IL181185A - Composition containing polymorphs a, b and c of azabicyclohexane, said polymorphs, process for their preparation and pharmaceutical compositions containing them - Google Patents

Composition containing polymorphs a, b and c of azabicyclohexane, said polymorphs, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL181185A
IL181185A IL181185A IL18118507A IL181185A IL 181185 A IL181185 A IL 181185A IL 181185 A IL181185 A IL 181185A IL 18118507 A IL18118507 A IL 18118507A IL 181185 A IL181185 A IL 181185A
Authority
IL
Israel
Prior art keywords
polymorph
polymorph form
acid addition
azabicyclo
addition salt
Prior art date
Application number
IL181185A
Other languages
English (en)
Other versions
IL181185A0 (en
Original Assignee
Dov Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dov Pharmaceutical Inc filed Critical Dov Pharmaceutical Inc
Publication of IL181185A0 publication Critical patent/IL181185A0/en
Publication of IL181185A publication Critical patent/IL181185A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
IL181185A 2004-08-18 2007-02-06 Composition containing polymorphs a, b and c of azabicyclohexane, said polymorphs, process for their preparation and pharmaceutical compositions containing them IL181185A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92074804A 2004-08-18 2004-08-18
PCT/US2005/029420 WO2006023659A2 (en) 2004-08-18 2005-08-17 Novel polymorphs of azabicyclohexane

Publications (2)

Publication Number Publication Date
IL181185A0 IL181185A0 (en) 2007-07-04
IL181185A true IL181185A (en) 2012-10-31

Family

ID=35968183

Family Applications (1)

Application Number Title Priority Date Filing Date
IL181185A IL181185A (en) 2004-08-18 2007-02-06 Composition containing polymorphs a, b and c of azabicyclohexane, said polymorphs, process for their preparation and pharmaceutical compositions containing them

Country Status (14)

Country Link
EP (1) EP1786417A4 (ko)
JP (1) JP2008510715A (ko)
KR (3) KR20070054208A (ko)
CN (1) CN101052393A (ko)
AU (1) AU2005277351A1 (ko)
BR (1) BRPI0515193A (ko)
CA (1) CA2619817A1 (ko)
IL (1) IL181185A (ko)
MX (1) MX2007001827A (ko)
NO (1) NO20071372L (ko)
NZ (1) NZ589033A (ko)
RU (1) RU2007109817A (ko)
WO (1) WO2006023659A2 (ko)
ZA (1) ZA200701570B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
EP2719384B1 (en) 2005-07-27 2018-08-08 Otsuka America Pharmaceutical, Inc. Novel 1-naphthyl-3-azabicyclo[3.1.0]hexanes:preparation and use to treat neuropsychiatric disorders
US20080045725A1 (en) * 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
AU2011336318A1 (en) * 2010-12-03 2013-07-04 Euthymics Bioscience, Inc. Preparation and use of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane in the treatment of conditions affected by monoamine neurotransmitters
EP2994129A4 (en) * 2013-05-07 2017-01-25 Euthymic Bioscience, Inc. Use of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane to treat addictive and alcohol-related disorders
KR101567003B1 (ko) 2013-12-27 2015-11-06 경희대학교 산학협력단 골편 고정장치 및 골편 절단을 위한 드릴 어셈블리
EP3310352A4 (en) 2015-06-17 2019-03-13 Otsuka America Pharmaceutical, Inc. CRYSTALLINE COMPOUNDS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435419A (en) * 1981-07-01 1984-03-06 American Cyanamid Company Method of treating depression using azabicyclohexanes
US6372919B1 (en) * 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent

Also Published As

Publication number Publication date
MX2007001827A (es) 2007-04-23
JP2008510715A (ja) 2008-04-10
IL181185A0 (en) 2007-07-04
KR20130004370A (ko) 2013-01-09
KR20070054208A (ko) 2007-05-28
KR20130108489A (ko) 2013-10-02
AU2005277351A1 (en) 2006-03-02
NO20071372L (no) 2007-05-18
BRPI0515193A (pt) 2008-07-08
NZ589033A (en) 2012-06-29
WO2006023659A2 (en) 2006-03-02
RU2007109817A (ru) 2008-09-27
WO2006023659A3 (en) 2006-12-07
CA2619817A1 (en) 2006-03-02
ZA200701570B (en) 2008-08-27
CN101052393A (zh) 2007-10-10
EP1786417A2 (en) 2007-05-23
EP1786417A4 (en) 2009-05-20

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Legal Events

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MM9K Patent not in force due to non-payment of renewal fees