AU2007235487A1 - Deazapurines useful as inhibitors of janus kinases - Google Patents
Deazapurines useful as inhibitors of janus kinases Download PDFInfo
- Publication number
- AU2007235487A1 AU2007235487A1 AU2007235487A AU2007235487A AU2007235487A1 AU 2007235487 A1 AU2007235487 A1 AU 2007235487A1 AU 2007235487 A AU2007235487 A AU 2007235487A AU 2007235487 A AU2007235487 A AU 2007235487A AU 2007235487 A1 AU2007235487 A1 AU 2007235487A1
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- Australia
- Prior art keywords
- compound according
- ring
- aliphatic
- optionally substituted
- nhc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229940039925 zyprexa Drugs 0.000 description 1
Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Neurology (AREA)
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- Tropical Medicine & Parasitology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78944106P | 2006-04-05 | 2006-04-05 | |
| US60/789,441 | 2006-04-05 | ||
| PCT/US2007/008367 WO2007117494A1 (en) | 2006-04-05 | 2007-04-05 | Deazapurines useful as inhibitors of janus kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2007235487A1 true AU2007235487A1 (en) | 2007-10-18 |
Family
ID=38377244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2007235487A Abandoned AU2007235487A1 (en) | 2006-04-05 | 2007-04-05 | Deazapurines useful as inhibitors of janus kinases |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US8741912B2 (enExample) |
| EP (1) | EP2001884A1 (enExample) |
| JP (2) | JP2009532475A (enExample) |
| KR (1) | KR20090018895A (enExample) |
| CN (1) | CN101460499A (enExample) |
| AU (1) | AU2007235487A1 (enExample) |
| CA (1) | CA2648250A1 (enExample) |
| IL (1) | IL194460A0 (enExample) |
| MX (1) | MX2008012860A (enExample) |
| NO (1) | NO20084652L (enExample) |
| RU (1) | RU2008143361A (enExample) |
| SG (1) | SG170828A1 (enExample) |
| WO (1) | WO2007117494A1 (enExample) |
| ZA (1) | ZA200808536B (enExample) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7507826B2 (en) | 2004-03-30 | 2009-03-24 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of JAK and other protein kinases |
| CA2609126A1 (en) * | 2005-05-20 | 2006-11-30 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| EP1926735A1 (en) | 2005-09-22 | 2008-06-04 | Incyte Corporation | Tetracyclic inhibitors of janus kinases |
| SI2455382T1 (sl) | 2005-12-13 | 2017-03-31 | Incyte Holdings Corporation | S heteroarilom substituirani pirolo(2,3b)piridini in pirolo(2,3-b)pirimidini kot zaviralci janus kinaze |
| WO2007084557A2 (en) | 2006-01-17 | 2007-07-26 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of janus kinases |
| AU2007235487A1 (en) | 2006-04-05 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Deazapurines useful as inhibitors of janus kinases |
| CN101678022A (zh) | 2006-12-21 | 2010-03-24 | 弗特克斯药品有限公司 | 可用作蛋白激酶抑制剂的5-氰基-4-(吡咯并[2,3b]吡啶-3-基)嘧啶衍生物 |
| EP2121692B1 (en) | 2006-12-22 | 2013-04-10 | Incyte Corporation | Substituted heterocycles as janus kinase inhibitors |
| ES2467665T5 (es) * | 2007-06-13 | 2022-11-03 | Incyte Holdings Corp | Sales del inhibidor de cinasas Janus (R)-3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-ciclopentilpropanonitrilo |
| CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
| WO2009145814A2 (en) * | 2008-03-10 | 2009-12-03 | Vertex Pharmaceuticals Incorporated | Pyrimidines and pyridines useful as inhibitors of protein kinases |
| EP2288610B8 (en) * | 2008-03-11 | 2016-10-12 | Incyte Holdings Corporation | Azetidine and cyclobutane derivatives as jak inhibitors |
| CL2009001884A1 (es) * | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco. |
| JOP20190230A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
| MY156727A (en) | 2009-05-22 | 2016-03-15 | Incyte Corp | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| PT2432472T (pt) * | 2009-05-22 | 2019-12-09 | Incyte Holdings Corp | 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octano- ou heptano-nitrilo como inibidores de jak |
| PL2440558T3 (pl) * | 2009-06-08 | 2015-10-30 | Takeda Pharmaceuticals Co | Związki dihydropirolonaftyrydynony jako inhibitory JAK |
| KR101903354B1 (ko) | 2009-06-17 | 2018-10-04 | 버텍스 파마슈티칼스 인코포레이티드 | 인플루엔자 바이러스 복제의 억제제 |
| UA110324C2 (en) * | 2009-07-02 | 2015-12-25 | Genentech Inc | Jak inhibitory compounds based on pyrazolo pyrimidine |
| EP2451813B1 (en) | 2009-07-08 | 2014-10-01 | Leo Pharma A/S | Heterocyclic compounds as jak receptor and protein tyrosine kinase inhibitors |
| WO2011028685A1 (en) | 2009-09-01 | 2011-03-10 | Incyte Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| CA2777114C (en) * | 2009-10-09 | 2018-10-23 | Incyte Corporation | Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| WO2011076734A1 (en) * | 2009-12-21 | 2011-06-30 | Euroscreen S.A. | Compounds, pharmaceutical composition and methods for use in treating inflammatory diseases |
| PH12012501337A1 (en) | 2009-12-30 | 2012-12-17 | Arqule Inc | Substituted pyrrolo-aminopyrimidine compounds |
| MX2012009541A (es) * | 2010-02-18 | 2012-10-01 | Incyte Corp | Derivados de ciclobutano y metilciclobutano como inhibidores de janus cinasa. |
| MX354212B (es) | 2010-03-10 | 2018-02-19 | Incyte Corp | Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1). |
| AU2015205858B2 (en) * | 2010-03-10 | 2017-04-13 | Incyte Holdings Corporation | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
| US20110288107A1 (en) | 2010-05-21 | 2011-11-24 | Bhavnish Parikh | Topical formulation for a jak inhibitor |
| EP2640699B1 (en) * | 2010-11-17 | 2015-10-07 | Actelion Pharmaceuticals Ltd. | Bridged spiro[2,4]heptane ester derivatives |
| EP2640725B1 (en) * | 2010-11-19 | 2015-01-07 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
| EA036970B1 (ru) * | 2010-11-19 | 2021-01-21 | Инсайт Холдингс Корпорейшн | Применение {1-{1-[3-фтор-2-(трифтометил)изоникотиноил] пиперидин-4-ил}-3-[4-(7h-пирроло[2,3-d]пиримидин-4-ил)-1н-пиразол-1-ил]азетидин-3-ил}ацетонитрила для лечения заболеваний, связанных с активностью jak1 |
| CA2818542A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
| WO2012078802A1 (en) * | 2010-12-08 | 2012-06-14 | Takeda Pharmaceutical Company Limited | PREPARATION OF SUBSTITUTED-4,5-DIHYDROPYRROLO[4,3,2-de][2,6]NAPHTHYRIDIN-3(1H)-ONES |
| KR20140014110A (ko) | 2010-12-16 | 2014-02-05 | 버텍스 파마슈티칼스 인코포레이티드 | 인플루엔자 바이러스 복제의 억제제 |
| CN103298817A (zh) * | 2011-01-07 | 2013-09-11 | 利奥制药有限公司 | 作为蛋白酪氨酸激酶抑制剂的新磺酰胺哌嗪衍生物及其药物用途 |
| US9993480B2 (en) | 2011-02-18 | 2018-06-12 | Novartis Pharma Ag | mTOR/JAK inhibitor combination therapy |
| CA2830882C (en) | 2011-03-22 | 2021-03-16 | Dinesh Barawkar | Substituted fused tricyclic compounds, compositions and medicinal applications thereof |
| WO2012158785A1 (en) * | 2011-05-17 | 2012-11-22 | Principia Biopharma Inc. | Azaindole derivatives as tyrosine kinase inhibitors |
| WO2012177606A1 (en) | 2011-06-20 | 2012-12-27 | Incyte Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| HK1198579A1 (en) | 2011-08-10 | 2015-04-30 | Novartis Pharma Ag | Jak p13k/mtor combination therapy |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物 |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| WO2013173720A1 (en) | 2012-05-18 | 2013-11-21 | Incyte Corporation | Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
