DK1809624T3 - Pyrimidinsulfonamidderivater som kemokinreceptor-modulatorer - Google Patents
Pyrimidinsulfonamidderivater som kemokinreceptor-modulatorerInfo
- Publication number
- DK1809624T3 DK1809624T3 DK05773278.6T DK05773278T DK1809624T3 DK 1809624 T3 DK1809624 T3 DK 1809624T3 DK 05773278 T DK05773278 T DK 05773278T DK 1809624 T3 DK1809624 T3 DK 1809624T3
- Authority
- DK
- Denmark
- Prior art keywords
- receptor modulators
- sulphonamide derivatives
- chemokin receptor
- pyrimidine sulphonamide
- pyrimidine
- Prior art date
Links
Classifications
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0419235A GB0419235D0 (en) | 2004-08-28 | 2004-08-28 | Compounds |
GB0502544A GB0502544D0 (en) | 2005-02-08 | 2005-02-08 | Compounds |
PCT/GB2005/003257 WO2006024823A1 (en) | 2004-08-28 | 2005-08-23 | Pyrimidine sulphonamide derivatives as chemokine receptor modulators |
Publications (1)
Publication Number | Publication Date |
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DK1809624T3 true DK1809624T3 (da) | 2014-01-20 |
Family
ID=35549576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05773278.6T DK1809624T3 (da) | 2004-08-28 | 2005-08-23 | Pyrimidinsulfonamidderivater som kemokinreceptor-modulatorer |
Country Status (28)
Country | Link |
---|---|
US (5) | US7838675B2 (da) |
EP (3) | EP2301933A1 (da) |
JP (3) | JP4795352B2 (da) |
KR (1) | KR101280095B1 (da) |
CN (1) | CN102796081B (da) |
AR (1) | AR050617A1 (da) |
AU (1) | AU2005279045B2 (da) |
BR (1) | BRPI0514735B8 (da) |
CA (1) | CA2578441C (da) |
CY (1) | CY1114803T1 (da) |
DK (1) | DK1809624T3 (da) |
ES (1) | ES2442678T3 (da) |
HK (1) | HK1103742A1 (da) |
HR (1) | HRP20140023T1 (da) |
IL (1) | IL181241A0 (da) |
ME (1) | ME01620B (da) |
MX (1) | MX2007002240A (da) |
MY (1) | MY148125A (da) |
NO (1) | NO338749B1 (da) |
NZ (1) | NZ553335A (da) |
PL (1) | PL1809624T3 (da) |
PT (1) | PT1809624E (da) |
RS (1) | RS53145B (da) |
RU (1) | RU2408587C2 (da) |
SI (1) | SI1809624T1 (da) |
TW (1) | TWI369983B (da) |
UY (1) | UY29085A1 (da) |
WO (1) | WO2006024823A1 (da) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6262286A (ja) * | 1985-09-13 | 1987-03-18 | 株式会社東芝 | 沸騰水型原子炉炉心 |
GB0217431D0 (en) | 2002-07-27 | 2002-09-04 | Astrazeneca Ab | Novel compounds |
JP2007538054A (ja) | 2004-05-19 | 2007-12-27 | ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 肥満および関係する病気の予防または治療のためのn−スルファモイル−n′−アリールピペラジンを含有する薬剤 |
CN102796081B (zh) | 2004-08-28 | 2015-04-22 | 阿斯利康(瑞典)有限公司 | 作为趋化因子受体调节剂的嘧啶磺酰胺衍生物 |
EP1891063B1 (en) | 2005-05-10 | 2012-07-25 | Vertex Pharmaceuticals, Inc. | Bicyclic derivatives as modulators of ion channels |
EP2099444A4 (en) | 2006-12-14 | 2012-11-07 | Nps Pharma Inc | USE OF D-SERIN DERIVATIVES FOR THE TREATMENT OF ANTIBODIES |
WO2008135786A1 (en) * | 2007-05-04 | 2008-11-13 | Astrazeneca Ab | Amino-thiazolyl- pyrimidine derivatives and their use for the treatment of cancer |
WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
RU2011101661A (ru) * | 2008-07-16 | 2012-08-27 | Астразенека Аб (Se) | Пиримидилсульфонамидное производное и его применение для лечения хемокин-опосредованных заболеваний |
AR076601A1 (es) | 2009-05-21 | 2011-06-22 | Chlorion Pharma Inc | Pirimidinas como agentes terapeuticos |
AR080375A1 (es) | 2010-03-05 | 2012-04-04 | Sanofi Aventis | Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida |
US8748603B2 (en) * | 2010-07-13 | 2014-06-10 | Astrazeneca Ab | Crystalline forms of N-[2-[[(2,3-difluorophenyl)methyl]THIO]-6-{[(1R,2S)-2,3-dihydroxy-1-methylpropyl]oxy}-4-pyrimidinyl]-1-azetidinesulfonamide |
JP6006308B2 (ja) * | 2011-07-12 | 2016-10-12 | アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag | ケモカイン受容体モジュレーターとしてのn−(6−((2r,3s)−3,4−ジヒドロキシブタン−2−イルオキシ)−2−(4−フルオロベンジルチオ)ピリミジン−4−イル)−3−メチルアゼチジン−1−スルホンアミド |
TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
PL3263133T3 (pl) | 2015-02-27 | 2020-10-05 | Kyushu University, National University Corporation | Związek pirydynonu i jego zastosowanie |
CA3017345A1 (en) * | 2016-03-11 | 2017-09-14 | Ardea Biosciences, Inc. | Cxcr-2 inhibitors for treating crystal arthropathy disorders |
US10660909B2 (en) | 2016-11-17 | 2020-05-26 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
WO2019165315A1 (en) | 2018-02-23 | 2019-08-29 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists alone or in combination |
WO2023028077A1 (en) | 2021-08-24 | 2023-03-02 | Genentech, Inc. | Sodium channel inhibitors and methods of designing same |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2540356A (en) * | 1949-03-12 | 1951-02-06 | Sharp & Dohme Inc | Sulfonamide derivatives |
GB866843A (en) * | 1958-12-08 | 1961-05-03 | Ici Ltd | Sulphonamidopyrimidines |
NL279406A (da) * | 1961-06-16 | |||
NL302745A (da) | 1962-12-29 | |||
US3457278A (en) * | 1964-10-15 | 1969-07-22 | Geigy Chem Corp | Cyclopropyl-4-sulfanilamido-pyrimidines |
US3452018A (en) * | 1966-08-29 | 1969-06-24 | American Home Prod | 1 - (2 - substituted - 6 - arylsulfonamidopyrimidin - 4 - yl)pyridinium hydroxide inner salts |
US3673184A (en) * | 1970-09-02 | 1972-06-27 | Dainippon Pharmaceutical Co | Certain 2-substituted-5,8-dihydro-5-oxopyrido{8 2,3-d{9 pyrimidine-6-carboxylic acid derivatives |
JPS61118372A (ja) | 1984-11-12 | 1986-06-05 | Nippon Mektron Ltd | 新規ピリミジン誘導体およびその製造法 |
JPS6442295A (en) | 1987-08-10 | 1989-02-14 | Seiko Epson Corp | Memory card mounting structure |
JPH03197467A (ja) | 1989-12-26 | 1991-08-28 | Nippon Kayaku Co Ltd | ピリミジノン誘導体その製法及びそれを有効成分とする殺虫・殺ダニ剤 |
WO1991015209A1 (en) | 1990-03-30 | 1991-10-17 | Merck & Co., Inc. | Substituted pyrimidines, pyrimidinones and pyridopyrimidines |
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
EP0880508B1 (en) | 1996-02-13 | 2003-04-16 | AstraZeneca AB | Quinazoline derivatives as vegf inhibitors |
IL125954A (en) | 1996-03-05 | 2003-06-24 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments having an antiangiogenic and/or vascular permeability reducing effect |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
IL137922A0 (en) | 1998-02-17 | 2001-10-31 | Tularik Inc | Anti-viral pyrimidine derivatives |
SE9802729D0 (sv) | 1998-08-13 | 1998-08-13 | Astra Pharma Prod | Novel Compounds |
GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
AU5108000A (en) | 1999-06-10 | 2001-01-02 | Yamanouchi Pharmaceutical Co., Ltd. | Novel nitrogen-contaiing heterocyclic derivatives or salts thereof |
SE9903544D0 (sv) | 1999-10-01 | 1999-10-01 | Astra Pharma Prod | Novel compounds |
GB2359078A (en) | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
JP2003522191A (ja) | 2000-02-11 | 2003-07-22 | アストラゼネカ・アクチエボラーグ | ケモカイン受容体活性のモジュレーターとしてのピリミジン化合物およびそれらの使用 |
JP2003535078A (ja) | 2000-05-31 | 2003-11-25 | アストラゼネカ アクチボラグ | 血管損傷活性のあるインドール誘導体 |
WO2002008213A1 (en) | 2000-07-07 | 2002-01-31 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as angiogenesis inhibitors |
BR0112224A (pt) | 2000-07-07 | 2003-06-10 | Angiogene Pharm Ltd | Composto, composição farmacêutica, uso de um composto ou de um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo, e, processo para preparar um composto |
BR0114082A (pt) | 2000-09-25 | 2003-07-22 | Actelion Pharmaceuticals Ltd | Compostos, composições farmacêuticas, uso de um ou mais compostos, e, processo para a fabricação de composições farmacêuticas |
US20030130264A1 (en) | 2001-02-16 | 2003-07-10 | Tularik Inc. | Methods of using pyrimidine-based antiviral agents |
CA2465711A1 (en) * | 2001-11-07 | 2003-05-15 | F. Hoffmann-La Roche Ag | Aminopyrimidines and pyridines |
TWI328007B (en) | 2002-01-16 | 2010-08-01 | Astrazeneca Ab | Novel compounds |
TWI314928B (en) | 2002-02-28 | 2009-09-21 | Novartis A | 5-phenylthiazole derivatives and use as pi3 kinase inhibitors |
MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
GB0217431D0 (en) | 2002-07-27 | 2002-09-04 | Astrazeneca Ab | Novel compounds |
ES2295685T3 (es) | 2002-08-24 | 2008-04-16 | Astrazeneca Ab | Derivados de pirimidina como moduladores de la actividad del receptor de quimioquinas. |
CN102796081B (zh) | 2004-08-28 | 2015-04-22 | 阿斯利康(瑞典)有限公司 | 作为趋化因子受体调节剂的嘧啶磺酰胺衍生物 |
RU2011101661A (ru) | 2008-07-16 | 2012-08-27 | Астразенека Аб (Se) | Пиримидилсульфонамидное производное и его применение для лечения хемокин-опосредованных заболеваний |
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