CY1112734T1 - Πρωτεϊνικος παραγοντας αυξησης παραγωγικοτητας, πρωτοτυπες κυτταρικες σειρες και χρησεις αυτων - Google Patents

Πρωτεϊνικος παραγοντας αυξησης παραγωγικοτητας, πρωτοτυπες κυτταρικες σειρες και χρησεις αυτων

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Publication number
CY1112734T1
CY1112734T1 CY20121100350T CY121100350T CY1112734T1 CY 1112734 T1 CY1112734 T1 CY 1112734T1 CY 20121100350 T CY20121100350 T CY 20121100350T CY 121100350 T CY121100350 T CY 121100350T CY 1112734 T1 CY1112734 T1 CY 1112734T1
Authority
CY
Cyprus
Prior art keywords
original cell
cell series
increase factor
productivity increase
protein productivity
Prior art date
Application number
CY20121100350T
Other languages
English (en)
Inventor
Volker Sandig
Ingo Jordan
Elisabeth Brundke
Original Assignee
Probiogen Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Probiogen Ag filed Critical Probiogen Ag
Publication of CY1112734T1 publication Critical patent/CY1112734T1/el

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/075—Adenoviridae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16651—Methods of production or purification of viral material
    • C12N2710/16652—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει μέθοδο παρασκευής μη-αδενοϊικού ιού-στόχου ή πρωτεϊνών-στόχων χρησιμοποιώντας σειρά κυττάρων ισχυρής έκφρασης που έχουν σταθερά ενσωματωμένο στο γονιδίωμά τους γονίδιο που κωδικοποιεί ειδική ετερόλογη ρυθμιστική πρωτεΐνη.
CY20121100350T 2005-11-08 2012-04-09 Πρωτεϊνικος παραγοντας αυξησης παραγωγικοτητας, πρωτοτυπες κυτταρικες σειρες και χρησεις αυτων CY1112734T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05110453A EP1783210A1 (en) 2005-11-08 2005-11-08 Productivity augmenting protein factors, novel cell lines and uses thereof
US75015605P 2005-12-14 2005-12-14
EP06807777A EP1945760B1 (en) 2005-11-08 2006-11-08 Productivity augmenting protein factor, novel cell lines and uses thereof

Publications (1)

Publication Number Publication Date
CY1112734T1 true CY1112734T1 (el) 2016-02-10

Family

ID=35985267

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100350T CY1112734T1 (el) 2005-11-08 2012-04-09 Πρωτεϊνικος παραγοντας αυξησης παραγωγικοτητας, πρωτοτυπες κυτταρικες σειρες και χρησεις αυτων

Country Status (20)

Country Link
US (1) US8815540B2 (el)
EP (2) EP1783210A1 (el)
JP (1) JP5468780B2 (el)
KR (1) KR101311973B1 (el)
CN (1) CN101356265B (el)
AT (1) ATE542890T1 (el)
AU (1) AU2006310999B2 (el)
BR (1) BRPI0618369B1 (el)
CA (1) CA2628689C (el)
CY (1) CY1112734T1 (el)
DK (1) DK1945760T3 (el)
ES (1) ES2380975T3 (el)
IL (1) IL191327A (el)
MY (1) MY147959A (el)
NZ (1) NZ568482A (el)
PL (1) PL1945760T3 (el)
PT (1) PT1945760E (el)
RU (1) RU2449015C2 (el)
SI (1) SI1945760T1 (el)
WO (1) WO2007054516A1 (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2098590A1 (en) * 2008-03-04 2009-09-09 ProBioGen AG Cell line from Rousettus as host cell for pathogen amplification
US8679839B2 (en) 2008-03-04 2014-03-25 Probiogen Ag Cell line from rousettus as host cell for pathogen amplification
EP2199385A1 (en) * 2008-12-16 2010-06-23 ProBioGen AG Specific and persistent activation of heat shock response in cell lines using a viral factor
CN108795983A (zh) * 2018-06-28 2018-11-13 深圳市疾病预防控制中心（深圳市卫生检验中心、深圳市预防医学研究所） 一种RXRα蛋白稳定高表达细胞系及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5804413A (en) * 1992-07-31 1998-09-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Herpes simplex virus strains for gene transfer
US5989805A (en) * 1995-10-27 1999-11-23 Board Of Trustees Operating Michigan State University Immortal avian cell line to grow avian and animal viruses to produce vaccines
CA2328087A1 (en) * 1998-05-01 1999-11-11 Abraham Scaria Partially deleted adenoviral vectors
WO1999057296A1 (en) * 1998-05-01 1999-11-11 Genzyme Corporation Partially deleted adenoviral vectors
EP1390398A2 (en) * 2001-05-30 2004-02-25 Transgene S.A. Adenovirus protein ix, its domains involved in capsid assembly, transcriptional activity and nuclear reorganization
EP1528101A1 (en) * 2003-11-03 2005-05-04 ProBioGen AG Immortalized avian cell lines for virus production
EA014190B1 (ru) * 2005-11-04 2010-10-29 Новартис Вэксинс Энд Диагностикс Срл Вакцины против гриппа, адсорбированные на алюминиевых адъювантах, для немедленного приёма

Also Published As

Publication number Publication date
EP1783210A1 (en) 2007-05-09
AU2006310999B2 (en) 2012-04-12
KR20080068104A (ko) 2008-07-22
RU2449015C2 (ru) 2012-04-27
NZ568482A (en) 2011-06-30
DK1945760T3 (da) 2012-03-05
PT1945760E (pt) 2012-03-28
WO2007054516A1 (en) 2007-05-18
JP5468780B2 (ja) 2014-04-09
JP2009514544A (ja) 2009-04-09
ES2380975T3 (es) 2012-05-22
CN101356265A (zh) 2009-01-28
EP1945760B1 (en) 2012-01-25
EP1945760A1 (en) 2008-07-23
CA2628689A1 (en) 2007-05-18
SI1945760T1 (sl) 2012-03-30
CA2628689C (en) 2014-02-25
PL1945760T3 (pl) 2012-05-31
BRPI0618369A2 (pt) 2011-08-30
BRPI0618369B1 (pt) 2022-04-12
AU2006310999A1 (en) 2007-05-18
US20120164727A1 (en) 2012-06-28
MY147959A (en) 2013-02-15
ATE542890T1 (de) 2012-02-15
US8815540B2 (en) 2014-08-26
CN101356265B (zh) 2013-04-03
RU2008122920A (ru) 2009-12-20
IL191327A (en) 2013-03-24
KR101311973B1 (ko) 2013-09-27

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