HUP0401052A2 - DNS-protein kináz inhibitorok - Google Patents
DNS-protein kináz inhibitorokInfo
- Publication number
- HUP0401052A2 HUP0401052A2 HU0401052A HUP0401052A HUP0401052A2 HU P0401052 A2 HUP0401052 A2 HU P0401052A2 HU 0401052 A HU0401052 A HU 0401052A HU P0401052 A HUP0401052 A HU P0401052A HU P0401052 A2 HUP0401052 A2 HU P0401052A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- ring
- atom
- optionally substituted
- carbon atoms
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 125000006413 ring segment Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
A találmány tárgya (I) általános képletű vegyületek és izomereik,sóik, szolvátjaik, kémiailag védett formáik és hatóanyag előalakjaikalkalmazása DNSPK aktivitás gátlására szolgáló gyógyszerelőállítására, ahol a képletben R1 és R2 jelentése egymástólfüggetlenül hidrogénatom, adott esetben helyettesített 1-7 szénatomosalkilcsoport, 3-20 szénatomos heterociklusos csoport vagy 5-20szénatomos arilcsoport, vagy azzal a nitrogénatommal együtt, amelyhezkapcsolódnak, egy adott esetben helyettesített, 4-8 gyűrűatomosheterociklusos gyűrűt képezhetnek, X és Y jelentése CR4 és oxigénatom,oxigénatom és CR'4, és NR<4 és nitrogénatom, ahol a telítetlen kötés agyűrűn a megfelelő helyen található és ahol az R3 és R4 vagy R'4csoportok egyikének jelentése egy adott esetben helyettesített, 3-20szénatomos heteroaril- vagy 5-20 szénatomos arilcsoport, és az R3 ésR4 vagy R'4 csoportok közül a másik jelentése hidrogénatom vagy R3 ésR4 vagy R<4 együtt -A-B- csoportot jelent, amely együttesen egykondenzált, adott esetben helyettesített aromás gyűrűt képvisel,feltéve, hogy amikor X és Y jelentése CR4 és oxigénatom, R3 és R4együttesen egy kondenzált benzol gyűrűt alkot, és R1 és R2 azzal anitrogénatommal együtt, amelyhez kapcsolódnak, egy morfolinocsoportotalkotnak, a kondenzált benzolgyűrű egyedüli szubsztituensként nemhordoz fenilszubsztituenst a 8-as helyzetben. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0119865.4A GB0119865D0 (en) | 2001-08-14 | 2001-08-14 | DNA-PK inhibitors |
PCT/GB2002/003781 WO2003024949A1 (en) | 2001-08-14 | 2002-08-14 | Dna-pk inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0401052A2 true HUP0401052A2 (hu) | 2004-09-28 |
HUP0401052A3 HUP0401052A3 (en) | 2007-05-29 |
Family
ID=9920420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0401052A HUP0401052A3 (en) | 2001-08-14 | 2002-08-14 | Dna-pk inhibitors |
Country Status (23)
Country | Link |
---|---|
US (2) | US7226918B2 (hu) |
EP (1) | EP1417196B1 (hu) |
JP (1) | JP4332032B2 (hu) |
KR (1) | KR100905457B1 (hu) |
CN (1) | CN1279034C (hu) |
AT (1) | ATE411987T1 (hu) |
AU (1) | AU2002362385B2 (hu) |
BR (1) | BR0211889A (hu) |
CA (1) | CA2454023A1 (hu) |
CY (1) | CY1110269T1 (hu) |
DE (1) | DE60229531D1 (hu) |
DK (1) | DK1417196T3 (hu) |
ES (1) | ES2315377T3 (hu) |
GB (2) | GB0119865D0 (hu) |
HK (1) | HK1070368A1 (hu) |
HU (1) | HUP0401052A3 (hu) |
MX (1) | MXPA04000804A (hu) |
NO (1) | NO20040636L (hu) |
NZ (1) | NZ530909A (hu) |
PL (1) | PL367081A1 (hu) |
PT (1) | PT1417196E (hu) |
WO (1) | WO2003024949A1 (hu) |
ZA (1) | ZA200400237B (hu) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0119865D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
GB0119863D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
US7049313B2 (en) | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
EA012240B1 (ru) * | 2003-04-03 | 2009-08-28 | Семафор Фармасьютикалз, Инк. | Пролекарства ингибиторов киназы pi-3 |
CN1867566B (zh) * | 2003-08-13 | 2010-06-16 | 库多斯药物有限公司 | 氨基吡喃酮和它们作为atm抑制剂的用途 |
US7402607B2 (en) * | 2004-09-20 | 2008-07-22 | Kudos Pharmaceuticals Limited | DNA-PK inhibitors |
