ATE409697T1 - 1,1a,5,5a-tetrahydro-3-thia- cyclopropaäaüpentalene: trizyklische thiophenderivate als s1p1/edg1-rezeptor-agonisten - Google Patents
1,1a,5,5a-tetrahydro-3-thia- cyclopropaäaüpentalene: trizyklische thiophenderivate als s1p1/edg1-rezeptor-agonistenInfo
- Publication number
- ATE409697T1 ATE409697T1 AT05772622T AT05772622T ATE409697T1 AT E409697 T1 ATE409697 T1 AT E409697T1 AT 05772622 T AT05772622 T AT 05772622T AT 05772622 T AT05772622 T AT 05772622T AT E409697 T1 ATE409697 T1 AT E409697T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclopropaäaüpentalene
- thia
- tetrahydro
- receptor agonists
- thiophene derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2004/008501 WO2006010379A1 (en) | 2004-07-29 | 2004-07-29 | Novel thiophene derivatives as immunosuppressive agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE409697T1 true ATE409697T1 (de) | 2008-10-15 |
Family
ID=34958296
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05772622T ATE409697T1 (de) | 2004-07-29 | 2005-07-20 | 1,1a,5,5a-tetrahydro-3-thia- cyclopropaäaüpentalene: trizyklische thiophenderivate als s1p1/edg1-rezeptor-agonisten |
Country Status (23)
Country | Link |
---|---|
US (1) | US7750040B2 (de) |
EP (1) | EP1805163B1 (de) |
JP (1) | JP4807884B2 (de) |
KR (1) | KR20070046849A (de) |
CN (1) | CN1993346B (de) |
AR (1) | AR050273A1 (de) |
AT (1) | ATE409697T1 (de) |
AU (1) | AU2005266529A1 (de) |
BR (1) | BRPI0513841A (de) |
CA (1) | CA2574305A1 (de) |
DE (1) | DE602005010109D1 (de) |
DK (1) | DK1805163T3 (de) |
ES (1) | ES2313391T3 (de) |
IL (1) | IL180962A0 (de) |
MX (1) | MX2007000972A (de) |
NO (1) | NO20071095L (de) |
PL (1) | PL1805163T3 (de) |
PT (1) | PT1805163E (de) |
RU (1) | RU2386626C2 (de) |
SI (1) | SI1805163T1 (de) |
TW (1) | TW200616994A (de) |
WO (2) | WO2006010379A1 (de) |
ZA (1) | ZA200700535B (de) |
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JP4678139B2 (ja) * | 2004-05-10 | 2011-04-27 | トヨタ自動車株式会社 | 自動車の暖房制御システム |
WO2006010379A1 (en) | 2004-07-29 | 2006-02-02 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as immunosuppressive agents |
BRPI0514316A (pt) | 2004-08-13 | 2008-06-10 | Praecis Pharm Inc | métodos e composições para modulação de atividade de receptor de esfingosina-1-fosfato (s1p) |
MX2007011670A (es) | 2005-03-23 | 2007-11-15 | Actelion Pharmaceuticals Ltd | Derivados de benzo(c) tiofeno hidrogenados como inmunomoduladores. |
KR20070116645A (ko) * | 2005-03-23 | 2007-12-10 | 액테리온 파마슈티칼 리미티드 | 스핑고신-1-포스페이트-1 수용체 길항제로서의 신규한티오펜 유도체 |
EP1863475B1 (de) * | 2005-03-23 | 2011-09-07 | Actelion Pharmaceuticals Ltd. | Neue thiophen-derivate als sphingosin-1-phosphat-1-rezeptorantagonisten |
WO2006137019A1 (en) | 2005-06-24 | 2006-12-28 | Actelion Pharmaceuticals Ltd | Novel thiophene derivatives |
AR057894A1 (es) * | 2005-11-23 | 2007-12-26 | Actelion Pharmaceuticals Ltd | Derivados de tiofeno |
TWI404706B (zh) * | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
CA2635124C (en) | 2006-01-24 | 2014-04-29 | Actelion Pharmaceuticals Ltd | Novel pyridine derivatives |
AR061841A1 (es) | 2006-09-07 | 2008-09-24 | Actelion Pharmaceuticals Ltd | Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores. |
AU2007292993B2 (en) * | 2006-09-07 | 2013-01-24 | Idorsia Pharmaceuticals Ltd | Pyridin-4-yl derivatives as immunomodulating agents |
