ATE442450T1 - Neue expressionswerkzeuge für multiproteinanwendungen - Google Patents
Neue expressionswerkzeuge für multiproteinanwendungenInfo
- Publication number
- ATE442450T1 ATE442450T1 AT04803271T AT04803271T ATE442450T1 AT E442450 T1 ATE442450 T1 AT E442450T1 AT 04803271 T AT04803271 T AT 04803271T AT 04803271 T AT04803271 T AT 04803271T AT E442450 T1 ATE442450 T1 AT E442450T1
- Authority
- AT
- Austria
- Prior art keywords
- multiprotein
- applications
- new expression
- host cells
- expression tools
- Prior art date
Links
- 241000701447 unidentified baculovirus Species 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 244000292604 Salvia columbariae Species 0.000 abstract 1
- 235000012377 Salvia columbariae var. columbariae Nutrition 0.000 abstract 1
- 235000001498 Salvia hispanica Nutrition 0.000 abstract 1
- 235000014167 chia Nutrition 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14041—Use of virus, viral particle or viral elements as a vector
- C12N2710/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vectore
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/70—Vectors containing special elements for cloning, e.g. topoisomerase, adaptor sites
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55207204P | 2004-03-09 | 2004-03-09 | |
| PCT/EP2004/013381 WO2005085456A1 (en) | 2004-03-09 | 2004-11-25 | New expression tools for multiprotein applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE442450T1 true ATE442450T1 (de) | 2009-09-15 |
Family
ID=34919595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04803271T ATE442450T1 (de) | 2004-03-09 | 2004-11-25 | Neue expressionswerkzeuge für multiproteinanwendungen |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20080004228A1 (de) |
| EP (2) | EP2133428A1 (de) |
| JP (1) | JP4597188B2 (de) |
| AT (1) | ATE442450T1 (de) |
| AU (1) | AU2004316874B2 (de) |
| CA (1) | CA2558313C (de) |
| DE (1) | DE602004023128D1 (de) |
| ES (1) | ES2333228T3 (de) |
| WO (1) | WO2005085456A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2468881A3 (de) | 2005-07-21 | 2012-08-15 | Abbott Laboratories | Mehrfache Genexpression mit sORF-Konstrukten und Verfahren mit Polyproteinen, Pro-Proteinen und Proteolyse |
| EP1783228A1 (de) * | 2005-11-08 | 2007-05-09 | ETH Zürich | Rekombinante Expression von Multiproteinkomplexen mit Hilfe von Multigenen |
| JP5152962B2 (ja) * | 2007-06-08 | 2013-02-27 | 国立大学法人静岡大学 | 目的タンパク質の製造方法 |
| GB0820631D0 (en) | 2008-11-11 | 2008-12-17 | London School Hygiene & Tropical Medicine | Vectors |
| EP2403940B1 (de) | 2009-03-06 | 2015-10-07 | Europäisches Laboratorium für Molekularbiologie (EMBL) | Nukleinsäuren zur klonierung und expression von multiproteinkomplexen |
| US20120115207A1 (en) * | 2009-04-03 | 2012-05-10 | Deutsches Krebsforschungszentrum | Enhanced production of papillomavirus-like particles with a modified baculovirus expression system |
| EP2952581A1 (de) * | 2009-05-01 | 2015-12-09 | Redbiotec AG | Rekombinante virusähnliche partikel, die durch einen mehrfachgenvektor codiert sind |
| CN101947317B (zh) * | 2010-09-27 | 2012-05-30 | 武汉大学 | 一种h5n1禽流感病毒样颗粒疫苗的规模化制备方法 |
| FR2978456B1 (fr) | 2011-07-27 | 2015-02-20 | Genethon | Systeme baculoviral pour l'expression d'un vecteur de therapie genique |
| US8945876B2 (en) | 2011-11-23 | 2015-02-03 | University Of Hawaii | Auto-processing domains for polypeptide expression |
| KR101328481B1 (ko) * | 2011-12-30 | 2013-11-13 | 이화여자대학교 산학협력단 | 염색체 통합용 효모 발현 벡터 및 이의 용도 |
| WO2013100713A2 (ko) * | 2011-12-30 | 2013-07-04 | 이화여자대학교 산학협력단 | 효모 염색체 통합 또는 산업 스트레인 형질전환용 효모 발현 벡터, 그리고 이들의 용도 |
| US9982239B2 (en) | 2012-06-12 | 2018-05-29 | Alternative Gene Expression S.L. | Baculoviral DNA elements for the expression of recombinant proteins in a host cell |
| ES2612854T3 (es) * | 2012-06-12 | 2017-05-19 | Alternative Gene Expression, S.L. | Elementos de ADN recombinante para la expresión de proteínas recombinantes en una célula huésped |
| CN105392362B (zh) | 2012-06-12 | 2018-11-09 | 替代基因表达公司 | 用于在宿主昆虫中表达重组蛋白的杆状病毒dna元件 |
