ATE411987T1 - Dna-pk-inhibitoren - Google Patents
Dna-pk-inhibitorenInfo
- Publication number
- ATE411987T1 ATE411987T1 AT02751439T AT02751439T ATE411987T1 AT E411987 T1 ATE411987 T1 AT E411987T1 AT 02751439 T AT02751439 T AT 02751439T AT 02751439 T AT02751439 T AT 02751439T AT E411987 T1 ATE411987 T1 AT E411987T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- dna
- ring
- activity
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0119865.4A GB0119865D0 (en) | 2001-08-14 | 2001-08-14 | DNA-PK inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE411987T1 true ATE411987T1 (de) | 2008-11-15 |
Family
ID=9920420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02751439T ATE411987T1 (de) | 2001-08-14 | 2002-08-14 | Dna-pk-inhibitoren |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7226918B2 (de) |
| EP (1) | EP1417196B1 (de) |
| JP (1) | JP4332032B2 (de) |
| KR (1) | KR100905457B1 (de) |
| CN (1) | CN1279034C (de) |
| AT (1) | ATE411987T1 (de) |
| AU (1) | AU2002362385B2 (de) |
| BR (1) | BR0211889A (de) |
| CA (1) | CA2454023A1 (de) |
| CY (1) | CY1110269T1 (de) |
| DE (1) | DE60229531D1 (de) |
| DK (1) | DK1417196T3 (de) |
| ES (1) | ES2315377T3 (de) |
| GB (2) | GB0119865D0 (de) |
| HK (1) | HK1070368A1 (de) |
| HU (1) | HUP0401052A3 (de) |
| MX (1) | MXPA04000804A (de) |
| NO (1) | NO20040636L (de) |
| NZ (1) | NZ530909A (de) |
| PL (1) | PL367081A1 (de) |
| PT (1) | PT1417196E (de) |
| WO (1) | WO2003024949A1 (de) |
| ZA (1) | ZA200400237B (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0119865D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| GB0119863D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| US7049313B2 (en) | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
| SG160211A1 (en) | 2003-04-03 | 2010-04-29 | Semafore Pharmaceuticals Inc | Pi-3 kinase inhibitor prodrugs |
| KR20060066722A (ko) | 2003-08-13 | 2006-06-16 | 쿠도스 파마슈티칼스 리미티드 | 아미노피론 및 ａｔｍ억제제로서의 이의 용도 |
| US20070238731A1 (en) * | 2004-09-20 | 2007-10-11 | Kudos Pharmaceuticals Limited | Dna-Pk Inhibitors |
| CN101115747A (zh) | 2005-02-09 | 2008-01-30 | 库多斯药物有限公司 | Atm抑制剂 |
| AR054438A1 (es) * | 2005-04-15 | 2007-06-27 | Kudos Pharm Ltd | Inhibidores de adn -pk |
| US7909830B2 (en) | 2005-08-25 | 2011-03-22 | Synthes Usa, Llc | Methods of spinal fixation and instrumentation |
| US20070049588A1 (en) * | 2005-08-31 | 2007-03-01 | Kudos Pharmaceuticals Limited | Atm inhibitor |
| JP2009543856A (ja) * | 2006-07-18 | 2009-12-10 | クドス ファーマシューティカルズ リミテッド | ２−アミノ置換４−オキソ−４ｈ−クロメン−８−イル−トリフルオロ−メタンスルホン酸エステルの合成 |
| US8318723B2 (en) * | 2006-08-16 | 2012-11-27 | Boehringer Ingelheim International Gmbh | Pyrazine compounds, their use and methods of preparation |
| WO2009008991A2 (en) * | 2007-07-06 | 2009-01-15 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health | Dna-pkcs modulates energy regulation and brain function |
| UY31232A1 (es) * | 2007-07-19 | 2009-03-02 | Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones | |
| US20110130386A1 (en) * | 2008-04-25 | 2011-06-02 | Mark Frigerio | Dna-pk inhibitors |
| WO2010136778A1 (en) * | 2009-05-29 | 2010-12-02 | Kudos Pharmaceuticals Limited | Dibenzothiophene derivatives as dna- pk inhibitors |
| FR2947548B1 (fr) * | 2009-07-02 | 2012-05-18 | Sanofi Aventis | Nouveaux derives de 1h-pyrimidin-2-one, leur preparation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| JP5680639B2 (ja) * | 2009-07-02 | 2015-03-04 | サノフイ | 新規６−モルホリン−４−イル−ピリミジン−４−（３ｈ）−オン誘導体、およびａｋｔ（ｐｋｂ）リン酸化阻害剤としてのこの医薬調製物 |
| SG10201403138WA (en) | 2009-07-02 | 2014-08-28 | Sanofi Sa | Novel 2,3-dihydro-1h-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof and pharmaceutical use thereof |
| CA2766909C (fr) | 2009-07-02 | 2018-06-05 | Sanofi | Nouveaux derives de 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one,leur preparation et leur utilisation pharmaceutique |
| CN102548970B (zh) * | 2009-07-02 | 2015-11-25 | 赛诺菲 | 新型(6-氧代-1,6-二氢嘧啶-2-基)酰胺衍生物、其制备方法以及其作为akt(pkb)磷酸化抑制剂的医药用途 |
| FR2951170B1 (fr) * | 2009-10-09 | 2011-12-02 | Sanofi Aventis | Nouveaux derives de 1h-pyrimidin-2-one, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| US20130109687A1 (en) * | 2010-04-30 | 2013-05-02 | Gary J. Nabel | Methods of treating hiv infection: inhibition of dna dependent protein kinase |
| SI2655375T1 (sl) | 2010-12-23 | 2015-03-31 | Sanofi | Derivati pirimidinona, njihova priprava in njihova farmacevtska uporaba |
| HUE030393T2 (en) | 2010-12-28 | 2017-05-29 | Sanofi Sa | New pyrimidine derivatives, a process for their preparation, and their pharmaceutical use as inhibitors of AKT (PKB) phosphorylation |
| US8530470B2 (en) * | 2011-04-13 | 2013-09-10 | Astrazeneca Ab | Chromenone derivatives |
| FR2992314B1 (fr) | 2012-06-22 | 2015-10-16 | Sanofi Sa | Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one et 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one comportant une morpholine substituee, leur preparation et leur utilisation pharmaceutique |
| FR2992316A1 (fr) | 2012-06-22 | 2013-12-27 | Sanofi Sa | Derives de pyrimidinones, leur preparation et leur application en therapeutique |
| CN102977063A (zh) * | 2012-11-26 | 2013-03-20 | 盛世泰科生物医药技术(苏州)有限公司 | 一种2-吗啡啉-8-苯基-4-苯并吡喃-4-酮的合成方法 |
| LT3527563T (lt) | 2013-03-12 | 2021-12-10 | Vertex Pharmaceuticals Incorporated | Dnr-pk inhibitoriai |
| EP3042900B1 (de) * | 2013-08-29 | 2020-09-23 | Fujifilm Corporation | Neuartige morpholinderivate oder salz davon |
| US11433047B2 (en) * | 2015-10-09 | 2022-09-06 | Neurotheryx Canada Ltd. | Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases |
| WO2018183868A1 (en) * | 2017-03-31 | 2018-10-04 | Bioventures, Llc | Inhibitors of dna pk and uses thereof |
| WO2020254872A2 (en) | 2019-06-17 | 2020-12-24 | Crispr Therapeutics Ag | Methods and compositions for improved homology directed repair |
| CA3181340A1 (en) | 2020-04-28 | 2021-11-04 | Intellia Therapeutics, Inc. | Methods of in vitro cell delivery |
| US20220228142A1 (en) | 2020-12-17 | 2022-07-21 | Vertex Pharmaceuticals Incorporated | Compositions and methods for editing beta-globin for treatment of hemaglobinopathies |
| WO2022221696A1 (en) | 2021-04-17 | 2022-10-20 | Intellia Therapeutics, Inc. | Inhibitors of dna-dependent protein kinase and compositions and uses thereof |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1303724A (de) | 1969-05-14 | 1973-01-17 | ||
| JPH0753725B2 (ja) * | 1987-10-08 | 1995-06-07 | 富山化学工業株式会社 | ４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤 |
| US5284856A (en) * | 1988-10-28 | 1994-02-08 | Hoechst Aktiengesellschaft | Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives |
| US5703075A (en) * | 1988-12-21 | 1997-12-30 | Pharmacia & Upjohn Company | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
| HUT58310A (en) | 1988-12-21 | 1992-02-28 | Upjohn Co | Anti-atherosclerotic and anti-thrombotic 1-benzopyran-4-one- and 2-amino-1,3-benzoxazin-4-one derivatives, process for producing them and pharmaceutical compositions containing them |
| JPH03215423A (ja) | 1990-01-18 | 1991-09-20 | Kyowa Hakko Kogyo Co Ltd | 血管拡張剤 |
| DE69127690T2 (de) | 1990-06-20 | 1998-02-12 | Pharmacia & Upjohn Company Kal | Antiatherosklerotische und antithrombotische 1-benzopyran-4-on- und 2-amino-1,3-benzoxazin-4-on-derivate |
| ATE128128T1 (de) * | 1990-06-29 | 1995-10-15 | Upjohn Co | Antiatherosclerotische und antithrombotische 2- amino-6-phenyl-4h-pyran-4-one. |
| US5302613A (en) * | 1990-06-29 | 1994-04-12 | The Upjohn Company | Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones |
| US5252735A (en) * | 1990-06-29 | 1993-10-12 | The Upjohn Company | Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones |
| EP0610519B1 (de) | 1992-09-02 | 1999-12-01 | Kyowa Hakko Kogyo Co., Ltd. | Anti-hiv-medikament |
| JP3521145B2 (ja) * | 1993-04-09 | 2004-04-19 | 富山化学工業株式会社 | 免疫調節剤，細胞接着阻害剤および自己免疫疾患の治療・予防剤 |
| US5378725A (en) | 1993-07-19 | 1995-01-03 | The Arizona Board Of Regents | Inhibition of phosphatidylinositol 3-kinase with wortmannin and analogs thereof |
| US5504103A (en) | 1993-08-25 | 1996-04-02 | Eli Lilly And Company | Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof |
| US5441947A (en) | 1993-08-25 | 1995-08-15 | Eli Lilly And Company | Methods of inhibiting vascular restenosis |
| US5468773A (en) | 1993-08-25 | 1995-11-21 | Eli Lilly And Company | Methods for inhibiting bone loss and cartilage degradation using wortmannin and its analogs |
| CA2133815A1 (en) | 1993-10-12 | 1995-04-13 | Jeffrey Alan Dodge | Inhibition of phosphatidylinositol 3-kinase with viridin, demethoxyviridin, viridiol, demethoxyviridiol, virone, wortmannolone, and analogs thereof |
| US6632789B1 (en) | 1994-04-29 | 2003-10-14 | The United States Of America As Represented By The Secretary Of The Navy | Methods for modulating T cell responses by manipulating intracellular signal transduction |
| US5480906A (en) | 1994-07-01 | 1996-01-02 | Eli Lilly And Company | Stereochemical Wortmannin derivatives |
| GB9521987D0 (en) | 1995-10-26 | 1996-01-03 | Ludwig Inst Cancer Res | Phosphoinositide 3-kinase modulators |
| US5733920A (en) * | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
| WO1997018323A2 (en) | 1995-11-16 | 1997-05-22 | Icos Corporation | Cell-cycle checkpoint phosphatidylinositol- (pik-) related kinases, genes coding therefor and methods for assaying and modulating enzymatic activity |
| GB2302021A (en) | 1996-10-16 | 1997-01-08 | Lilly Co Eli | Inhibiting bone loss or resorption |
| EP0990028A4 (de) | 1997-06-06 | 2000-09-27 | Mayo Foundation For Medical | Screening auf inhibitoren der phosphatidylinositol verwandten kinase |
| WO1998056391A1 (en) | 1997-06-13 | 1998-12-17 | President And Fellows Of Harvard College | Methods for treating human cancers |
| FR2776291B1 (fr) | 1998-03-18 | 2000-06-16 | Pf Medicament | Nouveaux derives bis-benzamides, leur procede de fabrication, les compositions pharmaceutiques les contenant et leur utilisation comme medicament |
| US6348311B1 (en) * | 1999-02-10 | 2002-02-19 | St. Jude Childre's Research Hospital | ATM kinase modulation for screening and therapies |
| US6387640B1 (en) * | 1999-02-10 | 2002-05-14 | St. Jude Children's Research Hospital | ATM kinase modulation for screening and therapies |
| EP1257537B1 (de) * | 2000-01-24 | 2007-05-30 | AstraZeneca AB | Durch einen morpholinrest substituierte therapeutische verbindungen |
| CN1245974C (zh) | 2000-06-28 | 2006-03-22 | 特瓦制药工业有限公司 | 卡维地洛 |
| AU2001288432A1 (en) | 2000-09-01 | 2002-03-22 | Icos Corporation | Materials and methods to potentiate cancer treatment |
| ES2236481T3 (es) | 2001-01-16 | 2005-07-16 | Glaxo Group Limited | Combinacion farmaceutica que contiene una 4-quinazolinamina y paclitaxel, carboplatino o vinorelbina para el tratamiento de cancer. |
| GB0119865D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| GB0119863D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| AU2002349912A1 (en) | 2001-10-24 | 2003-05-06 | Iconix Pharmaceuticals, Inc. | Modulators of phosphoinositide 3-kinase |
| US6894055B2 (en) | 2001-10-24 | 2005-05-17 | Iconix Pharmaceuticals Inc. | Thieno-2′,3′ -5,6pyrimido[3,4-A]-1,2,4-triazole derivatives as modulators of phoshoinositide 3-kinase |
| US7049313B2 (en) * | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
| AU2003209990B8 (en) | 2002-02-25 | 2008-10-30 | Kudos Pharmaceuticals Ltd | Pyranones useful as ATM inhibitors |
| DE60335359D1 (de) | 2002-04-30 | 2011-01-27 | Kudos Pharm Ltd | Phthalazinonderivate |
| KR20060066722A (ko) | 2003-08-13 | 2006-06-16 | 쿠도스 파마슈티칼스 리미티드 | 아미노피론 및 ａｔｍ억제제로서의 이의 용도 |
| US20070238731A1 (en) | 2004-09-20 | 2007-10-11 | Kudos Pharmaceuticals Limited | Dna-Pk Inhibitors |
| CN101115747A (zh) * | 2005-02-09 | 2008-01-30 | 库多斯药物有限公司 | Atm抑制剂 |
| AR054438A1 (es) | 2005-04-15 | 2007-06-27 | Kudos Pharm Ltd | Inhibidores de adn -pk |
| UY31232A1 (es) | 2007-07-19 | 2009-03-02 | Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones |
-
2001
- 2001-08-14 GB GBGB0119865.4A patent/GB0119865D0/en not_active Ceased
-
2002
- 2002-08-14 HU HU0401052A patent/HUP0401052A3/hu unknown
- 2002-08-14 WO PCT/GB2002/003781 patent/WO2003024949A1/en active IP Right Grant
- 2002-08-14 MX MXPA04000804A patent/MXPA04000804A/es active IP Right Grant
- 2002-08-14 PL PL02367081A patent/PL367081A1/xx not_active Application Discontinuation
- 2002-08-14 CN CNB028159780A patent/CN1279034C/zh not_active Expired - Fee Related
- 2002-08-14 NZ NZ530909A patent/NZ530909A/en not_active IP Right Cessation
- 2002-08-14 PT PT02751439T patent/PT1417196E/pt unknown
- 2002-08-14 JP JP2003528797A patent/JP4332032B2/ja not_active Expired - Fee Related
- 2002-08-14 GB GB0401411A patent/GB2393653B/en not_active Expired - Fee Related
- 2002-08-14 EP EP02751439A patent/EP1417196B1/de not_active Expired - Lifetime
- 2002-08-14 CA CA002454023A patent/CA2454023A1/en not_active Abandoned
- 2002-08-14 AU AU2002362385A patent/AU2002362385B2/en not_active Ceased
- 2002-08-14 DK DK02751439T patent/DK1417196T3/da active
- 2002-08-14 ES ES02751439T patent/ES2315377T3/es not_active Expired - Lifetime
- 2002-08-14 BR BR0211889-0A patent/BR0211889A/pt not_active IP Right Cessation
- 2002-08-14 DE DE60229531T patent/DE60229531D1/de not_active Expired - Lifetime
- 2002-08-14 KR KR1020047002182A patent/KR100905457B1/ko not_active IP Right Cessation
- 2002-08-14 US US10/486,816 patent/US7226918B2/en not_active Expired - Lifetime
- 2002-08-14 AT AT02751439T patent/ATE411987T1/de active
-
2004
- 2004-01-13 ZA ZA200400237A patent/ZA200400237B/xx unknown
- 2004-02-12 NO NO20040636A patent/NO20040636L/no not_active Application Discontinuation
-
2005
- 2005-04-15 HK HK05103214A patent/HK1070368A1/xx not_active IP Right Cessation
-
2007
- 2007-06-05 US US11/758,332 patent/US7674823B2/en not_active Expired - Fee Related
-
2009
- 2009-01-14 CY CY20091100039T patent/CY1110269T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0211889A (pt) | 2004-09-21 |
| AU2002362385B2 (en) | 2008-07-31 |
| HUP0401052A3 (en) | 2007-05-29 |
| KR20040032152A (ko) | 2004-04-14 |
| CA2454023A1 (en) | 2003-03-27 |
| DK1417196T3 (da) | 2009-03-02 |
| GB2393653A (en) | 2004-04-07 |
| CN1279034C (zh) | 2006-10-11 |
| HK1070368A1 (en) | 2005-06-17 |
| DE60229531D1 (de) | 2008-12-04 |
| JP4332032B2 (ja) | 2009-09-16 |
| GB0401411D0 (en) | 2004-02-25 |
| EP1417196B1 (de) | 2008-10-22 |
| ZA200400237B (en) | 2004-08-18 |
| JP2005503414A (ja) | 2005-02-03 |
| EP1417196A1 (de) | 2004-05-12 |
| GB2393653B (en) | 2005-02-02 |
| US7674823B2 (en) | 2010-03-09 |
| KR100905457B1 (ko) | 2009-07-02 |
| NZ530909A (en) | 2005-10-28 |
| GB0119865D0 (en) | 2001-10-10 |
| HUP0401052A2 (hu) | 2004-09-28 |
| PT1417196E (pt) | 2009-01-02 |
| PL367081A1 (en) | 2005-02-21 |
| WO2003024949A1 (en) | 2003-03-27 |
| ES2315377T3 (es) | 2009-04-01 |
| US7226918B2 (en) | 2007-06-05 |
| US20070238729A1 (en) | 2007-10-11 |
| US20040192687A1 (en) | 2004-09-30 |
| CN1543457A (zh) | 2004-11-03 |
| MXPA04000804A (es) | 2004-06-03 |
| CY1110269T1 (el) | 2015-01-14 |
| NO20040636L (no) | 2004-04-02 |
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