AU2002328999B8 - Novel benzo-fused heterocycles as endothelin antagonists - Google Patents

Novel benzo-fused heterocycles as endothelin antagonists Download PDF

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Publication number
AU2002328999B8
AU2002328999B8 AU2002328999A AU2002328999A AU2002328999B8 AU 2002328999 B8 AU2002328999 B8 AU 2002328999B8 AU 2002328999 A AU2002328999 A AU 2002328999A AU 2002328999 A AU2002328999 A AU 2002328999A AU 2002328999 B8 AU2002328999 B8 AU 2002328999B8
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Australia
Prior art keywords
phenyl
benzo
acetic acid
oxo
benzyl
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AU2002328999A
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AU2002328999B2 (en
AU2002328999A1 (en
Inventor
Martin Bolli
Christoph Boss
Martine Clozel
Walter Fischli
Judith Marfurt
Thomas Weller
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Actelion Pharmaceuticals Ltd
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Actelion Pharmaceuticals Ltd
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AU2002328999A 2001-08-09 2002-07-31 Novel benzo-fused heterocycles as endothelin antagonists Ceased AU2002328999B8 (en)

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Application Number Priority Date Filing Date Title
EP0109235 2001-08-09
AU87670/01 2001-08-09
PCT/EP2002/008523 WO2003013545A1 (en) 2001-08-09 2002-07-31 Novel benzo-fused heterocycles as endothelin antagonisits

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AU2002328999A1 AU2002328999A1 (en) 2003-06-19
AU2002328999B2 AU2002328999B2 (en) 2008-05-15
AU2002328999B8 true AU2002328999B8 (en) 2008-06-05

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AU2002328999A Ceased AU2002328999B8 (en) 2001-08-09 2002-07-31 Novel benzo-fused heterocycles as endothelin antagonists

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DE602005003951T4 (de) 2004-05-14 2012-10-11 Millennium Pharmaceuticals, Inc. Verbindungen und verfahren zur inhibierung der mitotischen progression durch hemmung von aurorakinase
WO2008021038A2 (en) 2006-08-09 2008-02-21 Millennium Pharmaceuticals, Inc. Pyridobenzazepine compounds and methods for inhibiting mitotic progression
CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
WO2008108445A1 (ja) 2007-03-07 2008-09-12 Takeda Pharmaceutical Company Limited ベンゾオキサゼピン誘導体およびその用途
MX2009011923A (es) * 2007-05-10 2009-11-18 Amr Technology Inc Tetrahidrobenzo-1,4-diazepinas aril- y heteroaril-sustituidas y uso de las mismas para bloquear reabsorcion de norepinefrina, dopamina y serotonina.
AU2008265655B2 (en) 2007-06-21 2014-02-06 Cara Therapeutics, Inc. Substituted imidazoheterocycles
US8119629B2 (en) 2007-10-03 2012-02-21 Bristol-Meyers Squibb Company Carboxamide GABAA α2 modulators
WO2010068520A2 (en) * 2008-12-11 2010-06-17 Cara Therapeutics, Inc. Substituted imidazoheterocycle derivatives
RU2535032C2 (ru) 2008-12-22 2014-12-10 Милленниум Фармасьютикалз, Инк. Сочетание ингибиторов аврора киназы и анти-cd 20 антител
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
CN104031049A (zh) 2010-02-19 2014-09-10 米伦纽姆医药公司 极光激酶抑制剂的结晶形式
CN101805283B (zh) * 2010-03-23 2013-01-02 渤海大学 含薁类结构的1,4-二氢吡啶类化合物及其制备方法
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
JP6360881B2 (ja) 2013-03-22 2018-07-18 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 触媒的ｍｔｏｒｃ１／２阻害薬及びオーロラａキナーゼの選択的阻害薬の組合せ
US20180207173A1 (en) 2015-07-21 2018-07-26 Millennium Pharmaceuticals, Inc. Administration of aurora kinase inhibitor and chemotherapeutic agents
CN112939855B (zh) * 2021-02-08 2024-03-26 马鞍山市泰博化工科技有限公司 一种制备含有薁环结构的1，4-二氢吡啶衍生物的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614498A (en) * 1990-06-07 1997-03-25 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic substance
US5420123A (en) * 1992-12-21 1995-05-30 Bristol-Myers Squibb Company Dibenzodiazepine endothelin antagonists
KR100340145B1 (ko) * 1993-08-26 2002-10-18 야마노우치세이야쿠 가부시키가이샤 벤즈아제핀유도체및이의중간체화합물
JP2000143636A (ja) * 1998-09-02 2000-05-26 Sumitomo Pharmaceut Co Ltd アミノ誘導体

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CA2454417A1 (en) 2003-02-20
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AU2002328999B2 (en) 2008-05-15
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