AU2007323042B2 - New process for the preparation of 2-imino-thiazolidin-4-one derivatives - Google Patents

New process for the preparation of 2-imino-thiazolidin-4-one derivatives Download PDF

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Publication number
AU2007323042B2
AU2007323042B2 AU2007323042A AU2007323042A AU2007323042B2 AU 2007323042 B2 AU2007323042 B2 AU 2007323042B2 AU 2007323042 A AU2007323042 A AU 2007323042A AU 2007323042 A AU2007323042 A AU 2007323042A AU 2007323042 B2 AU2007323042 B2 AU 2007323042B2
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AU
Australia
Prior art keywords
thiazolidin
hydroxy
benz
ylidene
phenyl
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AU2007323042A
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AU2007323042A1 (en
Inventor
Stefan Abele
Martin Bolli
Gunther Schmidt
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Laboratoires Juvise Pharmaceuticals SAS
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Laboratoires Juvise Pharmaceuticals SAS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2007323042A 2006-11-23 2007-11-22 New process for the preparation of 2-imino-thiazolidin-4-one derivatives Active AU2007323042B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IBPCT/IB2006/054409 2006-11-23
IB2006054409 2006-11-23
PCT/IB2007/054752 WO2008062376A2 (en) 2006-11-23 2007-11-22 New process for the preparation of 2-imino-thiazolidin-4-one derivatives

Publications (2)

Publication Number Publication Date
AU2007323042A1 AU2007323042A1 (en) 2008-05-29
AU2007323042B2 true AU2007323042B2 (en) 2012-12-20

Family

ID=39316391

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007323042A Active AU2007323042B2 (en) 2006-11-23 2007-11-22 New process for the preparation of 2-imino-thiazolidin-4-one derivatives

Country Status (13)

Country Link
US (1) US8263780B2 (https=)
EP (2) EP2094676B1 (https=)
JP (1) JP4669564B2 (https=)
KR (1) KR101255879B1 (https=)
CN (2) CN101541772B (https=)
AU (1) AU2007323042B2 (https=)
CA (1) CA2669069C (https=)
DK (2) DK2094676T3 (https=)
ES (2) ES2523401T3 (https=)
IL (1) IL198847A (https=)
MX (1) MX2009005048A (https=)
TW (1) TWI460166B (https=)
WO (1) WO2008062376A2 (https=)

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* Cited by examiner, † Cited by third party
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USRE43728E1 (en) 2003-11-21 2012-10-09 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
USRE43833E1 (en) 2003-11-21 2012-11-27 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
US8912340B2 (en) 2006-11-23 2014-12-16 Actelion Pharmaceuticals Ltd. Process for the preparation of 2-imino-thiazolidin-4-one derivatives
PL2278960T5 (pl) 2008-03-17 2020-06-29 Actelion Pharmaceuticals Ltd. Schemat dawkowania dla selektywnego agonisty receptora sip1
GB0819182D0 (en) 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms
SMT202000298T1 (it) * 2012-08-17 2020-07-08 Actelion Pharmaceuticals Ltd Processo per la produzione di (2z,5z)-5-(3-cloro-4((r)-2,3-diidrossipropossi) benziliden)-2-(propilimmino)-3-(o-tolil)tiazolidin-4-one e intermedio usato in detto processo
MA41139B1 (fr) 2014-12-11 2026-02-27 Laboratoires Juvise Pharmaceuticals Combinaison pharmaceutique comprenant du ponesimod et son utilisation dans le traitement de la sclérose en plaque
KR20200013086A (ko) 2014-12-11 2020-02-05 액테리온 파마슈티칼 리미티드 선택적 s1p1 수용체 효능제에 대한 투약 섭생
JOP20190207A1 (ar) 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود
EP3684358A4 (en) 2017-09-19 2021-01-13 Teva Pharmaceuticals International GmbH NEW CRYSTALLINE POLYMORPHIC SHAPE OF PONESIMOD
US11186556B1 (en) 2018-10-16 2021-11-30 Celgene Corporation Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof
US11014897B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof
US11014940B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Thiazolidinone and oxazolidinone compounds and formulations
US11013723B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms of a thiazolidinone compound, compositions and methods of use thereof
KR20220034151A (ko) * 2019-07-10 2022-03-17 바이엘 악티엔게젤샤프트 2-(페닐이미노)-1,3-티아졸리딘-4-온의 제조 방법
BR112022000185A2 (pt) * 2019-07-10 2022-02-22 Bayer Ag Método de preparação de 2-(fenilimino)-1,3-tiazolidin-4-onas
JP7749552B2 (ja) 2019-10-31 2025-10-06 イドルシア・ファーマシューティカルズ・リミテッド Ｃｘｃｒ７アンタゴニストのｓ１ｐ１受容体調節剤との合剤
KR20200019639A (ko) 2020-01-30 2020-02-24 전대연 만남의 스마트 도착시스템
IL295464A (en) * 2020-02-18 2022-10-01 Bayer Ag Process of preparing 2-(phenylimino)-3-alkyl-1,3-thiazolidin-4-ones
EP4387960A1 (en) 2021-08-17 2024-06-26 Teva Czech Industries s.r.o Polymorphs of ponesimod
EP4212156A1 (en) 2022-01-13 2023-07-19 Abivax Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator
WO2023152691A1 (en) * 2022-02-10 2023-08-17 Metrochem Api Pvt Ltd Process for the preparation of ponesimod and its intermediates thereof
CN117924210B (zh) * 2024-01-22 2026-04-03 赣南师范大学 一种2-亚氨基噻唑烷-4-酮类化合物的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005054215A1 (en) * 2003-11-21 2005-06-16 Actelion Pharmaceuticals Ltd 5-(benz- (z) -ylidene) -thiazolidin-4-one derivatives as immunosuppressant agents

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WO2001036402A1 (en) * 1998-07-14 2001-05-25 Fujimoto Brothers Co., Ltd. Novel 2-(n-cyanoimino)thiazolidin-4-one derivatives
US6353006B1 (en) * 1999-01-14 2002-03-05 Bayer Corporation Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
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GB0819182D0 (en) 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms

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Also Published As

Publication number Publication date
ES2523401T3 (es) 2014-11-25
EP2489662B1 (en) 2014-08-06
TWI460166B (zh) 2014-11-11
EP2489662A1 (en) 2012-08-22
JP2010510976A (ja) 2010-04-08
CA2669069C (en) 2015-02-17
KR101255879B1 (ko) 2013-04-17
CN101541772B (zh) 2013-04-17
KR20090081009A (ko) 2009-07-27
US8263780B2 (en) 2012-09-11
US20110201821A2 (en) 2011-08-18
US20100317867A1 (en) 2010-12-16
CN101541772A (zh) 2009-09-23
AU2007323042A1 (en) 2008-05-29
MX2009005048A (es) 2009-05-25
CA2669069A1 (en) 2008-05-29
DK2489662T3 (da) 2014-10-20
JP4669564B2 (ja) 2011-04-13
WO2008062376A2 (en) 2008-05-29
EP2094676B1 (en) 2013-04-10
CN103087004A (zh) 2013-05-08
DK2094676T3 (da) 2013-06-10
TW200831474A (en) 2008-08-01
IL198847A (en) 2015-07-30
ES2410793T3 (es) 2013-07-03
IL198847A0 (en) 2010-02-17
WO2008062376A3 (en) 2008-07-10
EP2094676A2 (en) 2009-09-02
BRPI0718986A2 (pt) 2014-02-11

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