NO20070494L - Substituerte azepinderivater som serotoninreseptormodulatorer - Google Patents

Substituerte azepinderivater som serotoninreseptormodulatorer

Info

Publication number
NO20070494L
NO20070494L NO20070494A NO20070494A NO20070494L NO 20070494 L NO20070494 L NO 20070494L NO 20070494 A NO20070494 A NO 20070494A NO 20070494 A NO20070494 A NO 20070494A NO 20070494 L NO20070494 L NO 20070494L
Authority
NO
Norway
Prior art keywords
receptor modulators
serotonin receptor
azepine derivatives
substituted azepine
substituted
Prior art date
Application number
NO20070494A
Other languages
English (en)
Inventor
Youssef L Bennani
Michael J Robarge
David C Bom
Norbert Varga
Lawrence N Tumey
Original Assignee
Athersys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Athersys Inc filed Critical Athersys Inc
Publication of NO20070494L publication Critical patent/NO20070494L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20070494A 2004-06-30 2007-01-25 Substituerte azepinderivater som serotoninreseptormodulatorer NO20070494L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58491604P 2004-06-30 2004-06-30
PCT/US2005/023282 WO2006004931A2 (en) 2004-06-30 2005-06-29 Substituted azepine derivatives as serotonin receptor modulators

Publications (1)

Publication Number Publication Date
NO20070494L true NO20070494L (no) 2007-03-23

Family

ID=35783355

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070494A NO20070494L (no) 2004-06-30 2007-01-25 Substituerte azepinderivater som serotoninreseptormodulatorer

Country Status (21)

Country Link
US (2) US7718647B2 (no)
EP (1) EP1778243B1 (no)
JP (1) JP5025469B2 (no)
KR (1) KR101216984B1 (no)
CN (1) CN1980710B (no)
AR (1) AR049954A1 (no)
AU (1) AU2005260636B2 (no)
BR (1) BRPI0512742A (no)
CA (1) CA2565683C (no)
CY (1) CY1113559T1 (no)
DK (1) DK1778243T3 (no)
ES (1) ES2398694T3 (no)
IL (1) IL179278A (no)
NO (1) NO20070494L (no)
NZ (1) NZ550891A (no)
RU (1) RU2485125C2 (no)
SI (1) SI1778243T1 (no)
TW (1) TWI358410B (no)
UA (1) UA88786C2 (no)
WO (1) WO2006004931A2 (no)
ZA (1) ZA200609234B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1981337B1 (en) * 2006-01-19 2015-09-02 Athersys, Inc. Thiophenyl azepines as serotonin 5-ht2c receptor ligands and uses thereof
EP2742936A1 (en) 2006-05-16 2014-06-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
WO2007140213A1 (en) 2006-05-26 2007-12-06 Forest Laboratories Holdings Limited Pyridoazepine derivatives
US8147315B2 (en) 2006-09-12 2012-04-03 Aristocrat Technologies Australia Ltd Gaming apparatus with persistent game attributes
WO2008120761A1 (ja) * 2007-03-30 2008-10-09 Nippon Shinyaku Co., Ltd. ヘテロアリール誘導体
JP5520051B2 (ja) 2007-11-15 2014-06-11 武田薬品工業株式会社 縮合ピリジン誘導体およびその用途
US20120253036A1 (en) 2009-12-11 2012-10-04 Yukinori Nagakura Agent for treating fibromyalgia
CN103002735B (zh) * 2010-05-21 2015-05-20 Abbvie公司 5-ht受体的调节剂和其使用方法
TWI522361B (zh) * 2010-07-09 2016-02-21 艾伯維公司 作為s1p調節劑的稠合雜環衍生物
EP2824106B1 (en) 2012-03-06 2016-11-23 Takeda Pharmaceutical Company Limited Tricyclic compound
EP2938345B1 (en) * 2012-12-21 2018-08-22 ABT Holding Company Benzazepines as serotonin 5-ht2c receptor ligands and uses thereof
US9309262B2 (en) 2013-03-13 2016-04-12 Abt Holding Company Thienylindole azepines as serotonin 5-HT2C receptor ligands and uses thereof
DE102013208337A1 (de) * 2013-05-07 2014-11-13 Henkel Ag & Co. Kgaa Aerosolzusammensetzung mit verbesserten Sprüheigenschaften
KR101917264B1 (ko) 2016-12-22 2018-11-13 한국과학기술연구원 5-ht7 수용체 조절제로 작용하는 아제핀 유도체
WO2018166855A1 (en) 2017-03-16 2018-09-20 Basf Se Heterobicyclic substituted dihydroisoxazoles
JPWO2019131902A1 (ja) 2017-12-27 2020-12-10 武田薬品工業株式会社 腹圧性尿失禁および便失禁の治療薬