| WO2014013014A1 (en) | 2012-07-18 | 2014-01-23 | Fundació Privada Centre De Regulació Genòmica (Crg) | Jak inhibitors for activation of epidermal stem cell populations |
| US9593115B2 (en) | 2012-09-21 | 2017-03-14 | Advinus Therapeutics Ltd. | Substituted fused tricyclic compounds, compositions, and medicinal applications thereof |
| ES2880814T3 (es) | 2012-11-15 | 2021-11-25 | Incyte Holdings Corp | Formas de dosificación de liberación sostenida de ruxolitinib |
| EP3489239B1 (en) | 2013-03-06 | 2021-09-15 | Incyte Holdings Corporation | Processes and intermediates for making a jak inhibitor |
| TWI789516B (zh) | 2013-08-07 | 2023-01-11 | 美商英塞特公司 | Jak1抑制劑之持續釋放劑型 |
| LT3421468T (lt) | 2013-11-13 | 2021-01-11 | Vertex Pharmaceuticals Incorporated | Gripo virusų replikacijos inhibitorių paruošimo būdai |
| HRP20191525T1 (hr) | 2013-11-13 | 2019-11-29 | Vertex Pharma | Inhibitori replikacije virusa influence |
| WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
| CN105777754B (zh) | 2014-12-16 | 2019-07-26 | 北京赛林泰医药技术有限公司 | 吡咯并嘧啶化合物 |
| WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| JP6704416B2 (ja) | 2015-05-13 | 2020-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | インフルエンザウイルスの複製の阻害剤を調製する方法 |
| KR102598246B1 (ko) * | 2016-07-26 | 2023-11-02 | 톈진 롱보진 파마시우티컬 씨오., 엘티디. | Jak 저해제로서 헤테로사이클릭 화합물, 및 이의 염 및 치료학적 용도 |
| WO2018041989A1 (en) | 2016-09-02 | 2018-03-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating refractory celiac disease type 2 |
| AR113922A1 (es) | 2017-12-08 | 2020-07-01 | Incyte Corp | Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas |
| HRP20220510T1 (hr) | 2018-01-30 | 2022-05-27 | Incyte Corporation | Postupci za pripravu (1-(3-fluoro-2-(trifluorometil)izonikotinil) piperidin-4-ona) |
| HUE067471T2 (hu) | 2018-03-30 | 2024-10-28 | Incyte Corp | Gennyes verejtékmirigy-gyulladás kezelése jak inhibitorok alkalmazásával |
| CN108586341B (zh) * | 2018-05-25 | 2020-05-08 | 天津商业大学 | 酰胺类化合物和其药用盐及其制备方法和药物用途 |
| BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
| EP3947737A2 (en) | 2019-04-02 | 2022-02-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| US20220202820A1 (en) | 2019-04-16 | 2022-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels |
| EP3725305A1 (en) | 2019-04-17 | 2020-10-21 | Zentiva K.S. | Pharmaceutical composition containing baricitinib hydrobromide |
| JP2022549506A (ja) | 2019-09-27 | 2022-11-25 | ディスク・メディシン・インコーポレイテッド | 骨髄線維症および関連状態を処置するための方法 |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
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| CN111704617B (zh) * | 2020-06-15 | 2022-08-23 | 嘉兴特科罗生物科技有限公司 | 一种小分子化合物 |
| CN112979634A (zh) * | 2021-02-06 | 2021-06-18 | 绍兴文理学院 | 一种含酰胺结构的噻唑类化合物及其制备方法和应用 |
| CN112979635A (zh) * | 2021-02-06 | 2021-06-18 | 绍兴文理学院 | 一种噻唑类化合物及其制备方法和应用 |
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| PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| WO2001042246A2 (en) | 1999-12-10 | 2001-06-14 | Pfizer Products Inc. | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS |
| JP2003518123A (ja) * | 1999-12-21 | 2003-06-03 | スージェン・インコーポレーテッド | ４−置換７−アザ−インドリン−２−オンおよびその蛋白質キナーゼ阻害剤としての使用 |
| IL162505A0 (en) * | 2001-12-19 | 2005-11-20 | The Quigley Corp | Method for treatment of peripheral neural and vascular ailments |
| CA2515132C (en) * | 2003-02-07 | 2012-01-03 | Vertex Pharmaceuticals Incorporated | Heteroaryl substituted pyrroles useful as inhibitors of protein kinases |
| AR045595A1 (es) * | 2003-09-04 | 2005-11-02 | Vertex Pharma | Composiciones utiles como inhibidores de proteinas quinasas |