TW200638938A (en) | 2005-02-09 | 2006-11-16 | Kudos Pharm Ltd | ATM inhibitors |
AR053358A1 (es) | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
US7909830B2 (en) * | 2005-08-25 | 2011-03-22 | Synthes Usa, Llc | Methods of spinal fixation and instrumentation |
TW200745094A (en) * | 2005-08-31 | 2007-12-16 | Kudos Pharm Ltd | ATM inhibitor |
US20090326223A1 (en) * | 2006-07-18 | 2009-12-31 | Roger John Griffin | Synthesis of 2-amino-substituted 4-oxo-4h-chromen-8.yl-trifluoro-methanesulfonic acid esters |
ATE517868T1 (de) * | 2006-08-16 | 2011-08-15 | Boehringer Ingelheim Int | Pyrazinverbindungen, ihre verwendung und herstellungsverfahren |
EP2170338A2 (en) * | 2007-07-06 | 2010-04-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dna-pkcs modulates energy regulation and brain function |
UY31232A1 (es) * | 2007-07-19 | 2009-03-02 | Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones | |
WO2009130469A1 (en) * | 2008-04-25 | 2009-10-29 | Kudos Pharmaceuticals Limited | Dna-pk inhibitors |
WO2010136778A1 (en) * | 2009-05-29 | 2010-12-02 | Kudos Pharmaceuticals Limited | Dibenzothiophene derivatives as dna- pk inhibitors |
RU2561130C2 (ru) | 2009-07-02 | 2015-08-20 | Санофи | НОВЫЕ ПРОИЗВОДНЫЕ 1,2,3,4-ТЕТРАГИДРОПИРИМИДО{1,2-a}ПИРИМИДИН-6-ОНА, ИХ ПОЛУЧЕНИЕ И ФАРМАЦЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ |
SG10201403138WA (en) | 2009-07-02 | 2014-08-28 | Sanofi Sa | Novel 2,3-dihydro-1h-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof and pharmaceutical use thereof |
SI2448927T1 (sl) | 2009-07-02 | 2014-06-30 | Sanofi | Novi (6-okso-1,6-dihidro-pirimidin-2-il)-amidni derivati, njihova priprava in njihova farmacevtska uporaba kot AKT fosforilacijski inhibitorji |
WO2011001115A1 (fr) | 2009-07-02 | 2011-01-06 | Sanofi-Aventis | Nouveaux derives de 6-morpholin-4-yl-pyrimidin-4- ( 3h ) -one, leur preparation pharmaceutique comme inhibiteurs de phos phorylat i on d ' akt ( pkb ) |
FR2947548B1 (fr) * | 2009-07-02 | 2012-05-18 | Sanofi Aventis | Nouveaux derives de 1h-pyrimidin-2-one, leur preparation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
FR2951170B1 (fr) * | 2009-10-09 | 2011-12-02 | Sanofi Aventis | Nouveaux derives de 1h-pyrimidin-2-one, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
WO2011137428A1 (en) * | 2010-04-30 | 2011-11-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of treating hiv infection: inhibition of dna dependent protein kinase |
US8815853B2 (en) | 2010-12-23 | 2014-08-26 | Sanofi | Pyrimidinone derivatives, preparation thereof and pharmaceutical use thereof |
LT2658844T (lt) | 2010-12-28 | 2017-02-10 | Sanofi | Nauji pirimidino dariniai, jų gamyba ir jų farmacinis panaudojimas kaip akt (pkb) fosforilinimo slopiklių |
UY34013A (es) * | 2011-04-13 | 2012-11-30 | Astrazeneca Ab | ?compuestos de cromenona con actividad anti-tumoral?. |
FR2992314B1 (fr) | 2012-06-22 | 2015-10-16 | Sanofi Sa | Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one et 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one comportant une morpholine substituee, leur preparation et leur utilisation pharmaceutique |
FR2992316A1 (fr) | 2012-06-22 | 2013-12-27 | Sanofi Sa | Derives de pyrimidinones, leur preparation et leur application en therapeutique |
CN102977063A (zh) * | 2012-11-26 | 2013-03-20 | 盛世泰科生物医药技术(苏州)有限公司 | 一种2-吗啡啉-8-苯基-4-苯并吡喃-4-酮的合成方法 |
HRP20211855T1 (hr) * | 2013-03-12 | 2022-03-04 | Vertex Pharmaceuticals Incorporated | Inhibitori dnk-pk |
EP3042900B1 (en) * | 2013-08-29 | 2020-09-23 | Fujifilm Corporation | Novel morpholine derivative or salt thereof |
US11433047B2 (en) * | 2015-10-09 | 2022-09-06 | Neurotheryx Canada Ltd. | Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases |
US20200101080A1 (en) * | 2017-03-31 | 2020-04-02 | Bioventures, Llc | Inhibitors of dna pk and uses thereof |
US20230022146A1 (en) | 2019-06-17 | 2023-01-26 | Vertex Pharmaceuticals Incorporated | Compositions and methods for editing beta-globin for treatment of hemaglobinopathies |
WO2021222287A2 (en) | 2020-04-28 | 2021-11-04 | Intellia Therapeutics, Inc. | Methods of in vitro cell delivery |
WO2022133246A1 (en) | 2020-12-17 | 2022-06-23 | Vertex Pharmaceuticals Incorporated | Compositions and methods for editing beta-globin for treatment of hemaglobinopathies |
CA3216875A1 (en) | 2021-04-17 | 2022-10-20 | Intellia Therapeutics, Inc. | Inhibitors of dna-dependent protein kinase and compositions and uses thereof |
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GB1303724A (hu) | 1969-05-14 | 1973-01-17 | ||
JPH0753725B2 (ja) | 1987-10-08 | 1995-06-07 | 富山化学工業株式会社 | 4h―1―ベンゾピラン―4―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤 |
US5284856A (en) | 1988-10-28 | 1994-02-08 | Hoechst Aktiengesellschaft | Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives |
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HUT58310A (en) * | 1988-12-21 | 1992-02-28 | Upjohn Co | Anti-atherosclerotic and anti-thrombotic 1-benzopyran-4-one- and 2-amino-1,3-benzoxazin-4-one derivatives, process for producing them and pharmaceutical compositions containing them |
JPH03215423A (ja) | 1990-01-18 | 1991-09-20 | Kyowa Hakko Kogyo Co Ltd | 血管拡張剤 |
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US6632789B1 (en) | 1994-04-29 | 2003-10-14 | The United States Of America As Represented By The Secretary Of The Navy | Methods for modulating T cell responses by manipulating intracellular signal transduction |
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GB2302021A (en) | 1996-10-16 | 1997-01-08 | Lilly Co Eli | Inhibiting bone loss or resorption |
AU7953598A (en) | 1997-06-06 | 1998-12-21 | Mayo Foundation For Medical Education And Research | Screening for phosphatidylinositol related-kinase inhibitors |
WO1998056391A1 (en) | 1997-06-13 | 1998-12-17 | President And Fellows Of Harvard College | Methods for treating human cancers |
FR2776291B1 (fr) | 1998-03-18 | 2000-06-16 | Pf Medicament | Nouveaux derives bis-benzamides, leur procede de fabrication, les compositions pharmaceutiques les contenant et leur utilisation comme medicament |
US6348311B1 (en) | 1999-02-10 | 2002-02-19 | St. Jude Childre's Research Hospital | ATM kinase modulation for screening and therapies |
US6387640B1 (en) | 1999-02-10 | 2002-05-14 | St. Jude Children's Research Hospital | ATM kinase modulation for screening and therapies |
ATE363471T1 (de) * | 2000-01-24 | 2007-06-15 | Astrazeneca Ab | Durch einen morpholinrest substituierte therapeutische verbindungen |
WO2002000216A1 (en) * | 2000-06-28 | 2002-01-03 | Teva Pharmaceutical Industries Ltd. | Carvedilol |
EP1351946A2 (en) | 2000-09-01 | 2003-10-15 | Icos Corporation | Materials and methods to potentiate cancer treatment |
AU2002236765A1 (en) | 2001-01-16 | 2002-07-30 | Glaxo Group Limited | Pharmaceutical combination for the treatment of cancer containing a 4-quinazolineamine and another anti-neoplastic agent |
GB0119863D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
GB0119865D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
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US6894055B2 (en) | 2001-10-24 | 2005-05-17 | Iconix Pharmaceuticals Inc. | Thieno-2′,3′ -5,6pyrimido[3,4-A]-1,2,4-triazole derivatives as modulators of phoshoinositide 3-kinase |
DK1485377T5 (da) | 2002-02-25 | 2010-12-06 | Kudos Pharm Ltd | Pyranoner egnede som ATM-inhibitorer |
US7049313B2 (en) | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
US7196085B2 (en) | 2002-04-30 | 2007-03-27 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
CN1867566B (zh) * | 2003-08-13 | 2010-06-16 | 库多斯药物有限公司 | 氨基吡喃酮和它们作为atm抑制剂的用途 |
US7402607B2 (en) * | 2004-09-20 | 2008-07-22 | Kudos Pharmaceuticals Limited | DNA-PK inhibitors |
TW200638938A (en) | 2005-02-09 | 2006-11-16 | Kudos Pharm Ltd | ATM inhibitors |
AR053358A1 (es) * | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
UY31232A1 (es) * | 2007-07-19 | 2009-03-02 | Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones |
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2001
- 2001-08-14 GB GBGB0119865.4A patent/GB0119865D0/en not_active Ceased
-
2002
- 2002-08-14 JP JP2003528797A patent/JP4332032B2/ja not_active Expired - Fee Related
- 2002-08-14 EP EP02751439A patent/EP1417196B1/en not_active Expired - Lifetime
- 2002-08-14 ES ES02751439T patent/ES2315377T3/es not_active Expired - Lifetime
- 2002-08-14 AU AU2002362385A patent/AU2002362385B2/en not_active Ceased
- 2002-08-14 MX MXPA04000804A patent/MXPA04000804A/es active IP Right Grant
- 2002-08-14 GB GB0401411A patent/GB2393653B/en not_active Expired - Fee Related
- 2002-08-14 HU HU0401052A patent/HUP0401052A3/hu unknown
- 2002-08-14 DK DK02751439T patent/DK1417196T3/da active
- 2002-08-14 NZ NZ530909A patent/NZ530909A/en not_active IP Right Cessation
- 2002-08-14 DE DE60229531T patent/DE60229531D1/de not_active Expired - Lifetime
- 2002-08-14 CA CA002454023A patent/CA2454023A1/en not_active Abandoned
- 2002-08-14 PL PL02367081A patent/PL367081A1/xx not_active Application Discontinuation
- 2002-08-14 AT AT02751439T patent/ATE411987T1/de active
- 2002-08-14 CN CNB028159780A patent/CN1279034C/zh not_active Expired - Fee Related
- 2002-08-14 BR BR0211889-0A patent/BR0211889A/pt not_active IP Right Cessation
- 2002-08-14 PT PT02751439T patent/PT1417196E/pt unknown
- 2002-08-14 WO PCT/GB2002/003781 patent/WO2003024949A1/en active IP Right Grant
- 2002-08-14 KR KR1020047002182A patent/KR100905457B1/ko not_active IP Right Cessation
- 2002-08-14 US US10/486,816 patent/US7226918B2/en not_active Expired - Lifetime
-
2004
- 2004-01-13 ZA ZA200400237A patent/ZA200400237B/xx unknown
- 2004-02-12 NO NO20040636A patent/NO20040636L/no not_active Application Discontinuation
-
2005
- 2005-04-15 HK HK05103214A patent/HK1070368A1/xx not_active IP Right Cessation
-
2007
- 2007-06-05 US US11/758,332 patent/US7674823B2/en not_active Expired - Fee Related
-
2009
- 2009-01-14 CY CY20091100039T patent/CY1110269T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US20040192687A1 (en) | 2004-09-30 |
US7674823B2 (en) | 2010-03-09 |
CN1543457A (zh) | 2004-11-03 |
AU2002362385B2 (en) | 2008-07-31 |
CY1110269T1 (el) | 2015-01-14 |
MXPA04000804A (es) | 2004-06-03 |
JP4332032B2 (ja) | 2009-09-16 |
DK1417196T3 (da) | 2009-03-02 |
NZ530909A (en) | 2005-10-28 |
GB2393653B (en) | 2005-02-02 |
JP2005503414A (ja) | 2005-02-03 |
BR0211889A (pt) | 2004-09-21 |
EP1417196B1 (en) | 2008-10-22 |
HK1070368A1 (en) | 2005-06-17 |
PT1417196E (pt) | 2009-01-02 |
ES2315377T3 (es) | 2009-04-01 |
WO2003024949A1 (en) | 2003-03-27 |
ATE411987T1 (de) | 2008-11-15 |
PL367081A1 (en) | 2005-02-21 |
NO20040636L (no) | 2004-04-02 |
KR100905457B1 (ko) | 2009-07-02 |
GB2393653A (en) | 2004-04-07 |
KR20040032152A (ko) | 2004-04-14 |
ZA200400237B (en) | 2004-08-18 |
DE60229531D1 (de) | 2008-12-04 |
US7226918B2 (en) | 2007-06-05 |
HUP0401052A3 (en) | 2007-05-29 |
EP1417196A1 (en) | 2004-05-12 |
CN1279034C (zh) | 2006-10-11 |
GB0119865D0 (en) | 2001-10-10 |
GB0401411D0 (en) | 2004-02-25 |
CA2454023A1 (en) | 2003-03-27 |
US20070238729A1 (en) | 2007-10-11 |
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FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |