ATE409697T1 - 1,1a,5,5a-tetrahydro-3-thia- cyclopropaäaüpentalene: trizyklische thiophenderivate als s1p1/edg1-rezeptor-agonisten - Google Patents

1,1a,5,5a-tetrahydro-3-thia- cyclopropaäaüpentalene: trizyklische thiophenderivate als s1p1/edg1-rezeptor-agonisten

Info

Publication number
ATE409697T1
ATE409697T1 AT05772622T AT05772622T ATE409697T1 AT E409697 T1 ATE409697 T1 AT E409697T1 AT 05772622 T AT05772622 T AT 05772622T AT 05772622 T AT05772622 T AT 05772622T AT E409697 T1 ATE409697 T1 AT E409697T1
Authority
AT
Austria
Prior art keywords
cyclopropaäaüpentalene
thia
tetrahydro
receptor agonists
thiophene derivatives
Prior art date
Application number
AT05772622T
Other languages
English (en)
Inventor
Martin Bolli
Daniel Bur
Martine Clozel
Walter Fischli
David Lehmann
Boris Mathys
Claus Mueller
Oliver Nayler
Michael Scherz
Thomas Weller
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Application granted granted Critical
Publication of ATE409697T1 publication Critical patent/ATE409697T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT05772622T 2004-07-29 2005-07-20 1,1a,5,5a-tetrahydro-3-thia- cyclopropaäaüpentalene: trizyklische thiophenderivate als s1p1/edg1-rezeptor-agonisten ATE409697T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2004/008501 WO2006010379A1 (en) 2004-07-29 2004-07-29 Novel thiophene derivatives as immunosuppressive agents

Publications (1)

Publication Number Publication Date
ATE409697T1 true ATE409697T1 (de) 2008-10-15

Family

ID=34958296

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05772622T ATE409697T1 (de) 2004-07-29 2005-07-20 1,1a,5,5a-tetrahydro-3-thia- cyclopropaäaüpentalene: trizyklische thiophenderivate als s1p1/edg1-rezeptor-agonisten

Country Status (23)

Country Link
US (1) US7750040B2 (de)
EP (1) EP1805163B1 (de)
JP (1) JP4807884B2 (de)
KR (1) KR20070046849A (de)
CN (1) CN1993346B (de)
AR (1) AR050273A1 (de)
AT (1) ATE409697T1 (de)
AU (1) AU2005266529A1 (de)
BR (1) BRPI0513841A (de)
CA (1) CA2574305A1 (de)
DE (1) DE602005010109D1 (de)
DK (1) DK1805163T3 (de)
ES (1) ES2313391T3 (de)
IL (1) IL180962A0 (de)
MX (1) MX2007000972A (de)
NO (1) NO20071095L (de)
PL (1) PL1805163T3 (de)
PT (1) PT1805163E (de)
RU (1) RU2386626C2 (de)
SI (1) SI1805163T1 (de)
TW (1) TW200616994A (de)
WO (2) WO2006010379A1 (de)
ZA (1) ZA200700535B (de)

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Also Published As

Publication number Publication date
RU2386626C2 (ru) 2010-04-20
CA2574305A1 (en) 2006-02-02
CN1993346B (zh) 2011-04-27
JP2008508210A (ja) 2008-03-21
DK1805163T3 (da) 2008-12-15
CN1993346A (zh) 2007-07-04
MX2007000972A (es) 2007-04-10
US7750040B2 (en) 2010-07-06
EP1805163A2 (de) 2007-07-11
SI1805163T1 (sl) 2009-02-28
PT1805163E (pt) 2008-12-05
PL1805163T3 (pl) 2009-04-30
AU2005266529A1 (en) 2006-02-02
NO20071095L (no) 2007-02-27
DE602005010109D1 (de) 2008-11-13
ES2313391T3 (es) 2009-03-01
IL180962A0 (en) 2007-07-04
BRPI0513841A (pt) 2008-05-20
JP4807884B2 (ja) 2011-11-02
AR050273A1 (es) 2006-10-11
EP1805163B1 (de) 2008-10-01
US20080064740A1 (en) 2008-03-13
WO2006010379A1 (en) 2006-02-02
ZA200700535B (en) 2008-10-29
KR20070046849A (ko) 2007-05-03
WO2006010544A3 (en) 2006-03-30
WO2006010544A2 (en) 2006-02-02
TW200616994A (en) 2006-06-01
RU2007107164A (ru) 2008-09-10

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