AR032957A1 - Metodos para identificar compuestos para regular la masa o funcion muscular utilizando receptores del factor liberador de corticotropina - Google Patents

Metodos para identificar compuestos para regular la masa o funcion muscular utilizando receptores del factor liberador de corticotropina

Info

Publication number
AR032957A1
AR032957A1 ARP020100806A ARP020100806A AR032957A1 AR 032957 A1 AR032957 A1 AR 032957A1 AR P020100806 A ARP020100806 A AR P020100806A AR P020100806 A ARP020100806 A AR P020100806A AR 032957 A1 AR032957 A1 AR 032957A1
Authority
AR
Argentina
Prior art keywords
crf2r
candidate compounds
increase
function
muscle mass
Prior art date
Application number
ARP020100806A
Other languages
English (en)
Inventor
Robert Joseph Isfort
Russell James Sheldon
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of AR032957A1 publication Critical patent/AR032957A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)

Abstract

Un método para identificar compuestos candidatos para regular la masa o funcion muscular esquelética, que comprende: a) contactar un compuesto de prueba con un CRF2R, b) determinar si el compuesto de prueba se fija al CRF2R; y c) identificar aquellos compuestos candidatos para regular la masa o funcion muscular esquelética. Un método para identificar compuestos terapéuticos candidatos de un grupo de uno o más compuestos candidatos que se ha determinado previamente que se fijan a o activan el CRF2R. Un método para identificar compuestos candidatos que prolongan o aumentan la activacion inducida por agonista de un CRF2R o una vía de transduccion de senal de CRF2R. Un método para identificar compuestos candidatos para aumentar la expresion de CRF2R o CRF. Un método para aumentar la masa o funcion muscular esquelética en un sujeto en que el aumento es deseable. Un método para tratar la atrofia muscular esquelética en un sujeto que requiere de tal tratamiento. Un anticuerpo purificado específico para un CRF2R en donde el anticuerpo es un anticuerpo quimérico o humano. Una composicion farmacéutica que comprende a) una cantidad segura y eficaz de un agonista de CRF2R y b) un portador farmacéuticamente aceptable.
ARP020100806A 2001-03-06 2002-03-06 Metodos para identificar compuestos para regular la masa o funcion muscular utilizando receptores del factor liberador de corticotropina AR032957A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/799,978 US6670140B2 (en) 2001-03-06 2001-03-06 Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors

Publications (1)

Publication Number Publication Date
AR032957A1 true AR032957A1 (es) 2003-12-03

Family

ID=25177205

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020100806A AR032957A1 (es) 2001-03-06 2002-03-06 Metodos para identificar compuestos para regular la masa o funcion muscular utilizando receptores del factor liberador de corticotropina

Country Status (28)

Country Link
US (3) US6670140B2 (es)
EP (1) EP1379873B1 (es)
JP (2) JP4331942B2 (es)
KR (2) KR100596991B1 (es)
CN (1) CN100520408C (es)
AR (1) AR032957A1 (es)
AT (1) ATE429242T1 (es)
AU (1) AU2002303121B2 (es)
BR (1) BR0207881A (es)
CA (1) CA2439170C (es)
CZ (1) CZ20032395A3 (es)
DE (1) DE60232063D1 (es)
ES (1) ES2325485T3 (es)
HU (1) HUP0402173A2 (es)
IL (1) IL157330A0 (es)
MA (1) MA26990A1 (es)
MX (1) MXPA03008114A (es)
MY (1) MY134755A (es)
NO (1) NO20033936L (es)
NZ (1) NZ527124A (es)
PE (1) PE20020993A1 (es)
PL (1) PL367187A1 (es)
RU (1) RU2260805C2 (es)
SA (1) SA02230159B1 (es)
SK (1) SK12132003A3 (es)
TW (1) TWI227780B (es)
WO (1) WO2002069908A2 (es)
ZA (1) ZA200305642B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL154102A0 (en) * 2000-08-04 2003-07-31 Res Dev Foundation Urocortin proteins and uses thereof
AU2001289916A1 (en) * 2000-09-22 2002-04-02 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Methods for improving the antagonistic/agonistic properties of peptidic antagonists/agonists of the corticotropin-releasing factor receptor (crfr)
US6670140B2 (en) * 2001-03-06 2003-12-30 The Procter & Gamble Company Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors
US6936585B2 (en) * 2002-01-16 2005-08-30 The Procter & Gamble Company Corticotropin releasing factor 2 receptor agonists
US7815905B2 (en) * 2006-01-27 2010-10-19 Research Development Foundation Methods of increasing insulin sensitivity or decreasing insulin secretion by administering corticotropin releasing factor receptor-2 inhibitors
WO2008047241A2 (en) * 2006-10-16 2008-04-24 Conjuchem Biotechnologies Inc. Modified corticotropin releasing factor peptides and uses thereof
GB0624282D0 (en) * 2006-12-05 2007-01-10 Cavalla David Treatment of cachexia
US8173378B2 (en) * 2007-05-23 2012-05-08 Pharmacome Llc Methods of using an alpha-1-adrenergic receptor having altered ligand affinity
WO2010036918A2 (en) * 2008-09-26 2010-04-01 University Of Massachusetts Intracellular dna receptor
SG10201602286RA (en) * 2010-12-23 2016-04-28 Amazentis Sa Compositions and methods for improving mitochondrial function and treating neurodegenerative diseases and cognitive disorders
WO2013074557A1 (en) * 2011-11-14 2013-05-23 Regeneron Pharmaceuticals, Inc. Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing gdf8 and/or activin a
RU2517259C1 (ru) * 2013-03-06 2014-05-27 Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации - Институт медико-биологических проблем Российской академии наук (ГНЦ РФ-ИМБП РАН) Способ профилактики и снижения деструкции белков скелетных мышц при их атрофии, вызванной гипокинезией и/или гравитационной разгрузкой
JP2015071549A (ja) * 2013-10-02 2015-04-16 株式会社ファンケル アトロジン−１抑制剤
RU2568903C2 (ru) * 2014-04-07 2015-11-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Алтайский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ оценки анаболического действия лекарственных препаратов
JP2019533021A (ja) 2016-10-20 2019-11-14 コーティーン インコーポレイテッド 不適応のストレス応答に寄与する疾患を処置する方法
MX2020008991A (es) 2018-03-01 2020-12-10 Regeneron Pharma Metodos para alterar la composicion corporal.

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US4489163A (en) * 1983-04-14 1984-12-18 The Salk Institute For Biological Studies rCRF and analogs
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US6670140B2 (en) * 2001-03-06 2003-12-30 The Procter & Gamble Company Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors

Also Published As

Publication number Publication date
CZ20032395A3 (cs) 2004-01-14
DE60232063D1 (de) 2009-06-04
US7572768B2 (en) 2009-08-11
EP1379873A4 (en) 2006-03-22
ES2325485T3 (es) 2009-09-07
US6670140B2 (en) 2003-12-30
EP1379873B1 (en) 2009-04-22
BR0207881A (pt) 2005-08-30
NO20033936L (no) 2003-11-05
JP4331942B2 (ja) 2009-09-16
TWI227780B (en) 2005-02-11
CA2439170C (en) 2011-05-10
IL157330A0 (en) 2004-02-19
WO2002069908A2 (en) 2002-09-12
PE20020993A1 (es) 2002-12-20
CN1820200A (zh) 2006-08-16
RU2260805C2 (ru) 2005-09-20
AU2002303121B2 (en) 2005-11-10
US20030165807A1 (en) 2003-09-04
MA26990A1 (fr) 2004-12-20
KR20060029704A (ko) 2006-04-06
RU2003129500A (ru) 2005-03-10
ZA200305642B (en) 2004-06-22
US20040101911A1 (en) 2004-05-27
JP2009029816A (ja) 2009-02-12
US7063954B2 (en) 2006-06-20
KR100598441B1 (ko) 2006-07-10
HUP0402173A2 (hu) 2005-01-28
PL367187A1 (en) 2005-02-21
KR20030086289A (ko) 2003-11-07
EP1379873A2 (en) 2004-01-14
SK12132003A3 (sk) 2004-05-04
JP2004532394A (ja) 2004-10-21
KR100596991B1 (ko) 2006-07-07
US20060198842A1 (en) 2006-09-07
NZ527124A (en) 2005-11-25
NO20033936D0 (no) 2003-09-05
ATE429242T1 (de) 2009-05-15
MY134755A (en) 2007-12-31
WO2002069908A3 (en) 2003-03-20
CN100520408C (zh) 2009-07-29
SA02230159B1 (ar) 2007-05-06
CA2439170A1 (en) 2002-09-12
MXPA03008114A (es) 2003-12-12

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