ATE354587T1 - Für den corticotropin-releasing-factor-typ-2- rezeptor (crfr2) spezifische antagonisten - Google Patents
Für den corticotropin-releasing-factor-typ-2- rezeptor (crfr2) spezifische antagonistenInfo
- Publication number
- ATE354587T1 ATE354587T1 AT99940042T AT99940042T ATE354587T1 AT E354587 T1 ATE354587 T1 AT E354587T1 AT 99940042 T AT99940042 T AT 99940042T AT 99940042 T AT99940042 T AT 99940042T AT E354587 T1 ATE354587 T1 AT E354587T1
- Authority
- AT
- Austria
- Prior art keywords
- present
- antagonist
- crfr2
- releasing factor
- relates
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 8
- 102000012289 Corticotropin-Releasing Hormone Human genes 0.000 title 1
- 108010022152 Corticotropin-Releasing Hormone Proteins 0.000 title 1
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 abstract 4
- 108091033319 polynucleotide Proteins 0.000 abstract 4
- 239000002157 polynucleotide Substances 0.000 abstract 4
- 108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 abstract 3
- 102100038018 Corticotropin-releasing factor receptor 1 Human genes 0.000 abstract 3
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 abstract 3
- 241000272517 Anseriformes Species 0.000 abstract 2
- KFUIXDNQSMKKJQ-ZLFMSJRASA-N chembl439883 Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1N(C(=O)CNC(=O)[C@H]2NC(=O)CC2)CCC1 KFUIXDNQSMKKJQ-ZLFMSJRASA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 108010086511 sauvagine Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98113896 | 1998-07-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE354587T1 true ATE354587T1 (de) | 2007-03-15 |
Family
ID=8232340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99940042T ATE354587T1 (de) | 1998-07-24 | 1999-07-23 | Für den corticotropin-releasing-factor-typ-2- rezeptor (crfr2) spezifische antagonisten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6846803B1 (de) |
| EP (1) | EP1100819B1 (de) |
| AT (1) | ATE354587T1 (de) |
| AU (1) | AU765512B2 (de) |
| CA (1) | CA2338561A1 (de) |
| DE (1) | DE69935227T2 (de) |
| WO (1) | WO2000005253A2 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6670140B2 (en) | 2001-03-06 | 2003-12-30 | The Procter & Gamble Company | Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors |
| AU2011348220B2 (en) | 2010-12-22 | 2017-09-07 | The Salk Institute For Biological Studies | Cyclic CRF antagonist peptides |
| KR20190060642A (ko) * | 2017-11-24 | 2019-06-03 | 고쿠리츠 다이가쿠 호우징 나고야 다이가쿠 | 심부전의 예방 또는 치료용 의약 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58183657A (ja) * | 1982-04-13 | 1983-10-26 | フア−ミタリア・カルロ・エルバ・ソシエタ・ペル・アツイオ−ニ | 生物学的に活性なペプチド |
| US5464757A (en) * | 1991-01-15 | 1995-11-07 | The Salk Institute For Biological Studies | DNA encoding CRF binding protein |
| US5663292A (en) * | 1994-12-12 | 1997-09-02 | The Salk Institute For Biological Studies | Cyclic CRF analogs |
-
1999
- 1999-07-23 DE DE69935227T patent/DE69935227T2/de not_active Expired - Lifetime
- 1999-07-23 US US09/744,441 patent/US6846803B1/en not_active Expired - Fee Related
- 1999-07-23 WO PCT/EP1999/005297 patent/WO2000005253A2/en not_active Ceased
- 1999-07-23 EP EP99940042A patent/EP1100819B1/de not_active Expired - Lifetime
- 1999-07-23 AT AT99940042T patent/ATE354587T1/de not_active IP Right Cessation
- 1999-07-23 CA CA002338561A patent/CA2338561A1/en not_active Abandoned
- 1999-07-23 AU AU54131/99A patent/AU765512B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000005253A3 (en) | 2000-06-15 |
| EP1100819B1 (de) | 2007-02-21 |
| AU5413199A (en) | 2000-02-14 |
| DE69935227D1 (de) | 2007-04-05 |
| WO2000005253A9 (en) | 2000-07-27 |
| DE69935227T2 (de) | 2007-10-31 |
| AU765512B2 (en) | 2003-09-18 |
| EP1100819A2 (de) | 2001-05-23 |
| US6846803B1 (en) | 2005-01-25 |
| CA2338561A1 (en) | 2000-02-03 |
| WO2000005253A2 (en) | 2000-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |