MXPA04001252A - Nuevos heterociclos benzo-fusionados como antagonistas de endotelina. - Google Patents
Nuevos heterociclos benzo-fusionados como antagonistas de endotelina.Info
- Publication number
- MXPA04001252A MXPA04001252A MXPA04001252A MXPA04001252A MXPA04001252A MX PA04001252 A MXPA04001252 A MX PA04001252A MX PA04001252 A MXPA04001252 A MX PA04001252A MX PA04001252 A MXPA04001252 A MX PA04001252A MX PA04001252 A MXPA04001252 A MX PA04001252A
- Authority
- MX
- Mexico
- Prior art keywords
- endothelin
- antagonisits
- fused heterocycles
- novel benzo
- preparation
- Prior art date
Links
- 125000000623 heterocyclic group Chemical group 0.000 title abstract 2
- 102000002045 Endothelin Human genes 0.000 title 1
- 108050009340 Endothelin Proteins 0.000 title 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 229940118365 Endothelin receptor antagonist Drugs 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000002308 endothelin receptor antagonist Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
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- Pharmacology & Pharmacy (AREA)
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- Diabetes (AREA)
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- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
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- Obesity (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0109235 | 2001-08-09 | ||
| PCT/EP2002/008523 WO2003013545A1 (en) | 2001-08-09 | 2002-07-31 | Novel benzo-fused heterocycles as endothelin antagonisits |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04001252A true MXPA04001252A (es) | 2004-05-27 |
Family
ID=8164539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04001252A MXPA04001252A (es) | 2001-08-09 | 2002-07-31 | Nuevos heterociclos benzo-fusionados como antagonistas de endotelina. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7238685B2 (enExample) |
| JP (1) | JP4364637B2 (enExample) |
| KR (1) | KR100909122B1 (enExample) |
| CN (1) | CN100418955C (enExample) |
| AR (1) | AR036386A1 (enExample) |
| AU (1) | AU2002328999B8 (enExample) |
| BR (1) | BR0211729A (enExample) |
| CA (1) | CA2454417A1 (enExample) |
| HU (1) | HUP0401107A3 (enExample) |
| IL (1) | IL159963A0 (enExample) |
| MX (1) | MXPA04001252A (enExample) |
| NO (1) | NO20040563L (enExample) |
| NZ (1) | NZ530741A (enExample) |
| WO (1) | WO2003013545A1 (enExample) |
| ZA (1) | ZA200400803B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602005003951T4 (de) | 2004-05-14 | 2012-10-11 | Millennium Pharmaceuticals, Inc. | Verbindungen und verfahren zur inhibierung der mitotischen progression durch hemmung von aurorakinase |
| WO2008021038A2 (en) | 2006-08-09 | 2008-02-21 | Millennium Pharmaceuticals, Inc. | Pyridobenzazepine compounds and methods for inhibiting mitotic progression |
| CL2007003244A1 (es) | 2006-11-16 | 2008-04-04 | Millennium Pharm Inc | Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer. |
| WO2008108445A1 (ja) | 2007-03-07 | 2008-09-12 | Takeda Pharmaceutical Company Limited | ベンゾオキサゼピン誘導体およびその用途 |
| MX2009011923A (es) * | 2007-05-10 | 2009-11-18 | Amr Technology Inc | Tetrahidrobenzo-1,4-diazepinas aril- y heteroaril-sustituidas y uso de las mismas para bloquear reabsorcion de norepinefrina, dopamina y serotonina. |
| AU2008265655B2 (en) | 2007-06-21 | 2014-02-06 | Cara Therapeutics, Inc. | Substituted imidazoheterocycles |
| US8119629B2 (en) | 2007-10-03 | 2012-02-21 | Bristol-Meyers Squibb Company | Carboxamide GABAA α2 modulators |
