DK1417196T3 - DNA-PK inhibitorer - Google Patents

DNA-PK inhibitorer

Info

Publication number
DK1417196T3
DK1417196T3 DK02751439T DK02751439T DK1417196T3 DK 1417196 T3 DK1417196 T3 DK 1417196T3 DK 02751439 T DK02751439 T DK 02751439T DK 02751439 T DK02751439 T DK 02751439T DK 1417196 T3 DK1417196 T3 DK 1417196T3
Authority
DK
Denmark
Prior art keywords
optionally substituted
dna
ring
activity
compounds
Prior art date
Application number
DK02751439T
Other languages
English (en)
Inventor
Roger John Griffin
Bernard Thomas Golding
David Richard Newell
Hilary Alan Calvert
Ian Robert Hardcastle
Niall Morrison Barr Martin
Graeme Cameron Murray Smith
Laurent Jean Martin Rigoreau
Xiao-Ling Fan Cockcroft
Vincent Junior Ming-Lai Loh
Paul Workman
Florence Irene Raynaud
Bernard Paul Nutley
Nicola Jane Curtin
Original Assignee
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Rec Tech Ltd filed Critical Cancer Rec Tech Ltd
Application granted granted Critical
Publication of DK1417196T3 publication Critical patent/DK1417196T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
DK02751439T 2001-08-14 2002-08-14 DNA-PK inhibitorer DK1417196T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0119865.4A GB0119865D0 (en) 2001-08-14 2001-08-14 DNA-PK inhibitors
PCT/GB2002/003781 WO2003024949A1 (en) 2001-08-14 2002-08-14 Dna-pk inhibitors

Publications (1)

Publication Number Publication Date
DK1417196T3 true DK1417196T3 (da) 2009-03-02

Family

ID=9920420

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02751439T DK1417196T3 (da) 2001-08-14 2002-08-14 DNA-PK inhibitorer

Country Status (23)

Country Link
US (2) US7226918B2 (da)
EP (1) EP1417196B1 (da)
JP (1) JP4332032B2 (da)
KR (1) KR100905457B1 (da)
CN (1) CN1279034C (da)
AT (1) ATE411987T1 (da)
AU (1) AU2002362385B2 (da)
BR (1) BR0211889A (da)
CA (1) CA2454023A1 (da)
CY (1) CY1110269T1 (da)
DE (1) DE60229531D1 (da)
DK (1) DK1417196T3 (da)
ES (1) ES2315377T3 (da)
GB (2) GB0119865D0 (da)
HK (1) HK1070368A1 (da)
HU (1) HUP0401052A3 (da)
MX (1) MXPA04000804A (da)
NO (1) NO20040636L (da)
NZ (1) NZ530909A (da)
PL (1) PL367081A1 (da)
PT (1) PT1417196E (da)
WO (1) WO2003024949A1 (da)
ZA (1) ZA200400237B (da)

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US7402607B2 (en) * 2004-09-20 2008-07-22 Kudos Pharmaceuticals Limited DNA-PK inhibitors
TW200638938A (en) 2005-02-09 2006-11-16 Kudos Pharm Ltd ATM inhibitors
AR053358A1 (es) 2005-04-15 2007-05-02 Cancer Rec Tech Ltd Inhibidores de adn - pk
US7909830B2 (en) * 2005-08-25 2011-03-22 Synthes Usa, Llc Methods of spinal fixation and instrumentation
TW200745094A (en) * 2005-08-31 2007-12-16 Kudos Pharm Ltd ATM inhibitor
US20090326223A1 (en) * 2006-07-18 2009-12-31 Roger John Griffin Synthesis of 2-amino-substituted 4-oxo-4h-chromen-8.yl-trifluoro-methanesulfonic acid esters
ATE517868T1 (de) * 2006-08-16 2011-08-15 Boehringer Ingelheim Int Pyrazinverbindungen, ihre verwendung und herstellungsverfahren
EP2170338A2 (en) * 2007-07-06 2010-04-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dna-pkcs modulates energy regulation and brain function
UY31232A1 (es) * 2007-07-19 2009-03-02 Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones
WO2009130469A1 (en) * 2008-04-25 2009-10-29 Kudos Pharmaceuticals Limited Dna-pk inhibitors
WO2010136778A1 (en) * 2009-05-29 2010-12-02 Kudos Pharmaceuticals Limited Dibenzothiophene derivatives as dna- pk inhibitors
RU2561130C2 (ru) 2009-07-02 2015-08-20 Санофи НОВЫЕ ПРОИЗВОДНЫЕ 1,2,3,4-ТЕТРАГИДРОПИРИМИДО{1,2-a}ПИРИМИДИН-6-ОНА, ИХ ПОЛУЧЕНИЕ И ФАРМАЦЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ
SG10201403138WA (en) 2009-07-02 2014-08-28 Sanofi Sa Novel 2,3-dihydro-1h-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof and pharmaceutical use thereof
SI2448927T1 (sl) 2009-07-02 2014-06-30 Sanofi Novi (6-okso-1,6-dihidro-pirimidin-2-il)-amidni derivati, njihova priprava in njihova farmacevtska uporaba kot AKT fosforilacijski inhibitorji
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FR2947548B1 (fr) * 2009-07-02 2012-05-18 Sanofi Aventis Nouveaux derives de 1h-pyrimidin-2-one, leur preparation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb)
FR2951170B1 (fr) * 2009-10-09 2011-12-02 Sanofi Aventis Nouveaux derives de 1h-pyrimidin-2-one, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb)
WO2011137428A1 (en) * 2010-04-30 2011-11-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of treating hiv infection: inhibition of dna dependent protein kinase
US8815853B2 (en) 2010-12-23 2014-08-26 Sanofi Pyrimidinone derivatives, preparation thereof and pharmaceutical use thereof
LT2658844T (lt) 2010-12-28 2017-02-10 Sanofi Nauji pirimidino dariniai, jų gamyba ir jų farmacinis panaudojimas kaip akt (pkb) fosforilinimo slopiklių
UY34013A (es) * 2011-04-13 2012-11-30 Astrazeneca Ab ?compuestos de cromenona con actividad anti-tumoral?.
FR2992314B1 (fr) 2012-06-22 2015-10-16 Sanofi Sa Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one et 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one comportant une morpholine substituee, leur preparation et leur utilisation pharmaceutique
FR2992316A1 (fr) 2012-06-22 2013-12-27 Sanofi Sa Derives de pyrimidinones, leur preparation et leur application en therapeutique
CN102977063A (zh) * 2012-11-26 2013-03-20 盛世泰科生物医药技术(苏州)有限公司 一种2-吗啡啉-8-苯基-4-苯并吡喃-4-酮的合成方法
HRP20211855T1 (hr) * 2013-03-12 2022-03-04 Vertex Pharmaceuticals Incorporated Inhibitori dnk-pk
EP3042900B1 (en) * 2013-08-29 2020-09-23 Fujifilm Corporation Novel morpholine derivative or salt thereof
US11433047B2 (en) * 2015-10-09 2022-09-06 Neurotheryx Canada Ltd. Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases
US20200101080A1 (en) * 2017-03-31 2020-04-02 Bioventures, Llc Inhibitors of dna pk and uses thereof
US20230022146A1 (en) 2019-06-17 2023-01-26 Vertex Pharmaceuticals Incorporated Compositions and methods for editing beta-globin for treatment of hemaglobinopathies
WO2021222287A2 (en) 2020-04-28 2021-11-04 Intellia Therapeutics, Inc. Methods of in vitro cell delivery
WO2022133246A1 (en) 2020-12-17 2022-06-23 Vertex Pharmaceuticals Incorporated Compositions and methods for editing beta-globin for treatment of hemaglobinopathies
CA3216875A1 (en) 2021-04-17 2022-10-20 Intellia Therapeutics, Inc. Inhibitors of dna-dependent protein kinase and compositions and uses thereof

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AR053358A1 (es) * 2005-04-15 2007-05-02 Cancer Rec Tech Ltd Inhibidores de adn - pk
UY31232A1 (es) * 2007-07-19 2009-03-02 Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones

Also Published As

Publication number Publication date
US20040192687A1 (en) 2004-09-30
US7674823B2 (en) 2010-03-09
CN1543457A (zh) 2004-11-03
AU2002362385B2 (en) 2008-07-31
CY1110269T1 (el) 2015-01-14
MXPA04000804A (es) 2004-06-03
JP4332032B2 (ja) 2009-09-16
NZ530909A (en) 2005-10-28
GB2393653B (en) 2005-02-02
JP2005503414A (ja) 2005-02-03
BR0211889A (pt) 2004-09-21
EP1417196B1 (en) 2008-10-22
HK1070368A1 (en) 2005-06-17
PT1417196E (pt) 2009-01-02
ES2315377T3 (es) 2009-04-01
WO2003024949A1 (en) 2003-03-27
ATE411987T1 (de) 2008-11-15
PL367081A1 (en) 2005-02-21
NO20040636L (no) 2004-04-02
KR100905457B1 (ko) 2009-07-02
GB2393653A (en) 2004-04-07
KR20040032152A (ko) 2004-04-14
ZA200400237B (en) 2004-08-18
HUP0401052A2 (hu) 2004-09-28
DE60229531D1 (de) 2008-12-04
US7226918B2 (en) 2007-06-05
HUP0401052A3 (en) 2007-05-29
EP1417196A1 (en) 2004-05-12
CN1279034C (zh) 2006-10-11
GB0119865D0 (en) 2001-10-10
GB0401411D0 (en) 2004-02-25
CA2454023A1 (en) 2003-03-27
US20070238729A1 (en) 2007-10-11

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