ES8800250A1 - Procedimiento para preparar acidos propano-fosfonosos susti-tuidos - Google Patents

Procedimiento para preparar acidos propano-fosfonosos susti-tuidos

Info

Publication number
ES8800250A1
ES8800250A1 ES547795A ES547795A ES8800250A1 ES 8800250 A1 ES8800250 A1 ES 8800250A1 ES 547795 A ES547795 A ES 547795A ES 547795 A ES547795 A ES 547795A ES 8800250 A1 ES8800250 A1 ES 8800250A1
Authority
ES
Spain
Prior art keywords
acid compounds
phosphonous acid
substituted propane
alkyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES547795A
Other languages
English (en)
Other versions
ES547795A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8800250A1 publication Critical patent/ES8800250A1/es
Publication of ES547795A0 publication Critical patent/ES547795A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
    • C07F9/4808—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof the acid moiety containing a substituent or structure which is considered as characteristic
    • C07F9/4816—Acyclic saturated acids or derivatices which can have further substituents on alkyl
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR ACIDOS PROPANO-FOSFONOSOS SUSTITUIDOS. CONSISTE EN TRATAR A UN COMPUESTO DE FORMULA (II) CON UN ACIDO MINERAL A TEMPERATURA ELEVADA, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES. SIENDO: R ELEVADO A 1, R ELEVADO A 2 Y R ELEVADO A 3, H, ALQUILO DE C 1 A 8, CICLOALQUILO DE C 3 A 6, ALQUILO DE C 1 A 4 Y OTROS; R ELEVADO A C, H O ALQUINO DE C 1 A 4; Q, H O Q ELEVADO A 0; Q ELEVADO A 0, ALQUILO DE C 1 A 4 O CATION ALCALINO; Y Z, -NH2. SE UTILIZAN COMO RELAJANTES MUSCULARES EN ESPASTICIDAD ESPINAL Y ESTEROSIS MULTIPLE. *FORMULA* Z
ES547795A 1984-10-12 1985-10-11 Procedimiento para preparar acidos propano-fosfonosos susti-tuidos Expired ES8800250A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848425872A GB8425872D0 (en) 1984-10-12 1984-10-12 Chemical compounds

Publications (2)

Publication Number Publication Date
ES8800250A1 true ES8800250A1 (es) 1987-10-16
ES547795A0 ES547795A0 (es) 1987-10-16

Family

ID=10568115

Family Applications (1)

Application Number Title Priority Date Filing Date
ES547795A Expired ES8800250A1 (es) 1984-10-12 1985-10-11 Procedimiento para preparar acidos propano-fosfonosos susti-tuidos

Country Status (16)

Country Link
US (4) US4656298A (es)
EP (1) EP0181833B1 (es)
JP (1) JPH0631275B2 (es)
AT (1) ATE53844T1 (es)
CA (1) CA1296736C (es)
DE (1) DE3577442D1 (es)
DK (2) DK168572C (es)
ES (1) ES8800250A1 (es)
FI (1) FI853923L (es)
GB (1) GB8425872D0 (es)
GR (1) GR852451B (es)
IE (1) IE58142B1 (es)
IL (1) IL76625A0 (es)
NO (1) NO854045L (es)
PT (1) PT81287B (es)
ZA (1) ZA857824B (es)

Families Citing this family (46)