| US7244735B2 (en) * | 2003-12-02 | 2007-07-17 | Vertex Pharmaceuticals Inc. | Heterocyclic protein kinase inhibitors and uses thereof |
| US7507826B2 (en) * | 2004-03-30 | 2009-03-24 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of JAK and other protein kinases |
| MXPA06011328A (es) * | 2004-04-02 | 2006-12-15 | Vertex Pharma | Azaindoles utiles como inhibidotes de roca y otras proteinas cinasas. |
| JP5213229B2 (ja) * | 2004-04-23 | 2013-06-19 | エグゼリクシス， インコーポレイテッド | キナーゼ調節因子および使用方法 |
| US20060122213A1 (en) * | 2004-06-30 | 2006-06-08 | Francoise Pierard | Azaindoles useful as inhibitors of protein kinases |
| US8633205B2 (en) * | 2005-02-03 | 2014-01-21 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of protein kinases |
| RU2383545C2 (ru) * | 2005-03-15 | 2010-03-10 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеинкиназы |
| CA2609126A1 (en) * | 2005-05-20 | 2006-11-30 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| SG151327A1 (en) * | 2005-09-30 | 2009-04-30 | Vertex Pharmaceuticals Incopor | Deazapurines useful as inhibitors of janus kinases |
| SI2455382T1 (sl) | 2005-12-13 | 2017-03-31 | Incyte Holdings Corporation | S heteroarilom substituirani pirolo(2,3b)piridini in pirolo(2,3-b)pirimidini kot zaviralci janus kinaze |
| WO2007084557A2 (en) * | 2006-01-17 | 2007-07-26 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of janus kinases |
| AU2007235487A1 (en) | 2006-04-05 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Deazapurines useful as inhibitors of janus kinases |
-
2007
- 2007-04-05 AU AU2007235487A patent/AU2007235487A1/en not_active Abandoned
- 2007-04-05 EP EP07754825A patent/EP2001884A1/en not_active Withdrawn
- 2007-04-05 KR KR1020087027078A patent/KR20090018895A/ko not_active Ceased
- 2007-04-05 JP JP2009504273A patent/JP2009532475A/ja active Pending
- 2007-04-05 CN CNA200780020405XA patent/CN101460499A/zh active Pending
- 2007-04-05 MX MX2008012860A patent/MX2008012860A/es not_active Application Discontinuation
- 2007-04-05 WO PCT/US2007/008367 patent/WO2007117494A1/en not_active Ceased
- 2007-04-05 SG SG201102383-5A patent/SG170828A1/en unknown
- 2007-04-05 US US11/732,845 patent/US8741912B2/en not_active Expired - Fee Related
- 2007-04-05 RU RU2008143361/04A patent/RU2008143361A/ru not_active Application Discontinuation
- 2007-04-05 CA CA002648250A patent/CA2648250A1/en not_active Abandoned
-
2008
- 2008-10-02 IL IL194460A patent/IL194460A0/en unknown
- 2008-10-03 US US12/245,069 patent/US20090227607A1/en not_active Abandoned
- 2008-10-07 ZA ZA2008/08536A patent/ZA200808536B/en unknown
- 2008-11-05 NO NO20084652A patent/NO20084652L/no not_active Application Discontinuation
-
2012
- 2012-02-23 US US13/403,169 patent/US20120316186A1/en not_active Abandoned
-
2013
- 2013-11-01 JP JP2013228595A patent/JP2014024869A/ja not_active Ceased
-
2014
- 2014-04-11 US US14/250,668 patent/US20140315931A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2001884A1 (en) | 2008-12-17 |
| NO20084652L (no) | 2008-12-03 |
| US20120316186A1 (en) | 2012-12-13 |
| US8741912B2 (en) | 2014-06-03 |
| US20090088445A1 (en) | 2009-04-02 |
| MX2008012860A (es) | 2009-01-07 |
| ZA200808536B (en) | 2012-07-25 |
| JP2009532475A (ja) | 2009-09-10 |
| WO2007117494A1 (en) | 2007-10-18 |
| CA2648250A1 (en) | 2007-10-18 |
| JP2014024869A (ja) | 2014-02-06 |
| CN101460499A (zh) | 2009-06-17 |
| US20140315931A1 (en) | 2014-10-23 |
| RU2008143361A (ru) | 2010-05-10 |
| KR20090018895A (ko) | 2009-02-24 |
| IL194460A0 (en) | 2009-08-03 |
| US20090227607A1 (en) | 2009-09-10 |
| SG170828A1 (en) | 2011-05-30 |
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| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |