ATE551352T1 - Peptidakzeptorbindungsverfahren - Google Patents

Peptidakzeptorbindungsverfahren

Info

Publication number
ATE551352T1
ATE551352T1 AT07005917T AT07005917T ATE551352T1 AT E551352 T1 ATE551352 T1 AT E551352T1 AT 07005917 T AT07005917 T AT 07005917T AT 07005917 T AT07005917 T AT 07005917T AT E551352 T1 ATE551352 T1 AT E551352T1
Authority
AT
Austria
Prior art keywords
peptide acceptor
binding method
acceptor binding
peptide
rna
Prior art date
Application number
AT07005917T
Other languages
German (de)
English (en)
Inventor
Markus Kurz
Peter Lohse
Richard Wagner
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE551352T1 publication Critical patent/ATE551352T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT07005917T 1999-07-27 2000-07-19 Peptidakzeptorbindungsverfahren ATE551352T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14583499P 1999-07-27 1999-07-27

Publications (1)

Publication Number Publication Date
ATE551352T1 true ATE551352T1 (de) 2012-04-15

Family

ID=22514769

Family Applications (2)

Application Number Title Priority Date Filing Date
AT07005917T ATE551352T1 (de) 1999-07-27 2000-07-19 Peptidakzeptorbindungsverfahren
AT00947524T ATE360706T1 (de) 1999-07-27 2000-07-19 Peptidakzeptor ligationsverfahren

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT00947524T ATE360706T1 (de) 1999-07-27 2000-07-19 Peptidakzeptor ligationsverfahren

Country Status (16)

Country Link
US (3) US6429300B1 (cg-RX-API-DMAC7.html)
EP (2) EP1196637B1 (cg-RX-API-DMAC7.html)
JP (2) JP4766808B2 (cg-RX-API-DMAC7.html)
KR (1) KR20020033743A (cg-RX-API-DMAC7.html)
AT (2) ATE551352T1 (cg-RX-API-DMAC7.html)
AU (2) AU781783B2 (cg-RX-API-DMAC7.html)
CA (2) CA2693274C (cg-RX-API-DMAC7.html)
CY (1) CY1113185T1 (cg-RX-API-DMAC7.html)
DE (1) DE60034566T2 (cg-RX-API-DMAC7.html)
DK (2) DK1870417T3 (cg-RX-API-DMAC7.html)
ES (2) ES2383332T3 (cg-RX-API-DMAC7.html)
HK (1) HK1045334A1 (cg-RX-API-DMAC7.html)
IL (1) IL147037A0 (cg-RX-API-DMAC7.html)
NO (1) NO20020348L (cg-RX-API-DMAC7.html)
PT (2) PT1196637E (cg-RX-API-DMAC7.html)
WO (1) WO2001007657A1 (cg-RX-API-DMAC7.html)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1196637B1 (en) * 1999-07-27 2007-04-25 Adnexus Therapeutics, Inc. Peptide acceptor ligation methods
US7186813B1 (en) 2000-01-11 2007-03-06 Nanogen Recognomics Gmbh Biomolecules having multiple attachment moieties for binding to a substrate surface
EP1268769A2 (de) * 2000-03-31 2003-01-02 Memorec Stoffel GmbH Medizinisch-Molekulare Entwicklung Verfahren zur extraktion von nukleinsäuren
US6962781B1 (en) 2000-05-19 2005-11-08 Proteonova, Inc. In vitro evolution of nucleic acids and encoded polypeptide
WO2003044194A1 (en) * 2001-11-16 2003-05-30 Proteonova, Inc. Selection and evolution of nucleic acids and polypeptides
US20040229271A1 (en) * 2000-05-19 2004-11-18 Williams Richard B. Compositions and methods for the identification and selection of nucleic acids and polypeptides
US7410761B2 (en) * 2000-05-19 2008-08-12 Proteonova, Inc. System for rapid identification and selection of nucleic acids and polypeptides, and method thereof
ATE415489T1 (de) * 2000-08-11 2008-12-15 Nanogen Recognomics Gmbh Hydrazidbausteine und hydratin-modifizierte biomoleküle
US7129229B2 (en) 2000-08-11 2006-10-31 Nanogen Recognomics Gmbh Hydrazide building blocks and hydrazide modified biomolecules
JP4963142B2 (ja) * 2000-12-14 2012-06-27 学校法人慶應義塾 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法
WO2002102820A1 (en) * 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
US20060234231A1 (en) * 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
US6893822B2 (en) 2001-07-19 2005-05-17 Nanogen Recognomics Gmbh Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
US20030027194A1 (en) * 2001-07-31 2003-02-06 Markus Kurz Modular assembly of nucleic acid-protein fusion multimers
DE10147074A1 (de) * 2001-09-25 2003-05-08 Beru Ag Verfahren zum Betreiben einer aus mehreren Heizelementen bestehenden mehrstufigen elektrischen Heizung
US7125669B2 (en) * 2001-11-27 2006-10-24 Compound Therapeutics, Inc. Solid-phase immobilization of proteins and peptides
DE20200926U1 (de) * 2002-01-23 2002-04-18 Hegenscheidt-MFD GmbH & Co. KG, 41812 Erkelenz Festwalzgerät einer Festwalzmaschine für Kurbelwellen
WO2003078050A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c-c bond upon reaction
US7413854B2 (en) * 2002-03-15 2008-08-19 Nuevolution A/S Method for synthesising templated molecules
EP1487850A2 (en) * 2002-03-15 2004-12-22 Nuevolution A/S A building block forming a c-c or a c-hetero atom bond upon reaction
AU2003214033A1 (en) * 2002-03-15 2003-09-29 Nuevolution A/S A building block capable of transferring a functional entity
AU2003247266A1 (en) * 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
US20040058886A1 (en) * 2002-08-08 2004-03-25 Dharmacon, Inc. Short interfering RNAs having a hairpin structure containing a non-nucleotide loop
SI3299463T1 (sl) * 2002-10-30 2021-03-31 Nuevolution A/S Encimsko kodiranje
US9121110B2 (en) * 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1597394A2 (en) * 2003-02-21 2005-11-23 Nuevolution A/S A method for obtaining structural information about an encoded molecule
US20070026397A1 (en) * 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
DE602004019764D1 (de) * 2003-03-20 2009-04-16 Nuevolution As Ligationsvermittelnde codierung von kleinen molekülen
WO2004110964A2 (en) * 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)
US20050095627A1 (en) * 2003-09-03 2005-05-05 The Salk Institute For Biological Studies Multiple antigen detection assays and reagents
ATE447626T1 (de) 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
CA2546343A1 (en) * 2003-11-20 2005-06-09 Sanofi Pasteur, Inc. Methods for purifying pertussis toxin and peptides useful therefor
BRPI0417302A (pt) 2003-12-05 2007-03-06 Compound Therapeutics Inc inibidores de receptores de fator de crescimento endotelial vascular do tipo 2
EP1692155A4 (en) * 2003-12-12 2008-08-06 Proteonova Inc SYSTEM AND METHOD FOR SELECTION OF NUCLEIC ACIDS AND POLYPEPTIDES
US20090239211A1 (en) * 2004-02-17 2009-09-24 Nuevolution A/S Method For Enrichment Involving Elimination By Mismatch Hybridisation
WO2005090566A2 (en) * 2004-03-22 2005-09-29 Nuevolution A/S Ligational encoding using building block oligonucleotides
CA2467321A1 (en) * 2004-05-14 2005-11-14 Paul J. Santerre Polymeric coupling agents and pharmaceutically-active polymers made therefrom
WO2006041194A1 (ja) * 2004-10-15 2006-04-20 Japan Science And Technology Agency ｍＲＮＡ－ピューロマイシン－タンパク質連結体作製用リンカー
US10206998B2 (en) 2005-01-12 2019-02-19 Proteonova, Inc. Modular targeted therapeutic agents and methods of making same
EP3431503A1 (en) 2005-01-12 2019-01-23 Proteonova, Inc. Method for making targeted therapeutic agents
ES2547554T3 (es) 2005-11-16 2015-10-07 Ambrx, Inc. Métodos y composiciones que comprenden aminoácidos no naturales
SI2336315T1 (sl) 2005-12-01 2017-12-29 Nuevolution A/S Postopki encimskega kodiranja za učinkovito sintezo velikih knjižnic
US7749957B2 (en) 2006-04-06 2010-07-06 E.I. Du Pont De Nemours And Company Clay-binding peptides and methods of use
AU2007325838B2 (en) 2006-11-22 2013-09-19 Bristol-Myers Squibb Company Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR
US9080256B2 (en) 2007-02-12 2015-07-14 Proteonova, Inc. Generation of library of soluble random polypeptides linked to mRNA
US7951559B2 (en) * 2007-07-25 2011-05-31 E.I. Du Pont De Nemours And Company Recombinant peptide production using a cross-linkable solubility tag
US7829311B2 (en) 2007-07-25 2010-11-09 E.I. Du Pont De Nemours And Company Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate
US7678883B2 (en) * 2007-07-25 2010-03-16 E.I. Du Pont De Nemours And Company Solubility tags for the expression and purification of bioactive peptides
US7794963B2 (en) 2007-11-02 2010-09-14 E.I. Du Pont De Nemours And Company Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
TW200938221A (en) 2007-11-30 2009-09-16 Abbott Lab Protein formulations and methods of making same
CN102007145A (zh) 2008-02-14 2011-04-06 百时美施贵宝公司 基于结合egfr的工程化蛋白质的靶向治疗剂
US9296810B2 (en) 2008-05-02 2016-03-29 Novartis Ag Fibronectin-based binding molecules and uses thereof
AU2009242484B2 (en) * 2008-05-02 2012-08-16 Epicentre Technologies Corporation Selective 5' ligation tagging of RNA
EP2291399B1 (en) 2008-05-22 2014-06-25 Bristol-Myers Squibb Company Multivalent fibronectin based scaffold domain proteins
KR20110036638A (ko) 2008-07-25 2011-04-07 리차드 더블유. 와그너 단백질 스크리닝 방법
CA2737035A1 (en) * 2008-09-30 2010-04-08 Abbott Laboratories Improved method of rna display
TWI496582B (zh) 2008-11-24 2015-08-21 必治妥美雅史谷比公司 雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子
US20100158837A1 (en) 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Iron oxide-binding peptides
US20100158846A1 (en) * 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Hair-binding peptides
US20100158822A1 (en) * 2008-12-18 2010-06-24 E .I. Du Pont De Nemours And Company Peptides that bind to silica-coated particles
US8287845B2 (en) * 2008-12-18 2012-10-16 E I Du Pont De Nemours And Company Hair-binding peptides
EP2414045A2 (en) 2009-03-30 2012-02-08 Johnson & Johnson Peptide-based systems for delivery of costmetic agents
WO2010114638A1 (en) 2009-03-30 2010-10-07 E. I. Du Pont De Nemours And Company Peptide-based tooth whitening reagents
JP5733784B2 (ja) * 2009-09-24 2015-06-10 国立大学法人埼玉大学 ｃＤＮＡ／ｍＲＮＡ−タンパク質連結体の効率的合成法
WO2011051327A2 (en) 2009-10-30 2011-05-05 Novartis Ag Small antibody-like single chain proteins
WO2011051466A1 (en) 2009-11-02 2011-05-05 Novartis Ag Anti-idiotypic fibronectin-based binding molecules and uses thereof
WO2011092233A1 (en) 2010-01-29 2011-08-04 Novartis Ag Yeast mating to produce high-affinity combinations of fibronectin-based binders
EP2534489A1 (en) 2010-02-10 2012-12-19 Novartis AG Methods and compounds for muscle growth
HUE030724T2 (en) * 2010-04-09 2017-06-28 Univ Utrecht Holding Bv Recombinant multimer influenza proteins
EP3540059A1 (en) 2010-04-16 2019-09-18 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
US9562089B2 (en) 2010-05-26 2017-02-07 Bristol-Myers Squibb Company Fibronectin based scaffold proteins having improved stability
RU2013108962A (ru) 2010-07-30 2014-09-10 Новартис Аг Молекулы фибронектина, содержащие карман, и их библиотеки
DE102010056289A1 (de) 2010-12-24 2012-06-28 Geneart Ag Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
WO2012125733A2 (en) 2011-03-15 2012-09-20 X-Body, Inc. Antibody screening methods
EP3415619B1 (en) 2011-04-28 2020-12-16 The Board of Trustees of the Leland Stanford Junior University Identification of polynucleotides associated with a sample
WO2013019794A1 (en) 2011-08-01 2013-02-07 The General Hospital Corporation Protein and peptide libraries
DK2771022T3 (da) 2011-10-11 2020-09-28 Viela Bio Inc Cd40l-specifikke tn3-afledte skeletter (scaffolds) og fremgangsmåder til anvendelse deraf
EP3712173B1 (en) 2011-12-05 2023-07-12 X-Body, Inc. Pdgf receptor beta binding polypeptides
EP2975121A4 (en) * 2013-03-13 2016-07-20 Univ Tokyo NUCLEIC LEFT
RU2678421C2 (ru) 2013-06-28 2019-01-28 Экс-Боди, Инк. Обнаружение антигена-мишени, фенотипический скрининг и его применение для идентификации специфичных эпитопов-мишеней клеток-мишеней
CN103382579B (zh) * 2013-07-06 2015-10-21 中国科学院成都生物研究所 一种体外筛选多肽的方法
EP3779440A1 (en) 2013-09-23 2021-02-17 X-Body, Inc. Methods and compositions for generation of binding agents against cell surface antigens
WO2015101516A1 (en) * 2013-12-31 2015-07-09 F. Hoffmann-La Roche Ag Enrichment of full-length oligonucleotides via transcription/translation-mediated purification
US10421958B2 (en) 2014-02-05 2019-09-24 Molecular Templates, Inc. Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
EA034886B1 (ru) 2014-03-20 2020-04-02 Бристол-Майерс Сквибб Компани Связывающие сывороточный альбумин домены фибронектина iii типа
JP6478392B2 (ja) * 2014-12-26 2019-03-06 国立研究開発法人産業技術総合研究所 核酸リンカー
EP3842451A1 (en) 2015-03-12 2021-06-30 MedImmune, LLC Method of purifying albumin-fusion proteins
JP6893504B2 (ja) 2015-09-23 2021-06-23 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 速い解離速度を有する血清アルブミン結合フィブロネクチンタイプｉｉｉドメイン
SG10201911917WA (en) 2016-05-02 2020-01-30 Encodia Inc Macromolecule analysis employing nucleic acid encoding
WO2017218858A1 (en) * 2016-06-15 2017-12-21 Genecapture, Inc. Compositions, methods and devices comprising stem-loop captor molecules
MA45491A (fr) 2016-06-27 2019-05-01 Juno Therapeutics Inc Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
CN110291402B (zh) 2016-06-27 2023-09-01 朱诺治疗学股份有限公司 鉴定肽表位的方法、结合此类表位的分子和相关用途
EP3604326B1 (en) 2017-03-21 2026-01-07 FUJIFILM Corporation Peptide compound and method for producing same, composition for screening use, and method for selecting peptide compound
CA3081441C (en) * 2017-10-31 2023-08-29 Encodia, Inc. Kits for analysis using nucleic acid encoding and/or label
IL297543A (en) 2017-11-30 2022-12-01 Arrakis Therapeutics Inc Nucleic acid-binding photoprobes and their uses
AU2019214347B2 (en) 2018-02-02 2023-09-28 Ripple Therapeutics Corporation Glass formulations comprising steroid dimers and uses thereof
TWI830718B (zh) * 2018-02-09 2024-02-01 日商住友化學股份有限公司 核酸分子之製造方法
EP3778914A4 (en) * 2018-03-30 2022-01-19 Sumitomo Chemical Company, Ltd. Method for producing single-strand rna
WO2019236644A1 (en) * 2018-06-05 2019-12-12 Arrakis Therapeutics, Inc. Encoded libraries and methods of use for screening nucleic acid targets
US12473326B2 (en) 2019-02-01 2025-11-18 Ripple Therapeutics Corporation Crystalline forms of dexamethasone dimers and uses thereof
CA3176134A1 (en) 2020-05-01 2021-11-04 Ripple Therapeutics Corporation Heterodimer compositions and methods for the treatment of ocular disorders

