JP5184783B2 - テトラヒドロビオプテリン、及びテトラヒドロビオプテリン類似体の製造方法 - Google Patents

テトラヒドロビオプテリン、及びテトラヒドロビオプテリン類似体の製造方法 Download PDF

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JP5184783B2
JP5184783B2 JP2006539994A JP2006539994A JP5184783B2 JP 5184783 B2 JP5184783 B2 JP 5184783B2 JP 2006539994 A JP2006539994 A JP 2006539994A JP 2006539994 A JP2006539994 A JP 2006539994A JP 5184783 B2 JP5184783 B2 JP 5184783B2
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JP2007534637A (ja
JP2007534637A5 (enExample
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モーザー，ルドルフ
グロエーン，ビオラ
シューマッハー，アンドレアス
マーティン，ピエール
シュピールフォーゲル，ディルク
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バイオマリン ファーマシューティカル インコーポレイテッド
メルック エプロファ アクチェンゲゼルシャフト
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2006539994A 2003-11-17 2004-11-17 テトラヒドロビオプテリン、及びテトラヒドロビオプテリン類似体の製造方法 Expired - Lifetime JP5184783B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US52036703P 2003-11-17 2003-11-17
US52036803P 2003-11-17 2003-11-17
US60/520,368 2003-11-17
US60/520,367 2003-11-17
PCT/US2004/038313 WO2005049614A2 (en) 2003-11-17 2004-11-17 Processes for preparing tetrahydrobiopterin, and analogs of tetrahydrobiopterin

Publications (3)

Publication Number Publication Date
JP2007534637A JP2007534637A (ja) 2007-11-29
JP2007534637A5 JP2007534637A5 (enExample) 2008-01-17
JP5184783B2 true JP5184783B2 (ja) 2013-04-17

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JP2006539994A Expired - Lifetime JP5184783B2 (ja) 2003-11-17 2004-11-17 テトラヒドロビオプテリン、及びテトラヒドロビオプテリン類似体の製造方法

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US (1) US7732599B2 (enExample)
EP (1) EP1776364A2 (enExample)
JP (1) JP5184783B2 (enExample)
AU (1) AU2004290692A1 (enExample)
CA (1) CA2545484A1 (enExample)
WO (1) WO2005049614A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06005451A (es) 2003-11-17 2007-01-26 Biomarin Pharm Inc Metodos y composiciones para el tratamiento de trastornos metabolicos.
US8003126B2 (en) 2004-11-17 2011-08-23 Biomarin Pharmaceutical Inc. Stable tablet formulation
JP2010515747A (ja) * 2007-01-12 2010-05-13 ビオマリン プハルマセウトイカル インコーポレイテッド テトラヒドロビオプテリンプロドラッグ
CA2682598C (en) 2007-04-11 2016-06-07 Biomarin Pharmaceutical Inc. Methods of administering tetrahydrobiopterin, associated compositions, and methods of measuring
CA2711160A1 (en) 2008-01-03 2009-07-16 Biomarin Pharmaceutical Inc. Pterin analog for treating bh4 responsive condition
WO2009088979A1 (en) 2008-01-07 2009-07-16 Biomarin Pharmaceutical Inc. Method of synthesizing tetrahydrobiopterin
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
CN102633799B (zh) * 2012-04-10 2014-06-25 凯莱英医药集团（天津）股份有限公司 一种从消旋体中间体拆分路线合成二盐酸沙丙蝶呤的方法
WO2013168693A1 (ja) * 2012-05-07 2013-11-14 白鳥製薬株式会社 セピアプテリン及びテトラヒドロラクトイルプテリンの製造法
WO2016189542A1 (en) 2015-05-28 2016-12-01 Natco Pharma Ltd Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin
MX2019000962A (es) 2016-07-26 2019-08-01 Biomarin Pharm Inc Novedosas proteinas de la capside del virus adenoasociado.
CN110312721A (zh) 2016-11-29 2019-10-08 显莎制药公司 墨蝶呤的多晶型物
KR102561697B1 (ko) 2016-11-29 2023-07-28 피티씨 테라퓨틱스 엠피, 인크. 세피아프테린의 다형체 및 그의 염
JP2020532535A (ja) 2017-09-01 2020-11-12 ピーティーシー セラピューティクス エムピー，インコーポレイテッド セピアプテリンを含む医薬組成物及びその使用
WO2019217513A2 (en) 2018-05-09 2019-11-14 Biomarin Pharmaceutical Inc. Methods of treating phenylketonuria
TW202005978A (zh) 2018-05-14 2020-02-01 美商拜奧馬林製藥公司 新穎肝靶向腺相關病毒載體
US12257252B2 (en) 2018-05-30 2025-03-25 Ptc Therapeutics Mp, Inc. Compositions and methods for increasing tetrahydrobiopterin plasma exposure
DK3801536T3 (da) 2018-05-30 2024-08-19 Ptc Therapeutics Mp Inc Indgivelse af sepiapterin uden mad til anvendelse i en fremgangsmåde til at øge sepiapterinplasmaeksponering
AR122409A1 (es) 2020-04-03 2022-09-07 Biomarin Pharm Inc Tratamiento de la fenilcetonuria con aav y formulaciones terapéuticas
GB202307239D0 (en) 2023-05-15 2023-06-28 Evox Therapeutics Ltd Gene therapies for Phenylketonuria

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS617287A (ja) 1984-06-21 1986-01-13 Kanegafuchi Chem Ind Co Ltd ５‐デオキシ‐ｌ‐アラビノースの製造法
JP2575781B2 (ja) * 1988-02-29 1997-01-29 日清製粉株式会社 ２，３−ジアシルオキシ−４−ヒドロキシ−トペンタナールおよびその製造方法

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Publication number Publication date
CA2545484A1 (en) 2005-06-02
EP1776364A2 (en) 2007-04-25
JP2007534637A (ja) 2007-11-29
US20070244322A1 (en) 2007-10-18
WO2005049614A3 (en) 2007-03-08
AU2004290692A1 (en) 2005-06-02
WO2005049614A2 (en) 2005-06-02
US7732599B2 (en) 2010-06-08

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