ES2400163T3 (es) * | 2006-09-08 | 2013-04-08 | Actelion Pharmaceuticals Ltd. | Derivados de piridil-3-ilo como agentes de inmunomodulación |
DE102007019679A1 (de) | 2006-11-06 | 2008-05-15 | Carl Zeiss Surgical Gmbh | Operationsmikroskop mit OCT-System |
DE102007019677A1 (de) | 2006-11-06 | 2008-05-08 | Carl Zeiss Surgical Gmbh | Operationsmikroskop mit OCT-System und Operationsmikroskop-Beleuchtungsmodul mit OCT-System |
DE102007019680A1 (de) | 2006-11-06 | 2008-05-08 | Carl Zeiss Surgical Gmbh | Ophthalmo-Operationsmikroskop mit OCT-System |
CA2679138C (en) * | 2007-03-16 | 2015-05-26 | Actelion Pharmaceuticals Ltd | Amino-pyridine derivatives as s1p1/edg1 receptor agonists |
WO2009011850A2 (en) * | 2007-07-16 | 2009-01-22 | Abbott Laboratories | Novel therapeutic compounds |
AU2008334297A1 (en) * | 2007-12-10 | 2009-06-18 | Actelion Pharmaceuticals Ltd | Thiophene derivatives as agonists of S1P1/EDG1 |
WO2009074969A2 (en) * | 2007-12-12 | 2009-06-18 | University Of Lausanne | Sphingosine-1-phosphate, analogs and antagonists for use as medicaments |
CN101965345B (zh) * | 2008-03-06 | 2014-05-28 | 埃科特莱茵药品有限公司 | 吡啶化合物 |
PL2252609T3 (pl) * | 2008-03-07 | 2013-09-30 | Idorsia Pharmaceuticals Ltd | Pochodne pirydyn-2-ylu jako środki immunomodulujące |
EP2278960B2 (de) | 2008-03-17 | 2019-11-13 | Actelion Pharmaceuticals Ltd. | Dosierschema für einen selektiven sip1-rezeptor-agonisten |
AU2009270511B2 (en) | 2008-07-15 | 2013-07-18 | Sanofi | Oxazolopyrimidines as Edg-1 receptor agonists |
KR20210099206A (ko) | 2008-07-23 | 2021-08-11 | 아레나 파마슈티칼스, 인크. | 자가면역성 및 염증성의 장애의 치료에 유용한 치환된 1,2,3,4-테트라히드로시클로펜타[b]인돌-3-일)아세트산 유도체 |
NZ591001A (en) | 2008-08-27 | 2012-11-30 | Arena Pharm Inc | Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders |
DE102009002514A1 (de) | 2009-04-21 | 2010-10-28 | Evonik Degussa Gmbh | Verfahren zur Herstellung von substituierten 1,4-Chinonmethiden |
ES2441845T3 (es) | 2009-07-16 | 2014-02-06 | Actelion Pharmaceuticals Ltd. | Derivados de piridin-4-ilo como agonistas de S1P1/EDG1 |
TWI503316B (zh) * | 2009-08-28 | 2015-10-11 | Arena Pharm Inc | 類大麻酚受體調節劑 |
CA2786994C (en) | 2010-01-27 | 2018-01-16 | Arena Pharmaceuticals, Inc. | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
SG10201501575VA (en) | 2010-03-03 | 2015-04-29 | Arena Pharm Inc | Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof |
EP2665720B1 (de) | 2011-01-19 | 2015-06-10 | Actelion Pharmaceuticals Ltd. | 2-methoxy-pyridin-4-yl-derivate |
PT2885266T (pt) | 2012-08-17 | 2020-05-29 | Actelion Pharmaceuticals Ltd | Processo para a preparação de (2z,5z)-5-(3-cloro-4-((r)-2,3-di-hidropropoxi)benzilideno)-2-(propilimino)-3-(o-tolil)tiazolidin-4-ona e intermediário utilizado no referido processo |
DE102013208091B4 (de) | 2013-05-02 | 2019-05-09 | Carl Zeiss Ag | Vorrichtung und Verfahren zum Vermessen einer Flächentopografie |
DE102014222629A1 (de) | 2014-11-05 | 2016-05-12 | Carl Zeiss Meditec Ag | Untersuchen eines Objekts mit OCT-Abtastlichtstrahlen |
DE202014011051U1 (de) | 2014-11-05 | 2017-07-26 | Carl Zeiss Meditec Ag | Vorrichtung für das Untersuchen eines Patientenauges |
DE202014011050U1 (de) | 2014-11-05 | 2017-07-26 | Carl Zeiss Meditec Ag | Vorrichtung für das Untersuchen eines Patientenauges |
NZ734220A (en) | 2015-01-06 | 2022-01-28 | Arena Pharm Inc | Methods of treating conditions related to the s1p1 receptor |
MX2017014846A (es) | 2015-05-20 | 2018-02-19 | Idorsia Pharmaceuticals Ltd | Forma cristalina del compuesto (s)-3-{4-[5-(2-ciclopentil-6-metoxi -piridin-4-il)-[1,2,4]oxadiazol-3-il]-2-etil-6-metil-fenoxi}-prop ano-1,2-diol. |
US10111841B2 (en) | 2015-06-19 | 2018-10-30 | University Of South Florida | Stabilization of alcohol intoxication-induced cardiovascular instability |
MA42807A (fr) | 2015-06-22 | 2018-07-25 | Arena Pharm Inc | Sel l-arginine cristallin d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclo-penta[b]indol-3-yl)acétique (composé 1) pour une utilisation dans des troubles associés au récepteur de s1p1 |
KR20190116416A (ko) | 2017-02-16 | 2019-10-14 | 아레나 파마슈티칼스, 인크. | 원발 담즙성 담관염을 치료하기 위한 화합물 및 방법 |
MA47503A (fr) | 2017-02-16 | 2021-04-21 | Arena Pharm Inc | Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales |
US11555015B2 (en) | 2018-09-06 | 2023-01-17 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
US11013723B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms of a thiazolidinone compound, compositions and methods of use thereof |
US11014897B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof |
US11014940B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Thiazolidinone and oxazolidinone compounds and formulations |
US11186556B1 (en) | 2018-10-16 | 2021-11-30 | Celgene Corporation | Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof |
CN113072519A (zh) * | 2021-04-01 | 2021-07-06 | 福建海西新药创制有限公司 | 一种利用微反应装置连续生产非布司他的方法 |
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ZA917371B (en) | 1990-09-20 | 1992-06-24 | Merrell Dow Pharma | Calcium uptake inhibitors |
US6423508B1 (en) | 1998-03-09 | 2002-07-23 | Smithkline Beecham Corporation | Polynucleotide sequences of human EDG-1c |
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US20040058894A1 (en) * | 2002-01-18 | 2004-03-25 | Doherty George A. | Selective S1P1/Edg1 receptor agonists |
WO2003105771A2 (en) | 2002-06-17 | 2003-12-24 | Merck & Co., Inc. | 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists |
DE10231370B4 (de) * | 2002-07-11 | 2006-04-06 | Sanofi-Aventis Deutschland Gmbh | Thiophenglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
EP1546110A4 (de) * | 2002-07-30 | 2008-03-26 | Univ Virginia | Verbindungen mit wirkung bei der signalübertragung mittels sphingosin-1-phosphat |
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CN1788008A (zh) | 2003-05-15 | 2006-06-14 | 麦克公司 | 作为s1p受体激动剂的3-(2-氨基-1-氮杂环基)-5-芳基-1,2,4-噁二唑 |
WO2005014525A2 (en) | 2003-08-12 | 2005-02-17 | Mitsubishi Pharma Corporation | Bi-aryl compound having immunosuppressive activity |
CA2539438A1 (en) | 2003-10-01 | 2005-04-14 | Merck And Co., Inc. | 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists |
WO2005058848A1 (en) | 2003-12-17 | 2005-06-30 | Merck & Co., Inc. | (3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists |
WO2006010379A1 (en) | 2004-07-29 | 2006-02-02 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as immunosuppressive agents |
EP1863475B1 (de) * | 2005-03-23 | 2011-09-07 | Actelion Pharmaceuticals Ltd. | Neue thiophen-derivate als sphingosin-1-phosphat-1-rezeptorantagonisten |
KR20070116645A (ko) * | 2005-03-23 | 2007-12-10 | 액테리온 파마슈티칼 리미티드 | 스핑고신-1-포스페이트-1 수용체 길항제로서의 신규한티오펜 유도체 |
MX2007011670A (es) | 2005-03-23 | 2007-11-15 | Actelion Pharmaceuticals Ltd | Derivados de benzo(c) tiofeno hidrogenados como inmunomoduladores. |
BRPI0612028A2 (pt) | 2005-06-08 | 2010-10-13 | Novartis Ag | oxadiazóis ou isodiazóis policìclicos e uso dos mesmos como ligantes de receptor s1p |
WO2006137019A1 (en) | 2005-06-24 | 2006-12-28 | Actelion Pharmaceuticals Ltd | Novel thiophene derivatives |
AR057894A1 (es) * | 2005-11-23 | 2007-12-26 | Actelion Pharmaceuticals Ltd | Derivados de tiofeno |
GB0601744D0 (en) | 2006-01-27 | 2006-03-08 | Novartis Ag | Organic compounds |
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-
2004
- 2004-07-29 WO PCT/EP2004/008501 patent/WO2006010379A1/en active Application Filing
-
2005
- 2005-07-20 DE DE602005010109T patent/DE602005010109D1/de active Active
- 2005-07-20 WO PCT/EP2005/007892 patent/WO2006010544A2/en active IP Right Grant
- 2005-07-20 MX MX2007000972A patent/MX2007000972A/es active IP Right Grant
- 2005-07-20 BR BRPI0513841-8A patent/BRPI0513841A/pt not_active IP Right Cessation
- 2005-07-20 AU AU2005266529A patent/AU2005266529A1/en not_active Abandoned
- 2005-07-20 RU RU2007107164/04A patent/RU2386626C2/ru not_active IP Right Cessation
- 2005-07-20 US US11/572,801 patent/US7750040B2/en not_active Expired - Fee Related
- 2005-07-20 DK DK05772622T patent/DK1805163T3/da active
- 2005-07-20 KR KR1020077003174A patent/KR20070046849A/ko not_active Application Discontinuation
- 2005-07-20 EP EP05772622A patent/EP1805163B1/de active Active
- 2005-07-20 AT AT05772622T patent/ATE409697T1/de not_active IP Right Cessation
- 2005-07-20 JP JP2007522982A patent/JP4807884B2/ja not_active Expired - Fee Related
- 2005-07-20 CA CA002574305A patent/CA2574305A1/en not_active Abandoned
- 2005-07-20 SI SI200530472T patent/SI1805163T1/sl unknown
- 2005-07-20 CN CN2005800255902A patent/CN1993346B/zh not_active Expired - Fee Related
- 2005-07-20 PT PT05772622T patent/PT1805163E/pt unknown
- 2005-07-20 PL PL05772622T patent/PL1805163T3/pl unknown
- 2005-07-20 ES ES05772622T patent/ES2313391T3/es active Active
- 2005-07-28 TW TW094125581A patent/TW200616994A/zh unknown
- 2005-07-28 AR ARP050103142A patent/AR050273A1/es not_active Application Discontinuation
-
2007
- 2007-01-18 ZA ZA200700535A patent/ZA200700535B/en unknown
- 2007-01-25 IL IL180962A patent/IL180962A0/en unknown
- 2007-02-27 NO NO20071095A patent/NO20071095L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ES2313391T3 (es) | 2009-03-01 |
RU2386626C2 (ru) | 2010-04-20 |
DK1805163T3 (da) | 2008-12-15 |
PL1805163T3 (pl) | 2009-04-30 |
CA2574305A1 (en) | 2006-02-02 |
NO20071095L (no) | 2007-02-27 |
KR20070046849A (ko) | 2007-05-03 |
AR050273A1 (es) | 2006-10-11 |
IL180962A0 (en) | 2007-07-04 |
US20080064740A1 (en) | 2008-03-13 |
JP2008508210A (ja) | 2008-03-21 |
CN1993346B (zh) | 2011-04-27 |
WO2006010544A3 (en) | 2006-03-30 |
AU2005266529A1 (en) | 2006-02-02 |
MX2007000972A (es) | 2007-04-10 |
ZA200700535B (en) | 2008-10-29 |
EP1805163B1 (de) | 2008-10-01 |
JP4807884B2 (ja) | 2011-11-02 |
BRPI0513841A (pt) | 2008-05-20 |
WO2006010379A1 (en) | 2006-02-02 |
WO2006010544A2 (en) | 2006-02-02 |
RU2007107164A (ru) | 2008-09-10 |
TW200616994A (en) | 2006-06-01 |
SI1805163T1 (sl) | 2009-02-28 |
PT1805163E (pt) | 2008-12-05 |
US7750040B2 (en) | 2010-07-06 |
EP1805163A2 (de) | 2007-07-11 |
CN1993346A (zh) | 2007-07-04 |
DE602005010109D1 (de) | 2008-11-13 |
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