ATE409236T1 - Derivatisierte nukleinsäuren und deren verwendung - Google Patents
Derivatisierte nukleinsäuren und deren verwendungInfo
- Publication number
- ATE409236T1 ATE409236T1 AT00950341T AT00950341T ATE409236T1 AT E409236 T1 ATE409236 T1 AT E409236T1 AT 00950341 T AT00950341 T AT 00950341T AT 00950341 T AT00950341 T AT 00950341T AT E409236 T1 ATE409236 T1 AT E409236T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acids
- derivatized nucleic
- sample
- nucleic acid
- derivatized
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14380499P | 1999-07-14 | 1999-07-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE409236T1 true ATE409236T1 (de) | 2008-10-15 |
Family
ID=22505724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00950341T ATE409236T1 (de) | 1999-07-14 | 2000-07-14 | Derivatisierte nukleinsäuren und deren verwendung |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1194592B1 (de) |
| AT (1) | ATE409236T1 (de) |
| AU (1) | AU6345700A (de) |
| CA (1) | CA2379132C (de) |
| DE (1) | DE60040335D1 (de) |
| WO (1) | WO2001006012A1 (de) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060275782A1 (en) | 1999-04-20 | 2006-12-07 | Illumina, Inc. | Detection of nucleic acid reactions on bead arrays |
| US7611869B2 (en) | 2000-02-07 | 2009-11-03 | Illumina, Inc. | Multiplexed methylation detection methods |
| US7582420B2 (en) | 2001-07-12 | 2009-09-01 | Illumina, Inc. | Multiplex nucleic acid reactions |
| WO2002101358A2 (en) * | 2001-06-11 | 2002-12-19 | Illumina, Inc. | Multiplexed detection methods |
| WO2003044216A2 (en) | 2001-11-19 | 2003-05-30 | Parallele Bioscience, Inc. | Multiplex oligonucleotide addition and target amplification |
| US20110151438A9 (en) | 2001-11-19 | 2011-06-23 | Affymetrix, Inc. | Methods of Analysis of Methylation |
| EP1319718A1 (de) * | 2001-12-14 | 2003-06-18 | Keygene N.V. | Hochdurchsatzanalyse und Detektion von mehreren Zielsequenzen |
| US20030235827A1 (en) * | 2002-06-25 | 2003-12-25 | Orchid Biosciences, Inc. | Methods and compositions for monitoring primer extension and polymorphism detection reactions |
| US7595883B1 (en) | 2002-09-16 | 2009-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Biological analysis arrangement and approach therefor |
| CA2499077A1 (en) * | 2002-09-19 | 2004-04-01 | Applera Corporation | Methods and composition for detecting targets |
| JP2006500034A (ja) | 2002-09-19 | 2006-01-05 | アプレラ コーポレイション | 標的を検出するための方法および組成物 |
| GB2414797A (en) * | 2003-01-21 | 2005-12-07 | Guoliang Fu | Quantitative multiplex detection of nucleic acids |
| WO2004065628A1 (en) * | 2003-01-21 | 2004-08-05 | Guoliang Fu | Quantitative multiplex detection of nucleic acids |
| WO2005026389A2 (en) * | 2003-08-29 | 2005-03-24 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Ligation-based method of analysis of single nucleotide polymorphisms on genomic dna |
| ES2539784T3 (es) * | 2003-09-02 | 2015-07-06 | Keygene N.V. | Procedimientos basados en OLA para la detección de secuencias de ácidos nucleicos objetivo |
| EP1689879A4 (de) * | 2003-11-12 | 2008-08-27 | Geneohm Sciences Inc | Nukleinsäurehybridisierungsverfahren |
| US20060019289A1 (en) * | 2004-06-30 | 2006-01-26 | Applera Corporation | Compositions and methods for gene expression analysis |
| WO2006005081A2 (en) * | 2004-06-30 | 2006-01-12 | Applera Corporation | Compositions and methods for identifying nucleotides in polynucleotide sequences |
| WO2010057525A1 (en) * | 2008-11-19 | 2010-05-27 | Fondazione Parco Tecnologico Padano | Oligonucleotide primers for nucleotide indexing of polymorphic pcr products and methods for their use |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| EP2674492B1 (de) * | 2011-02-10 | 2018-04-04 | Mitsubishi Chemical Corporation | Verfahren zum nachweis von nukleinsäuren |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| EP3225698B1 (de) | 2011-09-06 | 2019-07-31 | Gen-Probe Incorporated | Geschlossene nukleinsäurestrukturen |
| DE102011055247A1 (de) | 2011-11-10 | 2013-05-16 | Albert-Ludwigs-Universität Freiburg | Multianalyt-Reportersystem |
| ES3019910T3 (en) | 2012-10-17 | 2025-05-21 | 10X Genomics Sweden Ab | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| CN105473744B (zh) | 2013-06-25 | 2020-06-19 | 普罗格诺西斯生物科学公司 | 采用微流控装置的空间编码生物分析 |
| GB2536446B (en) * | 2015-03-17 | 2020-06-03 | Salisbury Nhs Found Trust | PCR method |
| CN113186256B (zh) | 2015-04-10 | 2025-05-23 | 十程基因技术瑞典公司 | 生物样本的空间区别、多重核酸分析 |
| WO2018186930A1 (en) * | 2017-04-06 | 2018-10-11 | MyOmicsDx, Inc | Method and kit for constructing nucleic acid library |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| CN113767177B (zh) | 2018-12-10 | 2025-01-14 | 10X基因组学有限公司 | 生成用于空间分析的捕获探针 |
| US12529094B2 (en) | 2018-12-10 | 2026-01-20 | 10X Genomics, Inc. | Imaging system hardware |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| WO2020243579A1 (en) | 2019-05-30 | 2020-12-03 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| WO2021092433A2 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
| US12241890B2 (en) | 2019-12-23 | 2025-03-04 | 10X Genomics, Inc. | Methods for generating barcoded nucleic acid molecules using fixed cells |
| FI3891300T3 (fi) | 2019-12-23 | 2023-05-10 | 10X Genomics Inc | Menetelmät spatiaalista analyysiä varten rna-templatoitua ligaatiota käyttäen |
| US12365942B2 (en) | 2020-01-13 | 2025-07-22 | 10X Genomics, Inc. | Methods of decreasing background on a spatial array |
| US12405264B2 (en) | 2020-01-17 | 2025-09-02 | 10X Genomics, Inc. | Electrophoretic system and method for analyte capture |
| US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
| US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
| US20210230681A1 (en) | 2020-01-24 | 2021-07-29 | 10X Genomics, Inc. | Methods for spatial analysis using proximity ligation |
| US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
| US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
| US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
| US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
| WO2021158925A1 (en) | 2020-02-07 | 2021-08-12 | 10X Genomics, Inc. | Quantitative and automated permeabilization performance evaluation for spatial transcriptomics |
| US12281357B1 (en) | 2020-02-14 | 2025-04-22 | 10X Genomics, Inc. | In situ spatial barcoding |
| US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
| EP4139485B1 (de) | 2020-04-22 | 2023-09-06 | 10X Genomics, Inc. | Verfahren zur räumlichen analyse unter verwendung von gezieltem rna-abbau |
| EP4153775B1 (de) | 2020-05-22 | 2024-07-24 | 10X Genomics, Inc. | Simultane räumlich-zeitliche messung der genexpression und der zellaktivität |
| EP4153776B1 (de) | 2020-05-22 | 2025-03-05 | 10X Genomics, Inc. | Räumliche analyse zur erkennung von sequenzvarianten |
| WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
| US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
| ES2981265T3 (es) | 2020-06-08 | 2024-10-08 | 10X Genomics Inc | Métodos para determinar un margen quirúrgico y métodos de uso del mismo |
| ES2999535T3 (en) | 2020-06-10 | 2025-02-26 | 10X Genomics Inc | Methods for determining a location of an analyte in a biological sample |
| EP4172362B1 (de) | 2020-06-25 | 2024-09-18 | 10X Genomics, Inc. | Räumliche analyse der dna-methylierung |
| US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
| US12209280B1 (en) | 2020-07-06 | 2025-01-28 | 10X Genomics, Inc. | Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis |
| US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
| US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
| US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
| WO2022140028A1 (en) | 2020-12-21 | 2022-06-30 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
| EP4305196B1 (de) | 2021-04-14 | 2025-04-02 | 10X Genomics, Inc. | Verfahren zur messung der fehllokalisierung eines analyten |
| WO2022236054A1 (en) | 2021-05-06 | 2022-11-10 | 10X Genomics, Inc. | Methods for increasing resolution of spatial analysis |
| WO2022256503A1 (en) | 2021-06-03 | 2022-12-08 | 10X Genomics, Inc. | Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis |
| WO2023034489A1 (en) | 2021-09-01 | 2023-03-09 | 10X Genomics, Inc. | Methods, compositions, and kits for blocking a capture probe on a spatial array |
| WO2023086880A1 (en) | 2021-11-10 | 2023-05-19 | 10X Genomics, Inc. | Methods, compositions, and kits for determining the location of an analyte in a biological sample |
| EP4305195A2 (de) | 2021-12-01 | 2024-01-17 | 10X Genomics, Inc. | Verfahren, zusammensetzungen und systeme für verbesserten in-situ-nachweis von analyten und raumanalyse |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5104792A (en) * | 1989-12-21 | 1992-04-14 | The United States Of America As Represented By The Department Of Health And Human Services | Method for amplifying unknown nucleic acid sequences |
| US5846717A (en) * | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
| US5994069A (en) * | 1996-01-24 | 1999-11-30 | Third Wave Technologies, Inc. | Detection of nucleic acids by multiple sequential invasive cleavages |
| US5503980A (en) * | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
| US5422252A (en) * | 1993-06-04 | 1995-06-06 | Becton, Dickinson And Company | Simultaneous amplification of multiple targets |
| US5876924A (en) * | 1994-06-22 | 1999-03-02 | Mount Sinai School Of Medicine | Nucleic acid amplification method hybridization signal amplification method (HSAM) |
| WO1996015271A1 (en) * | 1994-11-16 | 1996-05-23 | Abbott Laboratories | Multiplex ligations-dependent amplification |
| US5985557A (en) * | 1996-01-24 | 1999-11-16 | Third Wave Technologies, Inc. | Invasive cleavage of nucleic acids |
| EP2369007B1 (de) * | 1996-05-29 | 2015-07-29 | Cornell Research Foundation, Inc. | Erkennung von Nukleinsäuresequenz-Unterschieden mittels der gleichzeitigen Ligaseerkennungs- und Polymerasekettenreaktion |
| US5935793A (en) * | 1996-09-27 | 1999-08-10 | The Chinese University Of Hong Kong | Parallel polynucleotide sequencing method using tagged primers |
| WO1998035058A2 (en) * | 1997-02-07 | 1998-08-13 | Ribozyme Pharmaceuticals, Inc. | Improved process for detection and quantification of nucleic acid molecules |
-
2000
- 2000-07-14 AT AT00950341T patent/ATE409236T1/de not_active IP Right Cessation
- 2000-07-14 AU AU63457/00A patent/AU6345700A/en not_active Abandoned
- 2000-07-14 CA CA2379132A patent/CA2379132C/en not_active Expired - Lifetime
- 2000-07-14 WO PCT/US2000/019176 patent/WO2001006012A1/en not_active Ceased
- 2000-07-14 EP EP00950341A patent/EP1194592B1/de not_active Expired - Lifetime
- 2000-07-14 DE DE60040335T patent/DE60040335D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60040335D1 (de) | 2008-11-06 |
| WO2001006012A1 (en) | 2001-01-25 |
| CA2379132C (en) | 2011-05-31 |
| EP1194592A1 (de) | 2002-04-10 |
| AU6345700A (en) | 2001-02-05 |
| EP1194592B1 (de) | 2008-09-24 |
| EP1194592A4 (de) | 2004-12-08 |
| CA2379132A1 (en) | 2001-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |