AU2001283891B2 - 9.Alpha.-chloro-6.alpha.-fluoro-17.alpha.hydroxy-16-methyl-17-beta-methoxycarbonyl-androst-1,4-dienes esterified in position 17.alpha. by a cyclic acyl group - Google Patents

9.Alpha.-chloro-6.alpha.-fluoro-17.alpha.hydroxy-16-methyl-17-beta-methoxycarbonyl-androst-1,4-dienes esterified in position 17.alpha. by a cyclic acyl group Download PDF

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Publication number
AU2001283891B2
AU2001283891B2 AU2001283891A AU2001283891A AU2001283891B2 AU 2001283891 B2 AU2001283891 B2 AU 2001283891B2 AU 2001283891 A AU2001283891 A AU 2001283891A AU 2001283891 A AU2001283891 A AU 2001283891A AU 2001283891 B2 AU2001283891 B2 AU 2001283891B2
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alkyl
formula
methyl
compound
compound according
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AU2001283891A1 (en
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David Beattie
Bernard Cuenoud
Thomas Hugo Keller
Gaynor Elizabeth Pilgrim
David Andrew Sandham
Simon James Watson
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU2001283891A 2000-06-28 2001-06-26 9.Alpha.-chloro-6.alpha.-fluoro-17.alpha.hydroxy-16-methyl-17-beta-methoxycarbonyl-androst-1,4-dienes esterified in position 17.alpha. by a cyclic acyl group Ceased AU2001283891B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0015876.6A GB0015876D0 (en) 2000-06-28 2000-06-28 Organic compounds
GB0015876.6 2000-06-28
PCT/EP2001/007249 WO2002000679A2 (en) 2000-06-28 2001-06-26 9.alpha.-chloro-6.alpha.-fluoro-17.alpha.-hydroxy-16-methyl-17-beta-methoxycarbonyl-androst-1,4-dienes esterified in position 17.alpha. by a cyclic acyl group

Publications (2)

Publication Number Publication Date
AU2001283891A1 AU2001283891A1 (en) 2002-03-28
AU2001283891B2 true AU2001283891B2 (en) 2004-06-17

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ID=9894607

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Application Number Title Priority Date Filing Date
AU2001283891A Ceased AU2001283891B2 (en) 2000-06-28 2001-06-26 9.Alpha.-chloro-6.alpha.-fluoro-17.alpha.hydroxy-16-methyl-17-beta-methoxycarbonyl-androst-1,4-dienes esterified in position 17.alpha. by a cyclic acyl group
AU8389101A Pending AU8389101A (en) 2000-06-28 2001-06-26 Organic compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU8389101A Pending AU8389101A (en) 2000-06-28 2001-06-26 Organic compounds

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US (1) US6921757B2 (enExample)
EP (1) EP1299409B1 (enExample)
JP (1) JP4065399B2 (enExample)
KR (1) KR100483865B1 (enExample)
CN (1) CN1214038C (enExample)
AR (1) AR030707A1 (enExample)
AT (1) ATE292639T1 (enExample)
AU (2) AU2001283891B2 (enExample)
BR (1) BR0112068A (enExample)
CA (1) CA2412541C (enExample)
CZ (1) CZ302513B6 (enExample)
DE (1) DE60109931T2 (enExample)
EC (1) ECSP014101A (enExample)
ES (1) ES2240499T3 (enExample)
GB (1) GB0015876D0 (enExample)
HU (1) HUP0300783A3 (enExample)
IL (2) IL153703A0 (enExample)
MX (1) MXPA02012830A (enExample)
MY (1) MY129523A (enExample)
NO (1) NO324055B1 (enExample)
NZ (1) NZ523194A (enExample)
PE (1) PE20020179A1 (enExample)
PL (1) PL207722B1 (enExample)
PT (1) PT1299409E (enExample)
RU (1) RU2277100C2 (enExample)
SK (1) SK286690B6 (enExample)
TW (1) TWI232868B (enExample)
WO (1) WO2002000679A2 (enExample)
ZA (1) ZA200300202B (enExample)

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