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US5243062A (en) * 1984-10-12 1993-09-07 Ciba-Geigy Corporation Substituted propane-phosphonous acid compounds
US4761405A (en) * 1987-03-04 1988-08-02 Nova Pharmaceutical Corporation Antagonists of specific excitatory amino acid neurotransmitter receptors having increased potency
GB8721442D0 (en) * 1987-09-11 1987-10-21 Ciba Geigy Ag Process
US5300679A (en) * 1987-12-04 1994-04-05 Ciba-Geigy Corporation Substituted propane-phosphinic acid compounds
US5190933A (en) * 1987-12-04 1993-03-02 Ciba-Geigy Corporation Substituted propane-phosphinic acid compounds
GB8728483D0 (en) * 1987-12-04 1988-01-13 Ciba Geigy Ag Chemical compounds
GB8820266D0 (en) * 1988-08-26 1988-09-28 Smith Kline French Lab Compounds
US5281747A (en) * 1989-05-13 1994-01-25 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
US5567840A (en) * 1989-05-13 1996-10-22 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
US5190934A (en) * 1989-06-03 1993-03-02 Ciba-Geigy Corporation P-subsituted propane-phosphinic acid compounds
IL114631A (en) * 1990-06-22 1998-12-06 Novartis Ag Anti-epileptic preparations containing antagonists of BABAG
EP0767174A1 (de) * 1991-11-21 1997-04-09 Ciba-Geigy Ag Neue Aminoalkanphosphinsäuren und ihre Salze
GB9125615D0 (en) * 1991-12-02 1992-01-29 Wyeth John & Brother Ltd Amines
AU662404B2 (en) * 1992-05-08 1995-08-31 Novartis Ag Novel N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids
GB9304619D0 (en) * 1993-03-06 1993-04-21 Ciba Geigy Ag Esters
USRE41920E1 (en) 1996-07-24 2010-11-09 Warner-Lambert Company Llc Isobutylgaba and its derivatives for the treatment of pain
US6753324B2 (en) * 1998-07-15 2004-06-22 Hassan Jomaa Phosphorous organic compounds and their use
US7319095B2 (en) 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
SE9904508D0 (sv) * 1999-12-09 1999-12-09 Astra Ab New compounds
SE9904507D0 (sv) 1999-12-09 1999-12-09 Astra Ab New compounds
BR0017170A (pt) * 2000-03-20 2003-11-04 Francois Bernard Aparelho de lançamento para lançar um objeto em um fluido, clipe, navio, e, método para lançar uma carga em um fluido
US7184014B2 (en) * 2000-10-05 2007-02-27 Semiconductor Energy Laboratory Co., Ltd. Liquid crystal display device
AR033779A1 (es) 2001-06-08 2004-01-07 Astrazeneca Ab Compuestos utiles en la enfermedad de reflujo
CA2477423A1 (en) * 2002-03-01 2003-09-12 Merck & Co., Inc. Aminoalkylphosphonates and related compounds as edg receptor agonists
US7195806B2 (en) * 2003-01-17 2007-03-27 Fina Technology, Inc. High gloss polyethylene articles
DE10356410A1 (de) * 2003-11-24 2005-06-23 Bioagency Ag Phosphororganische Verbindungen und deren Verwendung
EP1691811B1 (en) 2003-12-11 2014-07-23 Sunovion Pharmaceuticals Inc. Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
SE0401653D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab New compounds
US7494985B2 (en) * 2004-11-03 2009-02-24 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use
US7566738B2 (en) * 2004-11-03 2009-07-28 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
CA2625153A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) * 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
CN101341130A (zh) 2005-12-23 2009-01-07 阿斯利康(瑞典)有限公司 用于治疗胃肠障碍的咪唑衍生物
AU2006327317B2 (en) 2005-12-23 2010-11-25 Astrazeneca Ab GABA-B receptor modulators
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
WO2008033572A1 (en) * 2006-09-15 2008-03-20 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2011113904A1 (en) 2010-03-17 2011-09-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Medicaments for the prevention and treatment of a disease associated with retinal ganglion cell degeneration
WO2012050907A2 (en) 2010-09-28 2012-04-19 The Regents Of The University Of California Gaba agonists in the treatment of disorders associated with metabolic syndrome and gaba combinations in treatment or prophylaxis of type i diabetes
CN102718717B (zh) * 2012-06-15 2015-03-11 河北鑫淘源环保科技有限公司 一种固体1,3-二羟甲基-5,5-二甲基海因的烘干方法

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US3374288A (en) * 1965-09-03 1968-03-19 Du Pont Polycarbonamide filaments containing polyalkylene oxide, sodium phenyl phosphinate and sodium aminoalkylphosphinate
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Also Published As

Publication number Publication date
DK168572B1 (da) 1986-04-13
PT81287B (pt) 1988-02-17
US4772738A (en) 1988-09-20
JPH0631275B2 (ja) 1994-04-27
ZA857824B (en) 1986-05-28
EP0181833A1 (en) 1986-05-21
ATE53844T1 (de) 1990-06-15
IE852512L (en) 1986-04-12
AU593778B2 (en) 1990-02-22
IL76625A0 (en) 1986-02-28
GR852451B (es) 1986-02-11
DK466185D0 (da) 1985-10-11
DE3577442D1 (de) 1990-06-07
NO854045L (no) 1986-04-14
DK466185A (da) 1986-04-13
US4656298A (en) 1987-04-07
CA1296736C (en) 1992-03-03
DK81093A (da) 1993-07-06
US5004826A (en) 1991-04-02
PT81287A (en) 1985-11-01
US4908465A (en) 1990-03-13
JPS6193189A (ja) 1986-05-12
GB8425872D0 (en) 1984-11-21
ES547795A0 (es) 1987-10-16
DK81093D0 (da) 1993-07-06
DK168572C (da) 1994-04-25
AU4857985A (en) 1986-04-24
FI853923L (fi) 1986-04-13
DK169626B1 (da) 1994-12-27
FI853923A0 (fi) 1985-10-09
IE58142B1 (en) 1993-07-14
EP0181833B1 (en) 1990-05-02

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PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20001102