EP1786417A4 - Novel polymorphs of azabicyclohexane - Google Patents

Novel polymorphs of azabicyclohexane

Info

Publication number
EP1786417A4
EP1786417A4 EP05785506A EP05785506A EP1786417A4 EP 1786417 A4 EP1786417 A4 EP 1786417A4 EP 05785506 A EP05785506 A EP 05785506A EP 05785506 A EP05785506 A EP 05785506A EP 1786417 A4 EP1786417 A4 EP 1786417A4
Authority
EP
European Patent Office
Prior art keywords
azabicyclohexane
novel polymorphs
polymorphs
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05785506A
Other languages
German (de)
French (fr)
Other versions
EP1786417A2 (en
Inventor
Eric J Hagen
Kevin Halloran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DOV Pharmaceutical Inc
Original Assignee
DOV Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DOV Pharmaceutical Inc filed Critical DOV Pharmaceutical Inc
Publication of EP1786417A2 publication Critical patent/EP1786417A2/en
Publication of EP1786417A4 publication Critical patent/EP1786417A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
EP05785506A 2004-08-18 2005-08-17 Novel polymorphs of azabicyclohexane Withdrawn EP1786417A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92074804A 2004-08-18 2004-08-18
PCT/US2005/029420 WO2006023659A2 (en) 2004-08-18 2005-08-17 Novel polymorphs of azabicyclohexane

Publications (2)

Publication Number Publication Date
EP1786417A2 EP1786417A2 (en) 2007-05-23
EP1786417A4 true EP1786417A4 (en) 2009-05-20

Family

ID=35968183

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05785506A Withdrawn EP1786417A4 (en) 2004-08-18 2005-08-17 Novel polymorphs of azabicyclohexane

Country Status (14)

Country Link
EP (1) EP1786417A4 (en)
JP (1) JP2008510715A (en)
KR (3) KR20070054208A (en)
CN (1) CN101052393A (en)
AU (1) AU2005277351A1 (en)
BR (1) BRPI0515193A (en)
CA (1) CA2619817A1 (en)
IL (1) IL181185A (en)
MX (1) MX2007001827A (en)
NO (1) NO20071372L (en)
NZ (1) NZ589033A (en)
RU (1) RU2007109817A (en)
WO (1) WO2006023659A2 (en)
ZA (1) ZA200701570B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
EP1915146A4 (en) 2005-07-27 2010-06-02 Dov Pharmaceutical Inc Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US20080045725A1 (en) * 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
EP2646019A4 (en) * 2010-12-03 2014-05-21 Euthymic Bioscience Inc Preparation and use of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane in the treatment of conditions affected by monoamine neurotransmitters
JP2016518406A (en) * 2013-05-07 2016-06-23 ユーシミクス・バイオサイエンス・インコーポレイテッドＥｕｔｈｙｍｉｃｓ Ｂｉｏｓｃｉｅｎｃｅ，Ｉｎｃ． Use of (+)-1- (3,4-dichlorophenyl) -3-azabicyclo [3.1.0] hexane to treat addictive and alcohol related disorders
KR101567003B1 (en) 2013-12-27 2015-11-06 경희대학교 산학협력단 Fixing Device for Splinters of a Bone and Drill Assembly for Cutting Splinters of a Bone
ES2922158T3 (en) 2015-06-17 2022-09-09 Otsuka America Pharmaceutical Inc crystalline compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435419A (en) * 1981-07-01 1984-03-06 American Cyanamid Company Method of treating depression using azabicyclohexanes
US6372919B1 (en) * 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CAIRA M R: "CRYSTALLINE POLYMORPHISM OF ORGANIC COMPOUNDS", TOPICS IN CURRENT CHEMISTRY, SPRINGER, BERLIN, DE, vol. 198, 1 January 1998 (1998-01-01), pages 163 - 208, XP001156954, ISSN: 0340-1022, ISBN: 978-3-540-36760-4, DOI: 10.1007/3-540-69178-2_5 *
SKOLNICK P ET AL: "Antidepressant-like actions of DOV 21,947: A triple reuptake inhibitor", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER BV, NL, vol. 461, no. 2-3, 14 February 2003 (2003-02-14), pages 99 - 104, XP002306753, ISSN: 0014-2999 *

Also Published As

Publication number Publication date
AU2005277351A1 (en) 2006-03-02
IL181185A0 (en) 2007-07-04
MX2007001827A (en) 2007-04-23
JP2008510715A (en) 2008-04-10
CA2619817A1 (en) 2006-03-02
WO2006023659A2 (en) 2006-03-02
NZ589033A (en) 2012-06-29
NO20071372L (en) 2007-05-18
KR20130108489A (en) 2013-10-02
RU2007109817A (en) 2008-09-27
WO2006023659A3 (en) 2006-12-07
KR20070054208A (en) 2007-05-28
CN101052393A (en) 2007-10-10
BRPI0515193A (en) 2008-07-08
EP1786417A2 (en) 2007-05-23
IL181185A (en) 2012-10-31
KR20130004370A (en) 2013-01-09
ZA200701570B (en) 2008-08-27

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