NO20040636L - DNA-PK-inhibitorer - Google Patents

DNA-PK-inhibitorer

Info

Publication number
NO20040636L
NO20040636L NO20040636A NO20040636A NO20040636L NO 20040636 L NO20040636 L NO 20040636L NO 20040636 A NO20040636 A NO 20040636A NO 20040636 A NO20040636 A NO 20040636A NO 20040636 L NO20040636 L NO 20040636L
Authority
NO
Norway
Prior art keywords
optionally substituted
dna
ring
activity
compounds
Prior art date
Application number
NO20040636A
Other languages
English (en)
Norwegian (no)
Inventor
Xiao-Ling Cockcroft
Roger John Griffin
David Richard Newell
Alan Hilary Calvert
Nicola Jane Curtin
Ian Robert Hardcastle
Thomas Bernard Golding
Barr Morrison Niall Martin
Murray Cameron Graeme Smith
Martin Jean Laurent Rigoreau
Jr Ming-Lai Vincent Loh
Paul Workman
Irene Dlorence Raynaud
Bernard Nutley
Original Assignee
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Rec Tech Ltd filed Critical Cancer Rec Tech Ltd
Publication of NO20040636L publication Critical patent/NO20040636L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
NO20040636A 2001-08-14 2004-02-12 DNA-PK-inhibitorer NO20040636L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0119865.4A GB0119865D0 (en) 2001-08-14 2001-08-14 DNA-PK inhibitors
PCT/GB2002/003781 WO2003024949A1 (en) 2001-08-14 2002-08-14 Dna-pk inhibitors

Publications (1)

Publication Number Publication Date
NO20040636L true NO20040636L (no) 2004-04-02

Family

ID=9920420

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20040636A NO20040636L (no) 2001-08-14 2004-02-12 DNA-PK-inhibitorer

Country Status (23)

Country Link
US (2) US7226918B2 (de)
EP (1) EP1417196B1 (de)
JP (1) JP4332032B2 (de)
KR (1) KR100905457B1 (de)
CN (1) CN1279034C (de)
AT (1) ATE411987T1 (de)
AU (1) AU2002362385B2 (de)
BR (1) BR0211889A (de)
CA (1) CA2454023A1 (de)
CY (1) CY1110269T1 (de)
DE (1) DE60229531D1 (de)
DK (1) DK1417196T3 (de)
ES (1) ES2315377T3 (de)
GB (2) GB0119865D0 (de)
HK (1) HK1070368A1 (de)
HU (1) HUP0401052A3 (de)
MX (1) MXPA04000804A (de)
NO (1) NO20040636L (de)
NZ (1) NZ530909A (de)
PL (1) PL367081A1 (de)
PT (1) PT1417196E (de)
WO (1) WO2003024949A1 (de)
ZA (1) ZA200400237B (de)

