ATE62906T1 - Pyrazolanaloge von mevalonolakton und abkoemmlinge davon, verfahren zu deren herstellung und deren verwendung. - Google Patents

Pyrazolanaloge von mevalonolakton und abkoemmlinge davon, verfahren zu deren herstellung und deren verwendung.

Info

Publication number
ATE62906T1
ATE62906T1 AT85903248T AT85903248T ATE62906T1 AT E62906 T1 ATE62906 T1 AT E62906T1 AT 85903248 T AT85903248 T AT 85903248T AT 85903248 T AT85903248 T AT 85903248T AT E62906 T1 ATE62906 T1 AT E62906T1
Authority
AT
Austria
Prior art keywords
3alkyl
phenoxy
fluoro
chloro
trifluoromethyl
Prior art date
Application number
AT85903248T
Other languages
English (en)
Inventor
James Richard Wareing
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Application granted granted Critical
Publication of ATE62906T1 publication Critical patent/ATE62906T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F13/00—Interconnection of, or transfer of information or other signals between, memories, input/output devices or central processing units
    • G06F13/38—Information transfer, e.g. on bus
    • G06F13/382—Information transfer, e.g. on bus using universal interface adapter
    • G06F13/387—Information transfer, e.g. on bus using universal interface adapter for adaptation of different data processing systems to different peripheral devices, e.g. protocol converters for incompatible systems, open system
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F13/00—Interconnection of, or transfer of information or other signals between, memories, input/output devices or central processing units
    • G06F13/38—Information transfer, e.g. on bus
    • G06F13/40—Bus structure
    • G06F13/4004—Coupling between buses
    • G06F13/4009—Coupling between buses with data restructuring
    • G06F13/4018—Coupling between buses with data restructuring with data-width conversion

Landscapes

  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Computer Hardware Design (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT85903248T 1984-06-22 1985-06-18 Pyrazolanaloge von mevalonolakton und abkoemmlinge davon, verfahren zu deren herstellung und deren verwendung. ATE62906T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62339384A 1984-06-22 1984-06-22
PCT/EP1985/000293 WO1986000307A2 (en) 1984-06-22 1985-06-18 Pyrazole analogs of mevalonolactone and derivatives thereof, processes for their production and their use
EP85903248A EP0200736B1 (de) 1984-06-22 1985-06-18 Pyrazolanaloge von mevalonolakton und abkömmlinge davon, verfahren zu deren herstellung und deren verwendung

Publications (1)

Publication Number Publication Date
ATE62906T1 true ATE62906T1 (de) 1991-05-15

Family

ID=24497918

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85903248T ATE62906T1 (de) 1984-06-22 1985-06-18 Pyrazolanaloge von mevalonolakton und abkoemmlinge davon, verfahren zu deren herstellung und deren verwendung.

Country Status (19)