| EP2970989A1 (de) * | 2013-03-14 | 2016-01-20 | Friedrich Miescher Institute for Biomedical Research | Verfahren zur herstellung von polycystronischen vektoren |
| WO2016114405A1 (ja) | 2015-01-16 | 2016-07-21 | 国立研究開発法人産業技術総合研究所 | ステルス性を有するｒｎａを使った遺伝子発現系および当該ｒｎａを含む遺伝子導入・発現ベクター |
| CN104630271A (zh) * | 2015-02-05 | 2015-05-20 | 浙江大学 | 可视化红色荧光杆状病毒的构建方法 |
| US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| US10262981B2 (en) * | 2016-04-29 | 2019-04-16 | Taiwan Semiconductor Manufacturing Company, Ltd. | Integrated circuit, system for and method of forming an integrated circuit |
| CN107988259B (zh) * | 2018-01-12 | 2020-01-21 | 中国科学院生物物理研究所 | SmartBac杆状病毒表达系统及其应用 |
| JP2021532836A (ja) | 2018-07-31 | 2021-12-02 | イモフォロン リミテッド | アデノウイルス ペントンベースのゼリーロールフォールドドメイン由来である多量体化ポリペプチド |
| JP2022512621A (ja) * | 2018-10-05 | 2022-02-07 | ボイジャー セラピューティクス インコーポレイテッド | Ａａｖ産生タンパク質をコードする操作された核酸コンストラクト |
| US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| BR112021026356A2 (pt) * | 2019-06-26 | 2022-04-12 | Virovek Inc | Sistema de expressão de baculovirus |
| WO2021110993A1 (en) * | 2019-12-04 | 2021-06-10 | Synbionik Gmbh | An efficient shuttle vector system for the expression of heterologous and homologous proteins for the genus zymomonas |
| MX2022009574A (es) | 2020-02-05 | 2022-11-16 | Imophoron Ltd | Polipéptidos modificados derivados de dominio variable de la base pentona de adenovirus. |
| CN111593072B (zh) * | 2020-05-12 | 2021-04-27 | 深圳海关动植物检验检疫技术中心 | 一种在昆虫细胞中共表达非洲猪瘟病毒四种结构蛋白的方法及其应用 |
| AU2021291071A1 (en) | 2020-06-18 | 2023-02-23 | Halo Therapeutics Ltd | Fatty acid complexes of coronavirus spike protein and their use |
| US11857622B2 (en) | 2020-06-21 | 2024-01-02 | Pfizer Inc. | Human cytomegalovirus GB polypeptide |
| EP4392566A2 (de) * | 2021-08-23 | 2024-07-03 | Bioverativ Therapeutics Inc. | Baculovirus-expressionssystem |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169784A (en) * | 1990-09-17 | 1992-12-08 | The Texas A & M University System | Baculovirus dual promoter expression vector |
| US5871986A (en) * | 1994-09-23 | 1999-02-16 | The General Hospital Corporation | Use of a baculovirus to express and exogenous gene in a mammalian cell |
| US6355240B1 (en) * | 1995-07-26 | 2002-03-12 | Basf Aktiengellschaft | Enhanced insecticidal insect virus through the expression of heterologous proteins with early promoters |
| CA2438153C (en) * | 2001-02-14 | 2015-06-02 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| AU2003253992A1 (en) * | 2002-07-18 | 2004-02-09 | Robert P. Bennett | Viral vectors containing recombination sites |
-
2004
- 2004-11-25 JP JP2007502200A patent/JP4597188B2/ja not_active Expired - Fee Related
- 2004-11-25 EP EP09011354A patent/EP2133428A1/de not_active Withdrawn
- 2004-11-25 EP EP04803271A patent/EP1723246B1/de not_active Not-in-force
- 2004-11-25 AU AU2004316874A patent/AU2004316874B2/en not_active Ceased
- 2004-11-25 AT AT04803271T patent/ATE442450T1/de not_active IP Right Cessation
- 2004-11-25 ES ES04803271T patent/ES2333228T3/es active Active
- 2004-11-25 CA CA2558313A patent/CA2558313C/en not_active Expired - Fee Related
- 2004-11-25 DE DE602004023128T patent/DE602004023128D1/de active Active
- 2004-11-25 WO PCT/EP2004/013381 patent/WO2005085456A1/en not_active Application Discontinuation
- 2004-11-25 US US10/592,066 patent/US20080004228A1/en not_active Abandoned
-
2015
- 2015-12-11 US US14/966,258 patent/US20160177336A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004316874B2 (en) | 2011-01-06 |
| CA2558313A1 (en) | 2005-09-15 |
| ES2333228T3 (es) | 2010-02-18 |
| EP1723246B1 (de) | 2009-09-09 |
| DE602004023128D1 (de) | 2009-10-22 |
| CA2558313C (en) | 2011-05-17 |
| JP4597188B2 (ja) | 2010-12-15 |
| EP2133428A1 (de) | 2009-12-16 |
| AU2004316874A1 (en) | 2005-09-15 |
| US20080004228A1 (en) | 2008-01-03 |
| WO2005085456A1 (en) | 2005-09-15 |
| EP1723246A1 (de) | 2006-11-22 |
| US20160177336A1 (en) | 2016-06-23 |
| JP2007527722A (ja) | 2007-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |