BRPI0515193A - novos polimorfos de azabiciclohexano - Google Patents

novos polimorfos de azabiciclohexano

Info

Publication number
BRPI0515193A
BRPI0515193A BRPI0515193-7A BRPI0515193A BRPI0515193A BR PI0515193 A BRPI0515193 A BR PI0515193A BR PI0515193 A BRPI0515193 A BR PI0515193A BR PI0515193 A BRPI0515193 A BR PI0515193A
Authority
BR
Brazil
Prior art keywords
forms
polymorphs
new
polymorph form
azabicyclohexane
Prior art date
Application number
BRPI0515193-7A
Other languages
English (en)
Inventor
Eric J Hagen
Kevin Halloran
Original Assignee
Dov Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dov Pharmaceutical Inc filed Critical Dov Pharmaceutical Inc
Publication of BRPI0515193A publication Critical patent/BRPI0515193A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

NOVOS POLIMORFOS DE AZABICICLOHEXANO, apresentando formas cristalinas polimórficas de sais de adição de ácido de (+)-1-(3,4-diclorofenil)-3-azabiciclo¢3. 1 0! hexano designadas como a forma polimorfa A, a forma polimorfa B e a forma polimorfa C, sendo que a forma polimorfa A é mais termodinamicamente estável do que as outras formas, métodos para a preparação e uso de tais formas polimorfas e as composições farmacêuticas que contêm tais formas polimorfas.
BRPI0515193-7A 2004-08-18 2005-08-17 novos polimorfos de azabiciclohexano BRPI0515193A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92074804A 2004-08-18 2004-08-18
PCT/US2005/029420 WO2006023659A2 (en) 2004-08-18 2005-08-17 Novel polymorphs of azabicyclohexane

Publications (1)

Publication Number Publication Date
BRPI0515193A true BRPI0515193A (pt) 2008-07-08

Family

ID=35968183

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515193-7A BRPI0515193A (pt) 2004-08-18 2005-08-17 novos polimorfos de azabiciclohexano

Country Status (14)

Country Link
EP (1) EP1786417A4 (pt)
JP (1) JP2008510715A (pt)
KR (3) KR20130108489A (pt)
CN (1) CN101052393A (pt)
AU (1) AU2005277351A1 (pt)
BR (1) BRPI0515193A (pt)
CA (1) CA2619817A1 (pt)
IL (1) IL181185A (pt)
MX (1) MX2007001827A (pt)
NO (1) NO20071372L (pt)
NZ (1) NZ589033A (pt)
RU (1) RU2007109817A (pt)
WO (1) WO2006023659A2 (pt)
ZA (1) ZA200701570B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
EP2719384B1 (en) 2005-07-27 2018-08-08 Otsuka America Pharmaceutical, Inc. Novel 1-naphthyl-3-azabicyclo[3.1.0]hexanes:preparation and use to treat neuropsychiatric disorders
US20080045725A1 (en) * 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
AU2011336318A1 (en) * 2010-12-03 2013-07-04 Euthymics Bioscience, Inc. Preparation and use of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane in the treatment of conditions affected by monoamine neurotransmitters
EP2994129A4 (en) * 2013-05-07 2017-01-25 Euthymic Bioscience, Inc. Use of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane to treat addictive and alcohol-related disorders
KR101567003B1 (ko) 2013-12-27 2015-11-06 경희대학교 산학협력단 골편 고정장치 및 골편 절단을 위한 드릴 어셈블리
SI3597189T1 (sl) 2015-06-17 2022-08-31 Otsuka America Pharmaceutical, Inc. Kristalinične spojine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435419A (en) * 1981-07-01 1984-03-06 American Cyanamid Company Method of treating depression using azabicyclohexanes
US6372919B1 (en) * 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent

Also Published As

Publication number Publication date
NO20071372L (no) 2007-05-18
CA2619817A1 (en) 2006-03-02
EP1786417A4 (en) 2009-05-20
IL181185A0 (en) 2007-07-04
KR20130108489A (ko) 2013-10-02
MX2007001827A (es) 2007-04-23
KR20070054208A (ko) 2007-05-28
CN101052393A (zh) 2007-10-10
RU2007109817A (ru) 2008-09-27
AU2005277351A1 (en) 2006-03-02
WO2006023659A3 (en) 2006-12-07
KR20130004370A (ko) 2013-01-09
JP2008510715A (ja) 2008-04-10
EP1786417A2 (en) 2007-05-23
NZ589033A (en) 2012-06-29
ZA200701570B (en) 2008-08-27
WO2006023659A2 (en) 2006-03-02
IL181185A (en) 2012-10-31

Similar Documents

Publication Publication Date Title
BRPI0515193A (pt) novos polimorfos de azabiciclohexano
UY31344A1 (es) Metansulfonamidas n-(3-ter-butil-5-(2,4-dioxo-3,4-dihidropirimidin-1(2h)-il)-2-metoxi-aril) sustituidas, solvatos, hidratos, formas cristalinas y sus sales farmacéuticamente aceptables,proceso de preparación,composiciones y aplicaciones.
EA200901609A1 (ru) Амиды пиразолкарбоновой кислоты, применимые в качестве микробиоцидов
ECSP109856A (es) Derivados de oxadiazol y su uso como potenciadores de los receptores metabotrópicos de glutamato - 842
MX2010003155A (es) Derivados de ciclopropil aril amida y uso de los mismos.
TW200638930A (en) Acetylene derivatives
EA201000269A1 (ru) Новые гербициды
HN2010001059A (es) Nuevo titulo modificado: compuestos derivados de pirimidina, un proceso para la preparacion de los mismos, una composicion farmaceutica que los comprenden y combinaciones de dichos compuestos con otros agentes.
CL2008000946A1 (es) Compuestos derivados de pirrolopirimidina, inhibidores de cianasa jak3; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de rechazo de transplantes, enfermedades autoinmun
CL2009001686A1 (es) Procedimiento de preparacion de agomelatina; y los compuestos intermediarios considerados.
NO20080784L (no) Histondeacetylaseinhibitorer
AR077416A2 (es) Compuesto polimorfo estable de flibanserina , procedimiento industrial para su preparacion y uso del mismo para preparar medicamentos
EA201000272A1 (ru) Трициклические мостиковые производные циклопентадиенона, как гербициды
EA201000395A1 (ru) Фунгицидные производные 2-алкилтио-2-хинолинилоксиацетамида
CL2007003100A1 (es) Compuestos derivados de pirimidina, inhibidores de cisteina proteasa; procesos de preparacion; sales de los compuestos; composicion farmaceutica; y uso para el tratamiento de la malaria.
CL2012003564A1 (es) Compuestos derivados de heteroaril limidazolona :composición farmacéutica;uso de los compuestos para la inhibición de jak1,jak2 y jak3; y combinaciones farmacéuticas.
IL183237A0 (en) Polymorphs of memantine hydrochloride
AR061311A1 (es) Procesos para preparar clorhidrato de cinacalcet y formas polimorficas del mismo
UA92670C2 (ru) Пиразолиновые соединения и их фармацевтическое применение, композиция на их основе
BRPI0608819A8 (pt) Formas cristalinas de um derivado de imidazol
EA201101060A1 (ru) Новые гербициды
DE602006009789D1 (de) Acetylenderivate
CL2009000281A1 (es) Compuestos derivados de 5,6-dihidro-pirrolo-[2,1-a]-isoquinolinas y pirrolo-[2,1-a]-isoquinolinas; composicion farmaceutica que comprende a dichos compuestos; y uso para el tratamaiento de trastornos de la fertilidad.
PL1831152T3 (pl) Pochodne tetraliny i indanu oraz ich zastosowanie jako antagonistów 5-HT
EA201101146A1 (ru) Новые гербициды

Legal Events

Date Code Title Description
B15G Petition not considered as such [chapter 15.7 patent gazette]

Free format text: DESCONHECIDA DA PETICAO NO 018070047132/SP DE 24/07/2007, O PEDIDO DE TRANSFERENCIA POR CESSAO DE ERIC J. HAGEN E KEVIN HALLORAN, PARA DOV PHARMACEUTICAL, INC., UMA VEZ QUE O DEPOSITO DE PATENTE FOI REALIZADO NO NOME DA PROPRIA CESSIONARIA.

B25A Requested transfer of rights approved

Owner name: EUTHYMICS BIOSCIENCE, INC. (US)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2475 DE 12-06-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.