AU2006275413B2 - Inhibitors of serine proteases - Google Patents
Inhibitors of serine proteases Download PDFInfo
- Publication number
- AU2006275413B2 AU2006275413B2 AU2006275413A AU2006275413A AU2006275413B2 AU 2006275413 B2 AU2006275413 B2 AU 2006275413B2 AU 2006275413 A AU2006275413 A AU 2006275413A AU 2006275413 A AU2006275413 A AU 2006275413A AU 2006275413 B2 AU2006275413 B2 AU 2006275413B2
- Authority
- AU
- Australia
- Prior art keywords
- aliphatic
- mixture
- optionally substituted
- isomer
- heterocycloaliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
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- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
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Landscapes
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- Life Sciences & Earth Sciences (AREA)
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- Wood Science & Technology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
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- Biomedical Technology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US70477205P | 2005-08-02 | 2005-08-02 | |
| US60/704,772 | 2005-08-02 | ||
| PCT/US2006/029988 WO2007016589A2 (en) | 2005-08-02 | 2006-08-01 | Inhibitors of serine proteases |
Publications (2)
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| AU2006275413A1 AU2006275413A1 (en) | 2007-02-08 |
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Country Status (17)
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| EP (3) | EP1910341B1 (ru) |
| JP (1) | JP2009505966A (ru) |
| KR (1) | KR20080033481A (ru) |
| CN (1) | CN101277950B (ru) |
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| AU (1) | AU2006275413B2 (ru) |
| CA (1) | CA2617679A1 (ru) |
| ES (1) | ES2401661T3 (ru) |
| IL (1) | IL189192A0 (ru) |
| MX (1) | MX2008001528A (ru) |
| NO (1) | NO20081012L (ru) |
| NZ (1) | NZ565540A (ru) |
| RU (2) | RU2441020C2 (ru) |
| TW (1) | TW200740813A (ru) |
| WO (1) | WO2007016589A2 (ru) |
| ZA (1) | ZA200801114B (ru) |
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| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| AR045596A1 (es) * | 2003-09-05 | 2005-11-02 | Vertex Pharma | Inhibidores de proteasas de serina en particular proteasa ns3-ns4a del vhc |
| MX2008001166A (es) | 2005-07-25 | 2008-03-18 | Intermune Inc | Nuevos inhibidores macrociclicos de la replicacion del virus de hepatitis c. |
| US20070105781A1 (en) * | 2005-08-02 | 2007-05-10 | Steve Lyons | Inhibitors of serine proteases |
| US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
| AR055395A1 (es) * | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| US7964624B1 (en) * | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| CN101489557B (zh) | 2006-02-27 | 2013-12-18 | 弗特克斯药品有限公司 | 包含vx-950的共晶体和包含所述共晶体的药物组合物 |
| EP2194039A1 (en) | 2006-03-16 | 2010-06-09 | Vertex Pharmceuticals Incorporated | Process for preparing optically enriched compounds |
| JP2009530382A (ja) * | 2006-03-23 | 2009-08-27 | シェーリング コーポレイション | Ｈｃｖプロテアーゼインヒビターとｃｙｐ３ａ４インヒビターとの組み合わせ、および関連する処置方法 |
| BRPI0710878A2 (pt) | 2006-04-11 | 2015-03-31 | Novartis Ag | Compostos orgânicos e seus usos |
| KR20090115970A (ko) * | 2007-02-27 | 2009-11-10 | 버텍스 파마슈티칼스 인코포레이티드 | 공-결정 및 그를 포함하는 제약 조성물 |
| CA2679426A1 (en) * | 2007-02-27 | 2008-09-04 | Luc Farmer | Inhibitors of serine proteases |
| US8492546B2 (en) * | 2007-08-30 | 2013-07-23 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| BRPI0817881A2 (pt) | 2007-10-10 | 2015-03-31 | Novartis Ag | Compostos orgânicos e seus usos |
| CA2712971A1 (en) | 2008-02-04 | 2009-08-13 | Idenix Pharamaceuticals, Inc. | Macrocyclic serine protease inhibitors |
| JP2012505897A (ja) * | 2008-10-15 | 2012-03-08 | インターミューン・インコーポレーテッド | 治療用抗ウイルス性ペプチド |
| UY32325A (es) * | 2008-12-19 | 2010-07-30 | Gilead Sciences Inc | Inhibidores de ns3 proteasa del vhc |
| US8102720B2 (en) * | 2009-02-02 | 2012-01-24 | Qualcomm Incorporated | System and method of pulse generation |
| TWI519530B (zh) | 2009-02-20 | 2016-02-01 | 艾伯維德國有限及兩合公司 | 羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途 |
| US8193372B2 (en) | 2009-03-04 | 2012-06-05 | Idenix Pharmaceuticals, Inc. | Phosphothiophene and phosphothiazole HCV polymerase inhibitors |
| EP2417134B1 (en) | 2009-04-08 | 2017-05-17 | Idenix Pharmaceuticals LLC. | Macrocyclic serine protease inhibitors |
| US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
| US8236798B2 (en) | 2009-05-07 | 2012-08-07 | Abbott Gmbh & Co. Kg | Carboxamide compounds and their use as calpain inhibitors |
| WO2010138889A1 (en) * | 2009-05-28 | 2010-12-02 | Concert Pharmaceuticals, Inc. | Peptides for the treatment of hcv infections |
| EP2461811B1 (en) | 2009-08-05 | 2016-04-20 | Idenix Pharmaceuticals LLC. | Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv |
| EP2483290A4 (en) * | 2009-09-28 | 2013-05-01 | Intermune Inc | CYCLIC PEPTIC INHIBITORS FOR REPLICATION OF HEPATITIS C VIRUS |
| WO2011041551A1 (en) * | 2009-10-01 | 2011-04-07 | Intermune, Inc. | Therapeutic antiviral peptides |
| US20110117055A1 (en) | 2009-11-19 | 2011-05-19 | Macdonald James E | Methods of Treating Hepatitis C Virus with Oxoacetamide Compounds |
| EP2513113B1 (en) | 2009-12-18 | 2018-08-01 | Idenix Pharmaceuticals LLC | 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors |
| US9051304B2 (en) | 2009-12-22 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Carboxamide compounds and their use as calpain inhibitors V |
| US8598211B2 (en) | 2009-12-22 | 2013-12-03 | Abbvie Inc. | Carboxamide compounds and their use as calpain inhibitors IV |
| CA2819087A1 (en) | 2010-12-09 | 2012-06-14 | AbbVie Deutschland GmbH & Co. KG | Carboxamide compounds and their use as calpain inhibitors v |
| PE20140471A1 (es) | 2011-01-04 | 2014-04-13 | Novartis Ag | Moduladores de la via del complemento y usos de los mismos |
| WO2012109398A1 (en) | 2011-02-10 | 2012-08-16 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating hcv infections |
| US20120252721A1 (en) | 2011-03-31 | 2012-10-04 | Idenix Pharmaceuticals, Inc. | Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor |
| US8853176B2 (en) | 2011-10-21 | 2014-10-07 | Abbvie Inc. | Methods for treating HCV |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| CN104023726A (zh) | 2011-10-21 | 2014-09-03 | 艾伯维公司 | 用于治疗hcv的一种或多种daa的联合治疗(例如，与abt-072或abt-333) |
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| AR057716A1 (es) | 2007-12-12 |
| IL189192A0 (en) | 2008-06-05 |
| NZ565540A (en) | 2011-06-30 |
| WO2007016589A3 (en) | 2007-03-29 |
| MX2008001528A (es) | 2008-04-04 |
| AU2006275413A1 (en) | 2007-02-08 |
| EP2256113A1 (en) | 2010-12-01 |
| RU2008108024A (ru) | 2009-09-10 |
| TW200740813A (en) | 2007-11-01 |
| EP1910341A2 (en) | 2008-04-16 |
| JP2009505966A (ja) | 2009-02-12 |
| WO2007016589A2 (en) | 2007-02-08 |
| US20140056847A1 (en) | 2014-02-27 |
| US20070105781A1 (en) | 2007-05-10 |
| CN101277950A (zh) | 2008-10-01 |
| ZA200801114B (en) | 2008-11-26 |
| NO20081012L (no) | 2008-04-25 |
| CA2617679A1 (en) | 2007-02-08 |
| EP1910341B1 (en) | 2013-01-02 |
| US20130177531A1 (en) | 2013-07-11 |
| EP2402331A1 (en) | 2012-01-04 |
| CN101277950B (zh) | 2013-03-27 |
| US20110171175A1 (en) | 2011-07-14 |
| KR20080033481A (ko) | 2008-04-16 |
| RU2011141559A (ru) | 2013-04-20 |
| RU2441020C2 (ru) | 2012-01-27 |
| ES2401661T3 (es) | 2013-04-23 |
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