| WO2010068520A2 (en) * | 2008-12-11 | 2010-06-17 | Cara Therapeutics, Inc. | Substituted imidazoheterocycle derivatives |
| RU2535032C2 (ru) | 2008-12-22 | 2014-12-10 | Милленниум Фармасьютикалз, Инк. | Сочетание ингибиторов аврора киназы и анти-cd 20 антител |
| JO3635B1 (ar) | 2009-05-18 | 2020-08-27 | Millennium Pharm Inc | مركبات صيدلانية صلبة وطرق لانتاجها |
| CN104031049A (zh) | 2010-02-19 | 2014-09-10 | 米伦纽姆医药公司 | 极光激酶抑制剂的结晶形式 |
| CN101805283B (zh) * | 2010-03-23 | 2013-01-02 | 渤海大学 | 含薁类结构的1,4-二氢吡啶类化合物及其制备方法 |
| US20130303519A1 (en) | 2012-03-20 | 2013-11-14 | Millennium Pharmaceuticals, Inc. | Methods of treating cancer using aurora kinase inhibitors |
| JP6360881B2 (ja) | 2013-03-22 | 2018-07-18 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | 触媒的mtorc1/2阻害薬及びオーロラaキナーゼの選択的阻害薬の組合せ |
| US20180207173A1 (en) | 2015-07-21 | 2018-07-26 | Millennium Pharmaceuticals, Inc. | Administration of aurora kinase inhibitor and chemotherapeutic agents |
| CN112939855B (zh) * | 2021-02-08 | 2024-03-26 | 马鞍山市泰博化工科技有限公司 | 一种制备含有薁环结构的1,4-二氢吡啶衍生物的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5614498A (en) * | 1990-06-07 | 1997-03-25 | Banyu Pharmaceutical Co., Ltd. | Endothelin antagonistic substance |
| US5420123A (en) * | 1992-12-21 | 1995-05-30 | Bristol-Myers Squibb Company | Dibenzodiazepine endothelin antagonists |
| KR100340145B1 (ko) * | 1993-08-26 | 2002-10-18 | 야마노우치세이야쿠 가부시키가이샤 | 벤즈아제핀유도체및이의중간체화합물 |
| JP2000143636A (ja) * | 1998-09-02 | 2000-05-26 | Sumitomo Pharmaceut Co Ltd | アミノ誘導体 |
-
2002
- 2002-07-31 HU HU0401107A patent/HUP0401107A3/hu unknown
- 2002-07-31 JP JP2003518554A patent/JP4364637B2/ja not_active Expired - Fee Related
- 2002-07-31 IL IL15996302A patent/IL159963A0/xx unknown
- 2002-07-31 MX MXPA04001252A patent/MXPA04001252A/es active IP Right Grant
- 2002-07-31 CA CA002454417A patent/CA2454417A1/en not_active Abandoned
- 2002-07-31 BR BR0211729-0A patent/BR0211729A/pt not_active IP Right Cessation
- 2002-07-31 CN CNB028155394A patent/CN100418955C/zh not_active Expired - Fee Related
- 2002-07-31 KR KR1020047001815A patent/KR100909122B1/ko not_active Expired - Fee Related
- 2002-07-31 NZ NZ530741A patent/NZ530741A/en not_active IP Right Cessation
- 2002-07-31 AU AU2002328999A patent/AU2002328999B8/en not_active Ceased
- 2002-07-31 WO PCT/EP2002/008523 patent/WO2003013545A1/en not_active Ceased
- 2002-07-31 US US10/486,602 patent/US7238685B2/en not_active Expired - Fee Related
- 2002-08-06 AR ARP020102979A patent/AR036386A1/es unknown
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2004
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- 2004-02-06 NO NO20040563A patent/NO20040563L/no not_active Application Discontinuation
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| US7238685B2 (en) | 2007-07-03 |
| HUP0401107A3 (en) | 2004-10-28 |
| IL159963A0 (en) | 2004-06-20 |
| CN100418955C (zh) | 2008-09-17 |
| HUP0401107A2 (hu) | 2004-08-30 |
| ZA200400803B (en) | 2005-05-03 |
| BR0211729A (pt) | 2004-08-24 |
| KR20040030937A (ko) | 2004-04-09 |
| NZ530741A (en) | 2006-08-31 |
| JP4364637B2 (ja) | 2009-11-18 |
| KR100909122B1 (ko) | 2009-07-23 |
| WO2003013545A1 (en) | 2003-02-20 |
| CA2454417A1 (en) | 2003-02-20 |
| NO20040563L (no) | 2004-03-08 |
| JP2005502644A (ja) | 2005-01-27 |
| AU2002328999B2 (en) | 2008-05-15 |
| CN1538848A (zh) | 2004-10-20 |
| AU2002328999B8 (en) | 2008-06-05 |
| AR036386A1 (es) | 2004-09-08 |
| US20050124605A1 (en) | 2005-06-09 |
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