ATE396254T1 - Auf produktsezernierung beruhende verfahren zur aufreinigung von zellen - Google Patents

Auf produktsezernierung beruhende verfahren zur aufreinigung von zellen

Info

Publication number
ATE396254T1
ATE396254T1 AT05727754T AT05727754T ATE396254T1 AT E396254 T1 ATE396254 T1 AT E396254T1 AT 05727754 T AT05727754 T AT 05727754T AT 05727754 T AT05727754 T AT 05727754T AT E396254 T1 ATE396254 T1 AT E396254T1
Authority
AT
Austria
Prior art keywords
cells
light
property
product
population
Prior art date
Application number
AT05727754T
Other languages
English (en)
Inventor
Manfred R Koller
Elie G Hanania
Annabeth Fieck
Timothy Eisfeld
Original Assignee
Cyntellect Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cyntellect Inc filed Critical Cyntellect Inc
Application granted granted Critical
Publication of ATE396254T1 publication Critical patent/ATE396254T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves

Landscapes

  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT05727754T 2004-03-15 2005-03-14 Auf produktsezernierung beruhende verfahren zur aufreinigung von zellen ATE396254T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/801,931 US7425426B2 (en) 2004-03-15 2004-03-15 Methods for purification of cells based on product secretion

Publications (1)

Publication Number Publication Date
ATE396254T1 true ATE396254T1 (de) 2008-06-15

Family

ID=34920875

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05727754T ATE396254T1 (de) 2004-03-15 2005-03-14 Auf produktsezernierung beruhende verfahren zur aufreinigung von zellen

Country Status (8)

Country Link
US (3) US7425426B2 (de)
EP (1) EP1725653B1 (de)
JP (2) JP4728319B2 (de)
AT (1) ATE396254T1 (de)
AU (1) AU2005224624B2 (de)
CA (1) CA2559736C (de)
DE (1) DE602005006985D1 (de)
WO (1) WO2005090555A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6753161B2 (en) * 1997-03-27 2004-06-22 Oncosis Llc Optoinjection methods
WO2001040454A1 (en) 1999-11-30 2001-06-07 Oncosis Method and apparatus for selectively targeting specific cells within a cell population
WO2002037938A2 (en) 2000-10-24 2002-05-16 Oncosis Llc Method and device for selectively targeting cells within a three -dimensional specimen
US20050095578A1 (en) * 2003-10-31 2005-05-05 Koller Manfred R. Method and apparatus for cell permeabilization
US7425426B2 (en) * 2004-03-15 2008-09-16 Cyntellect, Inc. Methods for purification of cells based on product secretion
KR20110106436A (ko) 2009-01-09 2011-09-28 신텔렉트 인코포레이티드 세포의 유전적 분석
US8788213B2 (en) 2009-01-12 2014-07-22 Intrexon Corporation Laser mediated sectioning and transfer of cell colonies
US10416165B2 (en) 2015-08-10 2019-09-17 National University Corporation University Of Toyama Method for producing antigen specific monoclonal antibody
PL413909A1 (pl) * 2015-09-15 2017-03-27 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Sposób detekcji i selekcji komórek hybrydomalnych produkujących pożądane przeciwciała
JP6541160B2 (ja) 2017-02-13 2019-07-10 株式会社片岡製作所 細胞処理装置および対象物の処理方法
JP6532063B2 (ja) 2017-02-13 2019-06-19 株式会社片岡製作所 細胞処理装置
JP6574028B1 (ja) 2018-06-29 2019-09-11 株式会社片岡製作所 細胞処理装置および細胞のレーザ処理方法

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3674926A (en) * 1968-10-15 1972-07-04 Reynolds Metals Co Feature counter with improved masking and grey level detection
US3864571A (en) 1971-02-10 1975-02-04 Wheeler International Inc Method and Apparatus for Automatically, Identifying and Counting Various Cells in Body Fluids
US4000417A (en) * 1975-08-25 1976-12-28 Honeywell Inc. Scanning microscope system with automatic cell find and autofocus
JPS5391754A (en) * 1977-01-21 1978-08-11 Canon Inc Scannint type photo detector
JPS53135660A (en) * 1977-04-30 1978-11-27 Olympus Optical Co Ltd Fluorescent photometric microscope using laser light
US4803992A (en) * 1980-10-28 1989-02-14 Lemelson Jerome H Electro-optical instruments and methods for producing same
US4395397A (en) * 1981-09-17 1983-07-26 Sidney Farber Cancer Institute, Inc. Apparatus and method for killing unwanted cells
US5272081A (en) * 1982-05-10 1993-12-21 Bar-Ilan University System and methods for cell selection
US4629687A (en) * 1982-07-29 1986-12-16 Board Of Trustees Of Michigan State University Positive selection sorting of cells
US4624915A (en) * 1982-07-29 1986-11-25 Board Of Trustees Of Michigan State University Positive selection sorting of cells
US4532402A (en) * 1983-09-02 1985-07-30 Xrl, Inc. Method and apparatus for positioning a focused beam on an integrated circuit
JPS6083584A (ja) * 1983-10-13 1985-05-11 Rikagaku Kenkyusho 生細胞内への物質移入法
US5103660A (en) * 1984-04-23 1992-04-14 Johnson Virgil T Removable steering wheel device, and methods of constructing and utilizing same
US4998284A (en) * 1987-11-17 1991-03-05 Cell Analysis Systems, Inc. Dual color camera microscope and methodology for cell staining and analysis
DE3708511A1 (de) * 1987-03-16 1988-09-29 Kratzer Michael Einrichtung zur selektiven zerstoerung von zellen
US5188633A (en) * 1987-03-16 1993-02-23 Michael Kratzer Device for selective destruction of cells
JPH07122902B2 (ja) 1987-04-17 1995-12-25 株式会社日立製作所 細胞位置検出装置
US4950592A (en) * 1987-05-12 1990-08-21 Eastman Kodak Company Blend of monoclonal antibodies
HU204856B (en) 1987-08-12 1992-02-28 Orszagos Mueszaki Fejlesztesi Process for releasing cell mixtures and tissues from undesired populations and for producing monoclonal antibody - hematoporphyrin conjugates
US5121436A (en) * 1987-08-14 1992-06-09 International Remote Imaging Systems, Inc. Method and apparatus for generating a plurality of parameters of an object in a field of view
US4965725B1 (en) * 1988-04-08 1996-05-07 Neuromedical Systems Inc Neural network based automated cytological specimen classification system and method
US5109276A (en) * 1988-05-27 1992-04-28 The University Of Connecticut Multi-dimensional multi-spectral imaging system
DE3836716A1 (de) * 1988-10-28 1990-05-03 Zeiss Carl Fa Verfahren zur auswertung von zellbildern
US5089384A (en) * 1988-11-04 1992-02-18 Amoco Corporation Method and apparatus for selective cell destruction using amplified immunofluorescence
JPH02168160A (ja) * 1988-12-22 1990-06-28 Omron Tateisi Electron Co 細胞選別装置
US6099522A (en) * 1989-02-06 2000-08-08 Visx Inc. Automated laser workstation for high precision surgical and industrial interventions
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5072382A (en) 1989-10-02 1991-12-10 Kamentsky Louis A Methods and apparatus for measuring multiple optical properties of biological specimens
DE59004780D1 (de) * 1989-12-22 1994-04-07 Asea Brown Boveri Faseroptischer Sensor.
US5093866A (en) * 1990-02-09 1992-03-03 Hamilton Equine Associates Limited Fluorescence and motility characterization system for cells, bacteria, and particles in fluids
US5202230A (en) * 1990-09-07 1993-04-13 Kamentsky Louis A Methods of detecting cut cells in a tissue section
US5235522A (en) * 1990-10-10 1993-08-10 Cell Analysis Systems, Inc. Method and apparatus for automated analysis of biological specimens
US5257182B1 (en) * 1991-01-29 1996-05-07 Neuromedical Systems Inc Morphological classification system and method
US5784162A (en) * 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
EP0501688A1 (de) * 1991-02-27 1992-09-02 Hitachi, Ltd. Apparat und Methode zur Einspiegelung eines Laserstrahls in einen Mikroskopstrahlengang
US5790710A (en) * 1991-07-12 1998-08-04 Jeffrey H. Price Autofocus system for scanning microscopy
US5548661A (en) 1991-07-12 1996-08-20 Price; Jeffrey H. Operator independent image cytometer
US5428690A (en) * 1991-09-23 1995-06-27 Becton Dickinson And Company Method and apparatus for automated assay of biological specimens
CA2077781A1 (en) 1991-09-23 1993-03-24 James W. Bacus Method and apparatus for automated assay of biological specimens
US5298963A (en) * 1992-02-26 1994-03-29 Mitsui Mining & Smelting Co., Ltd. Apparatus for inspecting the surface of materials
US6007814A (en) * 1992-06-15 1999-12-28 Sloan-Kettering Institute For Cancer Research Therapeutic uses of the hypervariable region of monoclonal antibody M195 and constructs thereof
JP3099049B2 (ja) 1992-07-29 2000-10-16 農林水産省果樹試験場長 電気的細胞融合及び電気的核酸導入のための大量処理用電極
JP3120387B2 (ja) * 1992-08-04 2000-12-25 ユニデン株式会社 コードレス電話装置
RU2054486C1 (ru) 1992-09-01 1996-02-20 Валерий Георгиевич Петухов Способ идентификации микроорганизмов
US5674698A (en) 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5450463A (en) * 1992-12-25 1995-09-12 Olympus Optical Co., Ltd. X-ray microscope
CA2102884A1 (en) * 1993-03-04 1994-09-05 James J. Wynne Dental procedures and apparatus using ultraviolet radiation
US5422720A (en) * 1993-07-21 1995-06-06 Becton Dickinson And Company Blood culture sensor station utilizing two distinct light sources
US5995645A (en) 1993-08-18 1999-11-30 Applied Spectral Imaging Ltd. Method of cancer cell detection
US5878746A (en) 1993-08-25 1999-03-09 Lemelson; Jerome H. Computerized medical diagnostic system
US5381224A (en) * 1993-08-30 1995-01-10 A. E. Dixon Scanning laser imaging system
US6251100B1 (en) * 1993-09-24 2001-06-26 Transmedica International, Inc. Laser assisted topical anesthetic permeation
EP0662512A3 (de) 1993-12-20 1997-01-15 Becton Dickinson Co Menschliche hämatopoietische Stammzellen.
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US5932872A (en) * 1994-07-01 1999-08-03 Jeffrey H. Price Autofocus system for scanning microscopy having a volume image formation
US5795755A (en) * 1994-07-05 1998-08-18 Lemelson; Jerome H. Method of implanting living cells by laser poration at selected sites
US5523543A (en) * 1994-09-09 1996-06-04 Litel Instruments Laser ablation control system and method
WO1996009600A1 (en) * 1994-09-20 1996-03-28 Neopath, Inc. Apparatus for identification and integration of multiple cell patterns
US5552605A (en) 1994-11-18 1996-09-03 Picker International, Inc. Motion correction based on reprojection data
WO1996018205A1 (en) * 1994-12-08 1996-06-13 Molecular Dynamics, Inc. Fluorescence imaging system employing a macro scanning objective
JP3077539B2 (ja) * 1994-12-22 2000-08-14 松下電器産業株式会社 レーザ加工方法
US5713364A (en) 1995-08-01 1998-02-03 Medispectra, Inc. Spectral volume microprobe analysis of materials
DE19529371C3 (de) 1995-08-10 2003-05-28 Nmi Univ Tuebingen Mikroelektroden-Anordnung
US6148096A (en) * 1995-09-15 2000-11-14 Accumed International, Inc. Specimen preview and inspection system
US6040139A (en) * 1995-09-19 2000-03-21 Bova; G. Steven Laser cell purification system
US5732150A (en) * 1995-09-19 1998-03-24 Ihc Health Services, Inc. Method and system for multiple wavelength microscopy image analysis
JPH10512959A (ja) * 1995-09-19 1998-12-08 コーネル・リサーチ・ファンデーション・インコーポレイテッド 多光子レーザ顕微鏡法
US6215892B1 (en) * 1995-11-30 2001-04-10 Chromavision Medical Systems, Inc. Method and apparatus for automated image analysis of biological specimens
US5646411A (en) * 1996-02-01 1997-07-08 Molecular Dynamics, Inc. Fluorescence imaging system compatible with macro and micro scanning objectives
DE69721993T2 (de) * 1996-04-25 2004-02-19 The Gleason Works Schneidwerkzeug für verzahnte gegenstände
US5750356A (en) * 1996-05-31 1998-05-12 Anergen, Inc. Method for monitoring T cell reactivity
US5952651A (en) * 1996-06-10 1999-09-14 Moritex Corporation Laser manipulation apparatus and cell plate used therefor
US6122396A (en) * 1996-12-16 2000-09-19 Bio-Tech Imaging, Inc. Method of and apparatus for automating detection of microorganisms
US5995143A (en) * 1997-02-07 1999-11-30 Q3Dm, Llc Analog circuit for an autofocus microscope system
