AU2004290692A1 - Processes for preparing tetrahydrobiopterin, and analogs of tetrahydrobiopterin - Google Patents

Processes for preparing tetrahydrobiopterin, and analogs of tetrahydrobiopterin Download PDF

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Publication number
AU2004290692A1
AU2004290692A1 AU2004290692A AU2004290692A AU2004290692A1 AU 2004290692 A1 AU2004290692 A1 AU 2004290692A1 AU 2004290692 A AU2004290692 A AU 2004290692A AU 2004290692 A AU2004290692 A AU 2004290692A AU 2004290692 A1 AU2004290692 A1 AU 2004290692A1
Authority
AU
Australia
Prior art keywords
groups
chain alkyl
group
alkyl substituted
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2004290692A
Other languages
English (en)
Inventor
Viola Groehn
Pierre Martin
Rudolf Moser
Andreas Schumacher
Dirk Spielvogel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Eprova AG
Biomarin Pharmaceutical Inc
Original Assignee
Merck Eprova AG
Biomarin Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Eprova AG, Biomarin Pharmaceutical Inc filed Critical Merck Eprova AG
Publication of AU2004290692A1 publication Critical patent/AU2004290692A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2004290692A 2003-11-17 2004-11-17 Processes for preparing tetrahydrobiopterin, and analogs of tetrahydrobiopterin Abandoned AU2004290692A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US52036703P 2003-11-17 2003-11-17
US52036803P 2003-11-17 2003-11-17
US60/520,367 2003-11-17
US60/520,368 2003-11-17
PCT/US2004/038313 WO2005049614A2 (en) 2003-11-17 2004-11-17 Processes for preparing tetrahydrobiopterin, and analogs of tetrahydrobiopterin

Publications (1)

Publication Number Publication Date
AU2004290692A1 true AU2004290692A1 (en) 2005-06-02

Family

ID=34623128

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004290692A Abandoned AU2004290692A1 (en) 2003-11-17 2004-11-17 Processes for preparing tetrahydrobiopterin, and analogs of tetrahydrobiopterin

Country Status (6)

Country Link
US (1) US7732599B2 (enExample)
EP (1) EP1776364A2 (enExample)
JP (1) JP5184783B2 (enExample)
AU (1) AU2004290692A1 (enExample)
CA (1) CA2545484A1 (enExample)
WO (1) WO2005049614A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE029533T2 (en) 2003-11-17 2017-03-28 Biomarin Pharm Inc Treatment of phenylketonuria with BH4
EP2436379A1 (en) 2004-11-17 2012-04-04 BioMarin Pharmaceutical Inc. Stable tablet formulation
CA2675134A1 (en) * 2007-01-12 2008-07-24 Biomarin Pharmaceutical Inc. Pterin analogs
DK3461503T3 (da) 2007-04-11 2022-02-14 Biomarin Pharm Inc Fremgangsmåder til indgivelse af tetrahydrobiopterin, associerede sammensætninger og målingsfremgangsmåder
RU2470642C2 (ru) 2008-01-03 2012-12-27 Байомарин Фармасьютикл Инк. Аналоги птерина для лечения состояния, чувствительного к вн4
AR070109A1 (es) 2008-01-07 2010-03-17 Biomarin Pharm Inc Metodo para sintetizar tetrahidobiopterina
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
CN102633799B (zh) * 2012-04-10 2014-06-25 凯莱英医药集团（天津）股份有限公司 一种从消旋体中间体拆分路线合成二盐酸沙丙蝶呤的方法
ES2681345T3 (es) * 2012-05-07 2018-09-12 Shiratori Pharmaceutical Co., Ltd. Método para producir sepiapterina y tetrahidrolactoilpterina
WO2016189542A1 (en) 2015-05-28 2016-12-01 Natco Pharma Ltd Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin
IL263801B2 (en) 2016-07-26 2024-01-01 Biomarin Pharm Inc Novel adeno-associated virus capsid proteins
IL266955B2 (en) 2016-11-29 2023-09-01 Ptc Therapeutics Mp Inc Polymorphs of spiafatrin and its salts
WO2018102314A1 (en) 2016-11-29 2018-06-07 Censa Pharmaceuticals Inc. Polymorphic form of sepiapterin
WO2019046849A1 (en) 2017-09-01 2019-03-07 Censa Pharmaceuticals Inc. PHARMACEUTICAL COMPOSITION COMPRISING SEPAPTERINE AND USES THEREOF
WO2019217513A2 (en) 2018-05-09 2019-11-14 Biomarin Pharmaceutical Inc. Methods of treating phenylketonuria
TW202005978A (zh) 2018-05-14 2020-02-01 美商拜奧馬林製藥公司 新穎肝靶向腺相關病毒載體
SMT202400430T1 (it) 2018-05-30 2024-11-15 Ptc Therapeutics Mp Inc Somministrazione di sepiapterina, senza alcun alimento, per uso in un metodo per incrementare l’esposizione plasmatica di sepiapterina
EP3801534A4 (en) 2018-05-30 2022-03-16 PTC Therapeutics MP, Inc. COMPOSITIONS AND METHODS TO INCREASE TETRAHYDROBIOPTERIN PLASMA EXPOSURE
TW202144575A (zh) 2020-04-03 2021-12-01 美商拜奧馬林製藥公司 使用ａａｖ及治療調配物之苯酮尿症治療
GB202307239D0 (en) 2023-05-15 2023-06-28 Evox Therapeutics Ltd Gene therapies for Phenylketonuria

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS617287A (ja) 1984-06-21 1986-01-13 Kanegafuchi Chem Ind Co Ltd ５‐デオキシ‐ｌ‐アラビノースの製造法
JP2575781B2 (ja) * 1988-02-29 1997-01-29 日清製粉株式会社 ２，３−ジアシルオキシ−４−ヒドロキシ−トペンタナールおよびその製造方法

Also Published As

Publication number Publication date
US20070244322A1 (en) 2007-10-18
WO2005049614A3 (en) 2007-03-08
WO2005049614A2 (en) 2005-06-02
JP2007534637A (ja) 2007-11-29
EP1776364A2 (en) 2007-04-25
JP5184783B2 (ja) 2013-04-17
US7732599B2 (en) 2010-06-08
CA2545484A1 (en) 2005-06-02

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MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period