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GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
US7049313B2 (en) * 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
JP2006523237A (ja) * 2003-04-03 2006-10-12 セマフォア ファーマシューティカルズ， インコーポレイテッド Ｐｉ−３キナーゼインヒビタープロドラッグ
DE602004026071D1 (de) 2003-08-13 2010-04-29 Kudos Pharm Ltd Aminopyrone und ihre verwendung als atm inhibitoren
BRPI0515498A (pt) 2004-09-20 2008-07-29 Kudos Pharm Ltd inibidores de dna-pk
TW200638938A (en) 2005-02-09 2006-11-16 Kudos Pharm Ltd ATM inhibitors
AR054438A1 (es) * 2005-04-15 2007-06-27 Kudos Pharm Ltd Inhibidores de adn -pk
US7909830B2 (en) * 2005-08-25 2011-03-22 Synthes Usa, Llc Methods of spinal fixation and instrumentation
UY29774A1 (es) * 2005-08-31 2007-03-30 Kudos Pharm Ltd Inhibidor de atm
US20090326223A1 (en) * 2006-07-18 2009-12-31 Roger John Griffin Synthesis of 2-amino-substituted 4-oxo-4h-chromen-8.yl-trifluoro-methanesulfonic acid esters
US8318723B2 (en) * 2006-08-16 2012-11-27 Boehringer Ingelheim International Gmbh Pyrazine compounds, their use and methods of preparation
WO2009008991A2 (en) * 2007-07-06 2009-01-15 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health Dna-pkcs modulates energy regulation and brain function
UY31232A1 (es) * 2007-07-19 2009-03-02 Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones
WO2009130469A1 (en) * 2008-04-25 2009-10-29 Kudos Pharmaceuticals Limited Dna-pk inhibitors
WO2010136778A1 (en) * 2009-05-29 2010-12-02 Kudos Pharmaceuticals Limited Dibenzothiophene derivatives as dna- pk inhibitors
PL2448939T3 (pl) 2009-07-02 2017-08-31 Sanofi Pochodne 2,3-dihydro-1h-imidazo {1,2-a} pirymidyn-5-onu, ich wytwarzanie i ich zastosowanie farmaceutyczne
FR2947548B1 (fr) * 2009-07-02 2012-05-18 Sanofi Aventis Nouveaux derives de 1h-pyrimidin-2-one, leur preparation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb)
SI2448927T1 (sl) 2009-07-02 2014-06-30 Sanofi Novi (6-okso-1,6-dihidro-pirimidin-2-il)-amidni derivati, njihova priprava in njihova farmacevtska uporaba kot AKT fosforilacijski inhibitorji
ES2487623T3 (es) 2009-07-02 2014-08-22 Sanofi Derivados de 6,7,8,9-tetrahidro-pirimido{1,2-a}pirimidin-4-ona, su preparación y su aplicación farmacéutica
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WO2012085244A1 (fr) 2010-12-23 2012-06-28 Sanofi Derives de pyrimidinone, leur preparation et leur utilisation pharmaceutique
WO2012089633A1 (fr) 2010-12-28 2012-07-05 Sanofi Nouveaux derives de pyrimidines, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb)
US8530470B2 (en) * 2011-04-13 2013-09-10 Astrazeneca Ab Chromenone derivatives
FR2992314B1 (fr) 2012-06-22 2015-10-16 Sanofi Sa Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one et 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one comportant une morpholine substituee, leur preparation et leur utilisation pharmaceutique
FR2992316A1 (fr) 2012-06-22 2013-12-27 Sanofi Sa Derives de pyrimidinones, leur preparation et leur application en therapeutique
CN102977063A (zh) * 2012-11-26 2013-03-20 盛世泰科生物医药技术(苏州)有限公司 一种2-吗啡啉-8-苯基-4-苯并吡喃-4-酮的合成方法
ME03336B (de) 2013-03-12 2019-10-20 Vertex Pharma Dna-pk-hemmer
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US11433047B2 (en) * 2015-10-09 2022-09-06 Neurotheryx Canada Ltd. Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases
WO2018183868A1 (en) * 2017-03-31 2018-10-04 Bioventures, Llc Inhibitors of dna pk and uses thereof
US20210008161A1 (en) 2019-06-17 2021-01-14 Crispr Therapeutics Ag Methods and compositions for improved homology directed repair
AU2021263745A1 (en) 2020-04-28 2022-12-08 Intellia Therapeutics, Inc. Methods of in vitro cell delivery
WO2022133246A1 (en) 2020-12-17 2022-06-23 Vertex Pharmaceuticals Incorporated Compositions and methods for editing beta-globin for treatment of hemaglobinopathies
KR20240017791A (ko) 2021-04-17 2024-02-08 인텔리아 테라퓨틱스, 인크. Dna-의존적 단백질 키나제의 억제제 및 이의 조성물 및 용도

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TW200638938A (en) * 2005-02-09 2006-11-16 Kudos Pharm Ltd ATM inhibitors
AR054438A1 (es) 2005-04-15 2007-06-27 Kudos Pharm Ltd Inhibidores de adn -pk
UY31232A1 (es) 2007-07-19 2009-03-02 Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones

Also Published As

Publication number Publication date
US20070238729A1 (en) 2007-10-11
PL367081A1 (en) 2005-02-21
GB0401411D0 (en) 2004-02-25
ATE411987T1 (de) 2008-11-15
CN1279034C (zh) 2006-10-11
DE60229531D1 (de) 2008-12-04
US7226918B2 (en) 2007-06-05
CY1110269T1 (el) 2015-01-14
GB2393653B (en) 2005-02-02
EP1417196B1 (de) 2008-10-22
PT1417196E (pt) 2009-01-02
DK1417196T3 (da) 2009-03-02
EP1417196A1 (de) 2004-05-12
AU2002362385B2 (en) 2008-07-31
CA2454023A1 (en) 2003-03-27
HUP0401052A3 (en) 2007-05-29
ES2315377T3 (es) 2009-04-01
NZ530909A (en) 2005-10-28
JP4332032B2 (ja) 2009-09-16
GB2393653A (en) 2004-04-07
KR100905457B1 (ko) 2009-07-02
HUP0401052A2 (hu) 2004-09-28
HK1070368A1 (en) 2005-06-17
GB0119865D0 (en) 2001-10-10
BR0211889A (pt) 2004-09-21
JP2005503414A (ja) 2005-02-03
US7674823B2 (en) 2010-03-09
WO2003024949A1 (en) 2003-03-27
MXPA04000804A (es) 2004-06-03
CN1543457A (zh) 2004-11-03
ZA200400237B (en) 2004-08-18
KR20040032152A (ko) 2004-04-14
US20040192687A1 (en) 2004-09-30

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