ATE73690T1 - Teilchentrennungsverfahren. - Google Patents

Teilchentrennungsverfahren.

Info

Publication number
ATE73690T1
ATE73690T1 AT86309967T AT86309967T ATE73690T1 AT E73690 T1 ATE73690 T1 AT E73690T1 AT 86309967 T AT86309967 T AT 86309967T AT 86309967 T AT86309967 T AT 86309967T AT E73690 T1 ATE73690 T1 AT E73690T1
Authority
AT
Austria
Prior art keywords
analyte
medium
particles
magnetic
magnetic particles
Prior art date
Application number
AT86309967T
Other languages
English (en)
Inventor
Edwin F Ullman
Nurith Kurn
Vartan E Ghazarossian
Litai Weng
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Application granted granted Critical
Publication of ATE73690T1 publication Critical patent/ATE73690T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326Magnetic particles
    • G01N33/54333Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/005Pretreatment specially adapted for magnetic separation
    • B03C1/01Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/24Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Steroid Compounds (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AT86309967T 1985-12-20 1986-12-19 Teilchentrennungsverfahren. ATE73690T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81120285A 1985-12-20 1985-12-20
EP86309967A EP0230768B1 (de) 1985-12-20 1986-12-19 Teilchentrennungsverfahren

Publications (1)

Publication Number Publication Date
ATE73690T1 true ATE73690T1 (de) 1992-04-15

Family

ID=25205867

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86309967T ATE73690T1 (de) 1985-12-20 1986-12-19 Teilchentrennungsverfahren.

Country Status (7)

