AU2002255267B2 - An orally administered agent and an orally administered agent/supporting substrate complex - Google Patents
An orally administered agent and an orally administered agent/supporting substrate complex Download PDFInfo
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- AU2002255267B2 AU2002255267B2 AU2002255267A AU2002255267A AU2002255267B2 AU 2002255267 B2 AU2002255267 B2 AU 2002255267B2 AU 2002255267 A AU2002255267 A AU 2002255267A AU 2002255267 A AU2002255267 A AU 2002255267A AU 2002255267 B2 AU2002255267 B2 AU 2002255267B2
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- Prior art keywords
- orally administered
- drug
- water
- administered agent
- agent
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2008201149A AU2008201149B2 (en) | 2001-04-24 | 2008-03-12 | A gel-forming composition |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001125804 | 2001-04-24 | ||
| JP2001-125804 | 2001-04-24 | ||
| PCT/JP2002/003920 WO2002087622A1 (en) | 2001-04-24 | 2002-04-19 | Oral preparations and supports for oral preparations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2008201149A Division AU2008201149B2 (en) | 2001-04-24 | 2008-03-12 | A gel-forming composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2002255267A1 AU2002255267A1 (en) | 2003-04-17 |
| AU2002255267B2 true AU2002255267B2 (en) | 2007-12-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002255267A Ceased AU2002255267B2 (en) | 2001-04-24 | 2002-04-19 | An orally administered agent and an orally administered agent/supporting substrate complex |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20080254102A9 (https=) |
| EP (1) | EP1391212A4 (https=) |
| JP (3) | JP4267926B2 (https=) |
| KR (1) | KR100890180B1 (https=) |
| CN (2) | CN1462194B (https=) |
| AU (1) | AU2002255267B2 (https=) |
| CA (1) | CA2445347C (https=) |
| TW (1) | TWI232755B (https=) |
| WO (1) | WO2002087622A1 (https=) |
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| DE19646392A1 (de) | 1996-11-11 | 1998-05-14 | Lohmann Therapie Syst Lts | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
| US8268333B2 (en) | 2001-04-24 | 2012-09-18 | Lintec Corporation | Orally administered agent and an orally administered agent/supporting substrate complex |
| JP4993652B2 (ja) * | 2004-03-31 | 2012-08-08 | リンテック株式会社 | 経口投与剤 |
| CA2445347C (en) * | 2001-04-24 | 2011-09-27 | Lintec Corporation | An orally administered agent and an orally administered agent/supporting substrate complex |
| AU2003302589A1 (en) * | 2002-12-02 | 2004-06-23 | Kyukyu Pharmaceutical Co., Ltd. | Method for producing orally administrable edible agent of laminate film form and pressure bonding apparatus of the agent. |
| US8469036B2 (en) | 2003-11-07 | 2013-06-25 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| JP2005298471A (ja) * | 2004-03-17 | 2005-10-27 | Lintec Corp | 薬剤の製造方法 |
| CN100455282C (zh) * | 2004-03-17 | 2009-01-28 | 琳得科株式会社 | 药剂的制造方法 |
| JP2005289867A (ja) * | 2004-03-31 | 2005-10-20 | Lintec Corp | 経口投与剤 |
| JP4547994B2 (ja) * | 2004-06-02 | 2010-09-22 | 救急薬品工業株式会社 | 塊状物質含有積層フィルム状の可食性口腔内投与剤の製造方法および塊状物質含有積層フィルム状の可食性口腔内投与剤 |
| JP4587785B2 (ja) * | 2004-11-12 | 2010-11-24 | リンテック株式会社 | 経口投与剤 |
| ES2540929T3 (es) * | 2005-02-01 | 2015-07-14 | Emisphere Technologies, Inc. | Sistema de administración de retención gástrica y liberación controlada |
| JP2006321792A (ja) * | 2005-04-18 | 2006-11-30 | Showa Denko Kk | 含水ゲル体及びその製造方法 |
| JP2007070344A (ja) * | 2005-08-11 | 2007-03-22 | Tsukioka:Kk | 内服薬 |
| JP4860312B2 (ja) * | 2006-03-22 | 2012-01-25 | リンテック株式会社 | 経口投与剤 |
| JP4953673B2 (ja) * | 2006-03-22 | 2012-06-13 | リンテック株式会社 | 経口投与剤 |
| US20090110715A1 (en) * | 2006-05-10 | 2009-04-30 | Kureha Corporation | Edible film Package Having Product for Oral Intake Enclosed Therein |
| JP5525678B2 (ja) * | 2006-08-04 | 2014-06-18 | リンテック株式会社 | 経口投与剤 |
| US8303741B2 (en) | 2007-03-30 | 2012-11-06 | Lintec Corporation | Process for producing preparation for oral administration |
| WO2008126488A1 (ja) | 2007-03-30 | 2008-10-23 | Lintec Corporation | 経口投与剤およびその製造方法 |
| CN101069742B (zh) * | 2007-06-06 | 2010-09-15 | 上海丽珠制药有限公司 | 一种胰激肽原酶片剂及其制备方法 |
| JP5435853B2 (ja) * | 2007-09-28 | 2014-03-05 | 興和株式会社 | 塩酸フェニレフリン含有速溶性フィルム製剤及びその製造方法 |
| AU2008305243B2 (en) * | 2007-09-28 | 2013-09-12 | Lintec Corporation | Medicinal preparation for oral administration |
| CN101883559B (zh) * | 2007-12-06 | 2011-12-28 | 琳得科株式会社 | 可食性薄膜 |
| EP2249802B1 (en) * | 2008-02-06 | 2013-01-16 | University of East Anglia | Composition and method for assisting swallowing |
| CA2719921A1 (en) * | 2008-03-28 | 2009-10-01 | Lintec Corporation | Orally-administered agent |
| TWI441659B (zh) * | 2008-09-29 | 2014-06-21 | Lintec Corp | Oral administration |
| JPWO2010110320A1 (ja) | 2009-03-25 | 2012-10-04 | リンテック株式会社 | 固形製剤 |
| JPWO2010110322A1 (ja) * | 2009-03-25 | 2012-10-04 | リンテック株式会社 | 固形製剤 |
| AU2010228257A1 (en) | 2009-03-25 | 2011-09-29 | Aska Pharmaceutical Co., Ltd. | Adhesion preventing composition, solid preparation and method for producing same |
| JP2011143153A (ja) * | 2010-01-18 | 2011-07-28 | Tsukioka:Kk | フィルムパック |
| AR080077A1 (es) | 2010-01-29 | 2012-03-14 | Colgate Palmolive Co | Tira dental para la administracion de tratamiento por la via oral |
| KR20130029758A (ko) | 2010-03-03 | 2013-03-25 | 코와 가부시키가이샤 | 불쾌한 맛을 갖는 약물을 함유하는 필름 제제 |
| JPWO2011118454A1 (ja) | 2010-03-23 | 2013-07-04 | リンテック株式会社 | 固形製剤 |
| JPWO2011118453A1 (ja) | 2010-03-23 | 2013-07-04 | リンテック株式会社 | 固形製剤 |
| KR101767288B1 (ko) | 2010-03-31 | 2017-08-10 | 모찌다 세이야쿠 가부시끼가이샤 | 복용 용이성 고형 제제 |
| MY158722A (en) * | 2010-07-29 | 2016-11-15 | Santen Pharmaceutical Co Ltd | "drug support body, and method for producing same" |
| CA2777428A1 (en) | 2011-05-20 | 2012-11-20 | Nitto Denko Corporation | Edible jelly-form composition, jelly-form preparation and method for producing jelly-form preparation |
| WO2013046453A1 (ja) | 2011-09-30 | 2013-04-04 | 持田製薬株式会社 | 易服用性固形製剤 |
| JP2013095687A (ja) * | 2011-10-31 | 2013-05-20 | Tsukioka Film Pharma Co Ltd | 口腔内貼付薬 |
| JP5318181B2 (ja) * | 2011-11-17 | 2013-10-16 | リンテック株式会社 | 経口投与剤 |
| US9452135B2 (en) | 2012-03-20 | 2016-09-27 | Particle Dynamics International, Llc | Gelling agent-based dosage form |
| KR102008417B1 (ko) * | 2012-12-04 | 2019-08-08 | 롯데정밀화학 주식회사 | 적층 필름 및 필름 적층방법 |
| CA2935191C (en) | 2013-12-31 | 2021-11-09 | Johnson & Johnson Consumer Inc. | Process for forming a shaped film product |
| KR102240525B1 (ko) * | 2013-12-31 | 2021-04-16 | 존슨 앤드 존슨 컨수머 인코포레이티드 | 다층의 형상화된 필름을 형성하기 위한 방법 |
| US20210000754A1 (en) * | 2019-07-02 | 2021-01-07 | Clifford T. Rowley | Transdermal patch providing improved permeability and composition |
