AU2008204335B2 - Diagnosis and treatment of Alzheimer's and other neurodementing diseases - Google Patents
Diagnosis and treatment of Alzheimer's and other neurodementing diseases Download PDFInfo
- Publication number
- AU2008204335B2 AU2008204335B2 AU2008204335A AU2008204335A AU2008204335B2 AU 2008204335 B2 AU2008204335 B2 AU 2008204335B2 AU 2008204335 A AU2008204335 A AU 2008204335A AU 2008204335 A AU2008204335 A AU 2008204335A AU 2008204335 B2 AU2008204335 B2 AU 2008204335B2
- Authority
- AU
- Australia
- Prior art keywords
- seq
- amino acid
- antibody
- sequence
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88452607P | 2007-01-11 | 2007-01-11 | |
| US88451307P | 2007-01-11 | 2007-01-11 | |
| US60/884,513 | 2007-01-11 | ||
| EP07000507A EP1944314A1 (en) | 2007-01-11 | 2007-01-11 | Diagnosis of Alzheimer's disease and other neurodementing disorders |
| EP07000521A EP1944315A1 (en) | 2007-01-11 | 2007-01-11 | Prophylaxis and therapy of alzheimer's disease and other neurodementing diseases |
| EP07000521.0 | 2007-01-11 | ||
| EP07000507.9 | 2007-01-11 | ||
| US60/884,526 | 2007-01-11 | ||
| US98166707P | 2007-10-22 | 2007-10-22 | |
| US98167507P | 2007-10-22 | 2007-10-22 | |
| EP07119002 | 2007-10-22 | ||
| EP07119026.8 | 2007-10-22 | ||
| US60/981,667 | 2007-10-22 | ||
| EP07119002.9 | 2007-10-22 | ||
| US60/981,675 | 2007-10-22 | ||
| EP07119026 | 2007-10-22 | ||
| PCT/IB2008/000456 WO2008084402A2 (en) | 2007-01-11 | 2008-01-11 | Diagnosis and treatment of alzheimer's and other neurodementing diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2008204335A1 AU2008204335A1 (en) | 2008-07-17 |
| AU2008204335B2 true AU2008204335B2 (en) | 2013-06-13 |
Family
ID=39609117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2008204335A Ceased AU2008204335B2 (en) | 2007-01-11 | 2008-01-11 | Diagnosis and treatment of Alzheimer's and other neurodementing diseases |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7939075B2 (enExample) |
| EP (1) | EP2104682B1 (enExample) |
| JP (1) | JP2010515717A (enExample) |
| AU (1) | AU2008204335B2 (enExample) |
| CA (1) | CA2675340C (enExample) |
| DK (1) | DK2104682T3 (enExample) |
| ES (1) | ES2610474T3 (enExample) |
| PL (1) | PL2104682T3 (enExample) |
| SI (1) | SI2104682T1 (enExample) |
| TW (1) | TW200844110A (enExample) |
| WO (1) | WO2008084402A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090280114A1 (en) * | 2002-04-12 | 2009-11-12 | Ramot At Tel Aviv University Ltd. | Prevention of brain inflammation as a result of induced autoimmune response |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| PL1976877T5 (pl) | 2005-11-30 | 2017-09-29 | Abbvie Inc | Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania |
| RU2442793C2 (ru) | 2005-11-30 | 2012-02-20 | Эбботт Лэборетриз | АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
| EP2143447A1 (en) * | 2008-07-11 | 2010-01-13 | Universität Konstanz | Bioconjugates comprising Aß-autoantibody-specific epitopes for active immunotherapy and diagnosis of Alzheimer's disease |
| ES2919563T3 (es) * | 2009-02-20 | 2022-07-27 | Enhanx Biopharm Inc | Sistema de administración de medicamentos a base de glutatión |
| KR101095630B1 (ko) * | 2009-06-17 | 2011-12-19 | 주식회사 이노파마스크린 | 베타 아밀로이드 펩타이드와 vegf의 상호작용을 억제하는 물질을 탐색 방법 및 그에 의해서 탐색된 저해제 |
