ATE510908T1 - Fad5-2, mitglied der desaturase-familie und verwendungen davon - Google Patents

Fad5-2, mitglied der desaturase-familie und verwendungen davon

Info

Publication number
ATE510908T1
ATE510908T1 AT07019867T AT07019867T ATE510908T1 AT E510908 T1 ATE510908 T1 AT E510908T1 AT 07019867 T AT07019867 T AT 07019867T AT 07019867 T AT07019867 T AT 07019867T AT E510908 T1 ATE510908 T1 AT E510908T1
Authority
AT
Austria
Prior art keywords
nucleic acid
desaturase
expression vectors
fad5
acid molecules
Prior art date
Application number
AT07019867T
Other languages
German (de)
English (en)
Inventor
Xiao Qui
Haiping Hong
Original Assignee
Bioriginal Food & Science Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26929655&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE510908(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bioriginal Food & Science Corp filed Critical Bioriginal Food & Science Corp
Application granted granted Critical
Publication of ATE510908T1 publication Critical patent/ATE510908T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/158Fatty acids; Fats; Products containing oils or fats
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12Fatty acids or derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083Miscellaneous (1.14.99)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409Fatty acids
    • C12P7/6427Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409Fatty acids
    • C12P7/6427Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6431Linoleic acids [18:2[n-6]]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409Fatty acids
    • C12P7/6427Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6432Eicosapentaenoic acids [EPA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409Fatty acids
    • C12P7/6427Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434Docosahexenoic acids [DHA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436Fatty acid esters
    • C12P7/6445Glycerides
    • C12P7/6472Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y114/00Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/19Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
    • C12Y114/19003Linoleoyl-CoA desaturase (1.14.19.3)
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/52Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
AT07019867T 2000-09-28 2001-09-28 Fad5-2, mitglied der desaturase-familie und verwendungen davon ATE510908T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23630300P 2000-09-28 2000-09-28
US29756201P 2001-06-12 2001-06-12

Publications (1)

Publication Number Publication Date
ATE510908T1 true ATE510908T1 (de) 2011-06-15

Family

ID=26929655

Family Applications (2)

Application Number Title Priority Date Filing Date
AT07019867T ATE510908T1 (de) 2000-09-28 2001-09-28 Fad5-2, mitglied der desaturase-familie und verwendungen davon
AT01985723T ATE463560T1 (de) 2000-09-28 2001-09-28 Fad4, fad5, fad5-2, and fad6, mitglieder der fettsäuredesaturasefamilie und ihre verwendungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT01985723T ATE463560T1 (de) 2000-09-28 2001-09-28 Fad4, fad5, fad5-2, and fad6, mitglieder der fettsäuredesaturasefamilie und ihre verwendungen

Country Status (13)

Country Link
US (7) US7087432B2 (enExample)
EP (3) EP1322752B2 (enExample)
JP (3) JP4071622B2 (enExample)
CN (3) CN100567483C (enExample)
AT (2) ATE510908T1 (enExample)
AU (3) AU2002218447C9 (enExample)
CA (1) CA2421267C (enExample)
DE (1) DE60141760D1 (enExample)
DK (2) DK1322752T3 (enExample)
ES (2) ES2343106T3 (enExample)
NO (2) NO331104B1 (enExample)
PT (2) PT1911837E (enExample)
WO (1) WO2002026946A2 (enExample)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566583B1 (en) * 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
US7247461B2 (en) * 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
US7211418B2 (en) * 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US20070244192A1 (en) * 1999-01-14 2007-10-18 Martek Biosciences Corporation Plant seed oils containing polyunsaturated fatty acids
US8003772B2 (en) 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
US7217856B2 (en) * 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
EP1392823B1 (en) * 2001-01-25 2011-11-30 Abbott Laboratories Desaturase genes and uses thereof
US6635451B2 (en) 2001-01-25 2003-10-21 Abbott Laboratories Desaturase genes and uses thereof
TWI324181B (en) 2001-04-16 2010-05-01 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
US7045683B2 (en) 2001-05-04 2006-05-16 Abbott Laboratories Δ4-desaturase genes and uses thereof
DE10137374A1 (de) * 2001-07-31 2003-02-27 Ipk Inst Fuer Pflanzengenetik Verfahren zur Herstellung von Arachidonsäure in transgenen Organismen
EP2261312A1 (en) 2001-12-12 2010-12-15 Martek Biosciences Corporation Extraction and Winterization of Lipids from Oilseed and Microbial Sources
CA2883729C (en) 2002-05-22 2017-03-07 Virginia M. Ursin Fatty acid desaturases from fungi
US7485414B2 (en) * 2002-08-30 2009-02-03 Rigel Pharmaceuticals, Inc. Modulators of angiogenesis
US20040172682A1 (en) 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
US8084074B2 (en) 2003-02-12 2011-12-27 E. I. Du Pont De Nemours And Company Production of very long chain polyunsaturated fatty acids in oil seed plants
ES2516641T3 (es) * 2003-03-26 2014-10-31 Dsm Ip Assets B.V. Sistemas de policétido sintasa de AGPI y usos de los mismos
JP4732333B2 (ja) * 2003-04-08 2011-07-27 ビーエーエスエフ プラント サイエンス ゲーエムベーハー ミドリムシ(Euglenagracilis)由来のΔ−4−デサチュラーゼを発現する植物およびPUFA含有油
PT2172536T (pt) 2003-08-01 2016-08-17 Basf Plant Science Gmbh Processo para a produção de ácidos gordos poli-insaturados em organismos transgénicos
US11952581B2 (en) 2003-08-01 2024-04-09 Basf Plant Science Gmbh Process for the production of polyunsaturated fatty acids in transgenic organisms
AU2004268196B2 (en) * 2003-08-21 2010-03-04 Monsanto Technology Llc Fatty acid desaturases from primula
US20050132441A1 (en) 2003-11-12 2005-06-16 Damude Howard G. Delta15 desaturases suitable for altering levels of polyunsaturated fatty acids in oilseed plants and oleaginous yeast
CA2558726C (en) 2004-02-27 2017-11-07 Basf Plant Science Gmbh Method for producing unsaturated .omega.-3-fatty acids in transgenic organisms
CN1930277B (zh) 2004-02-27 2011-02-02 巴斯福植物科学有限公司 在转基因植物中产生多不饱和脂肪酸的方法
JP2007533310A (ja) * 2004-04-16 2007-11-22 モンサント テクノロジー エルエルシー トウモロコシにおける脂肪酸デサチュラーゼの発現
ES2529572T3 (es) 2004-04-22 2015-02-23 Commonwealth Scientific And Industrial Research Organisation Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes
PL1756280T3 (pl) * 2004-04-22 2015-04-30 Commw Scient Ind Res Org Synteza długołańcuchowych wielonienasyconych kwasów tłuszczowych w komórkach rekombinowanych
AU2005250074B2 (en) 2004-06-04 2011-04-14 Fluxome Sciences A/S Metabolically engineered cells for the production of polyunsaturated fatty acids
US7550651B2 (en) 2004-06-25 2009-06-23 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
DK1780275T3 (da) 2004-07-12 2011-02-21 Suntory Holdings Ltd Polypeptid med en delta5-fedtsyre-desaturationsaktivitet, polynukleotid kodende for polypeptidet og anvendelse deraf
US7138391B2 (en) * 2004-08-09 2006-11-21 Silverbrook Research Pty Ltd Hydrophilizable and hydrophilic cyanine dyes
AU2006219823A1 (en) 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
DE102005013779A1 (de) 2005-03-22 2006-09-28 Basf Plant Science Gmbh Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen
MX338235B (es) 2005-06-07 2016-04-08 Dsm Nutritional Products Ag Microorganismos eucarioticos para producir lipidos y antioxidantes.
DE102005038036A1 (de) * 2005-08-09 2007-02-15 Basf Plant Science Gmbh Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure in transgenen Nutzpflanzen
WO2007061742A1 (en) 2005-11-23 2007-05-31 E. I. Du Pont De Nemours And Company Delta-9 elongases and their use in making polyunsaturated fatty acids
AR059376A1 (es) 2006-02-21 2008-03-26 Basf Plant Science Gmbh Procedimiento para la produccion de acidos grasos poliinsaturados
BRPI0708535A2 (pt) * 2006-03-03 2011-05-31 Monsanto Technology Llc meios para melhora da saúde cardiovascular
MX340759B (es) * 2006-03-15 2015-03-11 Dsm Ip Assets B V * Aceites de semillas vegetales que contienen ácidos grasos poli-insaturados.
US7943823B2 (en) 2006-04-28 2011-05-17 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
EP2082053B1 (en) 2006-08-01 2016-04-13 DSM Nutritional Products AG Process for producing microbial oil comprising polyunsaturated fatty acids
BRPI0716075A2 (pt) 2006-08-29 2013-08-06 Commw Scient Ind Res Org sÍntese de Ácidos graxos
EP2062574B1 (en) * 2006-09-08 2015-03-25 Kaneka Corporation Composition comprising reduced coenzyme q10 and lysolecithin
JP5101894B2 (ja) * 2007-01-15 2012-12-19 サントリーホールディングス株式会社 高度不飽和脂肪酸及びこれを含有する脂質の製造方法
DK2129777T3 (en) * 2007-04-03 2016-01-25 Du Pont MULTIZYMER AND USE THEREOF FOR THE PRODUCTION OF polyunsaturated fatty acids
US7943365B2 (en) 2007-05-03 2011-05-17 E.I. Du Pont De Nemours And Company Δ-5 desaturases and their use in making polyunsaturated fatty acids
CA2695161C (en) * 2007-07-13 2018-05-22 Ocean Nutrition Canada Limited D4 desaturases and d5 elongases
BRPI0821508B1 (pt) 2007-12-11 2018-12-26 Synthetic Genomics Inc cultura celular compreendendo uma cianobactéria recombinante da espécie synechococcus elongatus e método para converter carbono inorgânico em ácidos graxos.
US8119784B2 (en) * 2008-04-02 2012-02-21 E. I. Du Pont De Nemours And Company Delta-4 desaturase and its use in making polyunsaturated fatty acids
WO2010000708A2 (en) 2008-07-01 2010-01-07 Basf Plant Science Gmbh Promoters from brassica napus for seed specific gene expression
JP2011529689A (ja) * 2008-08-01 2011-12-15 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー Δ6デサチュラーゼおよび多価不飽和脂肪酸生成におけるそれらの使用
CA3015426C (en) * 2008-11-18 2020-01-14 Commonwealth Scientific And Industrial Research Organisation Recombinant cells comprising exogenous .delta.5 and .delta.6 desaturases, .delta.5 and .delta.6 elongases, and .delta.4 desaturases
ES2752196T3 (es) 2009-03-16 2020-04-03 Dsm Ip Assets Bv Producción de proteínas en microorganismos del filo Labyrinthulomycota
ES2717102T3 (es) * 2009-03-19 2019-06-19 Dsm Ip Assets Bv Moléculas de ácido nucleico de ácido graso poliinsaturado sintasas, y polipéptidos, composiciones y métodos de preparación y usos de los mismos
US20100272875A1 (en) * 2009-04-24 2010-10-28 Monsanto Technology Llc Omega-3 enriched cereal, granola, and snack bars
CA2760326A1 (en) 2009-05-13 2010-11-18 Basf Plant Science Company Gmbh Acyltransferases and uses thereof in fatty acid production
JP2012529277A (ja) 2009-06-08 2012-11-22 ロザムステッド リサーチ リミテッド 新規の脂肪酸伸長成分およびその使用
WO2011008565A1 (en) 2009-06-29 2011-01-20 Synthetic Genomics, Inc. Acyl-acp thioesterase genes and uses therefor
US9493520B2 (en) 2009-07-17 2016-11-15 Basf Plant Science Company Gmbh Fatty acid desaturases and elongases and uses thereof
US9428757B2 (en) 2009-08-31 2016-08-30 Basf Plant Science Company Gmbh Regulatory nucleic acid molecules for enhancing seed-specific gene expression in plants promoting enhanced polyunsaturated fatty acid synthesis
EP2481799A4 (en) 2009-09-24 2013-08-07 Univ Kyushu Nat Univ Corp METHOD FOR THE TRANSFORMATION OF STRAMENOPILES
EP2504438A1 (en) 2009-11-24 2012-10-03 BASF Plant Science Company GmbH Novel fatty acid elongase and uses thereof
WO2011064181A1 (en) 2009-11-24 2011-06-03 Basf Plant Science Company Gmbh Novel fatty acid desaturase and uses thereof
US9388437B2 (en) 2010-06-25 2016-07-12 Basf Plant Science Company Gmbh Acyltransferases and uses thereof in fatty acid production
AU2011317632B2 (en) 2010-10-21 2016-08-18 Basf Plant Science Company Gmbh Novel fatty acid desaturases, elongases, elongation components and uses therof
JP2012096498A (ja) * 2010-11-05 2012-05-24 Tomoegawa Paper Co Ltd 両面印刷用熱転写受像シートおよびその製造方法
CN102559710B (zh) * 2011-06-27 2013-10-30 中国农业科学院油料作物研究所 等鞭金藻δ4-脂肪酸去饱和酶基因及其克隆方法
HUE033766T2 (en) 2012-06-15 2018-01-29 Commw Scient Ind Res Org Production of long chain polyunsaturated fatty acids in plant cells
AU2013298113A1 (en) 2012-08-03 2015-01-29 Basf Plant Science Company Gmbh Novel enzymes, enzyme components and uses thereof
EP2970926B1 (en) 2013-03-13 2018-01-31 DSM Nutritional Products AG Engineering microorganisms
US10731169B2 (en) 2013-07-05 2020-08-04 Basf Plant Science Company Gmbh Gene expression or activity enhancing elements
US10329541B2 (en) 2013-12-17 2019-06-25 Basf Plant Science Company Gmbh Methods for conversion of the substrate specificity of desaturases
EA037817B1 (ru) 2013-12-18 2021-05-25 Коммонвелт Сайнтифик Энд Индастриэл Рисерч Организэйшн Экстрагированный растительный липид, содержащий длинноцепочечные полиненасыщенные жирные кислоты
CA2953008C (en) 2014-06-27 2024-03-19 Nuseed Pty Ltd Lipid comprising docosapentaenoic acid
US11484560B2 (en) 2014-11-14 2022-11-01 Basf Plant Science Company Gmbh Stabilising fatty acid compositions
CA3026079C (en) 2016-06-01 2024-10-01 Cargill Inc FISH FOOD PREPARED FROM OILSEED PLANTS PRODUCING OMEGA-3 FATTY ACIDS
CN107236679A (zh) * 2017-04-27 2017-10-10 广州弘宝元生物科技有限公司 一种高产不饱和脂肪酸重组工程菌株及其构建方法
CN112040766A (zh) * 2018-04-13 2020-12-04 嘉吉公司 栽培含lc-pufa的转基因芸苔属植物的方法
WO2020168277A1 (en) 2019-02-14 2020-08-20 Cargill, Incorporated Brassica plants producing elevated levels of polyunsaturated fatty acids
AU2021373697A1 (en) 2020-11-04 2023-06-08 Basf Plant Science Company Gmbh Harvest management
WO2022204454A1 (en) 2021-03-25 2022-09-29 Cargill, Incorporated Fertilizer management