Country Link
EP (1) EP0230768B1 (de)
JP (1) JP2806924B2 (de)
AT (1) ATE73690T1 (de)
AU (1) AU601386B2 (de)
CA (1) CA1304006C (de)
DE (1) DE3684448D1 (de)
ES (1) ES2030667T3 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512332A (en) * 1985-10-04 1996-04-30 Immunivest Corporation Process of making resuspendable coated magnetic particles
JPS62197425A (ja) * 1986-02-25 1987-09-01 Toyo Soda Mfg Co Ltd 球状熱可塑性樹脂の製造方法
ZA877772B (en) * 1986-10-23 1988-04-20 Amoco Corporation Target and background capture methods and apparatus for affinity assays
SE8701962D0 (sv) * 1987-05-13 1987-05-13 Bo Hakan Nygren Sett att isolera och/eller bestemma halten av ett organiskt emne genom kovalent koppling av en for emnet specifik motreaktant till ytadsorberad, hydrofoberad vattenloslig polymer
US5136095A (en) * 1987-05-19 1992-08-04 Syntex (U.S.A.) Inc. Reversible agglutination mediators
US4812401A (en) * 1987-05-19 1989-03-14 Syntex (U.S.A.) Inc. Reversible agglutination mediators for separating cells from whole blood
CA1318588C (en) * 1988-01-19 1993-06-01 Henry Jeong Method and device for separating plasma from red cells
AU609241B2 (en) * 1988-01-29 1991-04-26 Abbott Laboratories Ion-capture assays and devices
US5459080A (en) * 1988-01-29 1995-10-17 Abbott Laboratories Ion-capture assays using a specific binding member conjugated to carboxymethylamylose
US5459078A (en) * 1988-01-29 1995-10-17 Abbott Laboratories Methods and reagents for performing ion-capture digoxin assays
US5866322A (en) * 1988-01-29 1999-02-02 Abbott Laboratories Method for performing Rubella assay
US5087570A (en) * 1988-05-10 1992-02-11 Weissman Irving L Homogeneous mammalian hematopoietic stem cell composition
US5108933A (en) * 1988-09-16 1992-04-28 Immunicon Corporation Manipulation of colloids for facilitating magnetic separations
SE462454B (sv) * 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5512439A (en) * 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
CA2003508C (en) * 1988-11-21 2000-01-25 Erik Hornes Monodisperse superparamagnetic particles for use in nucleic acid analyses
CA1341592C (en) * 1989-07-07 2009-04-14 Abbott Laboratories Ion capture reagents and methods for performing binding assays
US5698271A (en) * 1989-08-22 1997-12-16 Immunivest Corporation Methods for the manufacture of magnetically responsive particles
US5541072A (en) * 1994-04-18 1996-07-30 Immunivest Corporation Method for magnetic separation featuring magnetic particles in a multi-phase system
SE501013C2 (sv) * 1990-10-01 1994-10-17 Pharmacia Biosensor Ab Förfarande för förbättring av analys med bindning till fast fas
US5242833A (en) * 1991-03-20 1993-09-07 Reference Diagnostics, Inc. Lipid fractionation
US5795470A (en) * 1991-03-25 1998-08-18 Immunivest Corporation Magnetic separation apparatus
FR2695939B1 (fr) * 1992-09-24 1995-03-03 Prolabo Sa Cellules transformées, humaines, animales ou végétales encapsulant dans leurs cytoplasmes au moins une particule de latex.
WO1995031726A1 (en) * 1994-05-11 1995-11-23 Genera Technologies Limited Methods of capturing species from liquids and assay procedures
CA2260991C (en) 1997-11-18 2009-03-24 Bio-Rad Laboratories, Inc. Multiplex flow immunoassays with magnetic particles as solid phase
EP1079967A4 (de) * 1998-04-13 2003-07-23 Luminex Corp Flüssige markierung mit fluorezierenden mikropartikeln
WO2000043551A1 (en) * 1999-01-26 2000-07-27 Cornell Research Foundation, Inc. Determining viral load in double negative t cells
US7871597B2 (en) 1999-04-09 2011-01-18 Amag Pharmaceuticals, Inc. Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents
DE60043188D1 (de) 1999-04-09 2009-12-03 Amag Pharmaceuticals Inc Hitzebeständige umhüllte kolloidale eisenoxide
WO2002027316A2 (en) * 2000-09-25 2002-04-04 Abbott Laboratories Methods and kits for decreasing interferences of assays samples containing plasma or serum in specific binding assays by using a large polycation
FR2855613B1 (fr) * 2003-05-26 2005-08-19 Biocytex Procede de detection et de quantification multiplex d'analytes dans un echantillon a l'aide de microspheres
JP2005296942A (ja) * 2004-03-15 2005-10-27 Hitachi Maxell Ltd 磁性複合粒子およびその製造方法
FR2869996B1 (fr) * 2004-05-05 2006-12-15 Diagast Soc Par Actions Simpli Utilisation de ferrofluides pour le phenotypage sanguin et applications derivees
US7867774B2 (en) 2004-10-12 2011-01-11 Luminex Corporation Methods for altering surface characteristics of microspheres
US8084275B2 (en) 2005-02-08 2011-12-27 Fujifilm Corporation Magnetic composite body, production method thereof, method for removing substance with mannose on its surface, and method for concentrating substance with mannose on its surface
JP2007040978A (ja) * 2005-06-30 2007-02-15 Fujifilm Corp 磁性体ナノ粒子を用いた目的成分の分離方法
FR2892820B1 (fr) 2005-11-03 2008-02-01 Diagast Soc Par Actions Simpli Procede magnetique d'immunodiagnostic pour la mise en evidence de complexe anticorps/antigene, en particulier de groupe sanguin
WO2007070381A2 (en) 2005-12-09 2007-06-21 Promega Corporation Nucleic acid purification with a binding matrix
GB0619645D0 (en) * 2006-10-05 2006-11-15 Smiths Group Plc Sensors and substances
MX2009013470A (es) * 2007-06-08 2010-01-27 Quest Diagnostics Invest Inc Analisis de lipoproteinas por movilidad diferencial de particulas cargadas.
FR2918460B1 (fr) 2007-07-02 2013-10-04 Najim Chaibi Nouveau dispositif permettant l'obtention des resultats des systemes abo,rhesus et autres pherotypes et systemes rares, rai.
FR2963108B1 (fr) 2010-07-21 2017-06-23 Diagast Procede magnetique d'immunodiagnostic et kit pour la mise en evidence de complexe anticorps/antigene de groupe/phenotype sanguin
FR2963107B1 (fr) 2010-07-21 2019-06-28 Diagast Complexe immuno-magnetique et son utilisation pour le groupage/phenotypage erythrocytaire
KR102352614B1 (ko) * 2013-03-14 2022-01-18 랜 바이오테크놀러지스, 인크. 생물제제의 검출을 위한 방법 및 물질
WO2014151836A1 (en) 2013-03-14 2014-09-25 Ran Biotechnologies, Inc. Methods and materials for microorganism capture
JP6399632B2 (ja) * 2013-10-02 2018-10-03 積水メディカル株式会社 赤血球含有サンプル中の対象物を検出するためのイムノクロマトグラフィー用テストストリップ、および該テストストリップを使用するイムノクロマトグラフィー
JP2015192995A (ja) * 2014-03-27 2015-11-05 東ソー株式会社 磁性微粒子及びその分散液の製造方法
WO2016172183A1 (en) 2015-04-21 2016-10-27 Ran Biotechnologies, Inc. Novel fluorinated surfactants
KR102156171B1 (ko) * 2018-12-03 2020-09-15 연세대학교 산학협력단 자성입자를 이용한 집진장치
CN114252613A (zh) * 2021-12-13 2022-03-29 重庆大学 一种用于检测HBsAg抗原蛋白的组合物及其使用方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2232295A (en) * 1938-07-14 1941-02-18 Charles H Lewis Process for treating liquids
CA940470A (en) * 1969-07-29 1974-01-22 Steven H. Corwin Flocculation of fermentation broths
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3933997A (en) 1974-03-01 1976-01-20 Corning Glass Works Solid phase radioimmunoassay of digoxin
US4001197A (en) * 1975-06-12 1977-01-04 Sala Magnetics, Inc. Magnetic separation method
US3970518A (en) 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
US4018886A (en) 1975-07-01 1977-04-19 General Electric Company Diagnostic method and device employing protein-coated magnetic particles
US4019994A (en) 1975-08-28 1977-04-26 Georgia-Pacific Corporation Process for the preparation of aqueous magnetic material suspensions
FR2334106A1 (fr) * 1975-12-02 1977-07-01 Pasteur Institut Gel magnetique convenant pour dosages immunoenzymatiques
US4070246A (en) 1976-04-09 1978-01-24 Abbott Laboratories Reactive matrices
US4115534A (en) 1976-08-19 1978-09-19 Minnesota Mining And Manufacturing Company In vitro diagnostic test
US4115535A (en) 1977-06-22 1978-09-19 General Electric Company Diagnostic method employing a mixture of normally separable protein-coated particles
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4318980A (en) 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
GB2019378A (en) * 1978-04-20 1979-10-31 Ici Ltd Flocculation and removal of organic or inorganic matter from suspensions
US4318707A (en) 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
FR2466282A1 (fr) * 1979-10-02 1981-04-10 Commissariat Energie Atomique Procede d'elimination des elements metalliques lourds en suspension dans un liquide a l'aide d'un adjuvant ferromagnetique finement divise
US4299916A (en) 1979-12-26 1981-11-10 Syva Company Preferential signal production on a surface in immunoassays
US4285819A (en) 1980-01-28 1981-08-25 California Institute Of Technology Functional magnetic microspheres
US4413070A (en) 1981-03-30 1983-11-01 California Institute Of Technology Polyacrolein microspheres
WO1983001398A1 (en) * 1981-10-13 1983-04-28 Snook, Harvey Apparatus and method for magnetic separation
US4454234A (en) 1981-12-30 1984-06-12 Czerlinski George H Coated magnetizable microparticles, reversible suspensions thereof, and processes relating thereto
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
JPS594487A (ja) * 1982-06-28 1984-01-11 Unyusho Daisan Kowan Kensetsu Kyokucho 赤潮の処理方法
US4564598A (en) 1982-07-12 1986-01-14 Syntex (U.S.A.) Inc. Limited volume method for particle counting
JPS59139910A (ja) * 1983-01-27 1984-08-11 Daido Steel Co Ltd 磁気分離処理方法
US4526681A (en) 1983-10-31 1985-07-02 Purdue Research Foundation Magnetic separation method utilizing a colloid of magnetic particles
GB8400070D0 (en) 1984-01-04 1984-02-08 Serono Diagnostics Ltd Magnetic assay reagents
US4523996A (en) 1984-02-22 1985-06-18 Westinghouse Electric Corp. Method of separating cationic from anionic beads in mixed resin beds
SE8401125L (sv) * 1984-03-01 1985-09-02 Ulf Schroder Sett vid diagnostisering in vitro och diagnostiskt medel
JPS61210516A (ja) 1985-03-15 1986-09-18 Hitachi Ltd 磁気記録媒体およびその製造法
US4806488A (en) 1985-09-06 1989-02-21 Syntex (U.S.A.) Inc. Ligand-receptor assays employing squarate dye compositions

Also Published As

Publication number Publication date
EP0230768A1 (de) 1987-08-05
AU6676386A (en) 1987-06-25
AU601386B2 (en) 1990-09-13
EP0230768B1 (de) 1992-03-18
CA1304006C (en) 1992-06-23
DE3684448D1 (de) 1992-04-23
ES2030667T3 (es) 1992-11-16
JP2806924B2 (ja) 1998-09-30
JPS62190466A (ja) 1987-08-20

Similar Documents

Publication Publication Date Title
ATE73690T1 (de) Teilchentrennungsverfahren.
US4677067A (en) Magnetotactic bacteria in clinical assay, immunoassay, and cell separation procedures and the like
EP1151297B1 (de) Verfahren zur erhöhung der bindungsstärke zwischen partnern, die spezifisch zu paaren binden
IL94087A0 (en) Methods,reagents and test kits for determining the presence or quantitiy of biological components in an analyzed sample
AU574281B2 (en) Process for the quantification of cell populations or subpopulations and a reagent suitable therefor
IL57722A (en) Dispersed metal particle labelled assay method and kit and reagents for use therein
ATE117436T1 (de) Verfahren und vorrichtung gekennzeichnet durch eine nicht-saugfähige, querfluss-ermöglichende membran.
TW326074B (en) Methods, kits and diagnostic systems for performing an affinity assay
KR960702616A (ko) 세포 결정을 위한 면역분석법(immunoassay for determination of cells)
ES2001447A6 (es) Un dispositivo de ensayo para determinar el tipo de sangre de una muestra de sangre
CA1140045A (en) Carcinoembryonic antigen determination
EP0348211A3 (en) Visual discrimination qualitative enzyme assay
EP0176252A3 (en) Assay method employing fluorescent cell incorporative dye
Cousino et al. Peer reviewed: pushing down the limits of detection: molecular needles in a haystack
DE19508772C2 (de) Verfahren und Verbindungen zur Detektion von Analyten mittels Remanenzmessung und deren Verwendung
EP1766401B1 (de) Verfahren zum einfachen und schnellen nachweis von zellen und biomolekülen mit hilfe paramagnetischer partikel
GB1592450A (en) Biological analysis
JPS63314466A (ja) 可逆的凝集メデイエーター
AU2375695A (en) Solid-phase filtration method for antigen and antibody assays in bloodgroup serology, and test kit
Strange et al. The rapid detection and determination of sparse bacterial populations with radioactively labelled homologous antibodies
EP0028133A3 (de) Verfahren zum Nachweis und zur Mengenbestimmung von Haptenen und Antigenen
GB1508133A (en) Biological analysis
Mattiasson et al. Partition Affinity Ligand Assay (PALA): Applications in the Analysis of Haptens, Macromolecules, and Cells
Yu Enhancing immunoassay possibilities using magnetic carriers in biological fluids
Varshney et al. Microfluidic Filter Chip Based Chemiluminescence Fiber Optic Biosensing Method for the Detection of E. coli O157: H7

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee