AU2008326381B2 - Biaryl PDE4 inhibitors for treating inflammation - Google Patents

Biaryl PDE4 inhibitors for treating inflammation Download PDF

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AU2008326381B2
AU2008326381B2 AU2008326381A AU2008326381A AU2008326381B2 AU 2008326381 B2 AU2008326381 B2 AU 2008326381B2 AU 2008326381 A AU2008326381 A AU 2008326381A AU 2008326381 A AU2008326381 A AU 2008326381A AU 2008326381 B2 AU2008326381 B2 AU 2008326381B2
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nhc
alkyl
chosen
cooh
mmol
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AU2008326381A1 (en
Inventor
Alex Burgin
Mark E. Gurney
Timothy Hagen
Georgeta Hategan
Alexander Kiselyov
Adalie Motta
Vincent Sandanayaka
Gary Schultz
Jasbir Singh
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Decode Genetics ehf
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Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009528363A (ja) 2006-02-28 2009-08-06 ヘリコン セラピューティクス，インコーポレイテッド Ｐｄｅ４インヒビターとしての治療用ピペラジン
JP2011504505A (ja) 2007-11-21 2011-02-10 デコード ジェネティクス イーエイチエフ 肺および心血管障害を治療するためのビアリールｐｄｅ４抑制剤
WO2010059838A2 (fr) * 2008-11-20 2010-05-27 Decode Genetics Ehf Inhibiteurs de pde4 sélectifs pour la forme longue de pde4 pour traiter une inflammation et éviter des effets secondaires
MX2012015252A (es) 2010-06-30 2013-05-30 Ironwood Pharmaceuticals Inc Estimuladores de sgc.
EP2600864B1 (fr) 2010-08-04 2019-01-09 University Of Virginia Patent Foundation Compositions et procédés pour le traitement de maladies inflammatoires
CN107266433A (zh) 2010-11-09 2017-10-20 铁木医药有限公司 sGC刺激剂
JP5886873B2 (ja) * 2010-12-24 2016-03-16 メルク・シャープ・エンド・ドーム・ベー・フェー Ｎ置換アゼチジン誘導体
CN102617457A (zh) * 2011-01-28 2012-08-01 天津药物研究院 一种制备罗氟司特的新方法
CN103012255B (zh) * 2011-09-21 2014-06-11 天津康鸿医药科技发展有限公司 罗氟司特晶型化合物、其制备方法、组合物及应用
CN102603676B (zh) * 2012-02-20 2014-02-12 徐江平 一种能避免呕吐反应的磷酸二酯酶4抑制剂
US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
MX2015006156A (es) 2012-11-20 2015-08-05 Vertex Pharma Compuestos utiles como inhibidores de endolamina 2,3-dioxigenasa.
CN103012408B (zh) * 2012-11-28 2015-02-04 中国科学院广州生物医药与健康研究院 依匹斯汀的合成方法
SG11201504709PA (en) * 2013-03-14 2015-07-30 Dart Neuroscience Llc Substituted pyridine and pyrazine compounds as pde4 inhibitors
EP3116875A1 (fr) 2014-03-14 2017-01-18 Wockhardt Limited Procédé de préparation de (2s, 5r)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylate de sodium
EP3209655B1 (fr) 2014-10-24 2020-07-15 Landos Biopharma, Inc. Agents thérapeutiques à base de lancl2
EP3165224A1 (fr) 2015-11-09 2017-05-10 Albert-Ludwigs-Universität Freiburg Utilisation d'inhibiteurs de pde4 pour la prophylaxie et/ou la thérapie de la dyslipoproteinémie et des troubles apparentés
WO2017089347A1 (fr) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Procédés et compositions pharmaceutiques pour le traitement de mélanomes résistant aux inhibiteurs de braf
AU2017294231B2 (en) 2016-07-05 2021-09-09 Guangzhou Maxinovel Pharmaceuticals Co., Ltd Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof
US11197891B2 (en) 2017-11-30 2021-12-14 Landos Biopharma, Inc. Therapies with lanthionine C-like protein 2 ligands and cells prepared therewith
EP3733659B1 (fr) 2017-12-29 2023-12-20 Guangzhou Maxinovel Pharmaceuticals Co., Ltd. Dérivé de vinyle aromatique ou d'éthyle aromatique, procédé de préparation associé, intermédiaire, composition pharmaceutique et application
CN110041253B (zh) * 2018-01-17 2022-03-29 上海翰森生物医药科技有限公司 吡啶类n-氧化衍生物及其制备方法和应用
US11104660B2 (en) 2019-04-23 2021-08-31 Tetra Discovery Partners, Inc. PDE4D inhibitors
AU2020407645B2 (en) 2019-12-20 2022-10-06 Nimmune Biopharma, Inc. Lanthionine C-like protein 2 ligands, cells prepared therewith, and therapies using same
WO2022057928A1 (fr) 2020-09-18 2022-03-24 上海医药集团股份有限公司 Composé carbonyle hétérocyclique et son utilisation
CN112374984A (zh) * 2020-11-06 2021-02-19 苏州求索生物科技有限公司 一种2-溴-4-羟基苯甲醚的制备工艺
KR102514860B1 (ko) * 2020-12-01 2023-03-29 한국과학기술연구원 5-ht7 세로토닌 수용체 활성 저해용 바이페닐 피롤리딘 및 바이페닐 다이하이드로이미다졸 유도체 및 이를 유효성분으로 포함하는 약학 조성물

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272147A (en) * 1991-07-09 1993-12-21 Pfizer Inc. Pyrazolopyrimidinone antianginal agents
US5594141A (en) * 1994-11-23 1997-01-14 Neurogen Corporation Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands
WO1997003967A1 (fr) * 1995-07-22 1997-02-06 Rhone-Poulenc Rorer Limited Composes aromatiques substitues et leur utilisation pharmaceutique
WO1997032853A1 (fr) * 1996-03-08 1997-09-12 Novartis Ag Composes triaryles
WO1999031062A1 (fr) * 1997-12-17 1999-06-24 Shionogi & Co., Ltd. Nouveaux composes de pyridine
WO1999048868A2 (fr) * 1998-03-26 1999-09-30 Sugen, Inc. Familles heterocycliques de composes destinees a la modulation de la tyrosine-kinase
WO2004041266A1 (fr) * 2002-11-08 2004-05-21 Takeda Pharmaceutical Company Limited Agent de controle de la fonction recepteur
WO2005030206A1 (fr) * 2003-09-24 2005-04-07 Imclone Systems Incorporated Derives d'aryl-1,3-azole et procedes permettant d'inhiber l'activite de l'heparanase
WO2005051298A2 (fr) * 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Nouvelles substances thyromimetiques contenant du phosphore
WO2005063729A1 (fr) * 2003-12-25 2005-07-14 Takeda Pharmaceutical Company Limited Derives d'acide 3-(4-benzyloxyphenyl) propanoique
WO2006056854A1 (fr) * 2004-11-23 2006-06-01 Pfizer Products Inc. Composes et derives de dibenzyl amine
WO2007056341A1 (fr) * 2005-11-08 2007-05-18 Vertex Pharmaceuticals Incorporated MODULATEURS HÉTÉROCYCLIQUES DE TRANSPORTEURS À CASSETTE LIANT l’ATP
WO2007087066A2 (fr) * 2005-12-28 2007-08-02 Vertex Pharmaceuticals Incorporated Modulateurs de transporteurs à cassette liant l'atp
WO2007131201A2 (fr) * 2006-05-05 2007-11-15 Irm Llc Composés et compositions modulant le mécanisme d'action de la hedgehog
WO2008021849A2 (fr) * 2006-08-09 2008-02-21 Smithkline Beecham Corporation Nouveaux composés comme antagonistes ou agonistes inverses à des récepteurs d'opioïdes

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0249963B1 (fr) * 1986-06-20 1992-04-22 Idemitsu Kosan Company Limited Polycarbonates
CA2144669A1 (fr) * 1994-03-29 1995-09-30 Kozo Akasaka Derives du biphenyle
CA2205969A1 (fr) * 1994-11-23 1996-05-30 Neurogen Corporation Composes aminomethyle aryle, ligands selectifs d'un sous-type de recepteur de dopamine
FR2754260B1 (fr) * 1996-10-04 1998-10-30 Adir Nouveaux derives substitues de biphenyle ou de phenylpyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2000014083A1 (fr) * 1998-09-09 2000-03-16 Inflazyme Pharmaceuticals Ltd. Δ-LACTONES η-PHENYL-SUBSTITUEES, LEURS ANALOGUES, ET LEURS UTILISATIONS
US6518257B1 (en) * 1999-10-22 2003-02-11 Takeda Chemical Industries, Ltd. 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof
BR0207846A (pt) * 2001-03-07 2005-09-13 Incyte San Diego Inc Derivados heterocìclicos para o tratamento de câncer e outras doenças proliferativas
AU2003225305A1 (en) * 2002-05-08 2003-11-11 Bristol-Myers Squibb Company Pyridine-based thyroid receptor ligands
AU2004224392A1 (en) * 2003-03-24 2004-10-07 Merck & Co., Inc. Biaryl substituted 6-membered heterocyles as sodium channel blockers
CA2520804A1 (fr) * 2003-04-03 2004-10-28 Merck & Co., Inc. Pyrazoles biaryle substitue utilises en tant que bloqueurs de canaux sodiques
US7557143B2 (en) * 2003-04-18 2009-07-07 Bristol-Myers Squibb Company Thyroid receptor ligands
NZ547044A (en) * 2003-11-10 2010-05-28 Merck Sharp & Dohme Substituted triazoles as sodium channel blockers
KR101316992B1 (ko) * 2004-12-23 2013-10-11 갈데르마 리써어치 앤드 디벨로프먼트 Ｒａｒ 수용체를 조절하는 신규 리간드, 및 인간 의학 및화장품에서의 그의 용도
BRPI0606476A2 (pt) * 2005-01-07 2009-06-30 Synta Pharmaceuticals Corp compostos para inflamação e usos imuno-relacionados e suas composições farmacêuticas
CA2635262C (fr) * 2005-12-30 2011-08-16 Merck & Co., Inc. Derives de 1, 3-oxazolidin-2-one utiles en tant qu'inhibiteurs de la cetp
CA2655913A1 (fr) * 2006-06-28 2008-01-03 Sanwa Kagaku Kenkyusho Co., Ltd. Nouveau derive heterocyclique bicyclique a 5-6 systemes et son utilisation pharmaceutique
JP2010522214A (ja) * 2007-03-21 2010-07-01 アルミラル， エセ．アー． アデノシンレセプターアンタゴニストとしての置換ピリミジン
JP2011504505A (ja) * 2007-11-21 2011-02-10 デコード ジェネティクス イーエイチエフ 肺および心血管障害を治療するためのビアリールｐｄｅ４抑制剤
FR2932180B1 (fr) * 2008-06-04 2012-08-10 Centre Nat Rech Scient Dihydro iso ca-4 et analogues : puissants cytotoxiques, inhibiteurs de la polymerisation de la tubuline

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272147A (en) * 1991-07-09 1993-12-21 Pfizer Inc. Pyrazolopyrimidinone antianginal agents
US5594141A (en) * 1994-11-23 1997-01-14 Neurogen Corporation Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands
WO1997003967A1 (fr) * 1995-07-22 1997-02-06 Rhone-Poulenc Rorer Limited Composes aromatiques substitues et leur utilisation pharmaceutique
WO1997032853A1 (fr) * 1996-03-08 1997-09-12 Novartis Ag Composes triaryles
WO1999031062A1 (fr) * 1997-12-17 1999-06-24 Shionogi & Co., Ltd. Nouveaux composes de pyridine
WO1999048868A2 (fr) * 1998-03-26 1999-09-30 Sugen, Inc. Familles heterocycliques de composes destinees a la modulation de la tyrosine-kinase
WO2004041266A1 (fr) * 2002-11-08 2004-05-21 Takeda Pharmaceutical Company Limited Agent de controle de la fonction recepteur
WO2005030206A1 (fr) * 2003-09-24 2005-04-07 Imclone Systems Incorporated Derives d'aryl-1,3-azole et procedes permettant d'inhiber l'activite de l'heparanase
WO2005051298A2 (fr) * 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Nouvelles substances thyromimetiques contenant du phosphore
WO2005063729A1 (fr) * 2003-12-25 2005-07-14 Takeda Pharmaceutical Company Limited Derives d'acide 3-(4-benzyloxyphenyl) propanoique
WO2006056854A1 (fr) * 2004-11-23 2006-06-01 Pfizer Products Inc. Composes et derives de dibenzyl amine
WO2007056341A1 (fr) * 2005-11-08 2007-05-18 Vertex Pharmaceuticals Incorporated MODULATEURS HÉTÉROCYCLIQUES DE TRANSPORTEURS À CASSETTE LIANT l’ATP
WO2007087066A2 (fr) * 2005-12-28 2007-08-02 Vertex Pharmaceuticals Incorporated Modulateurs de transporteurs à cassette liant l'atp
WO2007131201A2 (fr) * 2006-05-05 2007-11-15 Irm Llc Composés et compositions modulant le mécanisme d'action de la hedgehog
WO2008021849A2 (fr) * 2006-08-09 2008-02-21 Smithkline Beecham Corporation Nouveaux composés comme antagonistes ou agonistes inverses à des récepteurs d'opioïdes

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