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8025A (en) * 1851-04-08 Apparatus eor boltiitg flouk
US4873191A (en) * 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4656134A (en) * 1982-01-11 1987-04-07 Board Of Trustees Of Leland Stanford Jr. University Gene amplification in eukaryotic cells
NL8200523A (nl) * 1982-02-11 1983-09-01 Univ Leiden Werkwijze voor het in vitro transformeren van planteprotoplasten met plasmide-dna.
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4441972A (en) * 1983-04-08 1984-04-10 D.E.P. Systems, Inc. Apparatus for electrofusion of biological particles
US4476004A (en) * 1983-04-08 1984-10-09 D.E.P. Systems, Inc. Apparatus for electrofusion of biological particles
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
US4806476A (en) * 1983-09-08 1989-02-21 Lovelace Medical Foundation Efficient cell fusion process
US4608339A (en) * 1983-10-25 1986-08-26 Yoakum George H Protoplast fusion method for high-frequency DNA transfection in human cells
US4736866B1 (en) * 1984-06-22 1988-04-12 Transgenic non-human mammals
FR2569723B1 (fr) * 1984-08-31 1986-09-19 Centre Nat Rech Scient Application des antibiotiques de la famille des phleomycines a titre d'agent de selection dans le domaine du genie genetique
US4686186A (en) * 1984-09-26 1987-08-11 Wisconsin Alumni Research Foundation Recombinant vector and eukaryotic host transformed thereby
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
US4970162A (en) * 1985-11-13 1990-11-13 The United States Of America As Represented By The Department Of Health And Human Services Human-mouse hybrid cell line expressing monocyte-macrophage properties
US4935350A (en) * 1985-11-18 1990-06-19 Amgen Materials and methods for controlling plasmid copy number and stability
US4784737A (en) * 1986-04-18 1988-11-15 The United States Department Of Energy Electromicroinjection of particles into living cells
US4923814A (en) * 1986-05-09 1990-05-08 Electropore, Inc. High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor
US4906576A (en) * 1986-05-09 1990-03-06 Electropore, Inc. High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor
US5215914A (en) * 1986-06-18 1993-06-01 American Registry Of Pathology Adherent and invasive mycoplasma
US5364761A (en) * 1986-07-24 1994-11-15 Daiichi Pharmaceutical Co., Ltd. Method for isolating a DNA encoding an autonomously replicating sequence
US4801540A (en) * 1986-10-17 1989-01-31 Calgene, Inc. PG gene and its use in plants
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US4997764A (en) * 1987-04-23 1991-03-05 New York University Transformation of human B-lympocytes with Epstein Barr virus and c-myc containing vectors
US5063162A (en) * 1987-04-24 1991-11-05 Hoffmann-La Roche Inc. Process for isolating nucleic acids utilizing protease digestion
CA1297431C (en) * 1987-04-24 1992-03-17 F. Hoffmann-La Roche Ag Process for the isolation of nucleic acids
US4873316A (en) * 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
DE3730246A1 (de) * 1987-09-09 1989-06-01 Boehringer Mannheim Gmbh Expressionsvektor und verfahren zur expression von heterologen proteinen in saeugerzellen
WO1989006555A1 (en) * 1988-01-21 1989-07-27 Massachusetts Institute Of Technology Transport of molecules across tissue using electroporation
US4955378A (en) * 1988-05-02 1990-09-11 University Of South Florida Apparatus and methods for performing electrofusion at specific anatomical sites
US5162215A (en) * 1988-09-22 1992-11-10 Amgen Inc. Method of gene transfer into chickens and other avian species
GB8823068D0 (en) * 1988-09-30 1988-11-09 Ici Plc Recombinant dna
US5175384A (en) * 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5272262A (en) * 1989-06-21 1993-12-21 City Of Hope Method for the production of catalytic RNA in bacteria
US5144019A (en) * 1989-06-21 1992-09-01 City Of Hope Ribozyme cleavage of HIV-I RNA
US5501967A (en) * 1989-07-26 1996-03-26 Mogen International, N.V./Rijksuniversiteit Te Leiden Process for the site-directed integration of DNA into the genome of plants
US5550318A (en) * 1990-04-17 1996-08-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
GB8918226D0 (en) * 1989-08-09 1989-09-20 Wellcome Found Dna assays
US5434086A (en) * 1989-08-22 1995-07-18 The Regents Of The University Of Michigan Method of testing potential cystic fibrosis treating compounds using cells in culture
US5240846A (en) * 1989-08-22 1993-08-31 The Regents Of The University Of Michigan Gene therapy vector for cystic fibrosis
US5149796A (en) * 1989-08-31 1992-09-22 City Of Hope Chimeric DNA-RNA catalytic sequences
ATE199398T1 (de) * 1989-10-24 2001-03-15 Chiron Corp Sekretion vom mit gamma-interferon signalpeptid gebundenen humänen protein
AU6882791A (en) * 1989-11-22 1991-06-13 Children's Hospital Of Los Angeles Bcr/abl transgenic animals as models for philadelphia chromosome positive chronic myelogenous and acute lymphoblastic leukemia
US5292658A (en) * 1989-12-29 1994-03-08 University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center Cloning and expressions of Renilla luciferase
US5436392A (en) * 1990-01-12 1995-07-25 Arizona Technology Development Corporation Transgenic plants expressing M. sexta protease inhibitor
CA2042093C (en) * 1990-05-09 2002-12-24 Gyula Hadlaczky Cell line carrying an excess of mammalian centromeres
US5387742A (en) * 1990-06-15 1995-02-07 Scios Nova Inc. Transgenic mice displaying the amyloid-forming pathology of alzheimer's disease
JPH06506105A (ja) * 1990-08-29 1994-07-14 ファーミング ビーブイ 哺乳動物細胞における相同性組換え
US5470730A (en) * 1990-09-28 1995-11-28 Immunex Method for producing TH -independent cytotoxic T lymphocytes
US5382524A (en) * 1990-10-24 1995-01-17 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-n-acetylgalactosaminidase
DK0506945T3 (da) * 1990-10-25 1999-04-26 Clague Pitman Hodgson Fremgangsmåde til genoverførsel under anvendelse af retrotransposoner
US5300431A (en) * 1991-02-26 1994-04-05 E. I. Du Pont De Nemours And Company Positive selection vector for the bacteriophage P1 cloning system
US5461032A (en) * 1991-03-01 1995-10-24 Fmc Corporation Insecticidally effective peptides
ATE204328T1 (de) * 1991-03-11 2001-09-15 Syngenta Ltd Biozide proteine
US5240840A (en) * 1991-04-05 1993-08-31 Regents Of The University Of Michigan Dna superfragment cloning
US5468634A (en) * 1991-06-24 1995-11-21 The University Of North Carolina At Chapel Hill Axl oncogene
US5358866A (en) * 1991-07-03 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Cytosine deaminase negative selection system for gene transfer techniques and therapies
US5288625A (en) * 1991-09-13 1994-02-22 Biologic Research Center Of The Hungarian Academy Of Sciences Mammalian artificial chromosomes
PH31293A (en) * 1991-10-10 1998-07-06 Rhone Poulenc Agrochimie Production of y-linolenic acid by a delta6-desaturage.
US5614393A (en) * 1991-10-10 1997-03-25 Rhone-Poulenc Agrochimie Production of γ-linolenic acid by a Δ6-desaturase
WO1993008270A1 (en) * 1991-10-15 1993-04-29 Agracetus, Inc. Particle-mediated transformation of mammalian unattached cells
US5246842A (en) * 1991-10-30 1993-09-21 The United States Of America As Represented By The Secretary Of Agriculture Production of eicosapentaenoic acid from filamentous fungi utilizing lactose as a primary carbon source
US5260191A (en) * 1992-01-30 1993-11-09 Agracetus, Inc. Method for diagnosing tumors
US5266600A (en) * 1992-02-28 1993-11-30 Bristol-Myers Squibb Company BU-4641V, an antibacterial, antiviral and antitumor antibiotic
JP3314241B2 (ja) * 1992-04-06 2002-08-12 ヤマハ発動機株式会社 自動二輪車用エンジンの排気浄化装置
US5501662A (en) * 1992-05-22 1996-03-26 Genetronics, Inc. Implantable electroporation method and apparatus for drug and gene delivery
EP0578627A1 (en) * 1992-07-09 1994-01-12 Monsanto Company Virus resistant plants
US5453357A (en) * 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5449604A (en) * 1992-10-21 1995-09-12 University Of Washington Chromosome 14 and familial Alzheimers disease genetic markers and assays
US5496731A (en) * 1993-03-25 1996-03-05 Xu; Hong-Ji Broad-spectrum tumor suppressor genes, gene products and methods for tumor suppressor gene therapy
US5468615A (en) * 1993-07-01 1995-11-21 The Upjohn Company Binding assay employing a synthetic gene for D4 dopamine receptors
US5413914A (en) * 1993-07-07 1995-05-09 The Regents Of The University Of Colorado Yeast assay to identify inhibitors of dibasic amino acid processing endoproteases
US5457182A (en) * 1994-02-15 1995-10-10 Merck & Co., Inc. FK-506 cytosolic binding protein, FKBP12.6
IT1274168B (it) 1994-04-15 1997-07-15 Eniricerche Spa Vettore plasmidico e suo impiego per la produzione di proteine eterologhe
US5625130A (en) * 1995-03-07 1997-04-29 Pioneer Hi-Bred International, Inc. Oilseed Brassica bearing an endogenous oil wherein the levels of oleic, alpha-linolenic, and saturated fatty acids are simultaneously provided in an atypical highly beneficial distribution via genetic control
US5543319A (en) * 1995-03-31 1996-08-06 Fred Hutchinson Cancer Research Center Recombination-proficient avian/mammalian microcell hybrids
WO1997016533A1 (en) * 1995-10-31 1997-05-09 The Regents Of The University Of California Mammalian artificial chromosomes and methods of using same
US6133503A (en) * 1995-10-31 2000-10-17 The Regents Of The University Of California Mammalian artificial chromosomes and methods of using same
US6025155A (en) * 1996-04-10 2000-02-15 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6077697A (en) * 1996-04-10 2000-06-20 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
DK0935667T3 (da) 1996-07-23 2007-04-10 Nagase Chemtex Corp Fremgangsmåde til fremstilling af docosahexaensyre og docosapentaensyre
US5968809A (en) * 1997-04-11 1999-10-19 Abbot Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
US6051754A (en) * 1997-04-11 2000-04-18 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants
ATE297994T1 (de) * 1997-04-11 2005-07-15 Calgene Llc Verfahren und zusammensetzungen für die synthese von langkettigen, mehrfach ungesättigten fettsäuren in pflanzen.
US6432684B1 (en) 1997-04-11 2002-08-13 Abbott Laboratories Human desaturase gene and uses thereof
US5972664A (en) * 1997-04-11 1999-10-26 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
GB9724783D0 (en) * 1997-11-24 1998-01-21 Inst Arable Crops Research Novel polypeptides
EP1042485A2 (en) * 1997-12-23 2000-10-11 University Of Bristol Desaturase
EP1086236B1 (en) 1998-06-12 2007-09-05 Calgene LLC Polyunsaturated fatty acids in plants
US6403349B1 (en) 1998-09-02 2002-06-11 Abbott Laboratories Elongase gene and uses thereof
WO2000020603A1 (en) * 1998-10-05 2000-04-13 Abbott Laboratories Altered fatty acid biosynthesis in insect cells using delta five desaturase
AU1097900A (en) 1998-10-05 2000-04-26 Abbott Laboratories Delta 6 and delta 12 desaturases and modified fatty acid biosynthesis and products produced therefrom
JP2002527051A (ja) 1998-10-09 2002-08-27 メルク エンド カムパニー インコーポレーテッド デルタ6脂肪酸デサチュラーゼ
ES2284286T5 (es) 1998-10-15 2011-01-03 Dsm Ip Assets B.V. Suplementos de pufa.
CA2791961A1 (en) 1998-12-07 2000-06-15 Washington State University Research Foundation Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
ES2286999T5 (es) 1999-03-04 2016-11-17 Suntory Holdings Limited Utilización de un material que contiene ácido docosapentaenoico
IL146782A0 (en) 1999-06-07 2002-07-25 Basf Plant Science Gmbh 6-acetylenase and 6-desaturase from ceratodon purpureus
JP3520328B2 (ja) 2000-10-06 2004-04-19 奈良先端科学技術大学院大学長 コーヒー属植物のテオブロミン合成酵素ポリペプチド及び当該ポリペプチドをコードする遺伝子
EP1392823B1 (en) * 2001-01-25 2011-11-30 Abbott Laboratories Desaturase genes and uses thereof
DE10137374A1 (de) * 2001-07-31 2003-02-27 Ipk Inst Fuer Pflanzengenetik Verfahren zur Herstellung von Arachidonsäure in transgenen Organismen
EP2302060B1 (en) 2002-03-16 2012-07-25 The University of York Desaturases
JP4732333B2 (ja) 2003-04-08 2011-07-27 ビーエーエスエフ プラント サイエンス ゲーエムベーハー ミドリムシ(Euglenagracilis)由来のΔ−4−デサチュラーゼを発現する植物およびPUFA含有油