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU629879A3 (ru) * 1974-11-26 1978-10-25 Лилли Индастриз Лимитед, (Фирма) Способ получени тиено(1,5) бензодиазепинов или их солей
ZA821020B (en) * 1981-02-18 1983-10-26 Thomae Gmbh Dr K Azepine derivatives, process for their preparation and pharmaceutical compositions thereof
DE3230696A1 (de) * 1982-08-18 1984-02-23 Dr. Karl Thomae Gmbh, 7950 Biberach Neue thieno-thiazol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
GB8800891D0 (en) * 1988-01-15 1988-02-17 Lilly Industries Ltd Pharmaceutical compounds
GB9025890D0 (en) * 1990-11-28 1991-01-09 Lilly Industries Ltd Pharmaceutical compounds
DE69410193T2 (de) * 1993-03-17 1998-09-03 Meiji Seika Co Neue verbindungen mit blutplättchenaggregationshemmender aktivität
EP0785939A1 (en) * 1994-10-11 1997-07-30 Takeda Chemical Industries, Ltd. Substituted heterobicyclic alkyl amines and their use as squalene oxide cyclase inhibitors
JPH1165082A (ja) * 1997-08-11 1999-03-05 Fujitsu Ltd フォトマスク及び半導体装置の製造方法
US6369222B1 (en) * 2000-07-18 2002-04-09 Hoffmann-La Roche Inc. mGluR antagonists and a method for their synthesis
WO2002024700A2 (en) * 2000-09-20 2002-03-28 Pharmacia & Upjohn Company SUBSTITUTED AZEPINO[4,5b]INDOLINE DERIVATIVES
JPWO2002074746A1 (ja) * 2001-03-16 2004-07-08 山之内製薬株式会社 ベンゾアゼピン誘導体
JP2003261566A (ja) * 2002-03-11 2003-09-19 Sankyo Co Ltd キノリジンを含有する医薬
US7452911B2 (en) * 2002-10-31 2008-11-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
NZ545836A (en) * 2003-09-17 2009-09-25 Janssen Pharmaceutica Nv Fused heterocyclic compounds as serotonin receptor modulators

Also Published As

Publication number Publication date
RU2007103465A (ru) 2008-08-10
ES2398694T3 (es) 2013-03-21
CY1113559T1 (el) 2016-06-22
TWI358410B (en) 2012-02-21
US7718647B2 (en) 2010-05-18
SI1778243T1 (sl) 2013-03-29
CN1980710B (zh) 2013-06-12
DK1778243T3 (da) 2013-02-04
ZA200609234B (en) 2008-08-27
BRPI0512742A (pt) 2008-04-15
AR049954A1 (es) 2006-09-20
CA2565683C (en) 2013-04-02
KR101216984B1 (ko) 2013-01-02
IL179278A0 (en) 2007-03-08
US20100190772A1 (en) 2010-07-29
CN1980710A (zh) 2007-06-13
IL179278A (en) 2014-11-30
EP1778243B1 (en) 2012-10-31
NZ550891A (en) 2009-10-30
WO2006004931A2 (en) 2006-01-12
EP1778243A2 (en) 2007-05-02
EP1778243A4 (en) 2009-09-30
TW200611906A (en) 2006-04-16
RU2485125C2 (ru) 2013-06-20
WO2006004931A3 (en) 2006-04-13
KR20070041544A (ko) 2007-04-18
JP2008505101A (ja) 2008-02-21
JP5025469B2 (ja) 2012-09-12
UA88786C2 (ru) 2009-11-25
AU2005260636A1 (en) 2006-01-12
AU2005260636B2 (en) 2011-04-14
CA2565683A1 (en) 2006-01-12
US20060003990A1 (en) 2006-01-05

Similar Documents

Publication Publication Date Title
DK1778243T3 (da) Substituerede azepinderivater som serotoninreceptormodulatorer
LTC1725537I2 (lt) Nauji junginiai, kaip opioido receptoriaus moduliatoriai
DK1668014T3 (da) Kondenserede heterocykliske forbindelser som serotoninreceptormodulatorer
ZA200700684B (en) Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators
DK1756096T3 (da) Indolylderivater som lever-X-receptormodulatorer
DK1891075T3 (da) Tricykliske spiroderivater som CRTH2-modulatorer
DK1863474T3 (da) Hidtil ukendte thiophenderivater som sphingosin-1-phosphat-1-receptoragonister
DK1904477T3 (da) Indol-3-carbonyl-spiro-piperodom-derivater som V1A-receptorantagonister
DK2094658T3 (da) Tetrahydrocyclopenta[B]indolforbindelser som androgenreceptormodulatorer
DK1809624T3 (da) Pyrimidinsulfonamidderivater som kemokinreceptor-modulatorer
DK1928845T3 (da) Aminodiazepiner som toll-lignende receptor-modulatorer
NO20051042L (no) Pyrimidylsulfonamidderivater som kemokinreseptormodulatorer
DK1761519T3 (da) Indolderivater som histaminreceptorantagonister
DK2091949T3 (da) Indolderivater som S1P1-receptor agonister
DK1833799T3 (da) 3-phenyl-pyrazol derivater, som modulatorer af 5-HT-2a-serotonin receptor nyttig til behandlingen af sygdomme relateret hertil
DK1656345T3 (da) Cykliske derivater som modulatorer af chemokinreceptoraktivitet
DK1940797T3 (da) 8-substituerede benzodiazepiner som toll-like receptor- modulatorer
DK1856110T3 (da) Oxyindol derivater som 5HT4-receptor agonister
DK1796663T3 (da) Tricykliske heteroaryl-piperaziner, pyrrolidiner og azetidiner som serotonin-receptor-modulatorer
DK2176220T3 (da) Pyrrolidin-2-on-derivater som androgenreceptormodulatorer.
DK2195311T3 (da) Pyridinderivater som S1P1/EDG1-receptormodulatorer
DK1833791T3 (da) 2,3,4,9-tetrahydor-1H-carbazolderivater som CRTH2 receptorantagonister
DK1928821T3 (da) Carboxamidderivater som muscarinreceptorantagonister
EP1799640A4 (en) AS SEROTONINSELECTIVE ACTIVE SUBSTANCES SUITABLE INDOL COMPOUNDS
DK1912976T3 (da) Indol-3-YL-carbonyl-piperidin-benzoimidazolderivater som V1A-receptorantagonister

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application