ATE429242T1 - Verfahren zur identifizierung von verbindungen zur regulierung der muskelmasse oder -funktion unter verwendung von corticotropin-releasing- factor-rezeptoren - Google Patents

Verfahren zur identifizierung von verbindungen zur regulierung der muskelmasse oder -funktion unter verwendung von corticotropin-releasing- factor-rezeptoren

Info

Publication number
ATE429242T1
ATE429242T1 AT02731122T AT02731122T ATE429242T1 AT E429242 T1 ATE429242 T1 AT E429242T1 AT 02731122 T AT02731122 T AT 02731122T AT 02731122 T AT02731122 T AT 02731122T AT E429242 T1 ATE429242 T1 AT E429242T1
Authority
AT
Austria
Prior art keywords
function
muscle mass
factor receptors
releasing factor
identifying compounds
Prior art date
Application number
AT02731122T
Other languages
English (en)
Inventor
Robert Isfort
Russell Sheldon
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Application granted granted Critical
Publication of ATE429242T1 publication Critical patent/ATE429242T1/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
AT02731122T 2001-03-06 2002-03-06 Verfahren zur identifizierung von verbindungen zur regulierung der muskelmasse oder -funktion unter verwendung von corticotropin-releasing- factor-rezeptoren ATE429242T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/799,978 US6670140B2 (en) 2001-03-06 2001-03-06 Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors
PCT/US2002/007476 WO2002069908A2 (en) 2001-03-06 2002-03-06 Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors

Publications (1)

Publication Number Publication Date
ATE429242T1 true ATE429242T1 (de) 2009-05-15

Family

ID=25177205

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02731122T ATE429242T1 (de) 2001-03-06 2002-03-06 Verfahren zur identifizierung von verbindungen zur regulierung der muskelmasse oder -funktion unter verwendung von corticotropin-releasing- factor-rezeptoren

Country Status (28)

Country Link
US (3) US6670140B2 (de)
EP (1) EP1379873B1 (de)
JP (2) JP4331942B2 (de)
KR (2) KR100598441B1 (de)
CN (1) CN100520408C (de)
AR (1) AR032957A1 (de)
AT (1) ATE429242T1 (de)
AU (1) AU2002303121B2 (de)
BR (1) BR0207881A (de)
CA (1) CA2439170C (de)
CZ (1) CZ20032395A3 (de)
DE (1) DE60232063D1 (de)
ES (1) ES2325485T3 (de)
HU (1) HUP0402173A2 (de)
IL (1) IL157330A0 (de)
MA (1) MA26990A1 (de)
MX (1) MXPA03008114A (de)
MY (1) MY134755A (de)
NO (1) NO20033936L (de)
NZ (1) NZ527124A (de)
PE (1) PE20020993A1 (de)
PL (1) PL367187A1 (de)
RU (1) RU2260805C2 (de)
SA (1) SA02230159B1 (de)
SK (1) SK12132003A3 (de)
TW (1) TWI227780B (de)
WO (1) WO2002069908A2 (de)
ZA (1) ZA200305642B (de)

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WO2002012307A1 (en) * 2000-08-04 2002-02-14 Research Development Foundation Urocortin proteins and uses thereof
WO2002024732A2 (en) * 2000-09-22 2002-03-28 Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften Methods for improving the antagonistic/agonistic properties of peptidic antagonists/agonists of the corticotropin-releasing factor receptor (crfr)
US6670140B2 (en) * 2001-03-06 2003-12-30 The Procter & Gamble Company Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors
US6936585B2 (en) * 2002-01-16 2005-08-30 The Procter & Gamble Company Corticotropin releasing factor 2 receptor agonists
WO2007090087A2 (en) * 2006-01-27 2007-08-09 Research Development Foundation Use of corticotropin releasing factor receptor-2 inhibitors for treating insulin-related diseases
WO2008047241A2 (en) * 2006-10-16 2008-04-24 Conjuchem Biotechnologies Inc. Modified corticotropin releasing factor peptides and uses thereof
GB0624282D0 (en) * 2006-12-05 2007-01-10 Cavalla David Treatment of cachexia
CA2687908A1 (en) * 2007-05-23 2008-12-04 Pharmacome Llc G-protein-conjugated receptor having altered ligand affinity, and use thereof
US8334101B2 (en) * 2008-09-26 2012-12-18 University Of Massachusetts Intracellular DNA receptor
PH12022550598A1 (en) * 2010-12-23 2024-03-11 Amazentis Sa Compositions and methods for improving mitochondrial function and treating neurodenegenerative diseases and cognitive disorders
DK2780368T3 (en) * 2011-11-14 2018-02-05 Regeneron Pharma COMPOSITIONS AND PROCEDURES FOR INCREASING MUSCLE MASS AND MUSCLE STRENGTH BY SPECIFIC ANTAGONIZATION OF GDF8 AND / OR ACTIVIN A
RU2517259C1 (ru) * 2013-03-06 2014-05-27 Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации - Институт медико-биологических проблем Российской академии наук (ГНЦ РФ-ИМБП РАН) Способ профилактики и снижения деструкции белков скелетных мышц при их атрофии, вызванной гипокинезией и/или гравитационной разгрузкой
JP2015071549A (ja) * 2013-10-02 2015-04-16 株式会社ファンケル アトロジン−１抑制剤
RU2568903C2 (ru) * 2014-04-07 2015-11-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Алтайский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ оценки анаболического действия лекарственных препаратов
KR20170135967A (ko) 2015-04-15 2017-12-08 리제너론 파마슈티칼스 인코포레이티드 Gdf8 억제제를 사용하여 강도 및 기능을 증가시키는 방법
KR20190084055A (ko) * 2016-10-20 2019-07-15 코르텐 인코포레이티드 부적응 스트레스 반응에서 기인한 질환의 치료 방법
MX2020008991A (es) 2018-03-01 2020-12-10 Regeneron Pharma Metodos para alterar la composicion corporal.
CN119746078B (zh) * 2025-03-04 2025-05-30 华中科技大学 一种参与396,404位点丝氨酸磷酸化tau蛋白聚集mRNA的筛选方法及其应用

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US4415558A (en) * 1981-06-08 1983-11-15 The Salk Institute For Biological Studies CRF And analogs
US4533654A (en) * 1982-09-29 1985-08-06 The Salk Institute For Biological Studies Urotensin peptides
US4489163A (en) * 1983-04-14 1984-12-18 The Salk Institute For Biological Studies rCRF and analogs
US4605642A (en) * 1984-02-23 1986-08-12 The Salk Institute For Biological Studies CRF antagonists
US4594329A (en) * 1984-05-14 1986-06-10 The Salk Institute For Biological Studies CRF analogs
US4801612A (en) * 1986-07-03 1989-01-31 Regents Of The University Of California Method of inhibiting inflammatory response
DE3703340A1 (de) * 1987-02-04 1988-08-18 Dirck Dr Med Oppermann Pharmazeutische zubereitung zur behandlung der herzinsuffizienz
US4908352A (en) * 1987-09-28 1990-03-13 The Salk Institute For Biological Studies Urotensin peptides
US5109111A (en) * 1988-09-23 1992-04-28 The Salk Institute For Biological Studies CRF antagonists
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ATE171212T1 (de) * 1994-06-14 1998-10-15 Neurocrine Biosciences Inc Corticotropin freisetzende rezeptoren des faktor 2
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US5786203A (en) * 1994-06-14 1998-07-28 Neurocrine Biosciences, Inc. Isolated nucleic acid encoding corticotropin-releasing factor2 receptors
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WO2002012307A1 (en) * 2000-08-04 2002-02-14 Research Development Foundation Urocortin proteins and uses thereof
US6670140B2 (en) * 2001-03-06 2003-12-30 The Procter & Gamble Company Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors

Also Published As

Publication number Publication date
SA02230159B1 (ar) 2007-05-06
PE20020993A1 (es) 2002-12-20
NO20033936D0 (no) 2003-09-05
JP2009029816A (ja) 2009-02-12
MXPA03008114A (es) 2003-12-12
AU2002303121B2 (en) 2005-11-10
CN1820200A (zh) 2006-08-16
NO20033936L (no) 2003-11-05
TWI227780B (en) 2005-02-11
PL367187A1 (en) 2005-02-21
AR032957A1 (es) 2003-12-03
NZ527124A (en) 2005-11-25
CA2439170A1 (en) 2002-09-12
CN100520408C (zh) 2009-07-29
EP1379873A2 (de) 2004-01-14
CA2439170C (en) 2011-05-10
KR100598441B1 (ko) 2006-07-10
ZA200305642B (en) 2004-06-22
JP4331942B2 (ja) 2009-09-16
WO2002069908A3 (en) 2003-03-20
MY134755A (en) 2007-12-31
CZ20032395A3 (cs) 2004-01-14
BR0207881A (pt) 2005-08-30
US20060198842A1 (en) 2006-09-07
US7063954B2 (en) 2006-06-20
KR100596991B1 (ko) 2006-07-07
MA26990A1 (fr) 2004-12-20
HUP0402173A2 (hu) 2005-01-28
SK12132003A3 (sk) 2004-05-04
RU2260805C2 (ru) 2005-09-20
IL157330A0 (en) 2004-02-19
DE60232063D1 (de) 2009-06-04
US20040101911A1 (en) 2004-05-27
US7572768B2 (en) 2009-08-11
KR20060029704A (ko) 2006-04-06
US6670140B2 (en) 2003-12-30
EP1379873A4 (de) 2006-03-22
US20030165807A1 (en) 2003-09-04
EP1379873B1 (de) 2009-04-22
WO2002069908A2 (en) 2002-09-12
JP2004532394A (ja) 2004-10-21
ES2325485T3 (es) 2009-09-07
RU2003129500A (ru) 2005-03-10
KR20030086289A (ko) 2003-11-07

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