AU2005277351A1 - Novel polymorphs of azabicyclohexane - Google Patents

Novel polymorphs of azabicyclohexane Download PDF

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Publication number
AU2005277351A1
AU2005277351A1 AU2005277351A AU2005277351A AU2005277351A1 AU 2005277351 A1 AU2005277351 A1 AU 2005277351A1 AU 2005277351 A AU2005277351 A AU 2005277351A AU 2005277351 A AU2005277351 A AU 2005277351A AU 2005277351 A1 AU2005277351 A1 AU 2005277351A1
Authority
AU
Australia
Prior art keywords
polymorph
polymorph form
acid addition
azabicyclo
addition salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2005277351A
Other languages
English (en)
Inventor
Eric J. Hagen
Kevin Halloran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DOV Pharmaceutical Inc
Original Assignee
DOV Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DOV Pharmaceutical Inc filed Critical DOV Pharmaceutical Inc
Publication of AU2005277351A1 publication Critical patent/AU2005277351A1/en
Priority to AU2012203400A priority Critical patent/AU2012203400B2/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
AU2005277351A 2004-08-18 2005-08-17 Novel polymorphs of azabicyclohexane Abandoned AU2005277351A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2012203400A AU2012203400B2 (en) 2004-08-18 2012-06-08 Novel polymorphs of azabicyclohexane

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92074804A 2004-08-18 2004-08-18
US10/920,748 2004-08-18
PCT/US2005/029420 WO2006023659A2 (en) 2004-08-18 2005-08-17 Novel polymorphs of azabicyclohexane

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2012203400A Division AU2012203400B2 (en) 2004-08-18 2012-06-08 Novel polymorphs of azabicyclohexane

Publications (1)

Publication Number Publication Date
AU2005277351A1 true AU2005277351A1 (en) 2006-03-02

Family

ID=35968183

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005277351A Abandoned AU2005277351A1 (en) 2004-08-18 2005-08-17 Novel polymorphs of azabicyclohexane

Country Status (14)

Country Link
EP (1) EP1786417A4 (ko)
JP (1) JP2008510715A (ko)
KR (3) KR20070054208A (ko)
CN (1) CN101052393A (ko)
AU (1) AU2005277351A1 (ko)
BR (1) BRPI0515193A (ko)
CA (1) CA2619817A1 (ko)
IL (1) IL181185A (ko)
MX (1) MX2007001827A (ko)
NO (1) NO20071372L (ko)
NZ (1) NZ589033A (ko)
RU (1) RU2007109817A (ko)
WO (1) WO2006023659A2 (ko)
ZA (1) ZA200701570B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
EP2719384B1 (en) 2005-07-27 2018-08-08 Otsuka America Pharmaceutical, Inc. Novel 1-naphthyl-3-azabicyclo[3.1.0]hexanes:preparation and use to treat neuropsychiatric disorders
US20080045725A1 (en) * 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
AU2011336318A1 (en) * 2010-12-03 2013-07-04 Euthymics Bioscience, Inc. Preparation and use of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane in the treatment of conditions affected by monoamine neurotransmitters
EP2994129A4 (en) * 2013-05-07 2017-01-25 Euthymic Bioscience, Inc. Use of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane to treat addictive and alcohol-related disorders
KR101567003B1 (ko) 2013-12-27 2015-11-06 경희대학교 산학협력단 골편 고정장치 및 골편 절단을 위한 드릴 어셈블리
EP3310352A4 (en) 2015-06-17 2019-03-13 Otsuka America Pharmaceutical, Inc. CRYSTALLINE COMPOUNDS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435419A (en) * 1981-07-01 1984-03-06 American Cyanamid Company Method of treating depression using azabicyclohexanes
US6372919B1 (en) * 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent

Also Published As

Publication number Publication date
MX2007001827A (es) 2007-04-23
JP2008510715A (ja) 2008-04-10
IL181185A0 (en) 2007-07-04
KR20130004370A (ko) 2013-01-09
KR20070054208A (ko) 2007-05-28
KR20130108489A (ko) 2013-10-02
NO20071372L (no) 2007-05-18
BRPI0515193A (pt) 2008-07-08
IL181185A (en) 2012-10-31
NZ589033A (en) 2012-06-29
WO2006023659A2 (en) 2006-03-02
RU2007109817A (ru) 2008-09-27
WO2006023659A3 (en) 2006-12-07
CA2619817A1 (en) 2006-03-02
ZA200701570B (en) 2008-08-27
CN101052393A (zh) 2007-10-10
EP1786417A2 (en) 2007-05-23
EP1786417A4 (en) 2009-05-20

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted