ZA200701570B - Novel polymorphs of azabicyclohexane - Google Patents

Novel polymorphs of azabicyclohexane

Info

Publication number
ZA200701570B
ZA200701570B ZA200701570A ZA200701570A ZA200701570B ZA 200701570 B ZA200701570 B ZA 200701570B ZA 200701570 A ZA200701570 A ZA 200701570A ZA 200701570 A ZA200701570 A ZA 200701570A ZA 200701570 B ZA200701570 B ZA 200701570B
Authority
ZA
South Africa
Prior art keywords
azabicyclohexane
novel polymorphs
polymorphs
novel
Prior art date
Application number
ZA200701570A
Inventor
Eric J Hagen
Halloran Kevin
Original Assignee
Dov Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dov Pharmaceutical Inc filed Critical Dov Pharmaceutical Inc
Publication of ZA200701570B publication Critical patent/ZA200701570B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
ZA200701570A 2004-08-18 2005-08-17 Novel polymorphs of azabicyclohexane ZA200701570B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92074804A 2004-08-18 2004-08-18

Publications (1)

Publication Number Publication Date
ZA200701570B true ZA200701570B (en) 2008-08-27

Family

ID=35968183

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200701570A ZA200701570B (en) 2004-08-18 2005-08-17 Novel polymorphs of azabicyclohexane

Country Status (14)

Country Link
EP (1) EP1786417A4 (en)
JP (1) JP2008510715A (en)
KR (3) KR20070054208A (en)
CN (1) CN101052393A (en)
AU (1) AU2005277351A1 (en)
BR (1) BRPI0515193A (en)
CA (1) CA2619817A1 (en)
IL (1) IL181185A (en)
MX (1) MX2007001827A (en)
NO (1) NO20071372L (en)
NZ (1) NZ589033A (en)
RU (1) RU2007109817A (en)
WO (1) WO2006023659A2 (en)
ZA (1) ZA200701570B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
EP1915146A4 (en) 2005-07-27 2010-06-02 Dov Pharmaceutical Inc Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US20080045725A1 (en) * 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
EP2646019A4 (en) * 2010-12-03 2014-05-21 Euthymic Bioscience Inc Preparation and use of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane in the treatment of conditions affected by monoamine neurotransmitters
JP2016518406A (en) * 2013-05-07 2016-06-23 ユーシミクス・バイオサイエンス・インコーポレイテッドＥｕｔｈｙｍｉｃｓ Ｂｉｏｓｃｉｅｎｃｅ，Ｉｎｃ． Use of (+)-1- (3,4-dichlorophenyl) -3-azabicyclo [3.1.0] hexane to treat addictive and alcohol related disorders
KR101567003B1 (en) 2013-12-27 2015-11-06 경희대학교 산학협력단 Fixing Device for Splinters of a Bone and Drill Assembly for Cutting Splinters of a Bone
ES2922158T3 (en) 2015-06-17 2022-09-09 Otsuka America Pharmaceutical Inc crystalline compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435419A (en) * 1981-07-01 1984-03-06 American Cyanamid Company Method of treating depression using azabicyclohexanes
US6372919B1 (en) * 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent

Also Published As

Publication number Publication date
AU2005277351A1 (en) 2006-03-02
IL181185A0 (en) 2007-07-04
MX2007001827A (en) 2007-04-23
JP2008510715A (en) 2008-04-10
EP1786417A4 (en) 2009-05-20
CA2619817A1 (en) 2006-03-02
WO2006023659A2 (en) 2006-03-02
NZ589033A (en) 2012-06-29
NO20071372L (en) 2007-05-18
KR20130108489A (en) 2013-10-02
RU2007109817A (en) 2008-09-27
WO2006023659A3 (en) 2006-12-07
KR20070054208A (en) 2007-05-28
CN101052393A (en) 2007-10-10
BRPI0515193A (en) 2008-07-08
EP1786417A2 (en) 2007-05-23
IL181185A (en) 2012-10-31
KR20130004370A (en) 2013-01-09

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