| DE102009034119A1 (de) * | 2009-07-20 | 2011-01-27 | Philipps-Universität Marburg | Verfahren, insbesondere Enzyme-linked Immunosorbent Assay (ELISA), zum in vitro Nachweis von Amyloid beta Autoantikörpern, Mikrotiterplatte und Testkit |
| EP2921486B1 (en) | 2009-08-07 | 2017-09-27 | American Life Science Pharmaceuticals, Inc. | Compositions and methods for treating beta-amyloid related diseases |
| WO2011130377A2 (en) | 2010-04-15 | 2011-10-20 | Abbott Laboratories | Amyloid-beta binding proteins |
| US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| GB201112056D0 (en) | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
| RS53496B1 (sr) * | 2011-10-04 | 2015-02-27 | Affiris Ag | POSTUPAK ZA DETEKCIJU Aβ-SPECIFIČNIH ANTITELA U BIOLOŠKOM UZORKU |
| KR101190573B1 (ko) * | 2011-10-07 | 2012-10-18 | 대한민국 | 혈액 내 아밀로이드-베타 항체에 특이적으로 결합하는 신규 Aβ22(pE)-42 펩티드를 유효성분으로 포함하는 치매 진단용 키트 |
| CN104662423A (zh) * | 2012-03-13 | 2015-05-27 | 杨森阿尔茨海默氏症免疫治疗公司 | 阿兹海默氏病的诊断、预后和监测中的寡聚体Aβ |
| AU2013203043B2 (en) | 2013-03-15 | 2016-10-06 | Takeda Pharmaceutical Company Limited | Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs |
| US10942190B2 (en) | 2014-01-21 | 2021-03-09 | Shimadzu Corporation | Measurement method for amyloid precursor protein cleavage peptides |
| WO2015121339A1 (en) * | 2014-02-14 | 2015-08-20 | RUHR-UNIVERSITäT BOCHUM | Biosensor for conformation and secondary structure analysis |
| WO2016054114A1 (en) | 2014-09-29 | 2016-04-07 | The Regents Of The University Of California | Compositions for expanding regulatory t cells (treg), and treating autoimmune and inflammatory diseases and conditions |
| EP3043354B1 (en) * | 2015-01-12 | 2018-01-03 | Heraeus Deutschland GmbH & Co. KG | Use of an electrically conductive composition as an electrically conductive adhesive for mechanically and electrically connecting electrical conductors to electrical contacts of solar cells |
| EP3324186B1 (en) | 2016-11-21 | 2020-09-16 | Ruhr-Universität Bochum | Method for the preselection of drugs for protein misfolding diseases |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| JP7418332B2 (ja) * | 2017-12-19 | 2024-01-19 | スロゼン オペレーティング, インコーポレイテッド | 抗フリズルド抗体及び使用方法 |
| CN118271444A (zh) * | 2017-12-19 | 2024-07-02 | 瑟罗泽恩奥普瑞汀公司 | Wnt替代分子和其用途 |
| CN111699003B (zh) | 2017-12-19 | 2024-05-03 | 瑟罗泽恩奥普瑞汀公司 | 抗lrp5/6抗体和使用方法 |
| KR20210124308A (ko) | 2019-01-30 | 2021-10-14 | 트루바인딩 아이엔씨. | 항-gal3 항체 및 이의 용도 |
| MX2022014786A (es) | 2020-05-26 | 2023-01-16 | Truebinding Inc | Metodos para tratar enfermedades inflamatorias mediante el bloqueo de galectina-3. |
| CN116472055A (zh) | 2020-08-07 | 2023-07-21 | 欧萨尔普罗席纳有限公司 | 治疗阿尔兹海默氏病的多表位疫苗 |
| WO2022104280A1 (en) | 2020-11-16 | 2022-05-19 | Surrozen Operating, Inc. | Liver-specific wnt signal enhancing molecules and uses thereof |
| AU2022227686A1 (en) | 2021-02-25 | 2023-07-27 | Lyell Immunopharma, Inc. | Ror1 targeting chimeric antigen receptor |
| TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
| WO2022251048A1 (en) | 2021-05-24 | 2022-12-01 | Eli Lilly And Company | Anti-amyloid beta antibodies and uses thereof |
| US20260167741A1 (en) * | 2022-10-18 | 2026-06-18 | Crosspoint Therapeutics Inc. | Human antibody fc domain variant and use thereof |