| US12357578B2 (en) * | 2020-10-23 | 2025-07-15 | Appco Pharma Llc | Ibuprofen and famotidine tablet |
| DE102021130950A1 (de) * | 2021-11-25 | 2023-05-25 | Lts Lohmann Therapie-Systeme Ag. | Applikationshilfe |
| KR20250012498A (ko) * | 2022-05-23 | 2025-01-24 | 교와 야쿠힝 고교 가부시키가이샤 | 겔 피막 및 경구 고형 조성물 |
| WO2026062705A1 (en) | 2024-09-23 | 2026-03-26 | Troikaa Pharmaceuticals Limited | Oromucosal liquid compositions of betahistine or its pharmaceutically acceptable salt(s) and processes for preparation thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4849246A (en) * | 1985-10-09 | 1989-07-18 | Wolfgang Schmidt | Process for producing an administration or dosage form for drugs, reagents or other active ingredients |
| US6153222A (en) * | 1994-06-07 | 2000-11-28 | Lts Lohmann Therapie - Systeme Gmbh | Volume-expandable, sheet-like application form suitable as an active substance carrier, in particular for oral application |
| US6242004B1 (en) * | 1997-04-23 | 2001-06-05 | Permatec Technologie Ag | Bioadhesive tablets |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2513852A (en) * | 1946-12-26 | 1950-07-04 | Alfonso M Donofrio | Method for encapsulating |
| GB1510857A (en) * | 1974-09-13 | 1978-05-17 | Kernforschungsanlage Juelich | Method of separating particles of nuclear fuel ans/or breeder material from a first liquid and introducing them into a second liquid |
| JPS5154917A (ja) * | 1974-11-01 | 1976-05-14 | Toppan Printing Co Ltd | Seizaihoho |
| JPS5513383Y2 (https=) * | 1975-02-21 | 1980-03-26 | ||
| JPS6168415A (ja) * | 1984-09-11 | 1986-04-08 | Toyobo Co Ltd | 口腔粘膜適用口臭除去剤 |
| JPS61280423A (ja) * | 1985-06-05 | 1986-12-11 | Kiyuukiyuu Yakuhin Kogyo Kk | 口腔内粘膜貼付剤 |
| US4712460A (en) | 1985-11-18 | 1987-12-15 | Biotrack, Inc. | Integrated drug dosage form and metering system |
| JPS62207208A (ja) * | 1986-03-07 | 1987-09-11 | Teijin Ltd | 経口フイルム状徐放性製剤 |
| US4855142A (en) | 1987-02-27 | 1989-08-08 | Ciba-Geigy Corporation | Pharmaceutical plaster |
| IE64726B1 (en) * | 1987-11-20 | 1995-08-23 | Elan Corp Plc | Pharmaceutical formulations for preventing drug tolerance |
| DE3827561C1 (https=) * | 1988-08-13 | 1989-12-28 | Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De | |
| JP2656338B2 (ja) * | 1989-01-31 | 1997-09-24 | 日東電工株式会社 | 口腔粘膜貼付製剤 |
| DE4018247A1 (de) | 1990-06-07 | 1991-12-12 | Lohmann Therapie Syst Lts | Herstellungsverfahren fuer schnellzerfallende folienfoermige darreichungsformen |
| JPH05124954A (ja) | 1991-10-29 | 1993-05-21 | Mitsubishi Kasei Corp | シート状固形薬剤組成物 |
| JPH069375A (ja) * | 1992-04-10 | 1994-01-18 | Takeda Chem Ind Ltd | 分割可能な連結錠剤 |
| JPH05310561A (ja) | 1992-04-27 | 1993-11-22 | Lion Corp | 口腔内適用基剤及び口腔内適用製剤 |
| US5744155A (en) * | 1993-08-13 | 1998-04-28 | Friedman; Doron | Bioadhesive emulsion preparations for enhanced drug delivery |
| GB9402203D0 (en) * | 1994-02-04 | 1994-03-30 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US5824339A (en) * | 1995-09-08 | 1998-10-20 | Takeda Chemical Industries, Ltd | Effervescent composition and its production |
| DE19539361A1 (de) * | 1995-10-23 | 1997-04-24 | Basf Ag | Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung |
| US5766620A (en) * | 1995-10-23 | 1998-06-16 | Theratech, Inc. | Buccal delivery of glucagon-like insulinotropic peptides |
| JP2791317B2 (ja) * | 1995-12-26 | 1998-08-27 | 株式会社三和化学研究所 | 多層フィルム製剤 |
| JPH09276374A (ja) * | 1996-04-08 | 1997-10-28 | Yomisu:Kk | 2度ごっくんこ |
| JPH1024091A (ja) * | 1996-07-10 | 1998-01-27 | Noboru Mori | 粒体物等のためのカウンティングスプーン |
| CA2262595C (en) * | 1996-08-15 | 2005-10-18 | Losan Pharma Gmbh | Easy to swallow oral medicament composition |
| JP2000024089A (ja) * | 1998-07-12 | 2000-01-25 | Yutaka Yoshino | 散剤投与具 |
| JP2000119128A (ja) * | 1998-10-13 | 2000-04-25 | Nitto Denko Corp | 化粧用ゲルシート及びその製造方法 |
| US6797283B1 (en) * | 1998-12-23 | 2004-09-28 | Alza Corporation | Gastric retention dosage form having multiple layers |
| CN100391438C (zh) | 1999-09-14 | 2008-06-04 | 史密丝克莱恩比彻姆公司 | 制备水性包被小球粒的方法 |
| GB0027357D0 (en) * | 2000-11-09 | 2000-12-27 | Bradford Particle Design Plc | Particle formation methods and their products |
| CA2445347C (en) * | 2001-04-24 | 2011-09-27 | Lintec Corporation | An orally administered agent and an orally administered agent/supporting substrate complex |
| ATE398465T1 (de) * | 2001-11-16 | 2008-07-15 | Givaudan Sa | Essbare folie |
-
2002
- 2002-04-19 CA CA2445347A patent/CA2445347C/en not_active Expired - Fee Related
- 2002-04-19 AU AU2002255267A patent/AU2002255267B2/en not_active Ceased
- 2002-04-19 CN CN028013735A patent/CN1462194B/zh not_active Expired - Fee Related
- 2002-04-19 KR KR1020027017540A patent/KR100890180B1/ko not_active Expired - Fee Related
- 2002-04-19 JP JP2002584964A patent/JP4267926B2/ja not_active Expired - Fee Related
- 2002-04-19 EP EP02724622A patent/EP1391212A4/en not_active Withdrawn
- 2002-04-19 CN CN2010101158635A patent/CN101785863B/zh not_active Expired - Fee Related
- 2002-04-19 WO PCT/JP2002/003920 patent/WO2002087622A1/ja not_active Ceased
- 2002-04-23 TW TW091108355A patent/TWI232755B/zh not_active IP Right Cessation
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2003
- 2003-10-23 US US10/690,811 patent/US20080254102A9/en not_active Abandoned
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2008
- 2008-08-29 JP JP2008221521A patent/JP5008205B2/ja not_active Expired - Fee Related
-
2011
- 2011-12-14 JP JP2011273769A patent/JP2012051951A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4849246A (en) * | 1985-10-09 | 1989-07-18 | Wolfgang Schmidt | Process for producing an administration or dosage form for drugs, reagents or other active ingredients |
| US6153222A (en) * | 1994-06-07 | 2000-11-28 | Lts Lohmann Therapie - Systeme Gmbh | Volume-expandable, sheet-like application form suitable as an active substance carrier, in particular for oral application |
| US6242004B1 (en) * | 1997-04-23 | 2001-06-05 | Permatec Technologie Ag | Bioadhesive tablets |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5008205B2 (ja) | 2012-08-22 |
| US20040137040A1 (en) | 2004-07-15 |
| EP1391212A1 (en) | 2004-02-25 |
| TWI232755B (en) | 2005-05-21 |
| US20080254102A9 (en) | 2008-10-16 |
| CA2445347A1 (en) | 2002-11-07 |
| JP2009007379A (ja) | 2009-01-15 |
| JPWO2002087622A1 (ja) | 2004-08-12 |
| JP4267926B2 (ja) | 2009-05-27 |
| WO2002087622A1 (en) | 2002-11-07 |
| KR20040002391A (ko) | 2004-01-07 |
| CN101785863B (zh) | 2013-06-05 |
| CN1462194B (zh) | 2013-04-24 |
| JP2012051951A (ja) | 2012-03-15 |
| CN101785863A (zh) | 2010-07-28 |
| KR100890180B1 (ko) | 2009-03-25 |
| CN1462194A (zh) | 2003-12-17 |
| CA2445347C (en) | 2011-09-27 |
| EP1391212A4 (en) | 2008-09-03 |
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