Also Published As

Publication number Publication date
EP2166087A2 (en) 2010-03-24
AU2007203008B2 (en) 2010-07-29
AU2007203008A1 (en) 2007-07-19
DK1322752T3 (da) 2010-07-19
US7087432B2 (en) 2006-08-08
JP4071622B2 (ja) 2008-04-02
CN101845446A (zh) 2010-09-29
EP2166087B1 (en) 2012-11-14
CA2421267A1 (en) 2002-04-04
CA2421267C (en) 2009-01-06
AU2002218447C9 (en) 2008-04-17
US20200002712A1 (en) 2020-01-02
US20060117414A1 (en) 2006-06-01
JP4456172B2 (ja) 2010-04-28
JP2009148297A (ja) 2009-07-09
ES2399806T3 (es) 2013-04-03
AU2002218447C1 (en) 2002-04-08
NO332128B1 (no) 2012-07-02
EP2166087A3 (en) 2010-04-07
PT1322752E (pt) 2010-05-06
US20120094904A1 (en) 2012-04-19
WO2002026946A3 (en) 2003-05-08
US8088906B2 (en) 2012-01-03
EP1911837A2 (en) 2008-04-16
NO20031405L (no) 2003-05-15
PT1911837E (pt) 2011-06-07
JP4365387B2 (ja) 2009-11-18
JP2006314321A (ja) 2006-11-24
EP1322752A2 (en) 2003-07-02
AU1844702A (en) 2002-04-08
JP2004516017A (ja) 2004-06-03
EP1911837A3 (en) 2008-04-30
NO20101157L (no) 2003-05-15
ATE463560T1 (de) 2010-04-15
DK1911837T3 (da) 2011-08-29
CN100567483C (zh) 2009-12-09
US20020156254A1 (en) 2002-10-24
AU2002218447B2 (en) 2007-03-29
NO331104B1 (no) 2011-10-10
CN101845446B (zh) 2016-01-20
US9359597B2 (en) 2016-06-07
EP1911837B1 (en) 2011-05-25
CN1551914A (zh) 2004-12-01
CN105483142A (zh) 2016-04-13
WO2002026946A2 (en) 2002-04-04
EP1322752B1 (en) 2010-04-07
US20110229944A1 (en) 2011-09-22
DE60141760D1 (de) 2010-05-20
US20160369289A1 (en) 2016-12-22
US7977469B2 (en) 2011-07-12
ES2343106T3 (es) 2010-07-23
EP1322752B2 (en) 2015-02-11
NO20031405D0 (no) 2003-03-27
US7671252B2 (en) 2010-03-02
US20090305365A1 (en) 2009-12-10

Similar Documents

Publication Publication Date Title
ATE510908T1 (de) Fad5-2, mitglied der desaturase-familie und verwendungen davon
DE60335708D1 (de) E exprimieren
NO20014716L (no) Ny klasse enzymer i den biosyntetiske vei for produksjon av triacylglycerol og rekombinante DNA-molekyler som koder for disse
ATE310090T1 (de) Gereinigte coprinus laccasen und nukleinsäuren welche dafür kodieren
DK1007691T3 (da) Fremgangsmåder og sammensætninger til syntese af langkædede polyumættede fedtsyrer
DE60315723D1 (de) Herstellung von Polyketiden und anderen natürlichen Produkten
AR001864A1 (es) Variantes de subtilasa un procedimiento para su obtención un proceso que comprende una mutación en el adn que codifica una subtilasa una secuencia de adn que codifica una subtilasa un vector y un huesped microbiano
BRPI0410681A (pt) moléculas de ácido nucléico isoladas, polipeptìdio, gene quimérico, célula hospedeira transformada, métodos para a produção de ácido linoléico e de ácidos graxos w-3, método para modular a biosìntese de ácidos graxos w-3 ou w-6, óleo microbial, e métodos para a obtenção de uma molécula de ácido nucléico
ATE334206T1 (de) Delta6-acetylenase und delta6-desaturase aus ceratodon purpureus
EP1446500A4 (en) METHOD OF REGULATING IMMUNE FUNCTION IN PRIMATES USING FOXP3 PROTEIN
DE69231745D1 (de) Gensequenzen kodierend für Flavonoid-Stoffwechselwegenzyme und deren Verwendung
ATE502116T1 (de) Fluoreszierende proteine aus nicht- biolumineszenten arten der klasse anthozoa, gene die diese proteine kodieren und deren verwendungen
AU4744501A (en) Renilla reniformis fluorescent proteins, nucleic acids encoding the fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items
WO2005058945A3 (de) Genvarianten die für proteine aus dem stoffwechselweg von feinchemikalien kodieren
WO2000009693A3 (en) Identification of the gene causing the mouse scurfy phenotype and its human ortholog
ATE335075T1 (de) L-aminosäure-oxidase aus rhodococcus-arten
WO2004024898A3 (en) Nematode fatty acid desaturase-like sequences
DK1005532T3 (da) Isolerede nukleinsyremolekyler kodende for SSX familiemedlemmer og anvendelser deraf
AU2002346803A1 (en) Genes encoding for carbon metabolism and energy-producing proteins
DK1032683T3 (da) Polypeptider med 5-aminolevulinsyre-syntase-aktivitet og nukleinsyrer, der koder for disse
ATE319821T1 (de) Verfahren und produkt zur regulation der reaktionsempfindlichkeit von zellen auf externe signale

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1911837

Country of ref document: EP