US6759206B1 (en) 1997-02-27 2004-07-06 Cellomics, Inc. System for cell-based screening
US6753161B2 (en) * 1997-03-27 2004-06-22 Oncosis Llc Optoinjection methods
US6534308B1 (en) 1997-03-27 2003-03-18 Oncosis, Llc Method and apparatus for selectively targeting specific cells within a mixed cell population
US5874266A (en) * 1997-03-27 1999-02-23 Palsson; Bernhard O. Targeted system for removing tumor cells from cell populations
WO1998052016A1 (en) 1997-05-09 1998-11-19 Morphometrix Technologies Inc. Multi-spectral imaging system and method for cytology
US5981268A (en) 1997-05-30 1999-11-09 Board Of Trustees, Leland Stanford, Jr. University Hybrid biosensors
US6326489B1 (en) 1997-08-05 2001-12-04 Howard Hughes Medical Institute Surface-bound, bimolecular, double-stranded DNA arrays
AU750395B2 (en) * 1997-09-30 2002-07-18 Yale University A method for selectively controlling membrane protein display and protein secretion in eukaryotic cells
JP3735190B2 (ja) * 1997-10-28 2006-01-18 オリンパス株式会社 走査型サイトメータ
US6005256A (en) * 1998-02-12 1999-12-21 Raytheon Company Method and apparatus for performing cell analysis based on simultaneous multiple marker emissions from neoplasia (CASMMEN)
US6156576A (en) 1998-03-06 2000-12-05 The Regents Of The University Of California Fast controllable laser lysis of cells for analysis
US6642018B1 (en) * 1998-03-27 2003-11-04 Oncosis Llc Method for inducing a response in one or more targeted cells
US6298264B1 (en) * 1998-08-31 2001-10-02 Duke University Apparatus and method for macromolecule delivery into living cells
AU2150300A (en) 1998-12-07 2000-06-26 Acacia Biosciences Inc. Multi-channel electrode arrays
US6424863B1 (en) * 1999-03-26 2002-07-23 Stephen T. Flock Delivery of pharmaceutical compounds and collection of biomolecules using electromagnetic energy and uses thereof
US6381224B1 (en) * 1999-03-31 2002-04-30 Motorola, Inc. Method and apparatus for controlling a full-duplex communication system
WO2001040454A1 (en) 1999-11-30 2001-06-07 Oncosis Method and apparatus for selectively targeting specific cells within a cell population
WO2002037938A2 (en) * 2000-10-24 2002-05-16 Oncosis Llc Method and device for selectively targeting cells within a three -dimensional specimen
US6509166B1 (en) * 2000-11-28 2003-01-21 Robert A. Levine Detection and quantification of one or more target analytes in a sample using spatially localized analyte reproduction
JP2002325572A (ja) * 2000-12-25 2002-11-12 Univ Osaka 外来物質の導入方法
EP1423505A2 (de) * 2001-08-06 2004-06-02 Vanderbilt University Vorrichtung und verfahren zur überwachung des zustands wenigstens einer zelle
JP2003076569A (ja) 2001-08-31 2003-03-14 Nippon Signal Co Ltd:The バス同期２重系コンピュータ
US6995143B2 (en) * 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
JP2003259076A (ja) 2002-03-04 2003-09-12 Ricoh Co Ltd 通信端末装置
US20050221325A1 (en) * 2002-05-22 2005-10-06 Greg Thill Detection of secreted polypeptides
US20040082017A1 (en) * 2002-08-14 2004-04-29 Boehringer Ingelheim Phamaceuticals, Inc. Methods and compositions for targeting secretory lysosomes
EP1664774A4 (de) * 2003-08-29 2007-06-27 Centocor Inc Schneller weg zum erhalten von säugerzellklonen mit hoher expression unter verwendung einer methylcellulose und immunpräzipitation-screening-verfahren
US20050095578A1 (en) * 2003-10-31 2005-05-05 Koller Manfred R. Method and apparatus for cell permeabilization
US7425426B2 (en) 2004-03-15 2008-09-16 Cyntellect, Inc. Methods for purification of cells based on product secretion
TWI270362B (en) 2004-12-28 2007-01-11 Ind Tech Res Inst Cell subcloning device
US7999161B2 (en) 2005-01-22 2011-08-16 Alexander Oraevsky Laser-activated nanothermolysis of cells
US8785193B2 (en) 2006-09-14 2014-07-22 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Dissection tool and methods of use
US8338166B2 (en) 2007-01-04 2012-12-25 Lawrence Livermore National Security, Llc Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
KR20110106436A (ko) 2009-01-09 2011-09-28 신텔렉트 인코포레이티드 세포의 유전적 분석
US8788213B2 (en) 2009-01-12 2014-07-22 Intrexon Corporation Laser mediated sectioning and transfer of cell colonies