Country Link
EP (1) EP0200736B1 (de)
JP (1) JPS61502467A (de)
KR (1) KR890001651B1 (de)
AT (1) ATE62906T1 (de)
AU (1) AU573368B2 (de)
CA (1) CA1249283A (de)
DE (1) DE3582674D1 (de)
DK (1) DK157543C (de)
ES (1) ES8703842A1 (de)
FI (1) FI860755A0 (de)
GR (1) GR851510B (de)
HU (1) HU198711B (de)
IL (1) IL75583A (de)
MY (1) MY101903A (de)
NZ (1) NZ212501A (de)
PL (1) PL151016B1 (de)
PT (1) PT80674B (de)
WO (1) WO1986000307A2 (de)
ZA (1) ZA854719B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668794A (en) * 1985-05-22 1987-05-26 Sandoz Pharm. Corp. Intermediate imidazole acrolein analogs
KR900001212B1 (ko) * 1985-10-25 1990-02-28 산도즈 파마슈티칼스 코오포레이숀 메바로노락톤 및 그것의 유도체의 헤테로사이클릭 유사체 및 그것의 생산방법 및 약학적인 그것의 용도
JPS6322056A (ja) * 1986-04-30 1988-01-29 サンド・アクチエンゲゼルシヤフト オレフイン性化合物の製造法
US4808621A (en) * 1986-07-07 1989-02-28 Warner-Lambert Company Trans-6-[2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl]- or ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
NZ221717A (en) * 1986-09-10 1990-08-28 Sandoz Ltd Azaindole and indolizine derivatives and pharmaceutical compositions
US4751235A (en) * 1986-12-23 1988-06-14 Sandoz Pharm. Corp. Anti-atherosclerotic indolizine derivatives
US4735958A (en) * 1986-12-22 1988-04-05 Warner-Lambert Company Trans-6-[2-[2-(substituted-phenyl)-3- (or 4-) heteroaryl-5-substituted-1H-pyrrol-1-yl]-ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one inhibitors of cholesterol biosynthesis
US4897490A (en) * 1987-02-25 1990-01-30 Bristol-Meyers Company Antihypercholesterolemic tetrazole compounds
US4898949A (en) * 1987-02-25 1990-02-06 Bristol-Myers Company Intermediates for the preparation of antihypercholesterolemic tetrazole compounds
AT401518B (de) * 1987-02-25 1996-09-25 Bristol Myers Squibb Co Neue tetrazol-verbindungen und verfahren zu ihrer herstellung
JP2569746B2 (ja) * 1987-08-20 1997-01-08 日産化学工業株式会社 キノリン系メバロノラクトン類
CA1336714C (en) * 1987-08-20 1995-08-15 Yoshihiro Fujikawa Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis
US4906624A (en) * 1987-09-08 1990-03-06 Warner-Lambert Company 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
US4997837A (en) * 1987-09-08 1991-03-05 Warner-Lambert Company 6-(((substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
DE3800785A1 (de) * 1988-01-09 1989-07-20 Hoechst Ag Substituierte 7-(pyridazin-5-yl)-3,5-dihydroxyheptan(en)- saeuren, ihre entsprechenden (delta)-lactone bzw. derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
US4822799A (en) * 1988-01-27 1989-04-18 Sandoz Pharm. Corp. Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals
NO890522L (no) * 1988-02-25 1989-08-28 Bayer Ag Substituerte imidazolinoner og imidazolinthioner.
JP2890448B2 (ja) * 1988-04-26 1999-05-17 日産化学工業株式会社 ピラゾロピリジン系メバロノラクトン類
US5024999A (en) * 1988-04-26 1991-06-18 Nissan Chemical Industries Ltd. Pyrazolopyridine type mevalonolactones useful as pharmaeuticals
DE68911834T2 (de) * 1988-10-13 1994-06-23 Sandoz Ag Verfahren zur Herstellung von 7-substituierten Hept-6-en- und Heptansäuren und Derivaten davon.
JPH04270285A (ja) * 1988-11-14 1992-09-25 Nissan Chem Ind Ltd ピラゾロピリミジン系メバロノラクトン類
IT1237793B (it) * 1989-12-21 1993-06-17 Zambon Spa Composti attivi come inibitori dell'enzima hmg-coa reduttasi
US5134155A (en) * 1991-08-08 1992-07-28 Ortho Pharmaceutical Corporation Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-coA reductase inhibitors
WO1993006236A1 (en) * 1991-09-20 1993-04-01 Zeneca Limited Enzymatic production of optical isomers of tetrahydropyran-2-ones
US5335293A (en) * 1992-06-16 1994-08-02 Key Technology, Inc. Product inspection method and apparatus
PL376733A1 (pl) 2002-11-01 2006-01-09 Takeda Pharmaceutical Company Limited Środek do zapobiegania lub leczenia neuropatii
MX2007005137A (es) 2004-11-23 2007-06-22 Warner Lambert Co Derivados del acido 7-(2h-pyrazol-3-il)-3, 5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de lipidemia.
WO2006087630A2 (en) * 2005-02-16 2006-08-24 Warner-Lambert Company Llc OXYPYRAZOLE HMG Co-A REDUCTASE INHIBITORS
EP1775299A1 (de) * 2005-10-05 2007-04-18 LEK Pharmaceuticals D.D. Verfahren zur Herstellung von HMG-CoA reduktase Inhibitoren
WO2007081019A1 (ja) * 2006-01-16 2007-07-19 Sankyo Agro Company, Limited （３－硫黄原子置換フェニル）ピラゾール誘導体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1261124B (de) * 1961-09-22 1968-02-15 Hoechst Ag Verfahren zur Herstellung von Pyrazolen
DE2920933A1 (de) * 1979-05-23 1980-12-04 Basf Ag 3-aryl-5-methyl-pyrazol-4-carbonsaeureester enthaltende herbizide
US4245106A (en) * 1979-07-05 1981-01-13 Monsanto Company Process for the preparation of 1-alkyl-3-aryl-4-pyrazolecarboxylates

Also Published As

Publication number Publication date
FI860755A7 (fi) 1986-02-20
IL75583A (en) 1989-09-10
DK157543B (da) 1990-01-22
FI860755L (fi) 1986-02-20
HUT39178A (en) 1986-08-28
ZA854719B (en) 1987-02-25
KR890001651B1 (ko) 1989-05-12
AU4546685A (en) 1986-01-24
WO1986000307A3 (en) 1986-04-10
HU198711B (en) 1989-11-28
CA1249283A (en) 1989-01-24
GR851510B (de) 1985-11-25
PT80674A (en) 1985-07-01
NZ212501A (en) 1988-06-30
EP0200736B1 (de) 1991-04-24
PL254121A1 (en) 1988-07-21
DE3582674D1 (de) 1991-05-29
EP0200736A1 (de) 1986-11-12
JPS61502467A (ja) 1986-10-30
KR860700253A (ko) 1986-08-01
AU573368B2 (en) 1988-06-02
WO1986000307A2 (en) 1986-01-16
MY101903A (en) 1992-02-15
PT80674B (en) 1987-03-17
IL75583A0 (en) 1985-10-31
ES8703842A1 (es) 1987-03-01
PL151016B1 (en) 1990-07-31
ES544407A0 (es) 1987-03-01
DK83886A (da) 1986-02-21
DK157543C (da) 1990-06-11
FI860755A0 (fi) 1986-02-20
DK83886D0 (da) 1986-02-21

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties