AU2001263484B2 - Methods of treating hepatitis delta virus infection with beta-l-2'- deoxy-nucleosides - Google Patents

Methods of treating hepatitis delta virus infection with beta-l-2'- deoxy-nucleosides Download PDF

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Publication number
AU2001263484B2
AU2001263484B2 AU2001263484A AU2001263484A AU2001263484B2 AU 2001263484 B2 AU2001263484 B2 AU 2001263484B2 AU 2001263484 A AU2001263484 A AU 2001263484A AU 2001263484 A AU2001263484 A AU 2001263484A AU 2001263484 B2 AU2001263484 B2 AU 2001263484B2
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alkyl
pharmaceutically acceptable
acyl
acceptable salt
triphosphate
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AU2001263484A
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AU2001263484A1 (en
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Martin L Bryant
Jean-Pierre Sommadossi
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Novartis AG
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Novartis AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2001263484A 2000-05-26 2001-05-29 Methods of treating hepatitis delta virus infection with beta-l-2'- deoxy-nucleosides Ceased AU2001263484B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20753800P 2000-05-26 2000-05-26
US60/207,538 2000-05-26
PCT/US2001/017301 WO2001091737A2 (en) 2000-05-26 2001-05-29 Methods for treating hepatitis delta virus infection with beta-l-2' deoxy-nucleosides

Related Child Applications (1)

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AU2006252214A Division AU2006252214A1 (en) 2000-05-26 2006-12-21 Methods for treating hepatitis delta virus infection with beta-L-2'-deoxy-nucleosides

Publications (2)

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AU2001263484A1 AU2001263484A1 (en) 2002-02-28
AU2001263484B2 true AU2001263484B2 (en) 2006-12-14

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Application Number Title Priority Date Filing Date
AU6348401A Pending AU6348401A (en) 2000-05-26 2001-05-29 Methods of treating hepatitis delta virus infection with beta-l-2'- deoxy-nucleosides
AU2001263484A Ceased AU2001263484B2 (en) 2000-05-26 2001-05-29 Methods of treating hepatitis delta virus infection with beta-l-2'- deoxy-nucleosides
AU2006252214A Abandoned AU2006252214A1 (en) 2000-05-26 2006-12-21 Methods for treating hepatitis delta virus infection with beta-L-2'-deoxy-nucleosides

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AU6348401A Pending AU6348401A (en) 2000-05-26 2001-05-29 Methods of treating hepatitis delta virus infection with beta-l-2'- deoxy-nucleosides

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US (1) US6596700B2 (enExample)
EP (1) EP1292313B1 (enExample)
JP (1) JP2004513070A (enExample)
KR (1) KR100854398B1 (enExample)
CN (1) CN100490818C (enExample)
AT (1) ATE275406T1 (enExample)
AU (3) AU6348401A (enExample)
BR (1) BR0111195A (enExample)
CA (1) CA2410488C (enExample)
DE (1) DE60105424T2 (enExample)
EA (1) EA005890B1 (enExample)
ES (1) ES2227203T3 (enExample)
IL (1) IL153078A0 (enExample)
MX (1) MXPA02011641A (enExample)
TR (1) TR200402565T4 (enExample)
WO (1) WO2001091737A2 (enExample)
ZA (2) ZA200210100B (enExample)

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US10100076B2 (en) 2000-10-18 2018-10-16 Gilead Pharmasset Llc Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation

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Publication number Priority date Publication date Assignee Title
US10100076B2 (en) 2000-10-18 2018-10-16 Gilead Pharmasset Llc Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation

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IL153078A0 (en) 2003-06-24
ZA200404304B (en) 2005-03-30
ZA200210100B (en) 2004-06-22
ATE275406T1 (de) 2004-09-15
EA005890B1 (ru) 2005-06-30
CA2410488C (en) 2009-10-27
BR0111195A (pt) 2004-07-20
US6596700B2 (en) 2003-07-22
TR200402565T4 (tr) 2004-12-21
CN100490818C (zh) 2009-05-27
DE60105424T2 (de) 2005-09-22
AU2006252214A1 (en) 2007-01-18
EP1292313A2 (en) 2003-03-19
CN1444483A (zh) 2003-09-24
KR100854398B1 (ko) 2008-08-26
AU6348401A (en) 2001-12-11
WO2001091737A3 (en) 2002-05-30
DE60105424D1 (de) 2004-10-14
CA2410488A1 (en) 2001-12-06
JP2004513070A (ja) 2004-04-30
WO2001091737A2 (en) 2001-12-06
ES2227203T3 (es) 2005-04-01
US20020035085A1 (en) 2002-03-21
MXPA02011641A (es) 2004-07-30
HK1050999A1 (en) 2003-07-18
KR20030031487A (ko) 2003-04-21
EP1292313B1 (en) 2004-09-08
EA200201263A1 (ru) 2003-06-26

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