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391723A (en) * 1989-05-31 1995-02-21 Neorx Corporation Oligonucleotide conjugates
US5843701A (en) 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
AU8124694A (en) * 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
DE19646372C1 (de) * 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
JP3974941B2 (ja) * 1995-11-21 2007-09-12 イェール ユニバーシティ 単分子セグメントの増幅および検出
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5842701A (en) * 1996-10-08 1998-12-01 Smith International, Inc. Dual functioning seal for rock bits
CA2268353A1 (en) 1996-10-10 1998-04-16 Henrik Garoff Alphavirus-retrovirus vectors
EP1477561B1 (en) * 1996-10-17 2008-12-10 Mitsubishi Chemical Corporation Molecule assigning genotype to phenotype and use thereof
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
WO1998031700A1 (en) 1997-01-21 1998-07-23 The General Hospital Corporation Selection of proteins using rna-protein fusions
US5935791A (en) * 1997-09-23 1999-08-10 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
CA2311416A1 (en) * 1997-12-22 1999-07-01 Genset S.A. Prostate cancer gene
US5985575A (en) * 1998-05-20 1999-11-16 Wisconsin Alumni Research Foundation Tethered function assay for protein function
EP1196637B1 (en) * 1999-07-27 2007-04-25 Adnexus Therapeutics, Inc. Peptide acceptor ligation methods
JP4803933B2 (ja) * 1999-08-27 2011-10-26 ブリストル−マイヤーズ スクウィブ カンパニー インビトロ翻訳タンパク質の符号化方法および選別方法

