WO2009067600A3 - Inhibiteurs de pde4 biaryle pour traiter une inflammation - Google Patents

Inhibiteurs de pde4 biaryle pour traiter une inflammation Download PDF

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Publication number
WO2009067600A3
WO2009067600A3 PCT/US2008/084193 US2008084193W WO2009067600A3 WO 2009067600 A3 WO2009067600 A3 WO 2009067600A3 US 2008084193 W US2008084193 W US 2008084193W WO 2009067600 A3 WO2009067600 A3 WO 2009067600A3
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WIPO (PCT)
Prior art keywords
pde4 inhibitors
treating inflammation
biaryl
formula
compounds
Prior art date
Application number
PCT/US2008/084193
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English (en)
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WO2009067600A2 (fr
Inventor
Jasbir Singh
Mark E Gurney
Alex Burgin
Vincent Sandanayaka
Alexander Kiselyov
Adalie Motta
Gary Schultz
Georgeta Hategan
Timothy Hagen
Original Assignee
Decode Genetics Ehf
Jasbir Singh
Mark E Gurney
Alex Burgin
Vincent Sandanayaka
Alexander Kiselyov
Adalie Motta
Gary Schultz
Georgeta Hategan
Timothy Hagen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Decode Genetics Ehf, Jasbir Singh, Mark E Gurney, Alex Burgin, Vincent Sandanayaka, Alexander Kiselyov, Adalie Motta, Gary Schultz, Georgeta Hategan, Timothy Hagen filed Critical Decode Genetics Ehf
Priority to CA2722582A priority Critical patent/CA2722582A1/fr
Priority to EP08851045A priority patent/EP2222638A2/fr
Priority to CN2008801251758A priority patent/CN102089279A/zh
Priority to JP2010535064A priority patent/JP2011505341A/ja
Priority to PCT/US2008/084193 priority patent/WO2009067600A2/fr
Priority to AU2008326381A priority patent/AU2008326381B2/en
Publication of WO2009067600A2 publication Critical patent/WO2009067600A2/fr
Publication of WO2009067600A3 publication Critical patent/WO2009067600A3/fr
Priority to IL205881A priority patent/IL205881A0/en

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    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
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    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
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    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Abstract

La présente invention concerne un genre de composés biaryle contenant au moins un cycle supplémentaire. Les composés sont des inhibiteurs de PDE4 utiles pour le traitement et la prévention d'un accident vasculaire cérébral, d'un infarctus du myocarde et de maladies et troubles inflammatoires cardiovasculaires. Les composés répondent à la formule générale I : (la formule doit être insérée ici). Un mode de réalisation particulier est (une seconde formule doit être insérée ici).
PCT/US2008/084193 2007-11-21 2008-11-20 Inhibiteurs de pde4 biaryle pour traiter une inflammation WO2009067600A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2722582A CA2722582A1 (fr) 2007-11-21 2008-11-20 Inhibiteurs de pde4 biaryle pour traiter une inflammation
EP08851045A EP2222638A2 (fr) 2007-11-21 2008-11-20 Inhibiteurs de pde4 biaryle pour traiter une inflammation
CN2008801251758A CN102089279A (zh) 2007-11-21 2008-11-20 用于治疗炎症的联芳基pde4抑制剂
JP2010535064A JP2011505341A (ja) 2007-11-21 2008-11-20 炎症性、心血管およびｃｎｓ障害を治療するビアリールｐｄｅ４抑制剤
PCT/US2008/084193 WO2009067600A2 (fr) 2007-11-21 2008-11-20 Inhibiteurs de pde4 biaryle pour traiter une inflammation
AU2008326381A AU2008326381B2 (en) 2007-11-21 2008-11-20 Biaryl PDE4 inhibitors for treating inflammation
IL205881A IL205881A0 (en) 2008-11-20 2010-05-20 Biaryl pde4 inhibitors for treating inflammation

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US98955107P 2007-11-21 2007-11-21
US60/989,551 2007-11-21
PCT/US2008/084193 WO2009067600A2 (fr) 2007-11-21 2008-11-20 Inhibiteurs de pde4 biaryle pour traiter une inflammation

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WO2009067600A3 true WO2009067600A3 (fr) 2009-07-30

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JP (1) JP2011505341A (fr)
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WO (1) WO2009067600A2 (fr)

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S. YOGI, K. HOKAMA, S. TAKAYOSHI, O. TSUGE: "Synthesis of Imido-Substituted 3,8-Diphenyl-1,2-diazacycloocta-2,4,6,8-tetraenes and their Thermolysis", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 60, February 1987 (1987-02-01), pages 731 - 735, XP002517828 *
See also references of EP2222638A2 *
SRINIVASARAO ARULANANDA BABU, MAKOTO YASUDA, AND AKIO BABA: "In(III)-Mediated Chemoselective Dehydrogenative Interaction of ClMe2SiH with Carboxylic Acids: Direct Chemo- and Regioselective Friedel?Crafts Acylation of Aromatic Ethers", ORGANIC LETTERS, vol. 9, no. 3, 12 January 2007 (2007-01-12), pages 405 - 408, XP002517831 *

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WO2009067600A2 (fr) 2009-05-28
EP2222638A2 (fr) 2010-09-01
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AU2008326381B2 (en) 2014-10-23
CA2722582A1 (fr) 2009-05-28
JP2011505341A (ja) 2011-02-24

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