ATE522510T1 - Fluoreszierende pyrazin-derivate und verwendungsverfahren dafür bei der überprüfung der nierenfunktion - Google Patents
Fluoreszierende pyrazin-derivate und verwendungsverfahren dafür bei der überprüfung der nierenfunktionInfo
- Publication number
- ATE522510T1 ATE522510T1 AT07013568T AT07013568T ATE522510T1 AT E522510 T1 ATE522510 T1 AT E522510T1 AT 07013568 T AT07013568 T AT 07013568T AT 07013568 T AT07013568 T AT 07013568T AT E522510 T1 ATE522510 T1 AT E522510T1
- Authority
- AT
- Austria
- Prior art keywords
- derivative
- spectral energy
- pyrazine derivatives
- formulas
- checking
- Prior art date
Links
- 230000003907 kidney function Effects 0.000 title abstract 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical class C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title 1
- 150000003216 pyrazines Chemical class 0.000 abstract 4
- 230000003595 spectral effect Effects 0.000 abstract 4
- 125000006575 electron-withdrawing group Chemical group 0.000 abstract 1
- 230000006870 function Effects 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
- C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J2219/12—Processes employing electromagnetic waves
- B01J2219/1203—Incoherent waves
- B01J2219/1206—Microwaves
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63861104P | 2004-12-23 | 2004-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE522510T1 true ATE522510T1 (de) | 2011-09-15 |
Family
ID=36570361
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05855315T ATE466000T1 (de) | 2004-12-23 | 2005-12-22 | Fluoreszente pyrazinderivate und verfahren zu deren anwendung bei der bewertung der nierenfunktion |
| AT07013568T ATE522510T1 (de) | 2004-12-23 | 2005-12-22 | Fluoreszierende pyrazin-derivate und verwendungsverfahren dafür bei der überprüfung der nierenfunktion |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05855315T ATE466000T1 (de) | 2004-12-23 | 2005-12-22 | Fluoreszente pyrazinderivate und verfahren zu deren anwendung bei der bewertung der nierenfunktion |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US8778309B2 (de) |
| EP (4) | EP1836175B1 (de) |
| JP (1) | JP2008525487A (de) |
| CN (2) | CN101087767A (de) |
| AT (2) | ATE466000T1 (de) |
| AU (1) | AU2005322114A1 (de) |
| CA (1) | CA2592021A1 (de) |
| DE (1) | DE602005020981D1 (de) |
| ES (2) | ES2375395T3 (de) |
| IL (1) | IL183962A0 (de) |
| WO (1) | WO2006071759A2 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007149479A1 (en) | 2006-06-22 | 2007-12-27 | Mallinckrodt Inc. | Pyrazine derivatives and uses thereof in renal monitoring |
| ATE466000T1 (de) | 2004-12-23 | 2010-05-15 | Mallinckrodt Inc | Fluoreszente pyrazinderivate und verfahren zu deren anwendung bei der bewertung der nierenfunktion |
| CA2616147A1 (en) | 2006-02-24 | 2007-09-20 | Mallinckrodt Inc. | Process for using optical agents |
| JP2009541323A (ja) * | 2006-06-22 | 2009-11-26 | マリンクロット インコーポレイテッド | 拡張された共役を有するピラジン誘導体およびその使用 |
| CN101687040A (zh) | 2007-03-01 | 2010-03-31 | 马林克罗特公司 | 整合光活性的小分子及其用途 |
| CA2641297A1 (en) * | 2008-07-11 | 2010-01-11 | Richard B. Dorshow | Pyrazine derivatives, methods of use, and methods for preparing same |
| WO2010121003A1 (en) | 2009-04-16 | 2010-10-21 | Mallinckrodt Inc. | Pyrazine derivatives for optical imaging and therapy |
| US9433700B2 (en) | 2009-04-27 | 2016-09-06 | Medibeacon Inc. | Tissue sealant compositions, vascular closure devices, and uses thereof |
| WO2011031955A2 (en) * | 2009-09-11 | 2011-03-17 | Mallinckrodt Inc. | Optical monitoring of leukemia |
| DE102011012674B3 (de) * | 2011-02-28 | 2012-04-26 | Ldiamon As | Verfahren und Nachweisvorrichtung zur Bestimmung eines Nierenfunktionsparameters |
| US11077211B2 (en) * | 2013-11-11 | 2021-08-03 | Medibeacon Inc. | Compositions and methods for assessing gut function |
| US10858359B2 (en) | 2016-06-07 | 2020-12-08 | Jacobio Pharmaceuticals Co., Ltd. | Heterocyclic ring derivatives useful as SHP2 inhibitors |
| CN109983001B (zh) | 2016-07-12 | 2023-04-04 | 锐新医药公司 | 作为变构shp2抑制剂的2,5-双取代型3-甲基吡嗪及2,5,6-三取代型3-甲基吡嗪 |
| CN106543089A (zh) * | 2016-11-04 | 2017-03-29 | 山东铂源药业有限公司 | 一种达沙替尼中间体的合成方法 |
| TWI820013B (zh) | 2017-01-23 | 2023-11-01 | 美商銳新醫藥公司 | 作為別構ｓｈｐ２抑制劑之雙環化合物 |
| JP7240320B2 (ja) | 2017-01-23 | 2023-03-15 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としてのピリジン化合物 |
| KR102306048B1 (ko) | 2017-01-30 | 2021-09-29 | 메디비콘 아이엔씨. | 확산 반사 보정을 갖는 형광 추적제의 비침습 모니터링 방법 |
| SG11201908820VA (en) | 2017-03-23 | 2019-10-30 | Jacobio Pharmaceuticals Co Ltd | Novel heterocyclic derivatives useful as shp2 inhibitors |
| EP3694848A1 (de) | 2017-10-12 | 2020-08-19 | Revolution Medicines, Inc. | Pyridin-, pyrazin- und triazinverbindungen als allosterische shp2-inhibitoren |
| KR20220003659A (ko) * | 2017-10-27 | 2022-01-10 | 메디비콘 아이엔씨. | 신장 기능 측정을 위한 조성물 및 시스템 |
| EP3700579A4 (de) * | 2017-10-27 | 2021-07-21 | MediBeacon Inc. | Verfahren zur bestimmung der renalen funktion |
| SG11201909366XA (en) | 2017-11-20 | 2019-11-28 | Medibeacon Inc | Method for preparing and analyzing fluorescent compounds in plasma |
| TW201927791A (zh) | 2017-12-15 | 2019-07-16 | 美商銳新醫藥公司 | 作為變構shp2抑制劑的多環化合物 |
| US11261165B2 (en) | 2019-01-16 | 2022-03-01 | Medibeacon Inc. | Two piece sensor assembly and method of use |
| KR20210124295A (ko) | 2019-01-28 | 2021-10-14 | 메디비콘 아이엔씨. | 가정용 경피 gfr 모니터링을 위한 시스템 및 방법 |
| CN110144050B (zh) * | 2019-06-28 | 2021-06-29 | 西北大学 | 一种具有MnO4-检测功能的稀土铕配位聚合物及其制备方法 |
| JP2022551501A (ja) | 2019-10-10 | 2022-12-09 | メディビーコン，インク． | ５－アミノウラシルの陽極酸化 |
| US20240025864A1 (en) * | 2020-11-09 | 2024-01-25 | Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. | Method for preparing 3,6-diaminopyrazine-2,5-dicarboxylic acid and synthetic intermediate thereof |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US3948895A (en) | 1971-09-28 | 1976-04-06 | E. I. Du Pont De Nemours And Company | Synthesis of 3,5-diaminopyrazinoic acid from 3,5-diamino-2,6-dicyanopyrazine and intermediates |
| IL39114A0 (en) * | 1971-04-13 | 1972-05-30 | Du Pont | Novel cyanopyrazines carbamoyl diaminopyrazines,and 3,5-diaminopyrazinoic acid,and their preparation |
| US3814757A (en) | 1971-04-13 | 1974-06-04 | Du Pont | Diamino substituted dicyano pyrazines and process |
| US3808209A (en) * | 1972-07-14 | 1974-04-30 | Du Pont | Tetraaminopyrazine,2,3,5-triamino-6-nitropyrazine,2,6-diamino-3,5-dinitropyrazine |
| US4517186A (en) * | 1982-09-30 | 1985-05-14 | Merck & Co., Inc. | 2-Amino-3,5-dicyano-6-(substituted)pyrazine antimicrobial compounds |
| DE3768479D1 (de) | 1986-08-13 | 1991-04-11 | Nippon Soda Co | 2,3-diaminoacrylonitrilderivate. |
| JPH0249775A (ja) | 1988-05-19 | 1990-02-20 | Nippon Soda Co Ltd | ６員環又は７員環を有する複素環化合物及びその製造方法 |
| JPH0217163A (ja) | 1988-07-05 | 1990-01-22 | Nippon Soda Co Ltd | ジアミノマレオニトリル及びジアミノアクリロニトリル誘導体の製造方法 |
| JPH0269457A (ja) | 1988-09-06 | 1990-03-08 | Nippon Soda Co Ltd | ピロール誘導体及びその製造法 |
| US5145610A (en) * | 1989-11-27 | 1992-09-08 | E. I. Du Pont De Nemours And Company | Organic optical elements and nonlinear optical devices |
| JPH04112877A (ja) | 1990-09-04 | 1992-04-14 | Nippon Soda Co Ltd | 新規シアノピラジン誘導体及びその製造方法 |
| EP0579835A4 (en) * | 1991-11-12 | 1994-06-01 | Nippon Soda Co | Wavelength conversion material for agriculture |
| JPH07149736A (ja) * | 1993-10-07 | 1995-06-13 | Nippon Soda Co Ltd | シアノピラジン誘導体および成形体 |
| JPH07278456A (ja) * | 1994-04-12 | 1995-10-24 | Nippon Soda Co Ltd | 蛍光着色剤 |
| JPH09143168A (ja) | 1995-11-22 | 1997-06-03 | Nippon Soda Co Ltd | ２，３−ジアミノアクリロニトリル誘導体および３，６−ジアミノ−２，５−ピラジンジカルボニトリルの製造方法 |
| JP3845848B2 (ja) | 1996-01-25 | 2006-11-15 | 日本曹達株式会社 | ２，３−ジアミノアクリロニトリル誘導体の製造方法 |
| JPH09249773A (ja) * | 1996-03-19 | 1997-09-22 | Nippon Soda Co Ltd | 波長変換能を有するポリオレフィン系樹脂組成物、その組成物用マスターバッチおよびその組成物を含む農業用フイルム |
| JP3986587B2 (ja) * | 1996-07-30 | 2007-10-03 | 日本曹達株式会社 | ピラジンジカルボン酸誘導体及びその製造方法 |
| US5928625A (en) * | 1997-03-13 | 1999-07-27 | Mallinckrodt Inc. | Method of measuring physiological function |
| JP4153060B2 (ja) | 1997-09-25 | 2008-09-17 | 日本曹達株式会社 | ピラジン環を主鎖に有するポリエステル系化合物、その製造方法および高分子色素 |
| JP2002523405A (ja) | 1998-08-20 | 2002-07-30 | アボット・ラボラトリーズ | レジオ選択的置換ピラジン異性体を製造するための方法 |
| US6440389B1 (en) | 2000-07-19 | 2002-08-27 | The General Hospital Corporation | Fluorescent agents for real-time measurement of organ function |
| US6733744B1 (en) * | 2000-10-16 | 2004-05-11 | Mallinckrodt Inc. | Indole compounds as minimally invasive physiological function monitoring agents |
| US7556797B2 (en) * | 2000-10-16 | 2009-07-07 | Mallinckrodt Inc. | Minimally invasive physiological function monitoring agents |
| EP1355640A1 (de) | 2001-01-23 | 2003-10-29 | Neurosearch A/S | Verwendung von nicht kompetitiven und selektiven glur5-antagonisten als modulierende verbindungen des glutamatrezeptors |
| JP4112877B2 (ja) | 2001-03-09 | 2008-07-02 | ダイセル化学工業株式会社 | 環状イミド系化合物で構成された触媒、及びこの触媒を用いた有機化合物の製造法 |
| ATE466000T1 (de) | 2004-12-23 | 2010-05-15 | Mallinckrodt Inc | Fluoreszente pyrazinderivate und verfahren zu deren anwendung bei der bewertung der nierenfunktion |
-
2005
- 2005-12-22 AT AT05855315T patent/ATE466000T1/de not_active IP Right Cessation
- 2005-12-22 DE DE602005020981T patent/DE602005020981D1/de active Active
- 2005-12-22 EP EP05855315A patent/EP1836175B1/de active Active
- 2005-12-22 EP EP07013568A patent/EP1854790B1/de active Active
- 2005-12-22 WO PCT/US2005/046732 patent/WO2006071759A2/en active Application Filing
- 2005-12-22 EP EP08017332A patent/EP2039688A1/de not_active Withdrawn
- 2005-12-22 ES ES07013568T patent/ES2375395T3/es active Active
- 2005-12-22 US US11/721,186 patent/US8778309B2/en active Active
- 2005-12-22 JP JP2007548504A patent/JP2008525487A/ja active Pending
- 2005-12-22 AT AT07013568T patent/ATE522510T1/de not_active IP Right Cessation
- 2005-12-22 AU AU2005322114A patent/AU2005322114A1/en not_active Abandoned
- 2005-12-22 CN CNA2005800446810A patent/CN101087767A/zh active Pending
- 2005-12-22 CA CA002592021A patent/CA2592021A1/en not_active Abandoned
- 2005-12-22 CN CN201010122903A patent/CN101812027A/zh active Pending
- 2005-12-22 ES ES05855315T patent/ES2345209T3/es active Active
- 2005-12-22 EP EP09011710A patent/EP2135863A1/de not_active Withdrawn
-
2007
- 2007-06-14 IL IL183962A patent/IL183962A0/en unknown
-
2013
- 2013-10-07 US US14/047,733 patent/US9376399B2/en active Active
-
2016
- 2016-06-10 US US15/178,720 patent/US10617687B2/en active Active
- 2016-06-10 US US15/178,799 patent/US20170298030A9/en not_active Abandoned
-
2022
- 2022-01-03 US US17/646,818 patent/US20220127237A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008525487A (ja) | 2008-07-17 |
| US20140039191A1 (en) | 2014-02-06 |
| US20220127237A1 (en) | 2022-04-28 |
| AU2005322114A1 (en) | 2006-07-06 |
| WO2006071759A2 (en) | 2006-07-06 |
| US10617687B2 (en) | 2020-04-14 |
| CN101812027A (zh) | 2010-08-25 |
| US9376399B2 (en) | 2016-06-28 |
| DE602005020981D1 (de) | 2010-06-10 |
| US20090010851A1 (en) | 2009-01-08 |
| CA2592021A1 (en) | 2006-07-06 |
| ATE466000T1 (de) | 2010-05-15 |
| ES2345209T3 (es) | 2010-09-17 |
| EP1854790B1 (de) | 2011-08-31 |
| WO2006071759A3 (en) | 2006-09-14 |
| US20160280665A1 (en) | 2016-09-29 |
| EP1854790A1 (de) | 2007-11-14 |
| IL183962A0 (en) | 2007-10-31 |
| CN101087767A (zh) | 2007-12-12 |
| EP1836175A2 (de) | 2007-09-26 |
| US20170298030A9 (en) | 2017-10-19 |
| EP1836175B1 (de) | 2010-04-28 |
| US20160280666A1 (en) | 2016-09-29 |
| ES2375395T3 (es) | 2012-02-29 |
| EP2135863A1 (de) | 2009-12-23 |
| EP2039688A1 (de) | 2009-03-25 |
| US8778309B2 (en) | 2014-07-15 |
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