Also Published As

Publication number Publication date
AU2005211548B2 (en) 2007-11-29
US20020182687A1 (en) 2002-12-05
EP1870417B1 (en) 2012-03-28
EP1196637B1 (en) 2007-04-25
EP1870417A2 (en) 2007-12-26
JP2003505094A (ja) 2003-02-12
PT1196637E (pt) 2007-07-04
US7790421B2 (en) 2010-09-07
EP1870417A3 (en) 2008-06-11
AU6111200A (en) 2001-02-13
EP1196637A1 (en) 2002-04-17
KR20020033743A (ko) 2002-05-07
US20060246549A1 (en) 2006-11-02
CA2377468A1 (en) 2001-02-01
ES2383332T3 (es) 2012-06-20
CA2693274C (en) 2013-05-28
DK1196637T3 (da) 2007-07-30
CA2377468C (en) 2010-04-20
ATE360706T1 (de) 2007-05-15
WO2001007657A1 (en) 2001-02-01
DK1870417T3 (da) 2012-07-16
JP5512463B2 (ja) 2014-06-04
US7078197B2 (en) 2006-07-18
JP4766808B2 (ja) 2011-09-07
AU2005211548A1 (en) 2005-10-13
HK1112007A1 (en) 2008-08-22
EP1196637A4 (en) 2003-11-12
US6429300B1 (en) 2002-08-06
IL147037A0 (en) 2002-08-14
AU781783B2 (en) 2005-06-16
NO20020348D0 (no) 2002-01-23
EP1870417B9 (en) 2012-08-01
JP2010284172A (ja) 2010-12-24
DE60034566T2 (de) 2008-01-03
NO20020348L (no) 2002-01-23
DE60034566D1 (de) 2007-06-06
CA2693274A1 (en) 2001-02-01
CY1113185T1 (el) 2016-04-13
PT1870417E (pt) 2012-06-01
HK1045334A1 (zh) 2002-11-22
ES2284508T3 (es) 2007-11-16

Similar Documents

Publication Publication Date Title
ATE551352T1 (de) Peptidakzeptorbindungsverfahren
BG107861A (en) Isothermal amplification of nucleic acids on a solid support
WO2004048514A3 (en) Methods for analyzing a nucleic acid
WO2003012119A3 (en) Nucleic acid amplification method
WO2003054511A3 (en) Methods for quantitating nucleic acids using coupled ligation and amplification
WO2004069184A3 (en) Methods for treating, preventing and detecting helicobacter infection
DE60213803D1 (en) Happier mapping
ID28489A (id) Metode untuk membuat 4-karboksiamino-2-disubstitusi 1,2,3,4-tetrahidroquinolin
AU2002246702A1 (en) Method of screening for gpr40 ligands
TR199802394A3 (tr) Proteinleri stabilize etmek için gelistirilmis proses.
EP1615946A4 (en) PROTEOLYTIC AND COVALENT ANTIBODIES
AU2001244609A1 (en) Novel protein, dna thereof and process for producing the same
AU1908100A (en) Isothermal nucleic acid amplification methods
IT1301737B1 (it) Premitallone per pneumatici.
FI980463L (fi) Itsereplikoituva vektori DNA-immunisaatiota varten HIV:tä vastaan
DE69811677D1 (de) Verfahren zur präparation von enantiomer-angereicherten, n-derivatisierten laktamen.
DK1341898T3 (da) Fremgangsmåde til aerob fermentering
NO995780D0 (no) Mikroorganismer som produserer 5-aminolevulinsyre, og fremgangsmåter for fremstilling av 5-aminolevulinsyre ved anvendelse derav
DK1123396T3 (da) Minimale promotorer og anvendelser deraf
FI20010221A0 (fi) Menetelmä entsyymin uuttamiseksi
AU2001256106A1 (en) Method for immobilizing nucleic acids
NL1012028A1 (nl) Aminozuursequentie.
TR199801514A3 (tr) N-Piruvil-L-Prolin üretimi için yöntem.
NO20040693L (no) Fermenteringsmetode.
BR0303226A (pt) Proteìnas de aderência e penetração de haemophilus