Also Published As

Publication number Publication date
EP1725653A1 (de) 2006-11-29
US8236521B2 (en) 2012-08-07
US20050202558A1 (en) 2005-09-15
US20080014606A1 (en) 2008-01-17
DE602005006985D1 (de) 2008-07-03
US7425426B2 (en) 2008-09-16
US20100136683A1 (en) 2010-06-03
JP2007529221A (ja) 2007-10-25
JP4728319B2 (ja) 2011-07-20
US7622274B2 (en) 2009-11-24
WO2005090555A1 (en) 2005-09-29
JP2011097957A (ja) 2011-05-19
CA2559736A1 (en) 2005-09-29
AU2005224624B2 (en) 2009-12-03
AU2005224624A1 (en) 2005-09-29
EP1725653B1 (de) 2008-05-21
CA2559736C (en) 2014-05-13
JP5580755B2 (ja) 2014-08-27

Similar Documents

Publication Publication Date Title
ATE396254T1 (de) Auf produktsezernierung beruhende verfahren zur aufreinigung von zellen
BRPI0513308A (pt) sistemas e métodos de análise de polìmeros de ácido nucléico e componentes relacionados
UY37994A (es) Moléculas de adn correspondientes a evento transgénico mon88017 y métodos para su detección
BRPI0508299A (pt) sistema livre de produto animal e processo para purificação de uma toxina botulina
CR7966A (es) Metodo y sistema mejorado pata detectar y/o predecir anomalias biologicas, tales como desordenes cerebrales
DK2018441T3 (da) Mærkede mikroorganismer og fremgangsmåde til mærkning
EA200602044A1 (ru) Молекулярно впечатанные полимеры, селективные по отношению к нитрозаминам, и способы их применения
ATE478342T1 (de) Kompakte vorrichtung, zusammensetzungen und verfahren zur reinigung von nukleinsäuren
ATE490306T1 (de) Methoden zur medikamentenaufspürung auf der basis von in vitro differenzierten zellen
BR0206318A (pt) Detecção de analitos
ATE409236T1 (de) Derivatisierte nukleinsäuren und deren verwendung
BRPI0720153A8 (pt) Composições e artigos que contêm uma matriz de polímero reticulada e um líquido ativo imobilizado assim como processos de utilização dos mesmos
ATE527385T1 (de) Mit tumoren assoziierte genetische variationen
WO2006006148A3 (en) Multi mode inspection method and apparatus
TW200636075A (en) Detection of nucleic acid variation by cleavage-amplification method
AR067924A1 (es) Procedimiento de purificacion o de deteccion de una proteina diana
ATE495254T1 (de) Biologisch wirksame moleküle, insbesondere auf grundlage von pna und sirna, verfahren zu deren zellspezifischen aktivierung sowie applikationskit zur verabreichung
ATE463294T1 (de) Verfahren zur konzentration und reinigung von biologischen verbindungen
CO6351824A2 (es) Biomarcadores de destruccion de articulaciones para terapia anti-interleucina -17a de reumatismo inflamatorio
DE602008006254D1 (de) Doppel-oligonukleotid-nukleinsäurenachweisverfahren
JP2011097957A5 (de)
ATE466079T1 (de) Nukleinsäure konstrukten, pharmazeutische kompositionen und methoden für die behandlung von krebs
ATE403151T1 (de) Trägerplatte zur durchführung funktioneller tests an biologischen zellen sowie verfahren zur beschichtung der trägerplatte
NO20080908L (no) Stasjonaer stotteseng til rensing, separering, pavising, modifisering og/eller immoblisering av malenheter og fremgangsmater for anvedelse derav
ATE333521T1 (de) Detektion von vancomycin-resistenten enterococcus-subspezies

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties