003-07-31 2008-11-07 Anti-CD19 antibodies
PCT/US2009/061666 WO2010053716A1 (en) 2008-11-07 2009-10-22 Improved anti-cd19 antibodies

Publications (2)

Publication Number Publication Date
AU2009311461A1 AU2009311461A1 (en) 2012-02-02
AU2009311461B2 true AU2009311461B2 (en) 2016-07-21

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Application Number Title Priority Date Filing Date
AU2009311461A Ceased AU2009311461B2 (en) 2008-11-07 2009-10-22 Improved anti-CD19 antibodies

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US (9) US7902338B2 (enExample)
EP (1) EP2352523B1 (enExample)
JP (3) JP5762965B2 (enExample)
CN (1) CN102209556B (enExample)
AU (1) AU2009311461B2 (enExample)
CA (1) CA2742254A1 (enExample)
IL (1) IL212701A (enExample)
WO (1) WO2010053716A1 (enExample)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8420086B2 (en) 2002-12-13 2013-04-16 Immunomedics, Inc. Camptothecin conjugates of anti-CD22 antibodies for treatment of B cell diseases
US7902338B2 (en) 2003-07-31 2011-03-08 Immunomedics, Inc. Anti-CD19 antibodies
US8034352B2 (en) * 2005-04-06 2011-10-11 Ibc Pharmaceuticals, Inc. Tetrameric cytokines with improved biological activity
US7608425B2 (en) * 2004-07-23 2009-10-27 Immunomedics, Inc. Methods for protein expression in mammalian cells in serum-free medium
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US20160319020A1 (en) 2016-11-03
EP2352523A1 (en) 2011-08-10
CN102209556B (zh) 2018-02-23
JP5951850B2 (ja) 2016-07-13
JP2012508169A (ja) 2012-04-05
US8147831B2 (en) 2012-04-03
US8624001B1 (en) 2014-01-07
US20130121913A1 (en) 2013-05-16
US7902338B2 (en) 2011-03-08
US20170152315A1 (en) 2017-06-01
US20140017197A1 (en) 2014-01-16
US20150252110A1 (en) 2015-09-10
EP2352523B1 (en) 2017-09-20
CN102209556A (zh) 2011-10-05
JP5762965B2 (ja) 2015-08-12
US20140112865A1 (en) 2014-04-24
JP2017019765A (ja) 2017-01-26
US20120189542A1 (en) 2012-07-26
US8337840B2 (en) 2012-12-25
US8486395B2 (en) 2013-07-16
IL212701A0 (en) 2011-07-31
US20100068136A1 (en) 2010-03-18
EP2352523A4 (en) 2012-11-28

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