CN100418955C - 新型苯并稠杂环 - Google Patents

新型苯并稠杂环 Download PDF

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Publication number
CN100418955C
CN100418955C CNB028155394A CN02815539A CN100418955C CN 100418955 C CN100418955 C CN 100418955C CN B028155394 A CNB028155394 A CN B028155394A CN 02815539 A CN02815539 A CN 02815539A CN 100418955 C CN100418955 C CN 100418955C
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phenyl
benzo
oxo
acetate
tetrahydrochysene
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Expired - Fee Related
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CNB028155394A
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Chinese (zh)
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CN1538848A (zh
Inventor
马丁·博利
克里斯托夫·博斯
马丁内·克洛泽尔
瓦尔特·菲施利
托马斯·韦勒
朱迪思·马尔富特
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Actelion Pharmaceuticals Ltd
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Actelion Pharmaceuticals Ltd
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CNB028155394A 2001-08-09 2002-07-31 新型苯并稠杂环 Expired - Fee Related CN100418955C (zh)

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EPPCT/EP01/09235 2001-08-09
EP0109235 2001-08-09

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CN1538848A CN1538848A (zh) 2004-10-20
CN100418955C true CN100418955C (zh) 2008-09-17

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JP (1) JP4364637B2 (enExample)
KR (1) KR100909122B1 (enExample)
CN (1) CN100418955C (enExample)
AR (1) AR036386A1 (enExample)
AU (1) AU2002328999B8 (enExample)
BR (1) BR0211729A (enExample)
CA (1) CA2454417A1 (enExample)
HU (1) HUP0401107A3 (enExample)
IL (1) IL159963A0 (enExample)
MX (1) MXPA04001252A (enExample)
NO (1) NO20040563L (enExample)
NZ (1) NZ530741A (enExample)
WO (1) WO2003013545A1 (enExample)
ZA (1) ZA200400803B (enExample)

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DE602005003951T4 (de) 2004-05-14 2012-10-11 Millennium Pharmaceuticals, Inc. Verbindungen und verfahren zur inhibierung der mitotischen progression durch hemmung von aurorakinase
WO2008021038A2 (en) 2006-08-09 2008-02-21 Millennium Pharmaceuticals, Inc. Pyridobenzazepine compounds and methods for inhibiting mitotic progression
CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
WO2008108445A1 (ja) 2007-03-07 2008-09-12 Takeda Pharmaceutical Company Limited ベンゾオキサゼピン誘導体およびその用途
MX2009011923A (es) * 2007-05-10 2009-11-18 Amr Technology Inc Tetrahidrobenzo-1,4-diazepinas aril- y heteroaril-sustituidas y uso de las mismas para bloquear reabsorcion de norepinefrina, dopamina y serotonina.
AU2008265655B2 (en) 2007-06-21 2014-02-06 Cara Therapeutics, Inc. Substituted imidazoheterocycles
US8119629B2 (en) 2007-10-03 2012-02-21 Bristol-Meyers Squibb Company Carboxamide GABAA α2 modulators
WO2010068520A2 (en) * 2008-12-11 2010-06-17 Cara Therapeutics, Inc. Substituted imidazoheterocycle derivatives
RU2535032C2 (ru) 2008-12-22 2014-12-10 Милленниум Фармасьютикалз, Инк. Сочетание ингибиторов аврора киназы и анти-cd 20 антител
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
CN104031049A (zh) 2010-02-19 2014-09-10 米伦纽姆医药公司 极光激酶抑制剂的结晶形式
CN101805283B (zh) * 2010-03-23 2013-01-02 渤海大学 含薁类结构的1,4-二氢吡啶类化合物及其制备方法
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
JP6360881B2 (ja) 2013-03-22 2018-07-18 ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. 触媒的mtorc1/2阻害薬及びオーロラaキナーゼの選択的阻害薬の組合せ
US20180207173A1 (en) 2015-07-21 2018-07-26 Millennium Pharmaceuticals, Inc. Administration of aurora kinase inhibitor and chemotherapeutic agents
CN112939855B (zh) * 2021-02-08 2024-03-26 马鞍山市泰博化工科技有限公司 一种制备含有薁环结构的1,4-二氢吡啶衍生物的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614498A (en) * 1990-06-07 1997-03-25 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic substance
US5420123A (en) * 1992-12-21 1995-05-30 Bristol-Myers Squibb Company Dibenzodiazepine endothelin antagonists
KR100340145B1 (ko) * 1993-08-26 2002-10-18 야마노우치세이야쿠 가부시키가이샤 벤즈아제핀유도체및이의중간체화합물
JP2000143636A (ja) * 1998-09-02 2000-05-26 Sumitomo Pharmaceut Co Ltd アミノ誘導体

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