| WO2025059487A2 (en) | 2023-09-15 | 2025-03-20 | Othair Prothena Limited | Cell penetrating agents and uses thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030059937A1 (en) * | 2000-06-16 | 2003-03-27 | Ruben Steven M. | Antibodies that immunospecifically bind BLyS |
| WO2003077858A2 (en) * | 2002-03-12 | 2003-09-25 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| US20040170626A1 (en) * | 2002-11-15 | 2004-09-02 | Genmab, Inc. | Human monoclonal antibodies against CD25 |
| WO2004080419A2 (en) * | 2003-03-12 | 2004-09-23 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| US20060246071A1 (en) * | 2004-12-21 | 2006-11-02 | Larry Green | Antibodies directed to angiopoietin-2 and uses thereof |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| CA1339014C (en) | 1987-10-08 | 1997-03-25 | Ronald E. Majocha | Antibodies to a4 amyloid peptide |
| WO1990003430A1 (en) | 1988-09-23 | 1990-04-05 | Cetus Corporation | Cell culture medium for enhanced cell growth, culture longevity and product expression |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| DE69233528T2 (de) | 1991-11-25 | 2006-03-16 | Enzon, Inc. | Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen |
| EP0683234B2 (en) | 1993-01-25 | 2007-06-06 | Takeda Chemical Industries, Ltd. | Antibody against beta-amyloid or their derivative and use thereof |
| US7427392B1 (en) | 1994-11-14 | 2008-09-23 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| SI0994728T1 (sl) | 1997-04-09 | 2009-02-28 | Intellect Neurosciences Inc | Rekombinantna protitelesa, specifična za beta-amiloidne konce, kodirana z DNA ter postopki za njihovo uporabo |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| DE19926068C1 (de) | 1999-06-08 | 2001-01-11 | Arne Skerra | Muteine des Bilin-Bindungsproteins |
| EP1237930B1 (en) | 1999-12-08 | 2006-11-08 | Intellect Neurosciences, Inc. | Chimeric amyloid beta peptides |
| US20020182660A1 (en) | 2000-02-18 | 2002-12-05 | Fong Kei-Lai L. | N- and C-terminus specific immunoassays for full length beta-amyloid peptide-Abeta(1-40), Abeta(1-39), Abeta(1-40), Abeta(1-42) , and Abeta(1-43) |
| US20030083277A1 (en) | 2000-02-24 | 2003-05-01 | Hersh Louis B. | Use of insulin degrading enzyme (IDE) for the treatment of alzheimer's disease in patients |
| EA006606B1 (ru) | 2000-02-24 | 2006-02-24 | Вашингтон Юниверсити | Гуманизированное антитело и его фрагмент, взаимодействующие с бета-амилоидным пептидом, и способы их применения |
| EP1172378A1 (en) | 2000-07-12 | 2002-01-16 | Richard Dr. Dodel | Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease |
| US20020009445A1 (en) | 2000-07-12 | 2002-01-24 | Yansheng Du | Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease |
| US6815175B2 (en) | 2001-03-16 | 2004-11-09 | Cornell Research Foundation, Inc. | Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder |
| ATE454137T1 (de) | 2001-07-25 | 2010-01-15 | Facet Biotech Corp | Stabile lyophilisierte pharmazeutische formulierung des igg-antikörpers daclizumab |
| US20030082191A1 (en) | 2001-08-29 | 2003-05-01 | Poduslo Joseph F. | Treatment for central nervous system disorders |
| US20050208050A1 (en) | 2001-11-09 | 2005-09-22 | Gerd Multhaup | Compounds for the diagnosis/prevention/treatment of alzheimer's disease |
| US20050227941A1 (en) | 2001-12-17 | 2005-10-13 | Karen Duff | Sequestration of ass in the periphery in the absence of immunomodulating agent as a therapeutic approach for the treatment or prevention of beta-amyloid related diseases |
| AR038568A1 (es) | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
| WO2004013172A2 (en) | 2002-07-24 | 2004-02-12 | Innogenetics N.V. | Fragments of beta-amyloid as targets for vaccination against alzheimer disease |
| WO2005025516A2 (en) | 2003-09-12 | 2005-03-24 | The Regents Of The University Of California | Monoclonal antibodies specific for conformational epitopes of prefibrillar aggregates |
| DE60336848D1 (de) | 2002-09-12 | 2011-06-01 | Univ California | Immunogene und entsprechende antikörper, die spezifisch sind für häufige hochmolekulare aggregations-zwischenprodukte von amyloiden aus proteinen unterschiedlicher sequenz |
| JP2006508072A (ja) | 2002-10-01 | 2006-03-09 | ノースウエスタン ユニバーシティ | アミロイドベータ由来拡散性リガンド(ADDLs)、ADDL代替物、ADDL結合性分子、およびそれらの使用 |
| AU2003279216A1 (en) | 2002-10-09 | 2004-05-04 | Rinat Neuroscience Corp. | Methods of treating alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof |
| US20050106626A1 (en) | 2002-10-20 | 2005-05-19 | George Pieczenik | Ligand binding of amyloid peptide protein epitope |
| AU2003303198A1 (en) | 2002-12-19 | 2004-07-14 | New York University | Method for treating amyloid disease |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| CA2538220A1 (en) | 2003-09-09 | 2005-03-24 | Takeda Pharmaceutical Company Limited | Use of antibody |
| WO2005051998A2 (en) * | 2003-11-28 | 2005-06-09 | Astrazeneca Ab | Antibodies binding to a c-terminal fragment of apolipoprotein e |
| JP4851348B2 (ja) | 2004-02-23 | 2012-01-11 | イーライ リリー アンド カンパニー | 抗Aβ抗体 |
| SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
| JP2008505645A (ja) | 2004-07-10 | 2008-02-28 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | ガン細胞に特異的な抗体を見出すための方法およびそれによって見出される抗体 |
| WO2006040153A2 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
| WO2006047254A1 (en) | 2004-10-22 | 2006-05-04 | Regents Of The University Of Minnesota | Assemblies of oligomeric amyloid beta protein and uses thereof |
| KR20070094890A (ko) * | 2004-10-25 | 2007-09-27 | 머크 앤드 캄파니 인코포레이티드 | 안티 addl 항체 및 그 용도 |
| US20060257396A1 (en) * | 2004-12-15 | 2006-11-16 | Jacobsen Jack S | Abeta antibodies for use in improving cognition |
| WO2006081171A1 (en) | 2005-01-24 | 2006-08-03 | Amgen Inc. | Humanized anti-amyloid antibody |
| PA8661401A1 (es) | 2005-01-28 | 2006-09-08 | Wyeth Corp | Formulaciones del liquido polipeptido estabilizado |
| KR20080021585A (ko) | 2005-03-05 | 2008-03-07 | 애보트 게엠베하 운트 콤파니 카게 | 스크리닝 방법, 비확산성 a-베타 올리고머의 정제 방법,당해 비확산성 a-베타 올리고머에 대한 선택적 항체 및당해 항체의 제조 방법 |
| ES2318918B1 (es) | 2005-04-01 | 2010-02-16 | Biotherapix Molecular Medicines, S.L.U. | Anticuerpos humanos con capacidad de union al peptido beta-amiloide y sus aplicaciones. |
| PE20061323A1 (es) | 2005-04-29 | 2007-02-09 | Rinat Neuroscience Corp | Anticuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos |
| WO2007062088A1 (en) | 2005-11-22 | 2007-05-31 | The Trustees Of The University Of Pennsylvania | Antibody treatment of alzheimer's and related diseases |
| PL1976877T5 (pl) | 2005-11-30 | 2017-09-29 | Abbvie Inc | Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania |
| NZ568012A (en) | 2005-12-12 | 2012-07-27 | Ac Immune Sa | A beta 1-42 specific monoclonal antibodies with therapeutic properties |
| MY169492A (en) | 2006-03-23 | 2019-04-15 | Bioarctic Neuroscience Ab | Improved protofibril selective antibodies and the use thereof |
| JP2010516651A (ja) * | 2007-01-17 | 2010-05-20 | メルク セローノ ソシエテ アノニム | Fc含有タンパク質の精製のための方法 |
| PL2246427T3 (pl) * | 2008-02-08 | 2017-06-30 | Immunas Pharma, Inc. | Przeciwciała zdolne do wiązania się swoiście do oligomerów amyloidu beta i ich stosowanie |
-
2008
- 2008-01-11 ES ES08719192.0T patent/ES2610474T3/es active Active
- 2008-01-11 TW TW097101288A patent/TW200844110A/zh unknown
- 2008-01-11 US US12/013,185 patent/US7939075B2/en active Active
- 2008-01-11 AU AU2008204335A patent/AU2008204335B2/en not_active Ceased
- 2008-01-11 WO PCT/IB2008/000456 patent/WO2008084402A2/en not_active Ceased
- 2008-01-11 SI SI200831731A patent/SI2104682T1/sl unknown
- 2008-01-11 EP EP08719192.0A patent/EP2104682B1/en active Active
- 2008-01-11 JP JP2009545252A patent/JP2010515717A/ja active Pending
- 2008-01-11 DK DK08719192.0T patent/DK2104682T3/en active
- 2008-01-11 PL PL08719192T patent/PL2104682T3/pl unknown
- 2008-01-11 CA CA2675340A patent/CA2675340C/en active Active
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2011
- 2011-04-05 US US13/079,886 patent/US20120040382A1/en not_active Abandoned
- 2011-04-05 US US13/079,852 patent/US8491903B2/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030059937A1 (en) * | 2000-06-16 | 2003-03-27 | Ruben Steven M. | Antibodies that immunospecifically bind BLyS |
| WO2003077858A2 (en) * | 2002-03-12 | 2003-09-25 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| US20040170626A1 (en) * | 2002-11-15 | 2004-09-02 | Genmab, Inc. | Human monoclonal antibodies against CD25 |
| WO2004080419A2 (en) * | 2003-03-12 | 2004-09-23 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| US20060246071A1 (en) * | 2004-12-21 | 2006-11-02 | Larry Green | Antibodies directed to angiopoietin-2 and uses thereof |
Non-Patent Citations (3)
| Title |
|---|
| Gaskin, F. et al., Journal of Experimental Medicine, 1993, vol 177, pages 1181-1186 * |
| Koo, E.H. et al., PNAS, 1993, vol 90, no.10, pages 4748-4752 * |
| Markaryan, A. et al., Biochemical and Biophysical Research Communications, 1999, vol 262, no. 1, pages 263-268 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20120039897A1 (en) | 2012-02-16 |
| US8491903B2 (en) | 2013-07-23 |
| WO2008084402A3 (en) | 2009-04-09 |
| AU2008204335A1 (en) | 2008-07-17 |
| JP2010515717A (ja) | 2010-05-13 |
| WO2008084402A2 (en) | 2008-07-17 |
| ES2610474T3 (es) | 2017-04-27 |
| EP2104682B1 (en) | 2016-09-21 |
| TW200844110A (en) | 2008-11-16 |
| US7939075B2 (en) | 2011-05-10 |
| EP2104682A2 (en) | 2009-09-30 |
| US20090028869A1 (en) | 2009-01-29 |
| CA2675340A1 (en) | 2008-07-17 |
| US20120040382A1 (en) | 2012-02-16 |
| DK2104682T3 (en) | 2017-01-16 |
| WO2008084402A8 (en) | 2009-08-27 |
| CA2675340C (en) | 2018-07-31 |
| SI2104682T1 (sl) | 2017-05-31 |
| PL2104682T3 (pl) | 2017-03-31 |
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